Teresa Karrer

RWTH Aachen University · Department of Psychiatry, Psychotherapy and Psychosomatics

Many theories of cognitive aging are based on evidence that dopamine (DA) declines with age. Here we performed a systematic meta-analysis of cross-sectional PET and SPECT studies on the average effects of age on distinct DA targets (receptors, transporters, or relevant enzymes) in healthy adults (N=95 studies including 2,611 subjects). Results reve...

Alterations in serotonin (5-HT) function have been hypothesized to underlie a range of physiological, emotional, and cognitive changes in older age. Here, we conducted a quantitative synthesis and comparison of the effects of age on 5-HT receptors and transporters from cross-sectional positron emission tomography and single-photon emission computed...

Psychiatric patients are treated every day by medical doctors based on clinical guidelines grounded in group definitions. Therapeutic intervention for a particular patient, however, frequently follows a trial-and-error path (cf. Rush et al. 2006). On average, only about 50% of patients benefit from a specific psychotropic drug therapy (Wong et al....

Background. The exploration and therapy of depression is challenged by heterogeneous etiologic mechanisms and various comorbidities. With the growing trend towards big data in psychiatry, exploration and therapy can increasingly target the individual patient. This novel objective requires special methods of analysis. Objectives. Hence, the opportun...

Every day, humans make countless decisions which require the integration of information about potential benefits (i.e., rewards) with other decision features (i.e., effort required, probability of an outcome, or time delays). Here we examine the overlap and dissociation of behavioral preferences and neural representations of subjective value in the...

Age-related alterations in serotonin (5-HT) function have been hypothesized to underlie a range of physiological, emotional, and cognitive changes in older age. Here, we conducted a quantitative synthesis and comparison of the effects of age on 5-HT receptors and transporters from cross-sectional PET and SPECT imaging studies. Random-effects meta-...

Schizophrenia is a devastating brain disorder that disturbs sensory perception, motor action, and abstract thought. Its clinical phenotype implies dysfunction of various mental domains, which has motivated a series of theories regarding the underlying pathophysiology. Aiming at a predictive benchmark of a catalogue of cognitive functions, we develo...