About
8
Publications
806
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
68
Citations
Publications
Publications (8)
Long noncoding RNAs (lncRNAs) have emerged as key coordinators of biological and cellular processes. Characterizing lncRNA expression across cells and tissues is key to understanding their role in determining phenotypes including human diseases. We present here FC-R2, a comprehensive expression atlas across a broadly defined human transcriptome, in...
The three-prime untranslated region (3'-UTR) of a mRNA influences its biological behavior, from stability, post-transcriptional control through miRNAs, and availability for translation. Alternative polyadenylation (APA) can modulate 3' end site selection, and approximately 50% of coding genes are subject to it. Global transcript shortening has been...
Long non-coding RNAs (lncRNAs) have emerged as key coordinators of biological and cellular processes. Characterizing lncRNA expression across cells and tissues is key to understanding their role in determining phenotypes including disease. We present hereFC-R2, a comprehensive expression atlas across a broadly-defined human transcriptome, inclusive...
In recent years, in depth exploration of genomes structure and function has revealed a central role for non-coding RNAs (ncRNAs) in orchestrating key biological and cellular processes through the fine tuning of gene expression regulation. Most importantly a role for ncRNAs has also started to emerge in human disease pathogenesis. This further speak...
Significance
Technological advances enable increasingly comprehensive profiling of the molecular landscapes of cells, and these data can inform the personalized treatment of complex diseases. Two major obstacles are the complexity of these data and the high degree of person-to-person heterogeneity. We develop a highly simplified, personalized data...
STAT3 is a transcriptional regulator that plays an important role in coordinating inflammation and immunity. In addition, there is a growing appreciation of the role STAT3 signaling plays in response to organ injury following diverse insults. Acute kidney injury (AKI) from ischemia-reperfusion injury is a common clinical entity with devastating con...
