Terry Kim

Duke University | DU · School of Medicine

Background Plasma and cerebrospinal fluid (CSF) levels of neuronal biomarkers have been associated with Alzheimer’s disease (AD). The aqueous humor, which can be collected during routine cataract surgery, may have similar concentrations of neuronal biomarkers to CSF. Method This proof‐of‐concept study prospectively enrolled adults without a diagno...

Preeya K Gupta,1 Laura M Periman,2 Edward Lain,3 Eric Donnenfeld,4 John Hovanesian,5 Terry Kim,6 William Trattler,7 Elizabeth Yeu,8 Edward Holland9 1Triangle Eye Consultants, Durham, NC, USA; 2Periman Eye Institute, Seattle, WA, USA; 3Sanova Dermatology, Pflugerville, TX, USA; 4Ophthalmic Consultants of Long Island, Garden City, NJ, USA; 5Harvard E...

Purpose: To evaluate whether intraoperative aberrometry improves the accuracy of refractive outcomes after cataract surgery in highly myopic, highly hyperopic, and post-refractive eyes. Methods: This single-center, retrospective review compared the spherical equivalent of postoperative refraction to that predicted by the Barrett Universal II for...

The endothelial cell is a critical structure within the cornea and is responsible for maintaining corneal clarity through its pump function. Endothelial cells are lost over time naturally but can be injured medically, surgically, or as a part of various dystrophies. Monitoring of endothelial cells can be performed clinically or more formally with s...

Over the past 2 decades, posterior lamellar keratoplasty (PLK) has emerged as an alternative to penetrating keratoplasty in the treatment of corneal endothelial disorders. The reasons for this trend include the search for a safer procedure to replace diseased endothelium that provides faster and better visual rehabilitation and reduces the need for...

Objective: To examine opioid prescribing following cataract surgery among patients who did or did not receive Omidria (phenylephrine and ketorolac intraocular solution 1.0%/0.3%) referred to as "P/K". Methods: The retrospective study compared adults over 65 without recent opioid use in the MarketScan databases who had a cataract-related surgical...

Objectives 1) To assess the utility of performing eye screenings for healthy basketball players. 2) To describe the traumatic injuries sustained by competitive college basketball players. Methods The eye screening examinations of the Duke University Men’s Basketball players over six seasons were reviewed retrospectively. Traumatic basketball-relat...

Purpose: To present a case series of Urrets-Zavalia syndrome (UZS) that developed after Descemet membrane endothelial keratoplasty (DMEK). Methods: A retrospective chart review was performed to identify patients who underwent DMEK by a single surgeon at the Duke Eye Center from 2017 to 2019 and subsequently developed UZS. Demographic data, preop...

Ocular injuries are common in basketball, and evidence indicates that ocular injuries may be more common in basketball than any other sport. Most of these injuries are benign and self-limiting without persistent visual impairment. However, the assessment of ocular injuries is of extreme importance and often requires an ophthalmologist’s assistance...

Purpose: To assess the effect of an educational video on 1) patient knowledge about cataract surgery, 2) patient perception of preoperative assessment visit quality, 3) face-to-face time with the surgeon, and 4) choices regarding premium intraocular lenses (IOLs) or laser-assisted cataract surgery (LACS). Setting: Eye clinic in an academic medic...

Members of the ASCRS Cornea Clinical Committee performed a review of the current literature on the corneal crosslinking (CXL) procedure for treating corneal ectasia. The members explored the data on the techniques currently in use and under investigation, including their advantages, safety profiles, risks, and cost analyses, compared with data on c...

Purpose: To determine the effects of epithelial basement membrane dystrophy (EBMD) and Salzmann nodular degeneration (SND) on optical biometry measurements. Setting: Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA. Design: Retrospective case series. Methods: Cataractous eyes with EBMD or SND scheduled for...

Any ocular surface disease (OSD), but most commonly, dry-eye disease (DED), can reduce visual quality and quantity and adversely affect refractive measurements before keratorefractive and phacorefractive surgeries. In addition, ocular surgery can exacerbate or induce OSD, leading to worsened vision, increased symptoms, and overall dissatisfaction p...

