Teddy J. Akiki

Teddy J. Akiki
Stanford University | SU · Department of Psychiatry and Behavioral Sciences

MD
Psychiatry, Network Neuroscience, Neuroimaging, Psychedelics, Ketamine, PTSD

About

37
Publications
9,506
Reads
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694
Citations
Education
June 2016 - June 2019
Yale University
Field of study
  • Psychiatry, PTSD, Ketamine, Neuroscience, Network Science
June 2012 - June 2016

Publications

Publications (37)
Article
Full-text available
Optimal integration and segregation of neuronal connections are necessary for efficient large-scale network communication between distributed cortical regions while allowing for modular specialization. This dynamic in the cortex is enabled at the network mesoscale by the organization of nodes into communities. Previous in vivo efforts to map the me...
Article
Full-text available
Disruption in the default mode network (DMN) has been implicated in numerous neuropsychiatric disorders, including posttraumatic stress disorder (PTSD). However, studies have largely been limited to seed-based methods and involved inconsistent definitions of the DMN. Recent advances in neuroimaging and graph theory now permit the systematic explora...
Article
Full-text available
More than six decades have passed since the discovery of monoaminergic antidepressants. Yet, it remains a mystery why these drugs take weeks to months to achieve therapeutic effects, although their monoaminergic actions are present rapidly after treatment. In an attempt to solve this mystery, rather than studying the acute neurochemical effects of...
Article
Full-text available
Purpose of review: Although a fine-grained understanding of the neurobiology of posttraumatic stress disorder (PTSD) is yet to be elucidated, the last two decades have seen a rapid growth in the study of PTSD using neuroimaging techniques. The current review summarizes important findings from functional and structural neuroimaging studies of PTSD,...
Preprint
Full-text available
After a decades long period of investigational dormancy, there is renewed interest in employing psychedelics as treatments for mental illness and addiction. The academic journals, journal articles, academic institutions, and countries that have helped sustain clinical psychedelic research and the evolution of the literature on clinical studies of p...
Article
Introduction Since Kahlbaum’s classic 19th-century description of catatonia our conceptualization of this syndrome, as well treatment options for it, have advanced considerably. However, little is known about the current state of the catatonia literature since a comprehensive bibliometric analysis of it has not yet been undertaken. Objective The p...
Chapter
Full-text available
A vast literature demonstrates that traumatic stress has deleterious effects on the brain; however, the precise mechanisms through which these neural alterations occur is not fully elucidated. Neurocircuitry and neuroplasticity have been identified as critical components in determining an individual's stress tolerance and response In this abridged...
Article
Full-text available
Background Major depressive disorder (MDD) treatment is characterized by low remission rate and often involves weeks to months of treatment. Identification of pretreatment biomarkers of response may play a critical role in novel drug development, in enhanced prognostic predictions, and perhaps in providing more personalized medicine. Using a networ...
Article
Full-text available
The societal burden of psychiatric disorders that result after exposure to psychological trauma is enormous. The study of trauma-related disorders using neurobiological and public health approaches is often disjointed. It is critical to emphasize the translational potential of neurobiological work and its relevance to the public health burden of ps...
Article
Full-text available
Posttraumatic stress disorder (PTSD) is a common and debilitating condition that develops in certain individuals after exposure to traumatic events, with a lifetime prevalence of 6.4% in the United States.1 PTSD is typically characterized by a chronic and often severe time course, with a substantial symptom burden and rate of disability.1 PTSD sym...
Article
Full-text available
Background: Identifying the neural correlates of ketamine treatment may facilitate and expedite the development of novel, robust, and safe rapid-acting antidepressants. Prefrontal cortex (PFC) global brain connectivity with global signal regression (GBCr) was recently identified as a putative biomarker of major depressive disorder (MDD). Accumulat...
Article
Full-text available
New approaches to the neurobiology of posttraumatic stress disorder (PTSD) are needed to address the reported crisis in PTSD drug development. These new approaches may require the field to move beyond a narrow fear-based perspective, as fear-based medications have not yet demonstrated compelling efficacy. Antidepressants, particularly recent rapid-...
