Tetyana Vasylyeva

Tetyana Vasylyeva
University of Oxford | OX · Department of Zoology

Doctor of Philosophy

About

47
Publications
5,244
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787
Citations
Introduction
Tetyana Vasylyeva is a Junior Research Fellow at New College, University of Oxford. Tetyana does research in Molecular Epidemiology.
Additional affiliations
August 2013 - September 2014
International HIV/AIDS Alliance in Ukraine
International HIV/AIDS Alliance in Ukraine
Position
  • Consultant
September 2012 - August 2014
University at Albany, The State University of New York
Position
  • Master's Student
June 2011 - July 2012
International HIV/AIDS Alliance
International HIV/AIDS Alliance
Position
  • Project Protect
Description
  • I worked as a project field coordinator. Project Protect is an intervention aimed to prevent HIV transmission from acutely/recently infected individuals to their risk partners.
Education
September 2012 - December 2013
September 2010 - May 2012
September 2006 - June 2010

Publications

Publications (47)
Article
Understanding the circumstances that lead to pandemics is important for their prevention. Here, we analyze the genomic diversity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early in the coronavirus disease 2019 (COVID-19) pandemic. We show that SARS-CoV-2 genomic diversity before February 2020 likely comprised only two distinct...
Article
Background Monitoring the emergence and spread of SARS-CoV-2 variants is an important public health objective. We investigated how the Gamma variant was established in New York City (NYC) in early 2021 in the presence of travel restrictions that aimed to prevent viral spread from Brazil, the country where the variant was first identified. Methods...
Article
Full-text available
Recombination is an evolutionary process by which many pathogens generate diversity and acquire novel functions. Although a common occurrence during coronavirus replication, detection of recombination is only feasible when genetically distinct viruses contemporaneously infect the same host. Here, we identify an instance of SARS-CoV-2 superinfection...
Article
Ukraine is one of the countries in Europe most affected by HIV. The escalation of open war on the European continent has affected HIV care in Ukraine in an unprecedented way. Treating physicians in Europe have little experience on how to handle HIV-specific care under these circumstances. A framework is urgently needed that both defines and sets ou...
Preprint
Background Monitoring the emergence and spread of SARS-CoV-2 variants is an important public health objective. Travel restrictions, aimed to prevent viral spread, have major economic consequences and unclear effectiveness despite considerable research. We investigated the introduction and establishment of the Gamma variant in New York City (NYC) in...
Article
Full-text available
During the COVID-19 pandemic, genomics and bioinformatics have emerged as essential public health tools. The genomic data acquired using these methods have supported the global health response, facilitated the development of testing methods and allowed the timely tracking of novel SARS-CoV-2 variants. Yet the virtually unlimited potential for rapid...
Preprint
Recombination is an evolutionary process by which many pathogens generate diversity and acquire novel functions. Although a common occurrence during coronavirus replication, recombination can only be detected when two genetically distinct viruses contemporaneously infect the same host. Here, we identify an instance of SARS-CoV-2 superinfection, whe...
Preprint
Full-text available
Background Due to practical challenges associated with genetic sequencing in low resource environments, the burden of hepatitis C virus (HCV) in forcibly displaced people is understudied. We examined the use of field-applicable HCV sequencing methods and phylogenetic analysis to determine HCV transmission dynamics in internally displaced people who...
Preprint
Full-text available
Since spring 2020, Ukraine has experienced at least two COVID-19 waves and has just entered a third wave in autumn 2021. The use of real-time genomic epidemiology has enabled the tracking of SARS-CoV-2 circulation patterns worldwide, thus informing evidence-based public health decision making, including implementation of travel restrictions and vac...
Article
Full-text available
Wide-scale SARS-CoV-2 genome sequencing is critical to tracking viral evolution during the ongoing pandemic. We develop the software tool, Variant Database (VDB), for quickly examining the changing landscape of spike mutations. Using VDB, we detect an emerging lineage of SARS-CoV-2 in the New York region that shares mutations with previously report...
Article
Full-text available
Vaccination and anti‐viral therapy with nucleos(t)ide analogues (NAs) are key approaches to reducing the morbidity, mortality and transmission of hepatitis B virus (HBV) infection. However, the efficacy of these interventions may be reduced by the emergence of drug resistance‐associated mutations (RAMs) and/or vaccine escape mutations (VEMs). We ha...
Article
Full-text available
The UK’s COVID-19 epidemic during early 2020 was one of world’s largest and unusually well represented by virus genomic sampling. Here we reveal the fine-scale genetic lineage structure of this epidemic through analysis of 50,887 SARS-CoV-2 genomes, including 26,181 from the UK sampled throughout the country’s first wave of infection. Using large-s...
Preprint
Full-text available
The UK’s COVID-19 epidemic during early 2020 was one of world’s largest and unusually well represented by virus genomic sampling. Here we reveal the fine-scale genetic lineage structure of this epidemic through analysis of 50,887 SARS-CoV-2 genomes, including 26,181 from the UK sampled throughout the country’s first wave of infection. Using large-s...
