Teresa Garcia Gasca

• Ph D
• Head of Department at Autonomous University of Queretaro

Call for Papers – Special Issue in Metabolites (MDPI): “Endocrine Disruptors, Nutritional Modulators and Metabolic Pathways in PCOS: From Exposure to Intervention” We are pleased to invite researchers to contribute original articles and reviews to this Special Issue, which aims to explore how exposure to endocrine-disrupting chemicals (EDCs) affec...

Background: rTBL-1, a recombinant lectin from Phaseolus acutifolius, exhibit proapoptotic activity on colon cancer cells and inhibitory properties on colon tumorigenesis in vivo. Apoptosis has been associated with a phospho-EGFR/phospho-p38/phospho-p53 mechanistic axis. Immunogenicity data have been observed in treated animals, but its possible inv...

Lectins are proteins that specifically recognize carbohydrates on cell membranes, triggering several cellular events such as apoptosis of cancer-transformed cells; however, the mechanisms of action remain incompletely understood. Our research group has reported that a concentrated fraction of Tepary bean lectins (Phaseolus acutifolius; TBLF) exhibi...

Pithecellobium dulce (P. dulce) is a Mexican plant that is consumed raw or in different preparations, and its anti-inflammatory and antioxidant properties have traditionally been useful in treating several conditions. However, the post-harvest drying process can alter the content of bioactive compounds in P. dulce. This study aims to evaluate the i...

Recently, we reported that a recombinant Tepary bean (Phaseolus acutifolius) lectin (rTBL-1) induces apoptosis in colon cancer cell lines and that cytotoxicity was related to differential recognition of β1-6 branched N-glycans. Sequencing analysis and resolution of the rTBL-1 3D structure suggest that glycan specificity could be strongly influenced...

The killer systems of S. cerevisiae are defined by the co-infection of two viral agents, an M virus and a helper virus. Each killer toxin is determined by the type of M virus (ScV-M1, ScV-M2, ScV-M28, and ScV-Mlus), which encodes a specific toxin (K1, K2, K28, and Klus). Since their discovery, interest in their potential use as antimicrobial agents...

Introduction: The gut microbiota plays important roles in physiological and immune processes. Some metabolic disorders and complications during pregnancy, such as gestational diabetes mellitus (GDM), have been associated with alterations in the gut microbiota. The aim of this study was to characterize alterations in fecal microbiota (as a non-invas...

La participación de la mujer en la esfera pública toma sin duda cada vez mayor relevancia, el ingreso a la educación superior y su participación en el ámbito laboral cada vez es más destacado, sin embargo, el camino sigue siendo difícil para la gran mayoría de ellas y lo es más aún cuando a la par llevan a cabo ambas actividades: son estudiantes un...

Background Gestational diabetes mellitus (GDM), a type of diabetes that occurs for the first time during pregnancy, may predispose the development of chronic degenerative diseases and metabolic alterations in mother and offspring. DNA methylation and microRNA (miRNA) expression are regulatory mechanisms of gene expression that may contribute to the...

Capsaicinoids are a unique chemical species resulting from a particular biosynthesis pathway of hot chilies (Capsicum spp.) that gives rise to 22 analogous compounds, all of which are TRPV1 agonists and, therefore, responsible for the pungency of Capsicum fruits. In addition to their human consumption, numerous ethnopharmacological uses of chili ha...

Gestational diabetes mellitus (GDM) is a common metabolic disorder, usually diagnosed during the third trimester of pregnancy that usually disappears after delivery. In GDM, the excess of glucose, fatty acids, and amino acids results in foetuses large for gestational age. Hyperglycaemia and insulin resistance accelerate the metabolism, raising the...

Las células dendríticas (DC) son subpoblaciones especializadas y terminalmente diferenciadas de células mieloides, con abundantes procesos membranosos que divergen como dendritas. Su presencia en los tejidos es ubicua y operan como presentadoras de antígeno profesionales. Una vez que las DC detectan signos de infección (patrones moleculares asociad...

Bioactive compounds in plant-based food have protective effects against metabolic alterations, including non-alcoholic fatty liver disease (NAFLD). Bean leaves are widely cultivated in the world and are a source of dietary fiber and polyphenols. High fat/high fructose diet animal models promote deleterious effects in adipose and non-adipose tissues...

