
Teresa Liliana WargasetiaMaranatha Christian University | Maranatha · Faculty of Medicine
Teresa Liliana Wargasetia
Doctor of Medicine
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70
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Publications (70)
Background
Oxidative stress caused by exposure to ultraviolet (UV) light on the skin can damage deoxyribonucleic acid (DNA) and cause keratinocytes to undergo apoptosis. Endogenous antioxidants which play a role in trapping free radicals are also unable to overcome excess reactive oxygen species (ROS) in the body due to UV exposure, so exogenous an...
Background: The proper processing of fruits and vegetable-based food products will improve appearance, taste, bioactivities, and preservation. Freeze-dried (FD) or lyophilization of foods extends shelf life and preserves food's nutritional value and bioactivities. The objective of this study is to compare the antioxidant properties, nutritional val...
Purpose: Lymphoma, the most predominant neoplastic disorder, is divided into Hodgkin and Non-Hodgkin Lymphoma classifications. Immunotherapeutic modalities have emerged as essential methodologies in combating lymphoid malignancies. Chimeric Antigen Receptor (CAR) T cells exhibit promising responses in chemotherapy-resistant B-cell non-Hodgkin lymph...
Background. Molecules and cytokines can be targeted in cancer therapy. Transforming growth factor-beta (TGF-β) is a cytokine that acts on protein kinase receptors in the plasma membrane. The signaling pathway of TGF-β can trigger the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) pathway, a signal transduction pathway important in cancer gro...
Thalassemia is a genetic blood disorder impacting hemoglobin production, varies in severity, and requires lifelong treatments. The advancement in somatic cell reprogramming through induced pluripotent stem cells (iPSCs) represents a personalized medicine approach that holds promise as a treatment for individuals with thalassemia. One source that co...
Myriad studies have shown that sea cucumber is a promising anti-inflammatory and anticancer agent. Therefore, a study to identify the active compounds contained in sea cucumber, which have the potential as nuclear factor kappa-light-chain-enhancer of activated B cell (NFκB) inhibitors was conducted. NFκB plays a significant role in regulating infla...
Purpose: Lymphoma, the most predominant neoplastic disorder, is divided into Hodgkin and Non-Hodgkin Lymphoma classifications. Immunotherapeutic modalities have emerged as essential methodologies in combating lymphoid malignancies. Chimeric Antigen Receptor (CAR) T cells exhibit promising responses in chemotherapy-resistant B-cell non-Hodgkin lymph...
div align="center"> Recent healthcare research has focused a great deal of interest on using genetic data analysis to predict the risk of hypertension. This paper presents a unique method for accurately predicting the vulnerability to hypertension by utilizing single nucleotide polymorphism (SNP) data. We present a novel neural network design utili...
Highlights:1. Elastase, hyaluronidase, and tyrosinase can all be inhibited by temulawak extract.2. Temulawak extract has strong anti-aging ability and can be used as a candidate for cosmetic applications. AbstractThe process of aging is the gradual loss of a tissue's capacity to heal and maintain normal or physiological form and function. Elastase,...
Oscillatoxins (OTXs) are cytotoxins produced by some marine cyanobacteria. Their unique structures show a great potency as an anticancer agent. The limited availability of OTX derivatives in nature provides little information about their biological activity. Some of OTX activities have been tested in the in vitro or in vivo studies toward cancer ce...
This study aims to analyze the potential of Thaflavine, a compound found in green tea (Camellia sinensis), as an inhibitor in inhibiting B-cell lymphoma through its interaction with the BCl2 apoptosis regulator using an in-silico approach. The research methodology involved the use of software tools such as PyMOL, PyRx, Protein Plus, and the Lepinsk...
Unlabelled:
Acute respiratory distress syndrome (ARDS) is a type of lung failure caused by fluids and hypoxemia. Mesenchymal stem cells (MSCs) have been shown to decrease levels of pro-inflammatory mediators and inflammatory cells. These cells have anti-inflammatory, anti-apoptotic, and anti-microbial activity, and protect against lung injury.
Ob...
