About
68
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Introduction
Terri L Meinking, President 2003-present
Global Health Association of Miami (GHAM)
International Research Team
Miami, FL 33186
Additional affiliations
January 2003 - present
Global Health Association of Miami (GHAM)
Position
- CEO
Description
- I started GHAM in Jan. 2003 while still Research Faculty in the Dept of Dermatology in a special division FEST ( Field Epidemiology Survey Team, which was started by Prof Taplin during Vietnam) at the University of Miami School of Medicine.
February 1992 - September 1993
Position
- Collaborating on triple Homicide and other forensic entomology research
March 1980 - September 2003
Position
- Reasearch Associate Professor Dermatology & Cutaneous Surgery (FEST)
Publications
Publications (68)
Head louse infestations continue to be a concern of public health in most countries, including the most developed ones. The present recommendations are intended to inform and stress the role and impact of the different authorities, institutions, industry, and the public in the control of head lice in order to reduce the prevalence of this parasite....
Unlabelled:
Head lice are a source of scalp irritation, social disruption, and loss of school time. Health care providers need authoritative information to help avoid the costs and risks of ineffective treatment. A review was completed to provide relevant information on infestation treatments available in the United States. Three major biomedical...
Background Ivermectin is a broad-spectrum parasiticide in widespread systemic use, including as an off-label treatment for head lice infestation. The potential of the topical use of ivermectin as a treatment for head lice infestation was suggested by an in vitro report of a novel lotion formulation.
Objectives This study investigated the relative e...
The emergence of resistance to treatment complicates the public health problem of head-louse infestations and drives the need for continuing development of new treatments. There are limited data on the activity of ivermectin as a topical lousicide.
In two multisite, randomized, double-blind studies, we compared a single application of 0.5% ivermect...
Pediculosis capitis, infestation with head lice, is common in all human societies. Chemical pediculicides are often used to control head louse infestations, particularly in wealthy communities. A significant number of different protocols have been used to test the efficacy and safety of pediculicides in clinical trials; this constrains scientific c...
The effects of feeding different types of human blood to human body lice, Pediculus humanus humanus L. (Phthiraptera: Pediculidae), on feeding success, longevity and numbers of eggs laid were investigated using an artificial blood-feeding system in the laboratory. No significant differences were found between lice fed on different human blood types...
Benzyl alcohol lotion 5% (BAL 5%) is a non-neurotoxic topical head lice treatment that is safe and effective in children as young as 6 months of age. The safety and efficacy of this pediculicide has been studied in 695 (confirm number) subjects in all phases of clinical development. Scanning electron micrographs (SEM) demonstrated that the active a...
This chapter discusses the lice, Pediculus and Pthirus. Lice are wingless, blood-sucking insects that belong to the order Phthiraptera. Although there are currently 4000 species of lice recognized, only 560 species suck blood and feed on mammals. Lice are very host-specific; therefore, human lice cannot be transmitted to or from other mammals. Ther...
Purpose:
The potential toxicity of currently FDA-approvedprescription and over-the-counter pediculicides, as well as lengthy treatmenttime, incomplete eradication, undesirable odor, and mounting resistance, leavespractitioners, parents and patients desperate for a safe, non-toxic cure. Benzyl alcohol lotion 5% (VIQ) is anon-toxic topical head lic...
One hundred seventy-two subjects with head lice participated in a five-way, investigator-blinded, parallel-group, active-controlled study comparing 0.5% malathion gel (30, 60, and 90 minutes applications), Ovide Lotion (0.5% malathion), and Nix Crème Rinse (1% permethrin). All subjects were treated on day 1. Participants were reevaluated at day 8 +...
Health authorities in the USA, Canada and Australia recommend a "no nit" policy, i.e. the immediate dismissal of all children who have head lice, eggs and/or nits on their hair from school, camp or child-care settings. These children would be readmitted to the institution only when all head lice, eggs and nits have been removed. The "no nit" policy...
Pediculosis capitis, infestation with head lice, is common in all human societies. Chemical pediculicides are often used to control head louse infestations, particularly in wealthy communities. A significant number of different protocols have been used to test the efficacy and safety of pediculicides in clinical trials; this constrains scientific c...