The removal and rate of recurrence of pterygium have been discussed for years. The disorder is highly associated with environmental factors, and recurrence rates can be unacceptably high and cannot be successfully predicted. New techniques and graft preparations and postoperative management strategies are helping to reduce the recurrence rates and...

Dysfunctional tear syndrome (DTS) is a common and complex condition affecting the ocular surface. The health and normal functioning of the ocular surface is dependent on a stable and sufficient tear film. Clinician awareness of conditions affecting the ocular surface has increased in recent years because of expanded research and the publication of...

Dysfunctional tear syndrome (DTS) is a common and complex condition affecting the ocular surface. The health and normal functioning of the ocular surface is dependent on a stable and sufficient tear film. Clinician awareness of conditions affecting the ocular surface has increased in recent years because of expanded research and the publication of...

Background: Given the rise in cases of fungal keratitis in recent years, this study was performed to better elucidate the microbiological profile, risk factors, and surgical intervention rates of fungal keratitis at a tertiary referral center in the Southeastern USA. Findings: This is a retrospective case series of fungal keratitis infections tr...

Drugs across many pharmacologic classes induce corneal epithelial changes. Many of these drugs have cationic amphiphilic structures, with a hydrophobic ring and hydrophilic cationic amine side chain that allow them to cross cell membranes. These drugs lead to intracellular phospholipid accumulation, often manifested in the cornea by vortex keratopa...

To describe the long-term results of fibrin adhesive use in the management of epithelial ingrowth after laser in situ keratomileusis (LASIK). Private practice, Minneapolis, Minnesota, and an academic medical center, Durham, North Carolina, USA. Retrospective case series. Patients with a history of LASIK had epithelial ingrowth removal with mechanic...

To evaluate the effectiveness of a hydrogel sealant versus a suture in preventing fluid egress after wound leakage in cataract surgery. Twenty-four ophthalmic clinical practices in the United States. Prospective randomized parallel-arm controlled multicenter subject-masked study. Healthy patients having uneventful clear corneal incision (CCI) catar...

Staphylococcus aureus is the most important and common pathogen that infects patients following cataract surgery, laser in situ keratomileusis, and photorefractive keratectomy. It is reported to be the second most common pathogen causing bacterial keratitis around the world. Of special concern are increasing reports of postoperative methicillin-res...

Purpose: To describe cases of interface haze, also known as textural interface opacity, after Descemet-stripping automated endothelial keratoplasty (DSAEK). Setting: Department of Cornea, External Disease, and Refractive Surgery Service, Duke Eye Center, Durham, North Carolina, USA. Design: Retrospective case series. Methods: Patients' clini...

To determine whether Descemet stripping automated endothelial keratoplasty (DSAEK) donor cornea graft thickness impacts measurements of best spectacle-corrected visual acuity (BSCVA), refractive error and intraocular pressure (IOP). Retrospective chart review in a tertiary care center at Duke University Eye Center. We studied 460 eyes that had unde...

To investigate the rates of Descemet's stripping automated endothelial keratoplasty (DSAEK) graft dislocation and failure in glaucomatous eyes, including eyes with history of trabeculectomy and/or aqueous shunts. A retrospective, case-control study on a total of 424 consecutive eyes undergoing DSAEK at an academic setting compared 96 glaucomatous e...

To evaluate wound morphology and integrity using contrast-enhanced spectral-domain optical coherence tomography (SD-OCT). Eighteen patients (18 eyes) undergoing unilateral routine cataract surgery were enrolled. SD-OCT imaging of the corneal wound was performed immediately following cataract surgery and on postoperative day 1. A topical contrast ag...

To report a series of dislocations of the donor graft into the posterior segment associated with Descemet stripping endothelial keratoplasty (DSAEK) and to identify possible risk factors for dislocation and clinical outcomes. Retrospective case series. Cases of donor graft dislocation into the posterior segment associated with endothelial keratopla...

In 2008, the American Society of Cataract and Refractive Surgery (ASCRS) surveyed its 9121 United States and international members to evaluate the changing trends and incidence, culture results, treatment, and visual outcomes of infectious keratitis following keratorefractive procedures worldwide. This paper presents and analyzes the results with c...