Oxidative stress and inflammation have a role in the development of various diseases. Oxidative stress and inflammation are associated with many proteins, including Kelch ECH associating protein 1 (KEAP1) and inducible nitric oxide synthase (iNOS) proteins. The active compounds contained in Holothuria scabra have antioxidant and anti-inflammatory p...
Herbal teas was are widely consumed by people around the world have high antioxidant activities. The flavor and color combination of specific teas enriches the aroma and appearance of the tea, producing a tea with fresh color and tastier flavor. This study determines the antioxidant activity of telang flower tea (Clitoria ternatea), pineapple tea (...
Tea is widely consumed for health purposes to prevent and treat various diseases. This paper reports the antioxidant activities of a herbal tea namely jahe (ginger, Zingiber officinale) telang (Clitoria ternatea L.), and the combination namely JaTe (jahe and telang). Each of jahe, telang, and JaTe teas were made of 2g ginger, 5 buds dried telang fl...
Objective: To evaluate the potential effect of human Wharton’s jelly mesenchymal stem cells (hWJMSCs) on acute respiratory distress syndrome in lipopolysaccharide (LPS)-induced rats.
Methods: The hWJMSCs (5×104/mL, 5×105/mL, 5×106/mL) were administered to rats on day 1 and day 8 after being induced by LPS (5 mg/kg body weight). TNF-α levels in the...
Many people around the world believed that herbal tea had a lot of antioxidants contained in it, thus it was widely drunk all over the world. However, the antioxidant capacities of herbal tea may be various because it is affected by the usage of different plants as its primary ingredient. As a result, this study examines the antioxidant activity of...
Cancer is a major health problem worldwide and the leading cause of death in many countries. It remains challenging to find anticancer treatments that work efficiently for varying types of cancer cells. Several studies revealed that nuclear factor kappa B (NF-κB) is a family of dimeric transcription factors that induce tumor promotion, progression,...
Background: Interleukin-1 receptor antagonist (IL-1Ra) also known as Anakinra is a receptor antagonist of IL-1 especially IL-1β. IL-1β increased in infected COVID-19 patient groups. This study aimed that the IL-1Ra contained in Conditioned Medium Wharton’s Jelly Mesenchymal Stem Cells (CM-WJMSCs) has the potential to inhibit IL-1β which is one of t...
The 2019 novel coronavirus (2019-nCoV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly from its origin in Wuhan City, Hubei Province, China, to the rest of the world. The efficacy of herbal treatment in the control of contagious disease was demonstrated during the 2003 outbreak of severe acute respiratory syndrome...
Breast cancer is the most common type of cancer in women globally. The overexpressed proteins, including EGFR, PI3K, AKT1,
and CDK4, have a role in the growth of breast cancer cells. The 3D peptide structure of sea cucumber Cucumaria frondosa was modeled
and then docked with EGFR, PI3K, AKT1, and CDK4 proteins using AutoDock Vina software. The dock...
Breast cancer is the most common type of cancer in women globally. The overexpressed proteins, including EGFR, PI3K, AKT1, and CDK4, have a role in the growth of breast cancer cells. The 3D peptide structure of sea cucumber Cucumaria frondosa was modeled and then docked with EGFR, PI3K, AKT1, and CDK4 proteins using AutoDock Vina software. The dock...
Objective: Circulating EPCs (endothelial progenitor cells) play a role in neovascularization and vascular repair. Oxidative stress impairs endothelial progenitor. Flavonoid is a phytochemical compound for antioxidant activity. Flavonoid effects toward oxidative stress, apoptosis, and expression of the cell markers on EPCs are not fully understood....
Breast cancer (BC) is the number one cause of deaths from cancer in women. Metastasis in BC is caused by immunosurveillance deficiency, including impairment of Natural Killer (NK) cell maturation, low NK activity, and decreasing cytotoxicity. This study was performed to improve activating receptors and cytotoxicity of NK cells using interleukin 15...
Sea cucumbers have a wide distribution and high abundance in Indonesia. Previous research has shown that sea cucumbers have an anticancer function and have toxicity to various types of cancer cells. Furthermore, we identified the anticancer compounds of the sea cucumber Holothuria scabra collected from the South Malang sea. H. scabra was extracted...
