Tejas S. Athni

Tejas S. Athni
Stanford University | SU · Beckman Center for Molecular Medicine

About

15
Publications
1,392
Reads
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33
Citations
Citations since 2016
15 Research Items
33 Citations
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201620172018201920202021202205101520

Publications

Publications (15)
Chapter
For as long as the species has existed, humans have been making use of the abundant resources found in nature. Mankind has harnessed the chemical properties of timber to produce fire, transformed straw and water reeds into thatched roofing, and spun the fibers of plants into cloth and fabric. As is evident in such examples, human society has consis...
Conference Paper
Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor. Patients with GBM have a median survival time of 15 months. Treatments currently available for GBM are quite limited and research into developing novel therapeutics is warranted. Currently, the thrust of GBM research is in the fields of immunotherapy, chemo...
Conference Paper
Scutellaria ocmulgee, a threatened species, is decreasing in population due to habitat destruction and poor seed set. Pollen – stigma interactions were studied to understand various events in flower development, pollination, fertilization and possible limiting factors. Pollen viability assessment with methyl thiazolydiphenyl-tetrazolium bromide (MT...
Article
The etiology of congenital heart defects (CHDs), which are among the most common human birth defects, is poorly understood because of its complex genetic architecture. Here, we show that two genes implicated in CHDs, Megf8 and Mgrn1, interact genetically and biochemically to regulate the strength of Hedgehog signaling in target cells. MEGF8, a tran...
Article
Full-text available
Vector‐borne diseases (VBDs) are embedded within complex socio‐ecological systems. While research has traditionally focused on the direct effects of VBDs on human morbidity and mortality, it is increasingly clear that their impacts are much more pervasive. VBDs are dynamically linked to feedbacks between environmental conditions, vector ecology, di...
Preprint
Full-text available
Background Mathematical models and empirical epidemiologic studies (e.g., randomized and observational studies) are complementary tools but may produce conflicting results for a given research question. We used sensitivity analyses and bias analyses to explore such discrepancies in a study of the indirect effects of influenza vaccination. Methods...
Article
Our world is undergoing rapid planetary changes driven by human activities, often mediated by economic incentives and resource management, affecting all life on Earth. Concurrently, many infectious diseases have recently emerged or spread into new populations. Mounting evidence suggests that global change—including climate change, land-use change,...
Article
Full-text available
The globalization of mosquito-borne arboviral diseases has placed more than half of the human population at risk. Understanding arbovirus ecology, including the role individual mosquito species play in virus transmission cycles, is critical for limiting disease. Canonical virus-vector groupings, such as Aedes - or Culex -associated flaviviruses, ha...
Preprint
Full-text available
Background: Climate change may influence the effectiveness of environmental interventions. We investigated if climate and environment modified the effect of low-cost, point-of-use water, sanitation, and handwashing (WASH) interventions on diarrhea and predicted intervention effectiveness under climate change scenarios. Methods: We analyzed data fro...
Preprint
Full-text available
Background Understanding pathogen-specific relationships with climate is crucial to informing interventions under climate change. Methods We matched spatiotemporal temperature, precipitation, surface water, and humidity data to data from a trial in rural Bangladesh that measured diarrhea and enteropathogen prevalence in children 0-2 years from 201...
Article
In trials of infectious disease interventions, rare outcomes and unpredictable spatiotemporal variation can introduce bias, reduce statistical power, and prevent conclusive inferences. Spillover effects can complicate inference if individual randomization is used to gain efficiency. Ring trials are a type of cluster-randomized trial that may increa...
Preprint
Full-text available
The globalization of mosquito-borne arboviral diseases has placed more than half of the human population at risk. Understanding arbovirus ecology, including the role individual mosquito species play in virus transmission cycles, is critical for limiting disease. Canonical virus-vector groupings, such as Aedes - or Culex -associated flaviviruses, ha...
Preprint
Full-text available
Our world is undergoing rapid planetary changes driven by human activities, often mediated by economic incentives and resource management, affecting all life on Earth. Concurrently, many infectious diseases have recently emerged or spread into new populations. Mounting evidence suggests that global change-including climate change, land-use change,...
Preprint
Full-text available
The etiology of congenital heart defects (CHDs), amongst the most common human birth defects, is poorly understood partly because of its complex genetic architecture. Here we show that two genes previously implicated in CHDs, Megf8 and Mgrn1, interact genetically and biochemically to regulate the strength of Hedgehog signaling in target cells. MEGF...

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