Amaranth has many interesting features, both nutritional and otherwise, that make it attractive as a food crop. Plants grown in greenhouses have higher yields but lower nutritional value compared to those grown in open fields. This prompted an interest in studying viable elicitors for the production of amaranth. Small hydrogen peroxide (H2O2) conce...

Stress is a condition that has been related to the development of risk behaviors for health such as sugar-sweetened beverages (SSBs) consumption. The aim of this study was to examine the link between SSBs consumption and perceived stress level in university students. This was an observational, cross-sectional and single-time-point study where the s...

Previous works showed that a Tepary bean lectin fraction (TBLF) induced apoptosis on colon cancer cells and inhibited early colonic tumorigenesis. One Tepary bean (TB) lectin was expressed in Pichia pastoris (rTBL-1), exhibiting similarities to one native lectin, where its molecular structure and in silico recognition of cancer-type N-glycoconjugat...

(1) Background: obesity is a global public health problem; various factors have been associated with this disease, and genetic factors play a very important role. Previous studies in multiple populations have associated a gene with fat mass and obesity (FTO). Thus, the present work aims to identify and determine associations between genetic variant...

Growing interest has recently been shown in Tepary beans (Phaseolus acutifolius) because they contain lectins and protease inhibitors that have been shown to have a specific cytotoxic effect on human cancer cells. Bean lectins offer protection against biotic and abiotic stress factors, so it is possible that mechanical foliar damage may increase le...

We present the purification and characterization of the two most abundant isoforms of lectins isolated from Tepary bean (Phaseolus acutifolius) seeds, which have been shown to differentially affect the survival of different cancer cells. They were separated by concanavalin A-affinity chromatography. After purification, to release the N-glycans, the...

High-fat/high-fructose diets promote early metabolic disorders in weight and lipid and glucose metabolism. Bioactive compounds such as polyphenols and fiber present in plant-based food prevent the development of metabolic disorders. The objective of the present study was to evaluate the effect of Phaseolus vulgaris L. Flor de Mayo Eugenia (FME) bea...

Obesity is one of the main public health problems in Mexico and the world and one from which a large number of pathologies derive. Single nucleotide polymorphisms (SNPs) of various genes have been studied and proven to contribute to the development of multiple diseases. SNPs of the leptin pathway have been associated with the control of hunger and...

ABSTRACT Apoptosis is a biological process that allows adequate cellular turnover and the elimination of damaged or infected cells. However, there are compensatory molecular mechanisms that promote cell proliferation after increased apoptotic events. These events are commonly mediated by mitogenic proteins, released by apoptotic cells, and received...

Simple Summary When two different species or subspecies of animals have progeny, we speak about hybrid organisms, which present a mixture of the genetic characteristics of their parents. This phenomenon occurs in nature in a common way, although most of the time the hybrids between species are sterile. In this work, the venom characteristics of hyb...

High-fat/high-fructose diets promote early metabolic disorders in weight, lipid and glucose metabolism. Bioactive compounds such as polyphenols and fiber present in plant-based food prevent metabolic disorders development. The objective of the present study was to evaluate the effect of bean leaves on early metabolic alterations in Wistar male rats...

Angiogenesis, the formation of new blood vessels, underlies tissue development and repair. Some medicinal plant-derived compounds can modulate the angiogenic response. Heliopsis longipes, a Mexican medicinal plant, is widely used because of its effects on pain and inflammation. The main bioactive phytochemicals from H. longipes roots are alkamides,...

Time-restricted feeding and food enriched in polyphenols are strategies to prevent or reduce metabolic disorders. Bean leaves (Phaseolus vulgaris L.) are a recognized source of polyphenolic compounds, whose effects on metabolic pathways are not well studied. We evaluated the combined effects of dietary supplementation with Phaseolus vulgaris leaves...

Background Vitamin D (VD) has been classically associated with calcium homeostasis and bone mineral density since it has a key role on mineralization and resorption. Immunomodulatory effects have been attributable to VD; low concentrations of VD have been associated with elevation of inflammatory markers. Inflammatory autoimmune diseases, such as m...

Affinin is mainly recognized by its antinociceptive effect. Recently, our research group demonstrated that this compound produces vasodilation via activation of the gasotransmitters signaling pathways. However, the molecular targets of affinin were not identified. Considering the structural similarity of this alkamide with anandamide, we hypothesiz...

