Theng Choon Ooi

Theng Choon Ooi
Universiti Kebangsaan Malaysia | ukm · Centre for Healthy Ageing and Wellness (H-CARE)

Doctor of Philosophy

About

25
Publications
1,954
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
166
Citations
Citations since 2016
21 Research Items
158 Citations
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050

Publications

Publications (25)
Article
Background: A complex of Zn and carnosine, called Zinc-L-carnosine (ZnC), enjoys a wide application as part of a Zn supplement therapeutic method as well as in treating peptic ulcers. However, researches fail to confirm the biological functions possessed by ZnC as well as tumor immune microenvironment in colorectal cancer (CRC). Methods: Cell co...
Article
Full-text available
The main objective of this study is to determine the association of various trace elements’ status with the 5-year mortality rate among community-dwelling older adults in Malaysia. This study was part of the Long-term Research Grant Scheme—Towards Useful Ageing (LRGS-TUA). The participants were followed up for five years, and their mortality status...
Article
Zinc (Zn) has an existence within large quantities in the human brain, while accumulating within synaptic vesicle. There is growing evidence that Zn metabolic equilibrium breaking participates into different diseases (e.g., vascular dementia, carcinoma, Alzheimer's disease). Carnosine refers to an endogenic dipeptide abundant in skeletal muscle and...
Article
Objectives: This study aimed to determine the relationship between oxidative stress, DNA damage, inflammation, and metabolic biomarkers as the mediating factor between Islamic Sunnah intermittent fasting (IF) practice and cognitive function among older adults with mild cognitive impairment (MCI). Design: This study was a 36 months prospective co...
Article
Full-text available
Purpose: This study evaluates the prevalence of and the multidimensional risk factors associated with age-related hearing loss (ARHL) among community-dwelling older adults in Malaysia. Patients and methods: A total of 253 participants aged 60 years and above participated in this cross-sectional study. The participants were subjected to pure tone...
Article
Aim The present study aims to determine the association of trace elements and oxidative and DNA damage biomarkers with fall incidence among community-dwelling older adults. Methods This study is part of the Long-term Research Grant Scheme – Towards Useful Ageing cohort study in Malaysia. Of a total of 174 participants with complete trace elements...
Preprint
Full-text available
Dysregulation in the secretion of high mobility group box 1(HMGB1) protein has been shown to modulate the progression of sepsis. Hence, the primary objective of this study is to explore the potential of zinc L-carnosine (ZnC) in inhibiting the secretion of HMGB1 from RAW 264.7 murine macrophages after induced with lipopolysaccharide (LPS). Generall...
Article
Full-text available
Research has proven that aerobic exercise improves glucose homeostasis among patients with type 2 diabetes mellitus (T2DM). Elastic resistance (tube or band) is suggested as a good alternative for home-based strength training among older adults including those with T2DM due to its low cost, simplicity, portability, and versatility. This study aimed...
Article
Full-text available
Ficus deltoidea var. deltoidea is used as traditional medicine for diabetes, inflammation, and nociception. However, the antimutagenic potential and cytoprotective effects of this plant remain unknown. In this study, the mutagenic and antimutagenic activities of F. deltoidea aqueous extract (FDD) on both Salmonella typhimurium TA 98 and TA 100 stra...
Article
Full-text available
Background Falls incidence rate and comprehensive data on factors that predict occasional and repeated falls from large population-based studies are scarce. In this study, we aimed to determine the incidence of falls and identify predictors of occasional and recurrent falls. This was done in the social, medical, physical, nutritional, biochemical,...
Article
Full-text available
Oxidative stress, DNA damage, and unresolved inflammation are the predisposing factors of many chronic and degenerative diseases, including cancer. Stingless bee honey (SBH) is recognized to have high medicinal value by the traditional medicine practitioners and has been used to treat various illnesses traditionally. This study aimed to determine t...