Pediculosis is increasing rapidly in the US and throughout the world due to drug resistance. This new investigational treatment for head lice, L.A. is pesticide free, works as a suffocant, will not cause resistance, and is environmentally safe. The mechanism of action of L.A. is to stun the respiratory spiracles open, thus enabling the treatment to...
Pediculosis is increasing rapidly in the US and throughout the world due to drug resistance. This new investigational treatment for head lice, L.A. is pesticide free, works as a suffocant, will not cause resistance, and is environmentally safe. The mechanism of action of L.A. is to stun the respiratory spiracles open, thus enabling the treatment to...
Pediculosis is increasing rapidly in the US and throughout the world due to drug resistance. This new investigational treatment for head lice, L.A. is pesticide free, works as a suffocant, will not cause resistance, and is environmentally safe. The mechanism of action of L.A. is to stun the respiratory spiracles open, thus enabling the treatment to...
Is migration from isolated indigenous island communities to Panama City associated with an increase in stress? Individuals were randomly sampled from two Kuna communities: 325 individuals in Panama City and 133 on a Caribbean island. Stress was assessed through the Milcom questionnaire, which explores physical symptoms and symptoms relevant to mood...
Head lice from Florida (SF-HL) and California (SC-HL) were resistant to permethrin compared with colonized susceptible lice from Panama (PA-HL) (5.5- and 3.4-fold, respectively) and Ecuador (EC-HL) (8.5- and 5.3-fold, respectively). Permethrin-resistant lice were cross-resistant to pyrethrum and DDT. DNA sequencing validated presence of kdr-type mu...
Our objective was to conduct a randomized, investigator-blinded evaluation of the pediculicidal and ovicidal activity of a reduced application time (20 minutes) of Ovide (0.5% malathion) compared to Nix (1% permethrin) in a south Florida population infested with Pediculus humanus capitis. Either Ovide or Nix was applied according to the label instr...
The anatomy and physiology of head lice make them extremely adaptable to their human hosts but also difficult to eradicate. Their coloring and small size make them difficult to see, and the larvae, or nymphs, have multiple exoskeletons for protection. When exposed to pediculicides, a nymph can shed its outer exoskeleton and receive only a sublethal...
The resistance levels of different human head louse populations from the USA to 1% permethrin were evaluated using permethrin-impregnated, filter paper disk-contact bioassay. Populations from southern California, south Florida and south central Texas showed 1.5-, 3.1-, and 1.5- to 5.1-fold resistance compared to insecticide-susceptible head louse p...
Parasitic diseases caused by helminths, or worms, account for billions of human infections worldwide. Although most human pathogens caused by these organisms are infrequent in the United States, skin manifestations of parasitic diseases are being seen much more frequently in dermatologists' offices due to the increase in immigration and travel. Hel...
Ivermectin is a potent antiparasitic drug and the first commercially available member of a new class of drugs (macrocyclic lactones) that has been approved for human use. Ivermectin has already proven to be highly effective in the elimination of river blindness as a public health burden. Side effects have been minor, and patient acceptance is good....
To determine if NIX (Warner Lambert Healthcare, Morris Plains, NJ) 1% Permethrin Creme Rinse Lice Treatment (1% PLT) without combing will effectively treat >/=95% of patients on day 2 or on day 15; to determine whether combing influences efficacy.
A randomized, observer-blinded study enrolled 95 infested adults and children. All patients were treat...
To compare the pediculicidal activity of 5 head lice products available in the United States on head lice from south Florida.
In vitro pediculicidal product comparison.
Lice Source Services, Inc, located in Plantation, Fla, a clinic for the treatment and grooming of individuals with pediculosis capitis.
Head lice were collected from healthy clients...
To evaluate the pediculicidal and ovicidal activity of 5 head lice products.
In vitro pediculicidal and ovicidal product comparison.
Tropical field station in Panama.
Head lice and eggs were harvested from healthy children infested with Pediculus capitis.
Within 2 hours of capture, lice were placed in continuous, direct contact with the pediculicid...
