Theodore Schurr

Theodore Schurr
University of Pennsylvania | UP · Department of Anthropology

Ph.D.

About

286
Publications
70,026
Reads
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10,549
Citations
Citations since 2017
44 Research Items
2291 Citations
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20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
Additional affiliations
July 2001 - December 2012
University of Pennsylvania
January 2000 - February 2012
University of Alberta
Position
  • Baikal Archeology Project
January 1999 - June 2001
SFBR
Position
  • Southwest Foundation for Biomedical Research
Education
September 1991 - May 1998
Emory University
Field of study
  • Biological Anthropology
September 1979 - June 1983
University of Georgia
Field of study
  • Zoology

Publications

Publications (286)
Article
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In this study, we present the results of community-engaged ancient DNA research initiated after the remains of 36 African-descended individuals dating to the late 18th century were unearthed in the port city of Charleston, South Carolina. The Gullah Society of Charleston, along with other Charleston community members, initiated a collaborative geno...
Article
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As a historical nomadic group in Central Asia, Kazaks have mainly inhabited the steppe zone from the Altay Mountains in the East to the Caspian Sea in the West. Fine scale characterization of the genetic profile and population structure of Kazaks would be invaluable for understanding their population history and modeling prehistoric human expansion...
Article
Mitochondrial DNA haplogroup J is the third most frequent haplogroup in modern‐day Scandinavia, although it did not originate there. To infer the genetic history of haplogroup J in Scandinavia, we examined worldwide mitogenome sequences using a maximum‐likelihood phylogenetic approach. Haplogroup J mitogenome sequences were gathered from GenBank (n...
Article
Based on current studies, the incidence of Ewing sarcoma (ES) varies significantly by race and ethnicity, with the disease being most common in patients of European ancestry. However, race/ethnicity has generally been self-reported rather than formally evaluated at a population level using DNA evidence. Additionally, mitochondrial dysfunction is a...
Article
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Micronesia began to be peopled earlier than other parts of Remote Oceania, but the origins of its inhabitants remain unclear. We generated genome-wide data from 164 ancient and 112 modern individuals. Analysis reveals five migratory streams into Micronesia. Three are East Asian related, one is Polynesian, and a fifth is a Papuan source related to m...
Article
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Following publication of the original article [1], it was reported that a key in Fig. 5 contained an error. The colors designating ‘Group A: U5a1’ and ‘Group C: U5b1 and U5b3’ in the key ‘Haplogroup % based on 4 major hierBAPS groupings’ were reversed. The correct Fig. 5 is included in this Correction and the original article [1] has been updated.
Article
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Background We combined an unsupervised learning methodology for analyzing mitogenome sequences with maximum likelihood (ML) phylogenetics to make detailed inferences about the evolution and diversification of mitochondrial DNA (mtDNA) haplogroup U5, which appears at high frequencies in northern Europe. Methods Haplogroup U5 mitogenome sequences we...
Article
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Objective In this study, we investigated the occurrence of papillomavirus (PV) infection in non-human primates (NHPs) in northeastern Argentina. We also explored their evolutionary history and evaluated the co-speciation hypothesis in the context of primate evolution. Methods We obtained DNA samples from 57 individuals belonging to wild and captiv...
Article
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The primary focus of this paper is to examine the extent to which the pattern of Neandertal fire use in southwest France occurred at other times and places during the European Late Pleistocene. In previous studies, both direct and indirect data showed a pattern of limited fire use in layers associated with colder intervals in MIS 4 and 3 and more f...
Article
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Northwest Pakistan has served as a point of entry to South Asia for different populations since ancient times. However, relatively little is known about the population genetic history of the people residing within this region. To better understand human dispersal in the region within the broader history of the subcontinent, we analyzed mtDNA divers...
Chapter
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This study examined Y-chromosome variation in 1614 mestizo Mexican males from different geographic regions to delineate the indigenous and colonial history of Mexico. The findings reveal a great diversity of paternal lineages within Mexican males, as well as a limited number of shared haplotypes among them. Native American haplogroups Q-L54 and Q-M...
Preprint
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Objective: In this study, we investigated the occurrence of papillomavirus (PV) infection in non-human primates (NHP, Platyrrhine) of northeastern Argentina by using broad-spectrum PCR primers at the L1 gene. In addition, we conducted a phylogenetic and coalescence analysis of viral sequences to explore their evolutionary history and evaluate the c...