Exercise-induced skeletal muscle adaptation requires degradation of cellular components carried out by autophagy. However, the alteration of autophagy by different intensity of exercise in skeletal muscle is still unknown. In the present study, we investigate whether low, moderate, and high-intensity exercises have different impacts on autophagy ge...
Purpose of Review
In this review, we describe a role of marine natural products in induction and inhibition of autophagy linked to cancers.
Recent Findings
Some of the compounds from marine organism showed ability to induce autophagy that directs death in cancer cells, as well as some of the others might prevent pro-survival autophagy process. The...
Context: Chronic kidney disease (CKD) can lead to terminal kidney failure. Previous study has shown that protein hydrolysate in yellow peas (Pisum sativum L.) can be used as a natural remedy for CKD. Aims: To obtain hydrolysate protein that is most effective in improving kidney function of cisplatin (CP)-induced Wistar rats, based on urea, creatini...
Introduction: Renal damage can be caused by various causes. One of them is drugs that are toxic to the renal, such as cisplatin (CP). In an attempt to find a remedy for antinephrotoxicity, several hydrolyzed proteins were investigated. This study was conducted to find out the effects of 8 peas protein hydrolysates (PPH) hydrolyzed using simple proc...
Introduction:
The most cases of cancer death, which are in the first rank among cancers suffered by women is breast cancer. The breast cancer therapy for patients has been done, but still not optimal, so it is necessary to understand the mechanism of therapy in model cell of breast cancer.
Aim:
This study aim to develop an isolation technique of...
Objective(s)
This study aims to evaluate the activity of mangosteen peels extract (MPE) as protection agent on induced-glucose mesangial cells (SV40 MES 13 cell line (Glomerular Mesangial Kidney, Mus Musculus)).
Materials and Methods
MPE was performed based on maceration method. Cytotoxic assay was performed based on MTS (3-(4,5-dimethylthiazol-2-...
Ineffectiveness of cancer therapy may originate in the incompatibility of the treatment with various mutations in the cancer cells. Finding novel anticancer treatments that work efficiently for varying types of cancer cells remains challenging. Previous studies have identified that compounds in sea cucumbers are capable of inhibiting the growth of...
Introduction
Breast cancer remains a major public health burden. Low efficacy, low safety and side-effects of some cancer drugs have increased the research interest for new anti-cancer drugs, particularly from natural products. Sea cucumber as one of marine organisms contains numerous bioactive compounds which have anti-oxidant, anti-inflammatory a...
One of the biggest problems in diagnosing nasopharyngeal carcinoma (NPC) is the lack of biomarkers to detect the disease in its early stages. Thus, the exploration of biomarkers, which have the potential to be used to diagnose NPC in its early stages, is crucial. NPC is allegedly controlled by microRNAs (miRNAs); these molecules can be secreted out...
Antioxidant agent can eliminate the free radicals due to oxidative stress that has been reported as the main cause of diabetes mellitus. This study evaluated the effect of Curcuma longa rhizomes and its compounds curcumin and bisdemethoxycurcumin as antioxidants and antidiabetic activity. The phytochemical assay was performed with modified Farnswor...
Purpose of Review
This article gives a brief overview on the role of sea cucumber active compounds in cancer cell killing that may be developed into a potent anti-cancer agent.
Recent Findings
The rapid development of knowledge and technology in molecular biology has as yet not succeeded in identifying a safe drug for cancer therapy. The central i...
Reactive oxygen species or ROS is formed in vivo and many of them are considered as strong oxidizing agents, and it's capable in destruction DNA and other biomolecules. Elevated ROS production generates development of malignancy. Moreover, the 'normal' rates of ROS generation may play a role in the increased risk of cancer development. Indeed, the...
Osteoarthritis is commonly the most joint disorder that rises with the aging of the population. The oxidative stress and overproduction of reactive oxygen species (ROS) are responsible for many process related to osteoarthritis such as the intracellular signaling process, apoptosis, extracellular matrix synthesis, dysfunction of the subchondral bon...