Article
Full-text available
Introduction In light of the COVID‐19 pandemic, considerable effort is going into identifying and protecting those at risk. Criminalization, stigmatization and the psychological, physical, behavioral, and economic consequences of substance use make people who inject drugs (PWID) extremely vulnerable to many infectious diseases. While relationships...
Article
Full-text available
Assessment of the long-term population-level effects of HIV interventions is an ongoing public health challenge. Following the implementation of a Transmission Reduction Intervention Project (TRIP) in Odessa, Ukraine, in 2013–2016, we obtained HIV pol gene sequences and used phylogenetics to identify HIV transmission clusters. We further applied th...
Article
Background and aims: We sought to characterise risk factors and patterns of HCV transmission amongst men who have sex with men (MSM). Methods: MSM with recently-acquired HCV (AHCV) were prospectively recruited ('clinic cohort') between January and September 2017. Clinical data and risk behaviours were identified and blood obtained for HCV whole...
Preprint
Full-text available
A bstract Birth-death processes have given biologists a model-based framework to answer questions about changes in the birth and death rates of lineages in a phylogenetic tree. Therefore birth-death models are central to macroevolutionary as well as phylodynamic analyses. Early approaches to studying temporal variation in birth and death rates usin...
Article
Full-text available
Introduction: Viral load is one of the most important determinants for HIV transmission. Identification of people with high viral load (PHVL) can be effective in limiting onward HIV transmission. In order to improve the identification of these individuals within risk networks, we determined a) the number of PHVL recruited through risk networks b)...
Article
Full-text available
Introduction: This paper examines the extent to which an intervention succeeded in locating people who had recently become infected with HIV in the context of the large-scale Ukrainian epidemic. Locating and intervening with people who recently became infected with HIV (people with recent infection, or PwRI) can reduce forward HIV transmission and...
Article
Full-text available
A growing body of evidence suggests that network-based interventions to reduce HIV transmission and/or improve HIV-related health outcomes have an important place in public health efforts to move towards 90–90–90 goals. However, the social processes involved in network-based recruitment may pose a risk to participants of increasing HIV-related stig...
Article
Full-text available
Background Estimation of temporal changes in HIV transmission patterns can help to elucidate the impact of preventative strategies and public health policies. Methods Portuguese HIV-1 subtype B and G pol genetic sequences were appended to global reference datasets to identify country-specific transmission clades. Bayesian birth-death models were u...
Article
Full-text available
While HIV-1 subtype B has caused a large epidemic in the Western world, its transmission in Ukraine remains poorly understood. We assessed the genetic diversity of HIV-1 subtype B viruses circulating in Ukraine, characterized the transmission group structure, and estimated key evolutionary and epidemiological parameters. We analyzed 120 HIV-1 subty...
Article
Full-text available
The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show t...
Article
Given globalization and other social phenomena, controlling the spread of infectious diseases has become an imperative public health priority. A plethora of interventions which in theory can mitigate the spread of pathogens have been proposed and applied. Evaluating the effectiveness of such interventions is costly and in many circumstances unreali...
Preprint
Full-text available
The yellow fever virus (YFV) epidemic that began in Dec 2016 in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes sp. vectors highlights the urgent need to monitor the risk of re-establishment of domestic YFV transmission in the Americas. We use a suite of epidemiological, spatial and genomic approaches to characteriz...
Article
Full-text available
Purpose: This paper presents an overview of different kinds of risk and social network methods and the kinds of research questions each can address. Recent findings: It also reviews what network research has discovered about how network characteristics are associated with HIV and other infections, risk behaviors, preventive behaviors, and care,...
Article
Full-text available
Introduction Providing HIV healthcare and Treatment as Prevention both depend on diagnosing HIV cases, preferably soon after initial infection. We hypothesized that tracing risk networks recruits higher proportions of undiagnosed positives than outreach-based testing or respondent-driven sampling (RDS) in Odessa, Ukraine. Methods The Transmission...
Article
Ukraine has one of the largest HIV epidemics in Europe, historically driven by people who inject drugs (PWID). The epidemic showed signs of stabilization in 2012, but the recent war in eastern Ukraine may be reigniting virus spread. We investigated the movement of HIV-infected people within Ukraine before and during the conflict. We analyzed HIV-1...
Conference Paper
Introduction Ukraine has one of the largest HIV epidemics in Europe that was historically driven by people who inject drugs (PWID). The epidemic showed signs of stabilisation since 2012, but the recent war in the East of the country might be reinforcing the virus spread. We have studied HIV flow within Ukraine in recent years and explored factors t...