Article
Background The province of Misiones is considered a region with a high mortality rate due to cervical cancer. To gain insight into this problem, we explored the association between genetic variation in the E6 and E7 oncogenes of HPV16 and the risk of cervical cancer. Methods We studied 160 women with cytological diagnosis of NILM, LSIL and H-SIL/C...
Article
After discovering the first kurgans in the steppes, the archaeologists were faced with the need to determine the social status of buried persons and the relationship between people buried within the same necropolis. Archaeology has developed its methods and criteria for assessing the social status of buried persons, such as the size of the burial k...
Article
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Background While well known for its Viking past, Norway's population history and the influences that have shaped its genetic diversity are less well understood. This is particularly true with respect to its demography, migration patterns, and dialectal regions, despite there being curated historical records for the past several centuries. In this s...
Article
Objectives Mitochondria are critical for the survival of eukaryotic organisms due to their ability to produce cellular energy, which drives virtually all aspects of host biology. However, the effects of mitochondrial DNA (mtDNA) variation in relation to disease etiology and adaptation within contemporary global human populations remains incompletel...
Article
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Objectives Gullah African Americans are descendants of formerly enslaved Africans living in the Sea Islands along the coast of the southeastern U.S., from North Carolina to Florida. Their relatively high numbers and geographic isolation were conducive to the development and preservation of a unique culture that retains deep African features. Althou...
Article
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Native Mexican populations are crucial for understanding the genetic ancestry of Aztec descendants and coexisting ethnolinguistic groups in the Valley of Mexico and elucidating the population dynamics of the prehistoric colonization of the Americas. Mesoamerican societies were multicultural in nature, and also experienced significant admixture duri...
Preprint
Full-text available
Objectives Gullah African Americans are descendants of formerly enslaved Africans living in the Sea Islands along the coast of the southeastern U.S., from North Carolina to Florida. Their relatively high numbers and geographic isolation were conducive to the development and preservation of a unique culture that retains deep African features. Althou...
Article
Full-text available
In 2013, the burials of 36 individuals of putative African ancestry were discovered during renovation of the Gaillard Center in downtown Charleston, South Carolina. The Charleston community facilitated a bioarchaeological and mitogenomic study to gain insights into the lives of these unknown persons, referred to as the Anson Street Ancestors, inclu...
Article
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The strategic location of Pakistan and its presence at the crossroads of Asia has resulted in it playing a central role in both prehistoric and historic human migratory events, thereby linking and facilitating contacts between the inhabitants of the Middle East, Central Asia, China and South Asia. Despite the importance of this region and its inhab...
Article
Background: The use of human and viral genetic markers offers a novel way to study human migration in multiethnic populations of Latin America. Objectives: Our goal was to characterize the genetic diversity and geographical origins of JC Polyomavirus (JCPyV) and the genetic ancestry of mitochondrial DNA (mtDNA) in inhabitants from 25 de Mayo, Mi...
Article
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Objectives: Ancient DNA (aDNA) and standard osteological analyses applied to 11 skeletons at a late17th to early18th century farmstead site in Delaware to investigate the biological and social factors of settlement and slavery in colonial America. Materials and methods: Osteological analysis and mitochondrial DNA (mtDNA) sequencing were conducte...
Article
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Objectives From a genetic perspective, relatively little is known about how mass emigrations of African, European, and Asian peoples beginning in the 16th century affected Indigenous Caribbean populations. Therefore, we explored the impact of serial colonization on the genetic variation of the first Caribbean islanders. Materials and methods Sixty...
Article
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david chitanava From the toponyms of Samegrelo (“sintsa”, “umpia”, “dzaghva”) The paper studies three Hydronyms of Samegrelo, which give important material, in regard to ancient history of the tribes of Iberian-Caucasian unity times residing in the territory in the ancient times and strengthens the opinion about the existence of this unity (IV-III...
Article
Insertions and deletions (indels) are small changes in the nucleotide sequence of a gene or segment of DNA that add or subtract one to several base pairs. Such changes are largely neutral in their effects on genetic function, and add to the overall sequence variation in human and primate populations. Indels occurring in genic regions may affect gen...
Article
The terms “haplotype” and “haplogroup” are used to refer to a set of genetic variants that define individual genotypes and the genetic lineages or clusters to which they belong, based on shared mutations. The mutations used to define haplotypes and haplogroups include single nucleotide polymorphisms (SNPs), indels, and short tandem repeats (STRs),...