The aim of cancer therapy is to specifically eradicate tumor cells while causing minimal damage to normal tissues and minimal side-effects. Because of this, the use of natural substances with low toxicity is a good option. Sea cucumbers are one of many potential marine animals that contain valuable nutrients and medicinal properties. The medicinal...
Latar Belakang: Penyakit jantung koroner (PJK) merupakan penyebab kematian nomor satu di dunia. Etiologi PJK tersering adalah aterosklerosis dengan dislipidemia sebagai salah satu faktor risiko. Berbagai upaya dilakukan untuk menurunkan kadar kolesterol LDL untuk penanganan dislipidemia. Tujuan: Penelitian ini untuk mengetahui efek minyak jagung da...
Salah satu cara pemberantasan nyamuk Culex yang merupakan vektor beberapa penyakit antara lain filariasis, Japanese encephalitis , St. Louis encephalitis , dan West Nile virus ialah dengan larvasida. Larvasida berbahan kimia ( temephos ) memiliki efek samping berbahaya bagi kesehatan dan lingkungan. Oleh sebab itu, dilakukan penelitian penggunaan d...
Lung cancer is a disease which has high incidence and mortality rate. It makes lung cancer become one of the biggest public health problems. The aim of this study is to find out the description of lung cancer patients in Immanuel Hospital Bandung from January 2013 to December 2014 based on the prevalence, gender, age, clinical features, metastasis,...
Cerebrospinal fluid (CSF) leak is one of Functional Endoscopic Sinus Surgery (FESS)complications. Since 2001, it was reported that there is one case of CSF leak as FESScomplication in ENT-HN Department, Faculty of Medicine, Maranatha Christian University -Immanuel Hospital in Bandung. The purpose of this case report is present clinical findings and...
Excessive intake of vitamin D in pregnant mice can cause fetal bone mass loss. This research aimed to study whether high dose supplementation of vitamin D3 can interfere femur bone calcification in fetal mice. This research used true experimental laboratory method using completely randomized design on five male mice and five female mice (Mus muscul...
Kelebihan asupan vitamin D pada mencit yang bunting dapat menyebabkan penurunan massa tulang janin. Penelitian dilakukan untuk mengetahui apakah pemberian suplementasi vitamin D3 dosis tinggi dapat mengganggu kalsifikasi tulang femur janin mencit. Metode eksperimental laboratorium dengan rancangan acak lengkap dilakukan menggunakan lima ekor mencit...
Jumlah kasus kanker yang disebabkan oleh obesitas diperkirakan sebesar 20%. The International Agency for Research into Cancer dan the World Cancer Research Fund melaporkan bahwa kanker yang sering dialami oleh penderita obesitas adalah kanker endometrium, adenokarsinoma esofagus, kolorektal, payudara postmenopause, prostat, dan ginjal. Risiko kegan...
Liver cancer is the fifth most common cancer in Indonesia. This research is to find out the prevalence and characteristics of liver cancer patients in Immanuel Hospital Bandung within the January 2013 until December 2014 period based on age, gender, clinical symptoms and predilections. This study was a descriptive verificative research with data re...
MicroRNAs (miRNAs) are involved in the signaling circuits regulation within a cell and their deregulation plays an important role in cancer development and progression. In this review, we discussed miRNA biogenesis, miRNA function and the effect of miRNA abnormalities in cellular pathways that led to transformation of normal cells into cancer cells...
Background: The pathogenesis of Gestational Trophoblastic Disease (GTD) is not clearly known.
Objective: In this study, immunoexpression of proteins Bcl-2 and Beclin-1 in trophoblastic lesions and normal trophoblastic tissue was conducted to study the mechanism of apoptotic and autophagic cell death that is expected to complete the study of GTD pat...
Objective: Cervical cancer is the second most common cancer as well as one of leading cause of cancer-related death for women worldwide. In regards to that issue, focus of this paper will be on popularly used Piperaceae members including Piper betle L, Piper cf fragile Benth, Piper umbellatum L, Piper aduncum L, Piper pellucidum L. This research wa...