Article
Full-text available
Early treatment, soon after infection, reduces HIV transmissions and benefits patients. The Transmission Reduction Intervention Project (TRIP) evaluated a network intervention to detect individuals recently infected (in the past 6 months). TRIP was conducted in Greece (2013–2015) and focused on drug injector networks. Based on HIV status, testing h...
Article
Objective Although our understanding of viral transmission among people who inject drugs (PWID) has improved, we still know little about when and how many times each injector transmits HIV throughout the duration of infection. We describe HIV dynamics in PWID to evaluate which preventive strategies can be efficient. Design Due to the notably scarc...
Article
Full-text available
Background We studied the association between sex in exchange for money, drugs or goods and HIV for women who inject drugs (WWID) in Ukraine, as previous data on this association from the post-USSR region are contradictory. Methods Data come from the Integrated Bio-Behavioral Survey of Ukrainian people who inject drugs collected in 2011 using resp...
Article
The number of public health applications for molecular epidemiology and social network analysis has increased rapidly since the improvement in computational capacities and the development of new sequencing techniques. Currently, molecular epidemiology methods are used in a variety of settings: from infectious disease surveillance systems to the des...
Article
Full-text available
Human immunodeficiency virus type 1 (HIV-1) was discovered in the early 1980s when the virus had already established a pandemic. For at least three decades the epidemic in the Western World has been dominated by subtype B infections, as part of a sub-epidemic that traveled from Africa through Haiti to United States. However, the pattern of the subs...
Article
Past research suggests that as many as 50% of onward human immunodeficiency virus (HIV) transmissions occur during acute and recent HIV infection. It is clearly important to develop interventions which focus on this highly infectious stage of HIV infection to prevent further transmission in the risk networks of acutely and recently infected individ...
Conference Paper
Stigma against people with HIV, including those who are recently infected and thus more likely to transmit the virus, can deter participation in community-based interventions and possibly lead to harms against those who do participate. We use baseline data from an HIV intervention project to assess community-level stigma and its relationship to per...
Article
Full-text available
The emergence of HIV-1 in Russia came soon after the collapse of the Soviet Union. With more than half a million cases within 5 years, the post-soviet Russian epidemic is one of the fastest and largest HIV outbreaks ever recorded. Although driven by intravenous drug users (IDUs), why the epidemic spread so rapidly and on a large scale is unclear. O...
Article
Current ideas about HIV prevention include a mixture of primarily biomedical interventions, socio-mechanical interventions such as sterile syringe and condom distribution, and behavioral interventions. This article presents a framework for socially-integrated transdisciplinary HIV prevention that may improve current prevention efforts. It first des...
Article
Full-text available
Economic and political instability and related "big events" are widespread throughout the globe. Although they sometimes lead to epidemic HIV outbreaks, sometimes they do not-and we do not understand why. Current behavioural theories do not adequately address these processes, and thus cannot provide optimal guidance for effective intervention. Base...
Article
Full-text available
BACKGROUND: Ukraine has the most severe HIV epidemic in Europe. There is an urgent need to im-prove the effectiveness of the preventive meas-ures to stop further spread of the epidemic. PDI was implemented as an alternative to traditional outreach work in educating IDUs and reducing their injection and sexual risky practices.
Article
Full-text available
Economic and political instability and related "big events" are widespread throughout the globe. Although they sometimes lead to epidemic HIV outbreaks, sometimes they do not—and we do not understand why. Current behavioural theories do not adequately address these processes, and thus cannot provide optimal guidance for effective intervention. Base...
Article
Vasylyeva T, Friedman SR, Smyrnov P (2012) “Project Protect” intervention. Testing a new approach for HIV prevention. Tobacco Control and Public Health in Eastern Europe 2 (Supplement 1, 2nd conference 'Economics, sociology, theory and practice of public health'):s35-s36 BACKGROUND. “Project Protect” aims to find highly infectious individuals throu...
Article
Full-text available
BACKGROUND. Ukraine is an Eastern European country affected by the HIV/AIDS epidemic. From the beginning, the key HIV transmission route in Ukraine was parenteral, mostly due to the injection drug use (IDU). It is widely hypothesized that epidemics of IDU and consequently of HIV started in different parts of Ukraine at different points in time, and...
Article
Full-text available
BACKGROUND: Epidemics of drug use and thus the spread of HIV have different duration in different regions, and, therefore, the prognosis of these epidemics may differ. We aimed to assess indicators measuring the peculiarities of injection drug use epidemics by region, informative for prevention activities among vulnerable to HIV groups. METHODS: D...

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