Article
For many decades, the term “polymorphism” has been used to describe genetic variants in population genetic studies. A number of different kinds of polymorphisms have been identified during this time, both protein and DNA forms, largely driven by advances in methods for assessing genetic sequence variation. This entry briefly summarizes the history...
Article
Genetic distances are quantitative measures of the genetic divergence between two sequences, individuals, or populations. They provide a relative estimate of the amount of time that has passed since two populations belonged to a single interbreeding group or ancestral population. Such distances also reflect historical relationships between populati...
Article
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Background Misiones Province in northeastern Argentina is considered to be a region with a high prevalence of HPV infection and a high mortality rate due to cervical cancer. The reasons for this epidemiological trend are not completely understood. To gain insight into this problem, we explored the relationship between mitochondrial DNA (mtDNA) ance...
Data
Mitochondrial DNA SNPs haplotypes and haplogroups. Legend: SNPs positions are denoted using the CRS sequence as reference. (DOCX)
Data
Association analysis between mtDNA ancestry and cervical lesions. Legend: aO.R. adjusted by sample center location and nationality (Model II). Significant associations are in boldface. (DOCX)
Data
Association analysis between Pap cytology, mtDNA haplogroups and HPV infection. Legend: O.R. adjusted by socio-demographic variables (Model V). Significant associations are shown in boldface. (DOCX)
Data
Association analysis between mtDNA haplogroups and cervical lesions. Legend: aO.R. adjusted by sample center location and nationality (Model III). Significant associations are in boldface. (DOCX)
Data
Association analysis between Pap cytology, mtDNA ancestry and HPV infection. Legend: aO.R. adjusted by socio-demographic variables (Model IV). Significant associations are in boldface. bIncluding: HPV18, HPV59, HPV45 (specie A7). (DOCX)
Article
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Objectives: In this study, we characterized genetic diversity in the Svans from northwestern Georgia to better understand the phylogeography of their genetic lineages, determine whether genetic diversity in the highland South Caucasus has been shaped by language or geography, and assess whether Svan genetic diversity was structured by regional res...
Article
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Aboriginal Australians represent one of the oldest continuous cultures outside Africa, with evidence indicating that their ancestors arrived in the ancient landmass of Sahul (present-day New Guinea and Australia) ~55 thousand years ago. Genetic studies, though limited, have demonstrated both the uniqueness and antiquity of Aboriginal Australian gen...
Article
Aboriginal Australians are one of the more poorly studied populations from the standpoint of human evolution and genetic diversity. Thus, to investigate their genetic diversity, the possible date of their ancestors’ arrival and their relationships with neighboring populations, we analyzed mitochondrial DNA (mtDNA) diversity in a large sample of Abo...
Article
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Nature Communications 5 : Article number: 3513 10.1038/ncomms4513 ( 2014 ); Published: 29 April 2016 ; Updated: 31 October 2016 This article was published without any competing financial interests statement.
Article
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The human Y chromosome contains highly informative markers for making historical inferences about the pre-Columbian peopling of Americas. However, the scarcity of these markers has limited its use in the inference of shared ancestry and past migrations relevant to the origin of the culturally and biologically diverse Native Americans. To identify n...
Article
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Many single-nucleotide polymorphisms (SNPs) in the non-recombining region of the human Y chromosome have been described in the last decade. High-coverage sequencing has helped to characterize new SNPs, which has in turn increased the level of detail in paternal phylogenies. However, these paternal lineages still provide insufficient information on...
Article
Background: -We hypothesized that endothelial cells having distinct mitochondrial genetic backgrounds would show variation in mitochondrial function and oxidative stress markers concordant with known differential cardiovascular disease susceptibilities. To test this hypothesis, mitochondrial bioenergetics were determined in endothelial cells from...
Article
The Genographic Project is a major international effort to assemble genetic data from populations located around the world and use them to reconstruct the migratory history of our species. A consortium of scientists based at 10 regional centers worked with indigenous human populations from various parts of the world to investigate their genetic his...
Article
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Historical discourses about the Caribbean often chronicle West African and European influence to the general neglect of indigenous people's contributions to the contemporary region. Consequently, demographic histories of Caribbean people prior to and after European contact are not well understood. Although archeological evidence suggests that the L...
Article
The oxytocin (OT) hormone pathway is involved in numerous physiological processes, and one of its receptor genes (OXTR) has been implicated in pair bonding behavior in mammalian lineages. This observation is important for understanding social monogamy in primates, which occurs in only a small subset of taxa, including Azara's owl monkey (Aotus azar...