The importance of the cornea to the ocular structure and visual system is often overlooked because of the cornea's unassuming transparent nature. The cornea lacks the neurobiological sophistication of the retina and the dynamic movement of the lens; yet, without its clarity, the eye would not be able to perform its necessary functions. The complexi...

To identify and evaluate the use of contrast agents in optical coherence tomography (OCT) for ophthalmic applications. Three agents-prednisolone acetate (PA), triamcinolone acetonide (TA), and lipid-based artificial tears (LBAT)-were tested in cadaveric porcine eyes imaged with hand-held spectral-domain OCT (SD-OCT). Anterior segment imaging was pe...

To evaluate complications and clinical outcomes of Descemet stripping automated endothelial keratoplasty in eyes with preexisting anterior chamber intraocular lenses. Retrospective review. Thirty-one patients who underwent Descemet stripping automated endothelial keratoplasty and who had a preexisting anterior chamber intraocular lens were identifi...

Objective: To determine if minimal threshold torsional ultrasound settings result in improved systemic metrics compared with standard linear torsional ultrasound in microcoaxial phacoemulsification. Materials and Methods: Cataracts of similar density, 2+ or greater nuclear sclerosis, in both eyes of 18 patients (N = 36 eyes) needing bilateral catar...

To evaluate the change and difference in the corneal surface, incision, and handpiece temperatures during longitudinal and torsional ultrasound (US) phacoemulsification with standard incisions (2.75 mm) and microincisions (2.20 mm) and the thermal effect on wounds. Department of Ophthalmology, Duke University, Durham, North Carolina, USA. In this p...

To characterize and determine the effect of tamsulosin (Flomax) on the human iris dilator muscle anatomy. Retrospective, case-control study. This study comprised 51 cadaveric eyes from 27 patients (14 with a history of tamsulosin use and 13 control patients) who underwent autopsy at the Duke University Medical Center, Durham, North Carolina. Patien...

We present a patient with poor visual acuity and contact lens intolerance due to advanced keratoconus who had femtosecond-assisted placement of two 0.35 mm intrastromal corneal ring segments (ICRS) in the right eye. Postoperatively, both rings migrated inferiorly and overlapped each other in a double-stacked formation. This resulted in a dramatic c...

To compare the effects of torsional and mixed ultrasound on clear corneal incision architecture, wound integrity, and apposition using standard (2.75 mm) and microincisional (2.2 mm) coaxial phacoemulsification. Twenty human cadaver eyes (4 groups of 5 eyes) underwent simulated coaxial phacoemulsification for 45 seconds of ultrasound time (group 1...

To directly compare intraoperative and clinical parameters using a torsional handpiece through microincision and standard clear corneal cataract wounds with appropriately configured tips and sleeves. Duke University Eye Center, Durham, North Carolina, USA. Cataracts in both eyes of 32 patients needing bilateral surgery were extracted using the OZil...

To determine if a biodendrimer adhesive will seal a clear corneal cataract incision. An experimental study in which 2.75-mm clear corneal cataract incisions were made in 8 human donor eyes. The corneas were mounted on an artificial anterior chamber. Leaking pressure was determined in 6 corneas. These corneas were then treated with adhesive and leak...

The purpose of this study was to evaluate the refractive change after Descemet stripping automated endothelial keratoplasty (DSAEK) surgery and its correlation with graft thickness and diameter. We retrospectively analyzed the refractive outcomes of 45 cases of DSAEK surgery that were performed at Duke University Eye Center between August 2005 and...

To investigate the population-based prevalence of keratoconus in US individuals aged 65 years and older. Multiyear retrospective cross-sectional claims analysis. Fee-for-service claims from a 5% national sample of Medicare beneficiaries aged 65 years and older were reviewed. Claims records were queried on an annual basis for the years 1999 through...

The aim of our study was to confirm the presence of inflammatory T-lymphocyte subpopulations (CD4 and CD8) in pterygium specimens with regards to clinical severity. Additionally, we examined the effect of topical anti-inflammatory agents on the presence of T-lymphocyte subpopulations. Pterygia from nineteen eyes of nineteen patients who underwent s...

To compare the corneal and aqueous penetration and pharmacokinetics of gatifloxacin 0.3% and moxifloxacin 0.5% ophthalmic solutions and their effect on corneal reepithelialization after penetrating keratoplasty. In this randomized, open-label, parallel-controlled study, corneal and aqueous penetration and the pharmacokinetic parameters of topically...

