Theodore J Angelopoulos

Theodore J Angelopoulos
University of Vermont Medical Center · Rehabilitation and Movement Sciences

Ph.D., MPH

About

245
Publications
43,088
Reads
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3,892
Citations
Additional affiliations
September 2018 - present
University of Vermont Medical Center
Position
  • Chair
August 2015 - August 2018
Emory and Henry College
Position
  • Managing Director
August 2010 - August 2015
University of Central Florida
Position
  • Professor and Director Laboratory of Applied Physiology
Education
August 1986 - April 1990
University of Pittsburgh
Field of study
  • Epidemiology
August 1986 - April 1991
University of Pittsburgh
Field of study
  • Exercise Physiology
January 1983 - April 1986
University of Pittsburgh
Field of study
  • Exercise Physiology

Publications

Publications (245)
Article
Full-text available
Background: Although regular exercise is recommended for preventing and treating overweight/obesity, the most effective exercise type for improving cardiometabolic health in individuals with overweight/obesity remains largely undecided. This network meta-analysis aimed to evaluate and rank the comparative efficacy of 5 exercise modalities on cardio...
Article
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This study examined the dose-response effects of a 1-year hybrid-type, multicomponent interval training programme (DoIT) on various musculoskeletal fitness parameters in inactive overweight and obese adults in a gym setting. Ninety-seven middle-aged (44.8±5.2 years) individuals with overweight/obesity (31.2±5.7 kg/m²) (66% female) were randomly ass...
Article
Full-text available
Background Interleukin‐15 (IL‐15) is a myokine associated with muscle strength, possibly by attenuating protein breakdown. A variant in the alpha‐receptor (IL‐15Rα 1775 A>C, rs2228059) partially modulates the muscle strength and size response to resistance training. We examined if this polymorphism associated with habitual physical activity among E...
Chapter
Cardiovascular disease (CVD) remains the largest source of morbidity and mortality in the United States and elsewhere in the developed world. In the most recent statistics, CVD accounts for 37 % of all mortality in the United States. Nutrition plays a pivotal role in either reducing the risk of cardiovascular disease or increasing it. Nutrition nee...
Chapter
The potential health consequences of consuming added sugars are controversial. It has been alleged that increased consumption of added sugars which contain fructose may be associated with increased risk of obesity, cardiovascular disease (CVD), diabetes (T2D), metabolic syndrome (metS), non-alcoholic fatty liver disease (NAFLD), and various neurolo...
Article
Full-text available
Background The angiotensin‐converting enzyme (ACE) insertion/deletion (I/D) polymorphism (rs4340) (ACE DIP) accounts for half of the variability in plasma ACE concentrations. ACE has been widely studied for its influence on sports performance; however, research on its influence in physical activity is limited and inconsistent. We examined the influ...
Article
Full-text available
Dramatic increases in obesity and diabetes have occurred worldwide over the past 30 years. Some investigators have suggested that these increases may be due, in part, to increased added sugars consumption. Several scientific organizations, including the World Health Organization, the Scientific Advisory Council on Nutrition, the Dietary Guidelines...
Article
Full-text available
Added sugars are a controversial and hotly debated topic. Consumption of added sugars has been implicated in increased risk of a variety of chronic diseases including obesity, cardiovascular disease, diabetes and non-alcoholic fatty liver disease (NAFLD) as well as cognitive decline and even some cancers. Support for these putative associations has...
Article
Full-text available
The relationship between sugar consumption and various health-related sequelas is controversial. Some investigators have argued that excessive sugar consumption is associated with increased risk of obesity, coronary heart disease, diabetes (T2D), metabolic syndrome, non-alcoholic fatty liver disease, and stimulation of reward pathways in the brain...
Conference Paper
Full-text available
PURPOSE: The angiotensin converting enzyme (ACE) insertion (I) deletion (D) polymorphism (ACE DIP) (rs4340) is a 287 base pair sequence within intron 16 of chromosome 17q23 that accounts for half of the variability in plasma ACE concentrations. Due to its influence on cardiovascular and renal regulation via the renin angiotensin aldosterone system,...
Conference Paper
Full-text available
PURPOSE: The angiotensin converting enzyme (ACE) insertion (I) deletion (D) polymorphism (ACE DIP) (rs4340) is a 287 base pair sequence within intron 16 of chromosome 17q23 that accounts for half of the variability in plasma ACE concentrations. Due to its influence on cardiovascular and renal regulation via the renin angiotensin aldosterone system,...
Article
Full-text available
The objective of the current study was to explore our hypothesis that average consumption of fructose and fructose containing sugars would not increase risk factors for cardiovascular disease (CVD) and the metabolic syndrome (MetS). A randomized, double blind, parallel group study was conducted where 267 individuals with BMI between 23 and 35 kg/m²...
