Théo van IngelgomUniversity of Liège | ulg · Department of Psychology: Cognition and Behavior
Théo van Ingelgom
PhD Student
About
8
Publications
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Citations since 2017
Introduction
Current research interest : Preventive and therapeutic effects of environnmental enrichment on alcohol addiction.
Methods currently used : Effects of physical exercise and social enrichment of housing in laboratory mice. Investigation of the preventive and therapeutic effects of voluntary wheel running and various social clusters on ethanol-induced behavioral sensitization in mice.
Additional affiliations
January 2020 - present
Education
September 2013 - September 2018
Publications
Publications (8)
Les modèles murins consanguins varient moins que les modèles non-consanguins ». Ceci constitue un parfait exemple d’un postulat scientifique largement répandu qui semble être raisonnable alors qu’il est en grande partie incorrecte. Pourquoi ? Car la variabilité dépend grandement de ce que l’on mesure. Bien entendu, si nous nous basons uniquement su...
Adolescence is a developmental period characterized by significant changes in brain architecture and behaviour. The immaturity of the adolescent brain is associated with heightened vulnerability to exogenous agents, including alcohol. Alcohol is the most consumed drug among teenagers, and binge-drinking during adolescence is a major public health c...
Adolescence is a developmental period characterized by significant changes in brain architecture and behaviors. The immaturity of the adolescent brain is associated with heightened vulnerability to exogenous agents, including alcohol. Alcohol is the most consumed drug among teenagers, and binge-drinking during adolescence is a major public health c...
Most mice ethanol sensitization studies focused on neurobiology at the expense of its behavioral characterization. Furthermore, relatively short ethanol exposures (10 to 20 injections) were used in these studies. The first aim of the present study is to better characterize the development and expression of ethanol sensitization after an extended ex...
Repeated administrations of addictive drugs induce gradual changes in some of their behavioral effects. This phenomenon is called "behavioral sensitization". In laboratory rodents, drug-induced behavioral sensitization is generally modeled as a progressive increase in the locomotor stimulant effects over repeated administrations of the same drug do...
Drug addiction is largely caused by long lasting neuro-behavioral adaptations due to the repeated exposure to drugs. Some of these adaptations lead to an enhancement of the behavioral responses to these drugs. This phenomenon is called "behavioral sensitization" or "reverse tolerance". This phenomenon has been largely proved for psychostimulants su...
Most mice ethanol sensitization studies focused on neurobiology at the expense of its behavioral characterization. Furthermore, relatively short ethanol exposures (10 to 20 injections) were used in these studies. The first aim of the present study is to better characterize the development and expression of ethanol sensitization after an extended ex...
Mémoire présenté en vue de l'obtention du diplôme de master en psychologie à finalité spécialisée en neuroscience cognitive et comportementale Théo van Ingelgom Service de neuroscience comportementale et psychopharmacologie expérimentale Mémoire présenté en vue de l'obtention du diplôme de master en psychologie à finalité spécialisée en neuroscienc...
Projects
Project (1)
Contemporary theories of drug addiction consider that alcohol dependence results from lasting neuro-behavioral adaptations caused by chronic alcohol consumption. Thus, over the repeated exposure to this drug, some effects of alcohol will decrease or even disappear. This phenomenon is called 'behavioral tolerance'. At the same time, other behavioral manifestations induced by this chronic alcohol consumption will increase or even appear. This second phenomenon is defined by the term of 'behavioral sensitization' or 'inverse tolerance'. These adaptive processes are two important facets of the shift from moderate to alcoholic addiction syndrom. The susceptibility to develop tolerance or sensitization to the effects of alcohol is particularly bound to living conditions. The enriched/impoverished environmental conditions in which an individual are living, especially during childhood and adolescence are important factors influencing the development of alcohol tolerance and sensitization. However, studying these effects in humans is impossible because they cannot be manipulated experimentally. The goal of this project is to study the influence of environmental enrichment in its 'physical activity' component (wheel-running) on behavioral tolerance and behavioral sensitization to the effects of alcohol (ethanol) using two mice models. More precisely, this project aims to investigate the preventive and therapeutic effects of exercise on the tolerance and sensitization induced by chronic alcohol use in mice. Mouse will be used here as an animal model of these phenomena as they occur most of the time in humans.
Is it possible to block or even prevent the development of these latter behavioral phenomena by providing the mice with an enriched environment, allowing free physical exercise? Can social isolation and environmental impoverishment during the sensitive period exacerbate the development of these behavioral reactions?