To report a case where fibrin glue was applied with a modified approach to secure the graft to the host bed in lamellar keratoplasty. One patient with epithelial membrane dystrophy, Salzmann nodular degeneration, and amyloid deposits in the cornea underwent lamellar keratoplasty by using fibrin glue. The glue components were applied separately: the...

Biodendrimer-based hydrogel adhesives were derived from biocompatible building blocks and poly(ethylene glycol) of 3,400, 10,000 and 20,000 g/mole. The leaking pressures were determined for these adhesives when used to seal 4.1-mm central lacerations and penetrating keratoplasties (PKPs) in enucleated porcine eyes. Three biodendrimers, ([G1]-PGLSA-...

To compare the effects of microincision bimanual phacoemulsification, standard coaxial phacoemulsification, and microincision coaxial phacoemulsification on clear corneal incision architecture and wound integrity. Department of Ophthalmology, Duke University, Durham, North Carolina, USA. A prospective study of 15 human cadaver eyes (3 groups of 5 e...

The synthesis of fourth-generation bola-type linear−dendritic macromolecules is described using a high yielding divergent method. These systems are composed of a non-immunogenic linear poly(ethylene glycol) core and dendritic wedges of succinic acid and glycerol connected by ester linkages in a triblock architecture. Three molecular weight PEGs (34...

New lysine-based dendrimers which upon reaction with a poly(ethylene glycol) di-activated ester afford a soft flexible hydrogel that can be used to seal a wound in the sclerotomy. These wounds are made during the common ophthalmic procedure of a vitrectomy. The rheological and swelling properties of the hydrogel can be tuned by either changing the...

A stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel. This hydrogel along with sutures w...

To describe a case of a traumatic late dislocation of a laser-assisted in situ keratomileusis (LASIK) flap complicated by epithelial ingrowth. Interventional case report. A 50-year-old woman presented 21 months after uncomplicated LASIK with painful vision loss in the right eye after minor trauma. A dislocation of the LASIK flap was noted at examin...

Dear Editor: We enjoyed reading Lai et al's interesting article on the comparison of retrobulbar and sub–Tenon's capsule injection of local anesthetic in vitreoretinal surgery. 1 We agree with the findings of the study. In the vitreoretinal services of our eye center, 50 retinal surgeries (scleral buckling, pars plana vitrectomy [PPV] alone, and PP...

To study the leading indications and changing trends for penetrating keratoplasty (PK) over the past 3 decades. This is a retrospective review of 696 cases of PK. The indications for PKs performed at the Duke University Eye Center during the years 1980-1981, 1990- 1991, and 2000-2001 were tabulated to determine trends over the past 3 decades. The m...

To evaluate 2 novel biodendrimer tissue adhesives in sealing and securing laser in situ keratomileusis (LASIK) flaps. Duke University Eye Center, Durham, North Carolina, USA. Laser in situ keratomileusis flaps were created in 10 human eye-bank eyes using the Hansatome microkeratome system (Bausch & Lomb). These eyes were divided into 2 groups. Flap...

Dendritic macromers are attractive macromolecules for hydrogel formation since high cross-linking densities at low polymer concentration can be obtained, varied physical properties can be observed based on the macromer structure, and low viscous aqueous solutions can be injected in an in vivo site of irregular shaped to form a well-integrated polym...

Research on dendrimers continues to expand as further advances in synthetic methodology and characterization techniques translate to additional applications. Recently, dendritic polymers composed of the natural metabolites glycerol and succinic acid were syn- thesized, functionalized, and evaluated as new medical materials. The design and synthesis...

To compare a biodendrimer adhesive with a conventional suture for repairing linear and stellate corneal lacerations. A keratome knife was used to create 4.1-mm full-thickness linear incisions (n = 36) and 3 x 4-mm full-thickness stellate incisions (n = 25) in the central cornea of enucleated human eyes. The incisions were sealed with either a sutur...

Novel first through fourth generation hybrid dendritic-linear copolymers, composed entirely of building blocks known to be biocompatible or degradable to natural metabolites in vivo, are described. Specifically, these copolymers are composed of poly(ethylene glycol), glycerol, and succinic acid and are synthesized using a divergent approach in high...

