Temir A Demir

Eskisehir Osmangazi University | ESOGU · Department of Chemistry

Reconstructing and interpreting past hydrological system changes from the Quaternary sediment-landform record presents many challenges especially when trying to establish causality. In such circumstances attempting to isolate individual drivers is perhaps unrealistic and thus inferences are made with respect to the combined influence of multiple co...

The Gediz River, one of the principal rivers of Western Anatolia, has an extensive Pleistocene fluvial archive that potentially offers a unique window into fluvial system behaviour on the western margins of Asia during the Quaternary. In this paper we review our work on the Quaternary Gediz River Project (2001e2010) and present new data which leads...

AIMS: To describe the phenotype associated with a novel heterozygous missense PPARG mutation discovered in a Turkish family and to compare the fat distribution and metabolic characteristics of subjects with the peroxisome proliferator activator receptor -γ (PPARG) mutation with those of a cluster of patients with familial partial lipodystrophy with...

Combining field reconstruction and landscape evolution modelling can be useful to investigate the relative role of different drivers on catchment response. The Geren Catchment (~45 km²) in western Turkey is suitable for such a study, as it has been influenced by uplift, climate change and lava damming. Four Middle Pleistocene lava flows (⁴⁰Ar/³⁹Ar-...

Aims: To describe the phenotype associated with a novel heterozygous missense PPARG mutation discovered in a Turkish family and to compare the fat distribution and metabolic characteristics of subjects with the peroxisome proliferator activator receptor -γ (PPARG) mutation with those of a cluster of patients with familial partial lipodystrophy wit...

Different inhalational anesthetics have various hemodynamic effects, either on the global circulation or on renal perfusion. The purpose of the current retrospective, single-center study was to evaluate allograft function of renal transplant recipients after transplantation surgery under either sevoflurane or isoflurane anesthesia. From January 200...

A terrestrial environmental reconstruction of an Early Pleistocene landscape from western Anatolia is presented. The basis of this reconstruction is a sedimentary stack comprising fluvial and colluvial slope deposits. Contained within this stack is a sequence comprising two massive laminar calcretes alternating with three reddish palaeosols. This e...

Infectious complications after renal transplantation (RT) are associated with significant morbidity. They continue to be the most frequent cause of mortality. We investigated the incidence of infections, the causative pathogens, and risk factors contributing to this complication during the first year. We included demographic and clinical data of th...

The importance of extrinsic drivers of fluvial system behaviour (climate, tectonics, eustatic sea level) over Quaternary timescales is well documented. However, comparatively fewer studies have been reported concerning the significance of more localised changes at reach to sub-catchment scale, over these extended (10exp4–10exp6 years) timescales. I...

The object of this study was to better define the relevant anatomy and innervation of the anterolateral abdominal wall musculature seeking to avoid abdominal wall complication after open donor nephrectomy. We dissected four cadavers and retrospectively assessed donor ultrasonographic imaging of anterolateral abdominal muscle atrophy after donor nep...

Purpose: To define the prevalence and some of the psychosocial characteristics of social anxiety disorder (SAD) in an urban population of Turkish children and adolescents. Subjects and methods: This was a two-stage cross-sectional urban-based study conducted in Fatih, Istanbul, Turkey. The initial sample included 1,482 students between the 4th a...

To demonstrate long-term changes in the prevalence of several types of metabolic derangements in subjects with nonfunctioning adrenal adenomas. 273 subjects with adrenal adenomas, including 231 with nonfunctioning adenoma and 42 with subclinical Cushing's syndrome (sCS), were evaluated with respect to anthropometric and laboratory characteristics a...

To evaluate the awareness and attitudes of health care professionals toward organ/tissue donation and transplantation. We included 309 health care professionals from 27 dialysis centers and eight organ transplantation centers in Istanbul in the present study conducted from April 2008 to August 2008. The 24-item questionnaire, including items concer...

As a treatment method for chronic renal failure (CRF), hemodialysis (HD) alters inorganic components containing trace elements. It was shown that decreased renal function is accompanied by insufficient antioxidant systems and/or increased free oxygen radicals. In this study, we aimed to investigate the effects of HD on trace element levels and oxid...

