Tero Karjalainen

University of Eastern Finland | UEF · Centre for Continuous Education

Abstract Background Recent discovery of mechanosensitive Piezo receptors in trigeminal ganglia suggested the novel molecular candidate for generation of migraine pain. However, the contribution of Piezo channels in migraine pathology was not tested yet. Therefore, in this study, we explored a potential involvement of Piezo channels in peripheral tr...

Many noninvasive techniques have been developed recently to explore the mechanical properties of soft tissue. In this paper, dynamic acoustic radiation force induced vibrations on a blood vessel wall were simulated using different stimulation frequencies and stiffness parameters for the vessel wall. The stimulation frequency was varied between 20 H...

Mechanical forces can stimulate the production of extracellular matrix molecules. We tested the efficacy of ultrasound to increase proteoglycan synthesis in bovine primary chondrocytes. The ultrasound-induced temperature rise was measured and its contribution to the synthesis was investigated using bare heat stimulus. Chondrocytes from five cellula...

Ultrasound-stimulated vibro-acoustography (USVA) is one of the recent noninvasive techniques that have been developed to explore mechanical properties of soft tissues. USVA is based on the interference of two focused ultrasound beams that have a slightly different frequency. This interference produces time variation to the acoustic radiation force...

Ultrasound-stimulated vibro-acoustography (USVA) is one of resent noninva- sive techniques that have been developed to explore mechanical properties of soft tissues. USVA is based on the interference of two focused ultrasound beams that have a slightly dif- ferent frequency. This interference produces time variation to the radiation force that vi-...

Increased stiffness of large arteries is known to be a strong indicator of cardiovascular risk. Current methods for determining arterial wall stiffness are either invasive or based on the indirect estimation using e.g. pulse pressure changes. In this paper, we have studied the feasibility of the method called Ultrasound Stimulated Acoustic Emission...

Given the high variability of tissue properties during sonication, temperature monitoring is one of the most crucial components for accurate thermal treatment of tissues with focused ultrasound and other thermotherapy devices. Recently, the method of ultrasound-stimulated acoustic emission (USAE) has been introduced as a potential method for measur...

Vibro-acoustography, a relatively new imaging modality, is applied to imaging ex vivo liver tissue from calves and New Zealand white rabbits. In the first series of experiments, calf liver tissue was heated while the USAE response and temperature were recorded. This demonstrated a strong temperature dependence of the USAE signal. In the second seri...