To determine whether a novel photocrosslinkable polymer synthesized from hyaluronic acid would seal experimental full-thickness corneal lacerations in a rabbit model. A solution of hyaluronic acid was modified with methacrylate groups (HA-MA), precipitated, dried, reconstituted in an aqueous solution, and sterilized before use. The viscous polymer...

Descemet membrane detachments are not uncommon following cataract surgery, and large and extensive detachments can have an impressive presentation, with severe corneal edema and marked reduction in visual acuity. Traditional treatment regimens have included observation (with the hopes of spontaneous resolution), anterior chamber injections of air o...

To describe a patient with Osler-Rendu-Weber syndrome who developed a nonsimultaneous intraoperative choroidal hemorrhage in each eye. Interventional case report. A 65-year-old Caucasian woman with Osler-Rendu-Weber syndrome developed a choroidal hemorrhage in the left eye during vitrectomy for a complicated retinal detachment with a poor visual ou...

To report the acute effects of laser in situ keratomileusis (LASIK) on the corneal endothelium. Twenty eyes of 10 consecutive patients (mean age, 38.1 +/- 10.84 years) underwent bilateral simultaneous LASIK for myopic astigmatism (spherical equivalent ranging from -1.75 to -7.13 diopters) without any complications. Each eye was evaluated by slit-la...

Topical anesthesia is safe and effective. The addition of intracameral lidocaine further enhances its analgesic effect. Patients report a high level of satisfaction with the degree of pain control, rapid return of visual function, and avoidance of retrobulbar needles. In certain patient populations, the use of topical anesthesia is clearly advantag...

To document the corneal astigmatism that occurs with macular translocation after scleral infolding surgery. Retrospective case series of a nonrandomized clinical trial. Eight consecutive age-related macular degeneration patients (eight eyes) with choroidal neovascularization who underwent macular translocation with scleral infolding at the Duke Uni...

A 77-YEAR-OLD Hispanic woman had decreased vision in both eyes following sequential bilateral cataract surgery at an outside institution. According to her medical records, she had undergone uncomplicated clear corneal cataract surgery in both eyes, 1 month apart. She had normal postoperative visual acuity and slitlamp examination results. Over the...

This clinical case report demonstrates blepharoptosis-induced corneal steepening and its subsequent resolution after blepharoptosis surgery. A 62-year-old man complaining of blurred vision without apparent cause on clinical examination underwent keratometry and computerized corneal topography, which revealed superior corneal steepening in both eyes...

To determine the causes of postoperative myopia associated with capsular bag distention syndrome (CBDS) and characterize the associated findings. Prospective, multicenter, nonrandomized, comparative (self-controlled) trial. Six eyes from six patients had CBDS develop after phacoemulsification and posterior chamber intraocular lens implantation. Ker...

This report describes an unusual reaction to injected subconjunctival corticosteroid. The authors examined a patient with large areas of conjunctival necrosis at the site of a previous subconjunctival corticosteroid injection. A Gram's strain and culture of the affected conjunctival area and the bottled corticosteroid suspension were negative. Necr...

The study aimed to evaluate the direct effect of intraocular lidocaine hydrochloride (HCl) 1% on corneal endothelial cell function, ultrastructure, and viability using an in vitro perfusion specular microscope system. Paired rabbit and human corneas were isolated and mounted in an in vitro specular microscope for endothelial perfusion evaluation. C...

The objective of this study was to evaluate the epithelium of human corneas stored in Optisol-GS (Chiron Intraoptics, Irvine, CA) for extended periods (2-34 days). Human corneas stored in Optisol-GS (n = 64) were obtained from the Georgia Eye Bank. Corneal epithelial viability was assessed by using the Calcein-AM (Molecular Probes, Inc., Eugene, OR...

The records of 39 patients undergoing 40 consecutive penetrating keratoplasties were reviewed to identify donor factors that might correlate with the presence of an epithelial defect on the first postoperative day. Of the 40 transplanted corneas, 13 (32.5%) had no epithelial defect, 18 (45%) had some epithelial defect, and nine (22.5%) had a total...