Ted Gansler

Ted Gansler
American Cancer Society · Intramural Research

MD, MPH, MBA

About

136
Publications
6,976
Reads
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12,351
Citations
Introduction
Ted Gansler is mostly retired. He was the Strategic Director of Pathology Research in the American Cancer Society's Intramural Research Department, where he did cancer-related research in Pathology, Health Services, and Epidemiology. Ted is still the is editor of the American Cancer Society journal, Ca: A Cancer Journal for Clinicians.
Additional affiliations
January 2016 - present
American Cancer Society
Position
  • Managing Director
January 1997 - January 2016
American Cancer Society
Position
  • Director of Medical Content
Education
September 1996 - May 2011
Rollins School of Public Health, Emory University
Field of study
  • Heath Outcomes
September 1993 - March 1996
September 1977 - June 1981

Publications

Publications (136)
Article
Full-text available
Background Identifying risk factors for women at high risk of symptom-detected breast cancers that were missed by screening would enable targeting of enhanced screening regimens. To this end, we examined associations of breast cancer risk factors by mode of detection in screened women from the Cancer Prevention Study (CPS)-II Nutrition Cohort. Met...
Article
The American Cancer Society (ACS) publishes the Diet and Physical Activity Guideline to serve as a foundation for its communication, policy, and community strategies and, ultimately, to affect dietary and physical activity patterns among Americans. This guideline is developed by a national panel of experts in cancer research, prevention, epidemiolo...
Article
Background: Cigarette smoking is causally linked to renal cell carcinoma (RCC). However, associations for individual RCC histologies are not well-described. Newly-available data on tobacco use from population-based cancer registries allow characterization of associations with individual RCC types. Methods: We analyzed data for 30,282 RCC cases f...
Article
PURPOSE To investigate the association of postdiagnosis body mass index (BMI) and weight change with prostate cancer–specific mortality (PCSM), cardiovascular disease–related mortality (CVDM), and all-cause mortality among survivors of nonmetastatic prostate cancer. METHODS Men in the Cancer Prevention Study II Nutrition Cohort diagnosed with nonm...
Article
Background: Research on the relationship of meat, fish and egg consumption and mortality among prostate cancer survivors is limited. Methods: In the Cancer Prevention Study-II Nutrition Cohort, men diagnosed with non-metastatic prostate cancer between baseline in 1992/1993 and 2015 were followed for mortality until 2016. Analyses of pre- and pos...
Article
Full-text available
Purpose Histopathologic grade provides an integrated measure of biologic features which affects cancer prognosis. In invasive ductal breast cancer (IDBC), the grade of the ductal carcinoma in situ (DCIS) and invasive components are usually concordant, suggesting grade is established early in tumorigenesis and may be linked to etiologic factors. In...
Article
Background: Given the potential complications of prostate biopsies, it is sometimes reasonable in selected patients to make a non-tissue diagnosis of prostate cancer. Little is known about prevalence and factors associated with non-tissue prostate cancer diagnoses in the United States. Methods: We identified 40 to 99-year-old prostate cancer pat...
Article
Full-text available
Purpose In a screened population, breast cancer-specific mortality is lower for screen-detected versus symptom-detected breast cancers; however, it is unclear whether this association varies by follow-up time and/or tumor characteristics. To further understand the prognostic utility of mode of detection, we examined its association with breast canc...
Conference Paper
Digital pathology images potentially contain novel patterns that may be perceived by modern deep learning models, but not humans. Prior unsupervised pattern recognition approaches have been used to reveal prognostically-relevant subtypes of glioblastoma (PMID: 28984190) and breast density segmentation (PMID: 26915120), and may complement supervised...
Conference Paper
Identifying risk factors for women at high risk of symptom-detected breast cancers that were missed by screening would enable targeting of alternative prevention strategies. To identify breast cancer risk factors by mode of detection, we examined these associations in heavily-screened women from the Cancer Prevention Study (CPS)-II Nutrition Cohort...
Conference Paper
Accumulating evidence suggests that excess body fatness is associated with an increased risk of aggressive prostate cancer. However, the roles of body mass index (BMI -kg/m²), reported before and after diagnosis, and weight change in long-term prostate cancer survival remain unclear. Prospective data from men diagnosed with non-metastatic prostate...
Conference Paper
Background: Machine learning (ML) methods are becoming more feasible for use in clinical and epidemiologic research of breast cancer, particularly when characterizing histopathology. Compared to supervised ML methods, unsupervised approaches represent an opportunity to distinguish features heretofore unknown. The purpose of this study was to use un...
Conference Paper
Accumulating evidence suggests that excess body fatness is associated with an increased risk of aggressive prostate cancer. However, the roles of body mass index (BMI -kg/m²), reported before and after diagnosis, and weight change in long-term prostate cancer survival remain unclear. Prospective data from men diagnosed with non-metastatic prostate...
Conference Paper