Adrenalectomy with adrenal autotransplantation used to be performed frequently for Cushing's disease in the past because of the limitations of conventional radiological techniques and the lack of adequate neurosurgical techniques. Today, however, bilateral adrenalectomy may be still required for selective patients with Cushing's syndrome when parti...

Because of the increased use of imaging interventions, more subjects have been diagnosed with adrenal incidentaloma in recent years. To evaluate the risk of mass enlargement, hormone hypersecretion and development of adrenal carcinomas during short-term followup. There were 317 subjects with incidentally discovered adrenal tumors in the registry. F...

CCl4 is an industrial agent with known toxic effects on the environment. There are so many studies about hepatotoxic effects of CCl4. We herein studied the effects of CCl4 on Na+/K+-ATPase and Ca2+/Mg2+-ATPase activities on erythrocyte membranes and trace element levels of serum erythrocyte and liver tissue of rats. Study was performed on control g...

Although the majority of adrenal incidentalomas (AI) are non-functioning, studies evaluating metabolic disturbances in this particular group are limited. The objective of this study is to investigate metabolic syndrome components and levels of plasma von Willebrand factor (VWF), fibrinogen, and D-dimer in subjects with non-functioning AI. Forty-fiv...

Objective: The aim of this study was to search for personality disorders in mothers of children diagnosed with autistic disorder according to DSM-IV. Method: Interviews were made with mothers of children diagnosed with autistic disorder (n=48) using the Structured Clinical Interview for DSM-III-R (SCID-II). Results: Twenty-five percent of the mothe...

This paper reports the latest details from an on-going investigation of the Early Pleistocene buried river terrace sequence of the Gediz River 40 km upstream of the Ala¿ehir graben in the Kula volcanic province, Western Turkey. Using clast lithology to characterise sediment provenance, we demonstrate that the buried Early Pleistocene terrace sequen...

Extracorporeal shockwave lithotripsy (SWL) has remained the preferred method of treatment of urinary stones since its introduction in 1980. Although SWL is classified as a potential first-line treatment for renal stones smaller than 2 cm and its overall success rate is higher than 85% for stone clearance, not all renal calculi are successfully frag...

Objective: The aim of this study was to search for axis I psychiatric disorders in the mothers of children diagnosed with autistic disorder according to DSM-IV. Method: Mothers of children with the diagnosis of autistic disorder according to DSM-IV (n=48) were interviewed using the Structured Clinical Interview for DSM-IV (SCID-I). Mothers complete...

Objectives: We aimed to determine the effects of duration of exclusive breast feeding in children with hyperactivity and snoring between the ages of 3 to 6 years old. Design and Methods: Cross-sectional evaluation of a between the ages of 3 to 6 years old selected preschool children. A total of 1396 children in 45 nursery classes of all primary sch...

This study was conducted to demonstrate the plasminogen activator inhibitor- 1 (PAI-1) and thrombin activatable fibrinolysis inhibitor antigen (TAFI-Ag) levels in non-alcoholic steatohepatitis (NASH). Twenty-seven patients with biopsy-proven NASH and 18 healthy controls (HC) were recruited for the study. Anthropometric data, liver histology (no.=20...

We suggest a working hypothesis for the geometry of the strike-slip faults that formed the boundaries between the Turkish, African and Arabian plates in the latest Miocene to Mid-Pliocene (LMMP), between ~7?6 Ma and ~3.5 Ma. This geometry differed significantly from the modern geometry; the northern Dead Sea Fault Zone (DSFZ) was located east of it...

In this paper, we report our latest observations concerning a Pliocene and Early Pleistocene record from Western Turkey. The sedimentary sequence described comprises the fluvial deposits of an Early Pleistocene palaeo-Gediz river system and its tributaries prior to the onset of volcanism around Kula and the subsequent lacustrine, volcaniclastic and...

The aim of this study was to investigate the relationship between penile color Doppler sonography (CDS) findings and sonographic endothelial parameters in patients with erectile dysfunction (ED), including intima-media thickness (IMT) of common carotid arteries (CCA) and flow-mediated dilatation (FMD) of brachial artery. Fifty-six ED patients were...