Article
Full-text available
Zinc l-carnosine (ZnC) is the chelate form of zinc and l-carnosine and is one of the zinc supplements available in the market. This study aims to determine the protective effects of ZnC against l-buthionine sulfoximine (BSO)–induced oxidative stress in CCD-18co human normal colon fibroblast cell line. CCD-18co cells were pretreated with ZnC (0–100...
Preprint
Full-text available
Background: Falls incidence rate and comprehensive data on factors that predict occasional and repeated falls from large population-based studies are scarce. This study aimed to determine the incidence of falls and identify predictors of occasional and recurrent falls within the social, medical, physical, nutritional, biochemical, cognitive dimensi...
Article
Full-text available
Intermittent fasting (IF) refers to various dietary regimens that cycle between a period of non-fasting and a period of total fasting. This study aimed to determine the effects of IF on cognitive function among elderly individuals who practice IF who have mild cognitive impairment (MCI). A total of 99 elderly subjects with MCI of Malay ethnicity wi...
Article
Zinc L-carnosine (ZnC) is a chelated compound of zinc and L-carnosine. This present study aims to determine the protective effects of ZnC against hydrogen peroxide (H2O2)-induced oxidative stress and genomic damage in CCD-18co human normal colon fibroblast cells. Generally, cells were pretreated with ZnC (0 – 100 µM) for 24 hours before challenged...
Article
Full-text available
This study aimed to determine the effects of tropical fruit juice mixture (pomegranate, white guava, and Roselle) on biochemical, behavioral, and histopathological changes of β-amyloid- (Aβ-) induced rats. Formulation 8 (F8) of tropical fruit juice mixture was chosen for this present study due to its high phenolic content and antioxidant capacity....
Article
Context: Zinc L-carnosine (ZnC) is a chelate of Zn and L-carnosine and is used clinically in the treatment of peptic ulcer. Objective: In this study, we aim to investigate the involvement of heme oxygenase-1 (HO-1) in the anti-inflammatory effects of ZnC in lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophages. Materials and methods: We use...
Article
Recent findings showed that stevioside can demonstrate anti-cancer property in selected cell lines. In this study, the cytotoxicity and genotoxicity of stevioside were examined on human colon carcinoma cell, HCT 116 (targeted cell) and human colon derived CCD18Co myofibroblast cell lines (non-targeted cell) using the MTT (3-(4, 5-dimethylthiazol-2-...
Article
Cancer is one of the major causes of death worldwide, and the incidence and mortality rates of cancer are expected to rise tremendously in the near future. Despite a better understanding of cancer biology and advancement in cancer management, current strategies in cancer treatment remain costly and ineffective. Hence, instead of putting more effort...
Article
This study aimed to investigate the role of the mitogen-activated protein kinases (MAPKs) signaling pathway in the anti-inflammatory effects of zinc carnosine (ZnC) in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Cells were pretreated with ZnC (0-100 μM) for 2 h prior to the addition of LPS (1 μg/ml). Following 24 h of treatment, ZnC was found...
Article
Full-text available
The aim of this study was to determine the knowledge level of calories and body mass index (BMI) among students in the Faculty of Health Science (FHS), National University of Malaysia. This comprises of studying of the interactions and relationships between independent variables such as type of schools, age, BMI, education level, gender and family...
Article
The aim of this study is to investigate the ability of zinc carnosine to protect the human lymphoblastoid (WIL2-NS) cell line from hydrogen peroxide-induced DNA damage. Cells were cultured with medium containing zinc carnosine at the concentrations of 0.4, 4, 16 and 32 μM for 9 days prior to treatment with 30 μM of hydrogen peroxide (30 min). Zinc...
Article
Full-text available
Three diorganotin(IV) complexes of the general formula R2Sn[RcC(O)N(RN)O] (Rc = aryl, RN = Alkyl) have been synthesized by refluxing in toluene the corresponding diorganotin(IV) oxides with the free ligand N-methyl p-fluorobenzohydroxamic acid, using a Dean and Stark water separator. The ligand was derived from the reaction of the corresponding p-f...

Network

Cited By