Digital pathology images potentially contain novel patterns that may be perceived by modern deep learning models, but not humans. Prior unsupervised pattern recognition approaches have been used to reveal prognostically-relevant subtypes of glioblastoma (PMID: 28984190) and breast density segmentation (PMID: 26915120), and may complement supervised...
Conference Paper
Background: Machine learning (ML) methods are becoming more feasible for use in clinical and epidemiologic research of breast cancer, particularly when characterizing histopathology. Compared to supervised ML methods, unsupervised approaches represent an opportunity to distinguish features heretofore unknown. The purpose of this study was to use un...
Conference Paper
p>Identifying risk factors for women at high risk of symptom-detected breast cancers that were missed by screening would enable targeting of alternative prevention strategies. To identify breast cancer risk factors by mode of detection, we examined these associations in heavily-screened women from the Cancer Prevention Study (CPS)-II Nutrition Coho...
Article
Full-text available
Purpose Many cancer survivors use complementary and alternative health methods (CAM). Because we are unaware of high-level evidence supporting CAM for preventing cancer recurrence, we studied post-treatment survivors who use CAM to assess (1) the percentage who included preventing recurrence as a motive for using CAM, (2) characteristics of survivo...
Article
Between 1991 and 2015, the cancer mortality rate declined dramatically in the United States, reflecting improvements in cancer prevention, screening, treatment, and survivorship care. However, cancer outcomes in the United States vary substantially between populations defined by race/ethnicity, socioeconomic status, health insurance coverage, and g...
Article
Background: Nuclear grade, believed to be established early in carcinogenesis, is an indicator of ductal carcinoma in situ (DCIS) prognosis. Women with high-grade DCIS have a higher risk of local recurrence compared to women with low-grade DCIS. Risk factors for DCIS overall are well-characterized but risk factors by grade are not. Given the progno...
Article
Stromal tumor-infiltrating lymphocytes (sTILs) are often prominent in HER2-enriched and triple negative breast cancers and predict a favorable prognosis for these subtypes. Clinical and epidemiological determinants of sTILs have not been defined in large cohorts. Accordingly, we analyzed these associations for 702 eligible, postmenopausal invasive...
Article
Full-text available
From the mid‐20th century, accumulating evidence has supported the introduction of screening for cancers of the cervix, breast, colon and rectum, prostate (via shared decisions), and lung. The opportunity to detect and treat precursor lesions and invasive disease at a more favorable stage has contributed substantially to reduced incidence, morbidit...
Article
This article summarizes cancer mortality trends and disparities based on data from the National Center for Health Statistics. It is the first in a series of articles that will describe the American Cancer Society's vision for how cancer prevention, early detection, and treatment can be transformed to lower the cancer burden in the United States, an...
Article
Full-text available
Purpose Although information from pathology reports is essential to the care of individuals with cancer and to population-level cancer control, no systematic evidence exists regarding the adequacy of breast pathology reporting in Ethiopia. This study audited pathology reports of mastectomy specimens from patients evaluated at the Tikur Anbessa Spec...
Article
Background: Prior studies of prostate cancer survivors suggest that smoking might be associated with higher prostate cancer-specific mortality (PCSM) after diagnosis with prostate cancer. However, most of these studies were small and questions remain regarding this association's strength and whether it persists after adjustment for stage and Gleas...
Article
Key Points • Distress is very common among individuals living with cancer, and can adversely affect quality of life and decrease adherence to treatment regimens. • All individuals diagnosed with cancer should be evaluated for distress and treated according to guideline recommendations. • Many individuals with cancer‐related distress remain undiagn...
Article
Purpose: Previous studies report infrequent use of shared decision making for prostate-specific antigen (PSA) testing. It is unknown whether this pattern has changed recently considering increased emphasis on shared decision making in prostate cancer screening recommendations. Thus, the objective of this study is to examine recent changes in share...
Chapter
Thyroid cancer is a relatively common disease with several diverse types. Management of individuals with suspected and diagnosed thyroid cancer requires expertise of primary care clinicians, endocrinologists, surgeons, radiation and medical oncologists, and other specialists. Our understanding of the molecular basis of thyroid cancer has improved c...
Article
Histological classification of renal cell carcinoma (RCC) has become increasingly important for clinical management. We identified 295,483 RCC diagnosed from 1998-2014 in the National Cancer Database (NCDB) to examine temporal trends in proportions of RCC with unspecified histology and several specific histologies from the 1998 and 2004 World Healt...
Article
Background: The presence of circulating antibodies to the p53 tumor-suppressor protein is a potential early detection colorectal cancer biomarker. However, studies of prediagnostic measures of p53 seropositivity in relation to colorectal cancer risk are limited. Methods: We conducted a nested case-control study of serum p53 autoantibodies and ri...
Article
Purpose: Non-representative biopsy sampling of prostate cancers with a biopsy Gleason score of 8 can adversely influence decisions regarding androgen deprivation among men receiving primary radiation therapy. The frequency of and factors associated with downgrading of Gleason 8 biopsies at prostatectomy are not well known. Materials and methods:...