Although the etiology of osteoporosis is different between men and women, the underlying pathophysiological mechanism is similar, namely an absolute or relative increase in bone resorption, leading to progressive bone loss. Transforming growth factor (TGF)-beta1 is a growth factor in human bone, which is produced by osteoblasts, and which has vario...

Primary hyperparathyroidism (PHPT) as a major cause of hypercalcemia is caused by excessive and incompletely regulated secretion of PTH from one or more of the four parathyroid glands. It contributes to the development of several conditions such as kidney stones, left ventricular hypertrophy, arrhytmias (1, 2) and skeletal manifestations such as os...

It is known that women with prior history of gestational diabetes mellitus (pGDM) feature obesity, insulin resistance and endothelial dysfunction which cause premature atherosclerosis. Transforming growth factor-beta 1 (TGF-beta1) is a key cytokine in obesity and insulin resistance and also play important roles in the development of atherosclerosis...

New high-precision Ar-Ar dating of basalt underlying the city of Diyarbakır, southeast Turkey, constrains the Quaternary incision history of the River Tigris, strengthening the pre-existing chronology based on magnetostratigraphy and K-Ar dates. The basalt, which overlies Tigris terrace gravel 70 m above the river, is part of the Karacadağ shield v...

We report four new Ar/Ar dates and 18 new geochemical analyses of Pleistocene basalts from the Karasu Valley of southern Turkey. These rocks have become offset left-laterally by slip on the N20{degrees}E-striking Amanos Fault. The geochemical analyses help to correlate some of the less-obvious offset fragments of basalt flows, and thus to measure a...

Objective: Risperidone, which is an atypical antipsychotic, is widely used in treating children and adolescents with many psychiatric disorders. Despite widespread clinical use, the safety of risperidone is a matter of concern for child psychiatrists. The aim of this study is to explore the supraventricular cardiac effects of risperidone. Methods:...

We report gravel of the River Euphrates, capped by basalt that is Ar-Ar dated to ~9 Ma, at Shireen in northern Syria. This gravel, preserved by the erosion-resistant basalt, allows us for the first time to reconstruct the history of this major river during the Late Miocene. In response to progressive regional surface uplift, the Euphrates extended...

Ectopic production of corticotropin-releasing hormone (CRH) by a pheochromocytoma is an infrequent cause of Cushing's syndrome. We report the case of a 43-year-old man with Cushing's syndrome due to a CRH-producing adrenal pheochromocytoma. The patient had clinical and biochemical evidence of hypercortisolism in conjunction with high ACTH levels an...

Biosorption of Acid Red 57 (AR57) on to Neurospora crassa was studied with variation of pH, contact time, biosorbent and dye concentrations and temperature to determine equilibrium and kinetic models. The AR57 biosorption was fast and equilibrium was attained within 40 min. Langmuir, Freundlich and Dubinin–Radushkevich (D–R) isotherm models were ap...

A set of 13 new unspiked K–Ar dates has been obtained for the Quaternary basaltic volcanism in the Kula area of western Turkey, providing improved age control for the fluvial deposits of the Gediz River that underlie these basalt flows. This dating is able, for the first time, to resolve different ages for the oldest basalts, assigned to category β...

The cement dust is one of the causes of pollution in the environment. In the present study, the cadmium concentrations of soil and plant specimens taken from a rural area exposed to cement factory emissions were determined and also the blood concentrations and sensitivity conditions in humans residing in this rural area were investigated. The 108 s...

Zinc (Zn), copper (Cu) and manganese (Mn) are involved in regulatory systems in the cell. Their role in neuromodulator activities and redox reactions has been implicated in the pathogenesis of neurological disorders. The aim of this study was to determine changes of Zn, Cu and Mn levels in brain tissue, blood and urine after experimental subarachno...

In the Arabian Platform of SE Turkey abundant evidence exists of fluvial incision by c. 110 +/- 10 m since the late Early Pleistocene, starting in or around marine oxygen isotope stage 22 at 870 ka. This incision, which has accompanied regional surface uplift as the isostatic response to regional erosion, has progressively 'locked' rivers into thei...