Among possible contributors to a progressive fall in renal perfusion and function with increasing age, some hypotheses have invoked the rise in blood pressure that occurs with age, and a high-protein diet typical of urban cultures. Kuna Amerinds residing in isolated islands off the Panamanian Coast have a very low protein intake and show no tendenc...
Despite all the available pediculicides and scabicides that have been developed in this century we still find ourselves facing a treatment dilemma. Although body lice are not abundant in the United States, they are still found in the homeless populations of our major cities. With the development of dichlorodiphenyltrichloroethane (DDT) in the early...
The ability to identify individual human hosts based on analyses of blood recovered from the digestive tract of hematophagous arthropods has been a long-term pursuit in both medical and forensic entomology. Blood meal individualization techniques can bring important advancements to studies of vector-borne disease epidemiology. Forensically, these a...
This article reviews the dangers related to marine animal envenomations in Florida. Venomous marine animals exhibit diverse mechanisms of injury and toxicity. Information regarding the morphology, behavior, and health hazards of these dangerous organisms is presented to help medical personnel recognize, diagnose and treat marine envenomations. Haza...
Since the mid-1980s, worldwide reports confirm that scabies in individuals infected with the human immunodeficiency virus (HIV) result in a wide range of-clinical manifestations which differ from those seen in immunocompetent patients. There is also general agreement that HIV-related scabies is more difficult to treat. Oral ivermectin has been show...
The indigenous Kuna who live on islands in the Panamanian Caribbean were among the first communities described with little age-related rise in blood pressure or hypertension. Our goals in this study were to ascertain whether isolated island-dwelling Kuna continue to show this pattern, whether migration to Panama City and its environs changed the pa...
IN THIS ISSUE of the Archives, Franz and colleagues1 report on the comparative percutaneous absorption of lindane and permethrin. They conclude that, for the treatment of scabies, 5% permethrin cream is at least 40 times less likely to cause toxic effects than 1% lindane lotion.
These authors correctly state that surprisingly little clinically rele...
Ivermectin is an anthelmintic agent that has been a safe, effective treatment for onchocerciasis (river blindness) when given in a single oral dose of 150 to 200 micrograms per kilogram of body weight. Anecdotal reports of improvement in patients who suffered from infestation with the mite Sarcoptes scabiei suggest that the ectoparasitic disease sc...
The ability to identify individual hosts of hematophagous arthropods via bloodmeal analyses is a continuing pursuit in both medical and forensic entomology. Characterization of human DNA from blood-feeding arthropods has been advanced substantially by preparation techniques, such as the polymerase chain reaction (PCR). Successful application of amp...
Seabather's eruption (SE) is a highly pruritic eruption under swimwear that occurs after bathing in the ocean. Its cause has been unknown. Few data have been collected since the classic description by Sams in 1949.
Our purpose was to describe the clinical and histopathologic findings in SE and to confirm the cause.
Patients with a pruritic eruption...
For 18 years treatment with lindane or crotamiton products has failed to stem the epidemic of scabies among the Kuna Indians in the San Blas islands of the Republic of Panama. Permethrin 5% cream was introduced as the only treatment in a programme to control scabies on an island of 756 inhabitants and involving workers recruited locally. Prevalence...
Permethrin 5% cream (Elimite) was approved as a treatment for scabies by the U.S. Food and Drug Administration in September 1989. in a doubie-biinded, randomized study, it was compared with crotamiton 10% cream (Eurax) for the treatment of scabies in children 2 months to 5 years of age. Two weeks after a singie overnight treatment, 14 (30%) of 47 c...
Scabies and pediculosis capitis are frequent and often unrecognized causes of multiple streptococcal and staphylococcal pyodermas.
Permethrin 1 per cent creme rinse (NIX) for head lice, and permethrin 5 per cent topical cream for scabies are new, highly effective, safe, and cosmetically elegant treatments which have shown superiority over older rem...
Permethrin 5% dermal cream (Burroughs Wellcome Co.) was compared in an investigator-blinded, randomized study against lindane 1% lotion (Kwell) for the treatment of microscopically confirmed scabies. Eleven of twenty-three patients treated with permethrin cream were cured in 2 weeks (48%). Only two patients had scabies 1 month following a single tr...