Article
Based on archeological and genetic data, the Altai-Sayan region appears to be the area from which human populations began expanding eastward toward Beringia some 25,000 years ago, and then much later to the west with the expansion of Turkic- and Mongolic-speaking groups. The initial human expansion into the New World appears to have occurred around...
Data
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Modern humans have occupied New Guinea and the nearby Bismarck and Solomon archipelagos of Island Melanesia for at least 40,000 years. Previous mitochondrial DNA (mtDNA) studies indicated that two common lineages in this region, haplogroups P and Q, were particularly diverse, with the coalescence for P considered significantly older than that for Q...
Article
Human papillomavirus type 16 (HPV16) plays a central role in the development of cervical cancer. Worldwide studies indicate the existence of HPV16 variants that show different geographic distributions and oncogenic potential. Our goal was to describe the genetic variation of HPV16 isolates identified in urban women with different grades of cervical...
Article
Puerto Rico and the surrounding islands rest on the eastern fringe of the Caribbean's Greater Antilles, located less than 100 miles northwest of the Lesser Antilles. Puerto Ricans are genetic descendants of pre-Columbian peoples, as well as peoples of European and African descent through 500 years of migration to the island. To infer these patterns...
Article
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The search for a method that utilizes biological information to predict humans' place of origin has occupied scientists for millennia. Over the past four decades, scientists have employed genetic data in an effort to achieve this goal but with limited success. While biogeographical algorithms using next-generation sequencing data have achieved an a...
Article
Full-text available
The search for a method that utilizes biological information to predict humans’ place of origin has occupied scientists for millennia. Over the past four decades, scientists have employed genetic data in an effort to achieve this goal but with limited success. While biogeographical algorithms using next-generation sequencing data have achieved an a...
Article
Full-text available
Understanding the evolution of mating systems, a central topic in evolutionary biology for more than 50 years, requires examining the genetic consequences of mating and the relationships between social systems and mating systems. Among pair-living mammals, where genetic monogamy is extremely rare, the extent of extra-group paternity rates has been...
Article
Mitochondrial DNA (mtDNA) sequence variation can influence the penetrance of complex diseases and climatic adaptation. While studies in geographically defined human populations suggest mtDNA mutations become fixed when they have conferred metabolic capabilities optimally suited for a specific environment, it has been challenging to definitively ass...
Article
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The human mitochondrial haplogroup C1 has a broad global distribution but is extremely rare in Europe today. Recent ancient DNA evidence has demonstrated its presence in European Mesolithic individuals. Three individuals from the 7,500 year old Mesolithic site of Yuzhnyy Oleni Ostrov, Western Russia, could be assigned to haplogroup C1 based on mito...
Article
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Although paternal care is rare in mammals, males of several primate taxa exhibit high degrees of this behavior. Studies a number of vertebrate species found a positive correlation between prolactin (PRL) levels and paternal care. Studies of maternal care in knockout mice also indicate that the prolactin receptor (PRLR) plays a critical role in the...
Article
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Next-generation DNA sequencing (NGS) technologies have made huge impacts in many fields of biological research, but especially in evolutionary biology. One area where NGS has shown potential is for high-throughput sequencing of complete mtDNA genomes (of humans and other animals). Despite the increasing use of NGS technologies and a better apprecia...
Article
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The Altiplano region of the South American Andes is marked by an inhospitable climate to which the autochthonous human populations adapted and then developed great ancient civilizations, such as the Tiwanaku culture and the Inca Empire. Since pre-Columbian times, different rulers established themselves around the Titicaca and Poopo Lakes. By the ti...
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To determine whether the incidence of and susceptibility to climatic droplet keratopathy (CDK), an acquired, often bilateral degenerative corneal disease, is influenced by the genetic background of the individuals who exhibit the disorder. To determine whether the disease expression was influenced by the genetic ancestry of CDK cases in native Mapu...
Article
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Dysfunctional bioenergetics has emerged as a key feature in many chronic pathologies such as diabetes and cardiovascular disease. This has led to the mitochondrial paradigm in which it has been proposed that mitochondrial DNA (mtDNA) sequence variation contributes to disease susceptibility. In this study we present a novel animal model of mtDNA pol...
Article
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Located in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe and the Mediterranean Basin. Populated since Paleolithic times, the complexity of human movements during the Neolithic, the Me...