Diabetes mellitus (DM) is a multifactorial disease; it represents a set of autoimmune, metabolic, and genetic disorders, which include hyperglycemia and insulin resistance. There are two types of DM; type 1, which is due to the acute destruction of insulinproducing cells in the pancreas, and type 2, in which insulin action or secretion becomes insu...

The production of heterologous proteins for medical use is an important area of interest. The optimization of the bioprocesses includes the improvement of time, costs, and unit operations. Our study shows that a lectin fraction from Tepary bean (Phaseolus acutifolius) (TBLF) has cytotoxic effects on colon cancer cells and in vivo antitumorigenic ac...

Although cognitive impairment (CI) is classically associated with aging, it has been proposed that neurological pathologies may increase the risk to suffer CI. Despite the evidence of an elevated prevalence of CI in patients with multiple sclerosis (MS), it is not considered among standard clinical evaluations, due the lack of specialists and time...

Muscle development involves coordinated molecular events leading to cell proliferation, fusion, differentiation, sarcomere assembly, and myofibrogenesis. However, under physiological or pathological stress, energy requirements and secretion of glucocorticoids increase, resulting in muscle atrophy because of the depletion of energy reserves. Glucoco...

The elongation of very long chain fatty acids (ELOVL) is a family of seven enzymes that have specific functions in the synthesis of fatty acids. Some have been shown to be related to insulin secretion (ELOVL2), and in the lipid profile (ELOVL6) and patients with various pathologies. The present work focused on the study of ELOVL polymorphs with cli...

The Tepary bean (Phaseolus acutifolius) lectin fraction (TBLF) exhibits differential cytotoxicity on colon cancer cells and inhibition of early tumorigenesis in the colon (50 mg/kg, three times per week, for 6 weeks). TBLF showed low toxicity with the ability to activate the immune system; however, some adverse effects are the loss in body weight g...

Background & aims Evening chronotype has been linked with obesity, diabetes and metabolic syndrome (MetS) in middle-aged and older adults. However, few studies have analyzed this association in young adults. The aim of this study was to assess potential associations between individual chronotype and cardiometabolic outcomes in young adults of two i...

Background: Obesity is a worldwide health problem. Genetic studies have shown the association between rs1805086 localized in myostatin (MSTN) gene with body fat; however, there is little evidence of its relation with metabolic disturbances. Aim: To determine whether rs1805086 is associated with obesity and metabolic disturbances in a Mexican adult...

Herein, we report the production of a recombinant Tepary bean lectin (rTBL-1), its three-dimensional (3D) structure, and its differential recognition for cancer-type glycoconjugates. rTBL-1 was expressed in Pichia pastoris, yielding 316 mg per liter of culture, and was purified by nickel affinity chromatography. Characterization of the protein show...

Lectins are bioactive proteins with the ability to recognize cell membrane carbohydrates in a specific way. Diverse plant lectins have shown diagnostic and therapeutic potential against cancer, and their cytotoxicity against transformed cells is mediated through the induction of apoptosis. Previous works have determined the cytotoxic activity of a...

A Tepary bean lectin fraction (TBLF) has been studied because it exhibits differential cytotoxic and anticancer effects on colon cancer. The present work focuses on the evaluation of the apoptotic mechanism of action on colon cancer cells. Initially, lethal concentrations (LC50) were obtained for the three studied cell lines (HT-29, RKO and SW-480)...

Muscle growth is regulated by several factors including the growth differentiation factor 8, known as myostatin, an inhibitor of myocyte differentiation and proliferation. Research on myostatin regulation was already conducted to improve growth rates in farmed animals, including aquatic species. To explore the effects of myostatin inactivation in a...

T cell acute lymphoblastic leukaemia is a type of cancer that develops from lymphoid progenitors, and chemotherapy is corner stone of the treatment. Thiopurine drugs, consisting of 6-mercaptopurine, 6-thioguanine, and azathioprine (Aza), can effectively treat this disease. To be activated, Aza must first be biotransformed to 6-mercaptopurine by thi...

Overweight/obesity, dyslipidemias, hypertension and hyperglycemia are strongly related to non-communicable diseases (NCD) in which genetic and environmental factors interact with each other. The Mexican population exhibit a genetic disposition to metabolic syndrome, type 2 diabetes, as well as many forms of dyslipidemia. This study aimed to determi...

Currently, the use of medicinal plants is one of the most important biotechnological alternatives in the treatment of numerous diseases, particularly non-communicable diseases. One such plant, Cnidoscolus aconitifolius, also known as “chaya” in Mexico, is a rich source of bioactive phytochemicals. It is widely distributed across Central America and...