Background: Our research is to explore the herbal medicine as an alternative therapy for obtaining chemotherapeutic drugs base on the antioxidant, cytotoxic and apoptotic inducer activities. Piperaceae including Piper betle L., Piper cf. fragile Benth, Piper umbellatum L., Piper aduncum L., Piper pellucidum L. are popularly used as herbal efficacy....
Various diseases including cancer and cardiovascular diseases are induced by free radicals via lipid peroxidation, protein peroxidation, DNA damage, and cellular degeneration in the cells. Piper betle L., commonly called betel, belongs to the Piperaceae family. It originated from South and South East Asia, and has been used as a traditional medicin...
Abstrak Penyakit trofoblas gestasional (PTG) mencakup mola hidatidosa (komplit dan parsial) dan tumor trofoblas gestasional (mola invasif, koriokarsinoma, placental site trophoblastic tumor, dan epithelioid trophoblastic tumour). Para ahli mempelajari kelainan perkembangan sel-sel trofoblas pada berbagai lesi trofoblastik PTG termasuk exaggerated p...
Abstruk: Otofogi adalah sistem degradasi intrasel yang berperan penting dalam pengaturan homeostatis protein dan sangat diperlukan untuk kelangsungan hidup sel yang menghadapi stres metabolik. Otofqgi merupakan salah satu kematian sel terprogram. Sejumlah penelitian menunjukkan peran otofagi sebagai peneksn tumor, namun pengaruh otofagi dalam pertu...
The occurrence of breast carcinoma is common in women. Ductal carcinoma in situ (DCIS) of the breast is breast carcinoma with tumor cells which exist in the breast glandular duct and have not infiltrated into stroma. Retrospective study has been made on 23 paraffin blocks of morphological breast DCIS variants, namely kribriform, solid, and komedo....
Tuberculosis pleural effusion is a manifestation of extrapulmonal tuberculosis, which is rampant in various countries in the world, including Indonesia. Nowadays one-third of the world population has been infected by tuberculosis. Every year there are approximately 8 million new tuberculosis patients throughout the world and nearly 3 million people...
Nowadays, cellular phones are widely used, but most people seem do not aware of the effect of radio frequency electromagnetic radiation (RFEMR) on human body, especially the male reproduction system. The objective of this study is to investigate the biological effects of RFEMR of cellular phone on sperm motility and sperm count. Sixteen mice of BAL...
Abstrak Kemajuan dalam bidang biologi molekuler telah memunculkan teknologi untuk memanipulasi gen-gen in vivo untuk pengobatan penyakit melalui terapi gen. Akhir-akhir ini, penyakit-penyakit target untuk terapi gen telah meluas dari kelainan metabolik kongenital menjadi penanganan terhadap penyakit kanker. Pendekatan terapi gen untuk pengobatan ka...
Abstrak Sejak beberapa dekade yang lalu, telah diketahui bahwa kelainan autistik berkaitan dengan pewarisan sifat. Untuk menentukan gen-gen yang terlibat dalam autisme, para peneliti melakukan skrining genom dengan menggunakan peta kromosom dan penanda. Penanda-penanda yang secara konsisten terdapat pada anggota-anggota keluarga penderita memberi p...
Abstrak Abstract In the last few years, very rapid progress in the cloning technology and its development towards human cloning has become a hotly-debated issue. Cloning, which is the process of formation of a number of individuals with the same genetic structure, can be done by means of embryo-splitting method and nuclear transfer. Human cloning t...
Abstrak Pendahuluan Bioinformatika adalah apli-kasi dari alat komputasi dan ana-lisis untuk menginterpretasikan data-data biologi. 1 Dewasa ini, bioinformatika berkembang menja-di kajian yang memadukan disi-plin ilmu biologi molekul, mate-matika dan teknik informasi. 2 Kajian bioinformatika tidak lepas dari perkembangan biologi molekul modern yang...
The imbalance between free radicals and antioxidants in the biology system can cause various diseases. Betel leaves (Piper betel L.), parts of a medicinal plant, are popularly used as a herbal remedy for diseases, but the scientific basis especially of their antioxidant properties remains unknown. To evaluate free radicals scavenger activity of eth...