Article
The effects of added sugars on various chronic conditions are highly controversial. Some investigators have argued that added sugars increase the risk of obesity, diabetes and cardiovascular disease. However, few randomized controlled trials are available to support these assertions. The literature is further complicated by animal studies, as well...
Article
Full-text available
Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a 12 week unilateral arm RT program. Maximum voluntary contraction (MVC...
Article
Full-text available
Background: Meta-analysis of genome-wide association studies identified obesity-related genetic variants. Due to the pleiotropic effects of related phenotypes, we tested six of these obesity-related genetic variants for their association with physical activity: fat mass and obesity-associated (FTO)(rs9939609)T>A, potassium channel tetramerization...
Conference Paper
Full-text available
PURPOSE: The angiotensin converting enzyme (ACE) insertion (I) deletion (D) polymorphism (ACE DIP) (rs4340) is a 287 base pair sequence within intron 16 of chromosome 17q23 that accounts for half of the variability in plasma ACE concentrations, with ACE II yielding lower concentrations than ACE DD. Due to its influence on cardiovascular and renal r...
Article
Full-text available
Cardiovascular disease (CVD) is the single largest cause of mortality in the United States and worldwide. Numerous risk factors have been identified for CVD, including a number of nutritional factors. Recently, attention has been focused on fructose-containing sugars and their putative link to risk factors for CVD. In this review, we focus on recen...
Article
Full-text available
The consumption of sugar and its relation to various potential adverse health consequences are the subjects of considerable debate and controversy. This supplement to Advances in Nutrition provides an expanded summary of a symposium held on 26 April 2014 entitled "Sugars and Health Controversies: What Does the Science Say?" as part of the ASN Scien...
Article
Full-text available
The impact of fructose, commonly consumed with sugars by humans, on blood pressure and uric acid has yet to be defined. A total of 267 weight-stable participants drank sugar-sweetened milk every day for 10 weeks as part of their usual, mixed-nutrient diet. Groups 1 and 2 had 9% estimated caloric intake from fructose or glucose, respectively, added...
Article
Full-text available
Daily lifestyle practices and habits profoundly affect the likelihood of developing cardiovascular disease (CVD). Abundant research and multiple recent consensus documents support the role of regular physical activity, not smoking cigarettes, maintaining a healthy body weight, controlling cholesterol levels, and controlling blood pressure to lower...
Article
Full-text available
The authors wish to thank Dr. Weijers (1) for his insightful comments on our article (2). Dr. Weijers is correct that most genetic variants identified using genome-wide association studies (GWAS) are not yet currently used in clinical practice to predict disease risk. Manolio et al. (3) addressed this lack of clinical use in an exquisite review in...
Article
Full-text available
The purpose of this study was to examine whether leptin levels affect the response of leptin to exercise training (ET) and whether this is also affected by C-reactive protein (CRP) or the three common Apolipoprotein E genotypes (APOE). Ninety-seven (male=45, female=52) sedentary individuals underwent 6 months of supervised ET. Blood was sampled pri...
Article
Full-text available
Genome-wide association studies have identified thousands of variants that are associated with numerous phenotypes. One such variant, rs13266634, a non-synonymous single nucleotide polymorphism in the solute carrier family 30 (zinc transporter) member eight gene, is associated with a 53% increase in risk of developing type 2 diabetes. We hypothesiz...
Article
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Both controversy and confusion exist concerning fructose, sucrose, and high-fructose corn syrup (HFCS) with respect to their metabolism and health effects. These concerns have often been fueled by speculation based on limited data or animal studies. In retrospect, recent controversies arose when a scientific commentary was published suggesting a po...
Article
Background: Women with systemic lupus erythematosus (SLE) display a 7- to 10-fold increased risk for cardiovascular disease (CVD) compared with non-SLE controls, yet many are unaware of this risk despite years spent in the healthcare system. It is not clear why they lack awareness of increased CVD risk or which factors influence awareness. Object...
Article
Purpose: An osteopontin (OPN; SPP1) gene promoter polymorphism modifies disease severity in Duchenne muscular dystrophy, and we hypothesized that it might also modify muscle phenotypes in healthy volunteers. Methods: Gene association studies were carried out for OPN (rs28357094) in the FAMuSS cohort (n = 752; mean ± SD age = 23.7 ± 5.7 yr). The...
Article
Full-text available