Introduction: aberrant crypt foci (ACF) are colon preneoplastic lesions that can be used as a tool to study preventive processes for colorectal cancer (CRC). This model consists of initiation induced by azoxymethane (AOM) and promoted by sodium dextran sulfate (DSS), simulating human colonic carcinogenesis in a rat model. There is no direct inform...

Tepary bean (Phaseolus acutifolius) lectin fraction (TBLF) has been shown to specifically bind and induce cell death of different types of cancer cells and also has exhibited an effect on early colon tumorigenesis. However, the development of a pharmaceutical formula is not possible yet because the production process is expensive and slow and provi...

Background and Aims: Cnidoscolus aconitifolius is a shrubby species that is used as an ornamental, medicinal and food plant in various parts of the world, known in Mexico as chaya. Little research has been published on its phenolic composition and antioxidant capacity. The objective of this study is to determine phenolic composition and antioxidant...

Aberrant crypt foci (ACF) is the precursor lesion of colorectal carcinogenesis (CRC), one of the most common malignancies in the world. Many studies have reported that people with higher phytochemical intake are at a reduced risk of developing ACF. One example of the botanical potential of preventive plant products is Cnidoscolus aconitifolius (CA)...

Snakebite envenoming is a serious medical problem in different areas of the world. In Latin America, the major prevalence is due to snakes of the family Viperidae, where rattlesnakes (Crotalus) are included. They produce hemotoxic venom which causes bleeding, tissue degradation and necrosis. Each venom has several enzymatic activities, producing di...

Abstract: The anticancer use of genistein (Gen) has been severely limited due to its low water solubility, low bioavail- ability, and instability under experimental conditions. To overcome these limitations, we propose a formulation of a hybrid nanomaterial (HNM) based upon the incorporation of Gen into PEGylated silica nanoparticles (PEG-SiNPs) (G...

It contains data about growth of Aeromonas dhakensis at several salinity, temeprature and pH levels; LC50 adn IC50 of Ad ECPs on 3T3-L1 cells; Kapla-Meier survival curves of tilapia challenged with Ad

Muscle development involves coordinated molecular events leading to cell proliferation, fusion, differentiation, sarcomere assembly, and myofibrogenesis. However, under physiological or pathological stress, energy requirements and secretion of glucocorticoids increase, resulting in muscle atrophy because of the depletion of energy reserves. Glucoco...

Lectins are proteins that have the ability to recognize and bind in a reversible and specific way to free carbohydrates or glycoconjugates of cell membranes. For these reasons, they have been extensively used in a wide range of industrial and pharmacological applications. Currently, there is great interest in their production on a large scale. Unfo...

Phenolic compounds are present in goat milk and cheese. The composition of goat milk and its products may vary depending on factors such as season, feeding system and heat treatment. The aim of this work is to quantify total phenolic compounds (TPC) and antioxidant capacity in pasteurized and unpasteurized samples of milk, milk whey, and cheese fro...

The Amaranth is a plant considered as a third millennium crop due to its nutritional properties and its agronomic versatility. Amaranth (Amaranthus hypochondriacus L.) can be cultivated in greenhouses or the open field. Greenhouse cultivation provides better yields but may affect chemical composition. In this study we compared antioxidant capacity,...

Previous work showed that Tepary bean (Phaseolus acutifolius) lectins exhibit differential cytotoxic effects on cancer cell lines by apoptosis induction. In vivo studies using a Tepary bean lectin fraction (TBLF, 50 mg/kg of body weight) after colon cancer induction in rats showed that TBLF inhibited early precancerous lesions without systemic toxi...

Phaseolus acutifolius (Tepary bean) lectins have been studied as cytotoxic molecules on colon cancer cells. The toxicological profile of a Tepary bean lectin fraction (TBLF) has shown low toxicity in experimental animals; exhibiting anti-nutritional effects such as a reduction in body weight gain and a decrease in food intake when using a dose of 5...