Article
Full-text available
Here we present functional neuroimaging-based network data (focused on the default mode network) collected from a cohort of US Veterans with history of combat exposure, combined with clinical assessments for PTSD and other psychiatric comorbidities. The data has been processed and analyzed using several network construction methods (signed, thresho...
Article
Purpose of the study: Prior studies showed posttraumatic stress disorder (PTSD)-related alterations in white matter integrity, but most of these studies have used region-based approaches. We address this limitation by investigating the relationship between PTSD severity and fractional anisotropy (FA) using a tract-based approach. Procedures: Str...
Preprint
Full-text available
Optimal integration and segregation of neuronal connections are necessary for efficient large-scale network communication between distributed cortical regions while allowing for modular specialization. This network dynamic is enabled at the corti-cal mesoscale by the organization of nodes into communities. Previous in vivo efforts to map the mesosc...
Poster
Full-text available
Manuscript Now Published at Molecular Neuropsychiatry. CITATION: Averill CL, Averill LA, Wrocklage KM, Scott JC, Akiki TJ, Schweinsburg B, Southwick SM, Krystal JH, Abdallah CG. Altered white matter diffusivity of the cingulum angular bundle in posttraumatic stress disorder. Mol Neuropsychiatry 2018;4:75–82. https://doi.org/10.1159/000490464
Poster
Full-text available
The Methodological Question: Can fMRI-derived restricted-network biomarkers serve as robust marker of PTSD symptomatology? Can these network-analyses identify abnormalities that can potentially be targeted using circuit-based therapeutics?
Article
Full-text available
Background Two decades of human neuroimaging research have associated volume reductions in the hippocampus with posttraumatic stress disorder. However, little is known about the distribution of volume loss across hippocampal subfields. Recent advances in neuroimaging methods have made it possible to accurately delineate 10 gray matter hippocampal s...
Data
This manuscript (https://goo.gl/ea9UU9) includes an animated 3D video that was created (in Blender) using meshes from one of the combat control (non-PTSD) participants described in the manuscript. It demonstrates the gray matter subfields of the hippocampus, walking through each one to better visualize the more hidden areas. This video is an excell...
Poster
Full-text available
Background: The discovery of the rapid acting antidepressant effects of ketamine have generated considerable interest in academia and industry about the prospect of targeting NMDA receptors (NMDAR) in the treatment of refractory depression. However, the results from clinical trials failing to reach primary outcomes, combined with recent preclinical...
Poster
Full-text available
Abstract Background The hippocampus and amygdala have been repeatedly implicated in the psychopathology of posttraumatic stress disorder (PTSD). While numerous structural neuroimaging studies examined these two structures in PTSD, these analyses have largely been limited to volumetric measures. Recent advances in vertex-based neuroimaging methods h...
Poster
Full-text available
Abstract Background: Two decades of human neuroimaging research have associated volume reductions in the hippocampus with posttraumatic stress disorder. However, little is known about the distribution of volume loss across hippocampal subfields. Recent advances in neuroimaging methods have made it possible to accurately delineate 10 gray matter hip...
Article
Full-text available
Background: The hippocampus and amygdala have been repeatedly implicated in the psychopathology of posttraumatic stress disorder (PTSD). While numerous structural neuroimaging studies examined these two structures in PTSD, these analyses have largely been limited to volumetric measures. Recent advances in vertex-based neuroimaging methods have mad...
Article
Full-text available
The anterior hippocampus (aHPC) has a central role in the regulation of anxiety-related behavior, stress response, emotional memory and fear. However, little is known about the presence and extent of aHPC abnormalities in posttraumatic stress disorder (PTSD). In this study, we used a multimodal approach, along with graph-based measures of global br...
Article
Full-text available
Complex systems, such as the brain, involve non-linear neuronal interactions. These in turn translate into self-organization and emergence of distinct patterns of activity. And although a loss of integrated neuronal activity or increased entropy during anesthesia has been described in the literature, it has not yet been well characterized. These in...

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Projects

Project (1)
Project
FEAST Complexity Analysis; Direction of Spread of Information;