Objective. We examined the influence of missense polymorphism, endothelial nitric oxide synthase (NOS3) +894 G>T (rs1799983), on habitual physical activity (PA) and the muscle strength response to resistance training (RT). Methods. Men () and women (; yr) were genotyped. Subjects reported hr/wk in vigorous and light intensity PA and sitting on the...
Article
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International Journal of Obesity is a monthly, multi-disciplinary forum for papers describing basic, clinical and applied studies in biochemistry, genetics and nutrition, together with molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders
Article
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Background: Strategies that may increase compliance to reduced energy intakes are needed to reduce the health burden of obesity. Conflicting evidence exists regarding the effects of snacking on satiety and energy intake. Methods: This study compared short-term satiety from two common snack foods, low fat popcorn or potato chips. Using a counterb...
Article
Full-text available
We investigated the influence of Leptin (LEP) and leptin receptor (LEPR) SNPs on habitual physical activity (PA) and body composition response to a unilateral, upper body resistance training (RT) program. European-derived American volunteers (men=111, women=131, 23.4±5.4yr, 24.4±4.6kg·m(-2)) were genotyped for LEP 19 G>A (rs2167270), and LEPR 326 A...
Article
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Given the rise in obesity and associated chronic diseases, it is critical to determine optimal weight management approaches that will also improve dietary composition and chronic disease risk factors. Few studies have examined all these weight, diet, and disease risk variables in subjects participating in recommended multi-disciplinary weight loss...
Article
Ankyrin repeat domain 6 (ANKRD6) is a ubiquitous protein that associates with early development in mammals and is highly expressed in the brain, spinal cord, and heart of humans. We examined the role of 8 ANKRD6 single-nucleotide polymorphisms (SNPs) on muscle performance and habitual physical activity (PA). Single-nucleotide polymorphisms were 545...
Conference Paper
Full-text available
Ghrelin (GHRL) acts on the central nervous system to regulate energy homeostasis. Ghrelin (GHRL) single nucleotide polymorphism (SNP) associates with obesity, the metabolic syndrome, and habitual physical activity (PA). PURPOSE: We sought to replicate whether the GHRL 408G>T (Leu72Met; rs696217) SNP associate with PA among healthy, Caucasian adults...
Article
Full-text available
Hepatic lipase (HL) and lipoprotein lipase (LPL) activities (HLA, LPLA) modify lipoproteins and facilitate their binding to hepatic receptors. Apolipoprotein E (APOE) physically interacts with the lipases, and the three common haplotypes of the APOE gene (ε2, ε3, and ε4) yield protein isoforms (E2, E3, and E4, respectively) that are functionally di...
Article
Unlabelled: Recently, a genome-wide association study (GWAS) that identified eight single-nucleotide polymorphisms (SNPs) associated with BMI highlighted a possible neuronal influence on the development of obesity. We hypothesized these SNPs would govern the response of BMI and subcutaneous fat to resistance training in young individuals (age = 24...
Article
Genome-wide association studies (GWASs) have identified polymorphic loci associated with coronary artery disease (CAD) risk factors (i.e. serum lipids) in adult populations (42-69 y). We hypothesized that younger populations would show a greater relative genetic component due to fewer confounding variables. We examined the influence of 20 GWAS loci...
Article
High-fructose corn syrup is often mischaracterized and misunderstood. This sweetener was introduced into the food supply in the United States in the late 1960s as a liquid sweetener alternative to sucrose and existed in relative obscurity for many years. It carries the designations “Generally Recognized As Safe” (GRAS) and “natural” from the US Foo...
Article
Baseline muscle size and muscle adaptation to exercise are traits with high variability across individuals. Recent research has implicated several chemokines and their receptors in the pathogenesis of many conditions that are influenced by inflammatory processes, including muscle damage and repair. One specific chemokine, chemokine (C-C motif) liga...
Article
Full-text available
Emerging data have revealed a negative association between adiposity and muscle quality (MQ). There is a lack of research to examine this interaction among young, healthy individuals, and to evaluate the contribution of adiposity to adaptation after resistance exercise (RE). The purpose of this investigation was to examine the influence of subcutan...
Article
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Converging lines of evidence suggest that AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. We hypothesized that AKT1 variants may play a role in the endophenotypes that make up metabolic syndrome. We studi...
Article
Full-text available
Previous studies have reported associations of polymorphisms in the IGF1 gene with phenotypes of body composition (BC). The purpose of this study was to identify phenotypes of BC and physical function that were associated with the IGF1 promoter polymorphism (rs35767, −C1245T). Subjects from the Health, Aging, and Body Composition Study, white males...