Digestive system cancers—those of the esophagus, stomach, small intestine, colon-rectum, liver, and pancreas—are highly related to genetics and lifestyle. Most are considered highly mortal due to the frequency of late diagnosis, usually in advanced stages, caused by the absence of symptoms or masked by other pathologies. Different tools are being i...

http://oajournals.clytoaccess.com/metabolic-alterations-mexican-young-adults-sensitivity-and-specificity-approaches-between

Heliopsis longipes roots have been widely used in Mexican traditional medicine to relieve pain, mainly, toothaches. Previous studies have shown that affinin, the major alkamide of these roots, induces potent antinociceptive and anti-inflammatory activities. However, the effect of H. longipes root extracts and affinin on the cardiovascular system ha...

Amaranth can be cultivated in greenhouses or open fields. The aim of this study was to compare the basic chemical composition and growth parameters of Amaranthus hypochondriacus grown in a greenhouse in comparison to the open field. Each cropping system was assigned an experimental area of 100 m2. Cultivation was performed directly in irrigated fur...

Artículo de revisión RESUMEN Entre los insectos existe una gran variedad de especies y muchas de ellas tienen la capacidad de interaccionar con el mundo vegetal. Este tipo de interacciones van desde aquellas de carácter mutualista hasta las antagónicas. El tipo de interacciones planta-insecto puede deberse en gran medida a la adaptación que tenga e...

Obesity and insulin resistance (IR) are interdependent multifactorial processes that cannot be understood separately. Obesity leads to systemic inflammation and increased levels of free fatty acids that provoke IR and lipotoxicity. At the same time, IR exacerbates adipose cell dysfunction, resulting in chronic inflammation and major lipotoxic effec...

Recent findings made by our group indicate that the iron content in Phaseolus vulgaris leaves is at least four times greater than in grains therefore, we evaluated the effect of supplementation with bean leaf (iron content of 275 mg/kg on a dry basis) in iron-deficient rats. Anemia was induced by feeding rats with an iron-deficient diet (IDD) for 1...

Two non-fetuin-binding lectins from tepary bean (Phaseolus acutifolius) seeds were purified and characterized. Both lectins LA and LB showed by two dimensional gel electrophoresis very similar apparent molecular mass, and their isoelectric point for both lectins were also very close. Mass spectrometry analysis confirmed these similarities showing h...

Phaseolus is the most important food legume for human consumption in the world. Its seeds consist mainly of carbohydrates and are a good source of nitrogen and protein. It also contains calcium, magnesium, potassium, phosphorus, copper, iron, zinc, manganese and sulfur. This legume is rich in bioactive components such as enzyme inhibitors, lectins,...

This study investigated the effect of a β- hydroxyphosphonate analog of L-carnitine (L-CA) (CAS number: 1220955- 20-3, Component: 1221068-91-2, C12H29NO4PI), (3-Hexanaminium, 1-(dimethoxyphosphinyl)-2-hydroxy-N,N,N,5- tetramethy-iodide (1:1), (2R, 3S)) on parameters related with type-2 diabetes in an in vitro model. Nontoxic concentrations of L-CA...

La presente invención hace referencia a glicoproteinas recombinantes bioactivas producidas mediante la modificación genética de plantas de frijol Tépari (Phaseolus acutifolius). Estas glicoproteínas se obtienen a través de una estrategia que permite conservar las glicosilaciones especie-especificas que Phaseolus acutifolius le confiere a sus lectin...

This study was conducted to evaluate the potential use of spineless cacti specie (Opuntia ficus indica var. copena [OFI]) and four native Opuntía species with spines (O. megacantha [OMA]; O. streptacantha [OSA]; O. hyptiacantha [OHA], and O. robusta [ORA]). As alternative feed supplements for ruminants, considering their chemical composition, in vi...

Our previous studies have shown that a lectin rich fraction (TBLF) extracted from Tepary bean seeds differentially inhibits cancer cells proliferation in vitro. Before testing the in vivo anticancer effect, the acute and subchronic toxicological assays in rats were conducted, where an oral dose of 50 mg/body weight kg was determined as the NOAEL. T...

The amount of lipids in a diet and their source are determining factors of the lipid profile. The purpose of this study was to evaluate the addition of six types of different commercial vegetable oils (avocado, canola, high oleic safflower, soybean, grape seed and partially hydrogenated vegetable oil) to the diet of Wistar rats at two different con...

Resumen: L a población mundial de la tercera edad va en cons-tante incremento, desgracia-un conjunto de enfermedades relacionadas con inadecuadas ingestas de alimentos y deriva-das del proceso natural degene-rativo. En este estudio observa-cional, transversal y descriptivo-mación de consumo energético mediante R24h en ancianos, comparando los regis...