Investigation of the Pleistocene sequence of the Gediz River, Western Turkey, has revealed a record of Early Pleistocene river terraces. Eleven terraces spanning the interval from 1.67 to 1.245 million years ago (MIS 59-37) are preserved beneath basaltic lava flows. The high number of terraces over this short time period reflects high-frequency sed...

The aim of this study was to determine the concentrations of nickel and cadmium in blood plasma of the people exposed to cement dust emissions and to investigate the effects of exposure period on the activities of Na+/K+ ATPase enzymes in their erythrocyte membranes. The study was carried out on people living in Eskişehir Çukurhisar rural area, loc...

The aim of the study was to determine the nickel concentrations of soil and plant specimens taken from a rural area exposed to cement factory emissions and also to determine the blood concentrations and sensitivity conditions observed in humans residing in this rural area. The study was carried out in Cukurhisar, a town in Eskişehir-Turkey, between...

Familial Mediterranean fever (FMF) is prevalent among Arabic, Turkish, Armenian, and Jewish people and it must always be considered in the differential diagnosis of patients from these ethnic groups presenting with recurrent abdominal pain with fever. In cases of fever and recurrent abdominal pain, acute pancreatitis is an important clinical condit...

To estimate the prevalence of rheumatoid arthritis (RA) in an urban area in Izmir, Turkey. The study was conducted in the Balcova and Narlidere districts of Izmir and a total of 2,887 people aged 20 years or older were contacted with a 98.2% acceptance rate. Nine medical doctors administered an RA questionnaire by face-to-face interview. Subjects r...

Plasma nitric oxide (NO), myeloperoxidase (MPO), and iron (Fe) levels were determined in bronchial asthma. The relations among these parameters in different stages of asthma were interpreted. Their association with airway inflammation observed in patients with bronchial asthma as well as the roles and the contributions to the pathological processes...

The aim of the study was to determine the chromium concentrations of soil and plant specimens taken from a rural area exposed to cement factory emissions and also to determine the blood concentrations and sensitivity conditions observed in humans residing in this rural area. The study was carried out in Cukurhisar, a town in Eskisehir-Turkey, betwe...

To detect the value of sICAM-1 in the diagnosis and follow-up of treatment of tuberculosis. sICAM-1 levels were evaluated before and after treatment in 30 patients with pulmonary tuberculosis, only before treatment in five patients with pneumonia, five with lung cancer, and five with bronchiectasis, and in 10 healthy volunteers. sICAM-1 levels were...

Soil and grass specimens from 10 different traffic-dense roads and 5 control places from heavy-traffic were analyzed by atomic absorption spectrophotometry for the control of vehicle-derived lead contamination in Eskisehir. Pb concentrations of the surface soils (46.69 ± 14.70 mg/kg) were significantly higher than those of the control areas. When t...

The aim of this study was to determine the effects of silver mining on individuals living in Gumus, a province of Kutahya in Turkey, which is located near a silver mine. For this purpose, two groups of subjects were chosen. The first group consisted of 59 people (n=59) above the age of 30 who had been potentially exposed to silver. The second group...

Roadside soils show considerable metal contamination due to both direct deposition of vehicle-derived metals and to relocation of the metals deposited on the road surface. In this prospective analytical study, accumulation of some metals including Pb, Cd, Zn, Ni, Cr, Mn in roadside soils sampled from 10 different traffic-dense roads and from 5 cont...

The effects of corticosteroids on skeletal muscle is investigated in patients with COLD by electromyography. 8 patients with COLD were treated with 1 mg/kg methylprednisolone in addition to routine O2 therapy and bronchodilators. The electromyographic findings were compared with 13 COLD patients who didn't take corticosteroids. There were no signif...

The penetration of oral 1000 mg/day ciprofloxacin into pleural fluid is investigated in 15 patients with exudative pleural effusion. After 4 days of ciprofloxacin therapy ciprofloxacin concentrations were measured in plasma and pleural exudate simultaneously by high-performance liquid chromatography (HPLC). Mean serum ciprofloxacin level was 1.58 +...