Permethrin 1% creme rinse (NIX) was tested as a treatment for Pediculus humanus var capitis (head lice) in a placebo-controlled, double-blinded, randomized study. As a positive control, a third arm of the study included nonrandomized, but investigator-blinded, treatment with 1% lindane shampoo (Kwell). At 14 days after treatment, 97% of patients tr...
Ovicidal activity and killing times were evaluated for six pediculicides, using viable eggs and recently fed head lice from infested children. Lice were continuously exposed to the products until death, and elapsed time was recorded. Eggs were immersed for ten minutes, rinsed, and dried. Four synergized pyrethrin products (RID, R&C Shampoo, A-200 P...
• Ovicidal activity and killing times were evaluated for six pediculicides, using viable eggs and recently fed head lice from infested children. Lice were continuously exposed to the products until death, and elapsed time was recorded. Eggs were immersed for ten minutes, rinsed, and dried. Four synergized pyrethrin products (RID, R&C Shampoo, A-200...
A trial of three treatment schedules, consisting of 1% gamma benzene hexachloride (GBH) lotion applied head to toe and left on the body for 2, 6, or 12 to 24 hours was conducted on an island of 2,076 persons, approximately 70% of whom had clinical evidence of scabies. The island is situated off the north coast of the Republic of Panama. Examination...
Proteinuria develops rapidly after the induction of experimental diabetes and is the major abnormality of renal function in chronically diabetic rats [1–9]. Proteinuria can be prevented or reversed by metabolically effective pancreatic islet transplantation or insulin treatment [3–6, 9]. Albumin is the protein moiety whose renal excretion has been...
Questions
Questions (4)
I was in the field in S America when two team members got dengue, one for the first time. The professor had had another serotype in Africa and had severe hemorrhagic fever and the sheets were soaked in blood and the fever of 106 didn't break for over 5 days.
I have evidence to suggest it does.
The Clinical Trials Supporting Benzyl Alcohol 5% (Ulesfia):A Safe and Effective Topical Treatment for Head Lice; TL Meinking, et al. Pediatric Dermatology Vol:27, No.1:19-24, 2010. It has been an inactive ingredient in all pyrethrin/PBO OTC, 10% in Natroba, in IV fluid as an antimicrobial, OTC Itch-X for bites, normal hair shampoos and conditioners as a preservative, etc. The FDA didn't even require a PK...then after about 500+ as young as 6 mth with no AE, the FDA decides on a PK??
I wanted to know if you have a photo that I can use at my roundtable at the ICP5 in Utah August2-7. Without having just reviewed your article while I was in the middle of an OVIDE lotion vs OVIDE gel Phase II study, I would have thought there was OVIDE resistance in S. FL, USA, since we have had permethrin and pyrethrin resistant head lice in this area for over 15 years. Every subject or household is given a "study host" to take them to each step in the study. The host also checks timing and that a rolled up wash cloth is held over their eyes during treatment The treatment team applies and times application then the subjects are escorted by the host to the shampoo area where the CTM is rinsed off with water into a plastic dish pan. That water is then poured through a flour sack towel that has the study # on it. I count the number of lice or the towel (often what we thought was mild turns out to be moderate or severe after treatment). I record the number of nymphs 1st, 2nd, 3rd instars , males and females and usually the 3rd instarts are the hardest to kill, because they haven't had their final mold so our protected by another exoskeleton.
Since I knew OVIDE lotion and a previous Ovide gel study would kill all lice by the time I got the towel, and it did kill all stages except on the one corner of the towel there were about 1st instars that were not fazed by OVIDE. With a 10X loop they were adult thrips (8 legs). Then we had another girl that just had thrips, also not responding to OVIDE. They turned out to be melon thrips and are not suppose to attack humans, but I guess no one told them that we weren't melon heads. I didn't take pictures, but if anyone has some that I can present at the ICP5 meeting in Utah in Aug. If any of these authors can get in touch with me that would be great to present those pictures at the workshop.