Article
Full-text available
Background: Large prospective cohort studies need to confirm the associations between recreational physical activity (PA), including the most common type-walking, and prostate cancer-specific mortality (PCSM) among prostate cancer patients. Objective: To investigate the associations of recreational PA, reported before and after diagnosis, with P...
Article
Answer questions and earn CME/CNE A measles outbreak originating in California during 2014 and 2015 called attention to the potential for infectious disease outbreaks related to underimmunized populations in the United States and the potential risk to pediatric patients with cancer attending school when such outbreaks occur. Compliance with vaccine...
Article
Context: - The incidence of prostate cancer with Gleason scores 2 through 4 has been decreasing for decades, largely because of evolving criteria for Gleason scores, including the 2005 International Society of Urological Pathology recommendation that scores of 2 through 4 should rarely, if ever, be diagnosed based on needle biopsy. Whether trends...
Article
Purpose: In a recent large prospective study, vasectomy was associated with modestly higher risk of prostate cancer, especially high-grade and lethal prostate cancer. However, evidence from prospective studies remains limited. Therefore, we assessed the associations of vasectomy with prostate cancer incidence and mortality in a large cohort in the...
Article
Objective: To investigate the associations of pre- and post-diagnostic recreational physical activity, and sitting time with prostate cancer specific mortality (PCSM) among men diagnosed with non-metastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Methods: 10,067 men were diagnosed with non-metastatic prostate cancer betw...
Article
Background: Cytology is an accurate, safe, cost-effective, and guideline-recommended method for pancreatic cancer diagnosis, particularly for unresectable disease. However, to the authors' knowledge, the frequency and determinants of its use have not been described to date. The current study examined patterns of cytological diagnosis among patient...
Article
An estimated 60,290 new cases of breast carcinoma in situ are expected to be diagnosed in 2015, and approximately 1 in 33 women is likely to receive an in situ breast cancer diagnosis in her lifetime. Although in situ breast cancers are relatively common, their clinical significance and optimal treatment are topics of uncertainty and concern for bo...
Article
BACKGROUND Cytology is an accurate, safe, cost-effective, and guideline-recommended method for the diagnosis of small cell lung carcinoma (SCLC), but little is known about whether its use varies by treatment facility and patient characteristics.METHODS Methods of diagnosis (cytology vs histology) for 86,830 patients with SCLC from 1314 facilities t...
Article
BACKGROUND The objective of this study was to investigate associations between earlier caregiving experience and the development of physical impairments over the subsequent 6 years among family caregivers of patients with cancer.METHODS Family caregivers of cancer survivors participated in a nationwide survey 2 years after their relative's cancer d...
Article
Full-text available
The National Cancer Survivorship Resource Center (The Survivorship Center) began in 2010 as a collaboration between the American Cancer Society and the George Washington University Cancer Institute and was funded by the Centers for Disease Control and Prevention. The Survivorship Center aims to improve the overall health and quality of life of post...
Article
Although there has been considerable progress in reducing cancer incidence in the United States, the number of cancer survivors continues to increase due to the aging and growth of the population and improvements in survival rates. As a result, it is increasingly important to understand the unique medical and psychosocial needs of survivors and be...
Article
Context: Prior studies reported associations of cancer center facility type and case volume with cancer outcomes (such as survival) and treatment-related processes (such as treatment with chemotherapy, surgery, or radiotherapy). Objective: To determine whether facility characteristics are associated with use of broad (lumped) vs narrow (split) d...
Article
Answer questions and earn CME/CNE Cancer survivors are often highly motivated to seek information about food choices, physical activity, and dietary supplements to improve their treatment outcomes, quality of life, and overall survival. To address these concerns, the American Cancer Society (ACS) convened a group of experts in nutrition, physical a...
Article
The American Cancer Society (ACS) publishes Nutrition and Physical Activity Guidelines to serve as a foundation for its communication, policy, and community strategies and, ultimately, to affect dietary and physical activity patterns among Americans. These Guidelines, published approximately every 5 years, are developed by a national panel of exper...
Article
The American Cancer Society (ACS) and Coalition of Cancer Cooperative Groups (CCCG) provide a clinical trial (CT) information/matching/eligibility service (Clinical Trials Matching Service [CTMS]). Patients' demographic and clinical data, enrollment status, and self-reported barriers to CT participation were analyzed to assess enrollment rates and...
Article
The first issue of CA: A Cancer Journal for Clinicians was published in November of 1950. On the 60th anniversary of that date, we briefly review several seminal contributions to oncology and cancer control published in our journal during its first decade. CA Cancer J Clin 2010. © 2010 American Cancer Society, Inc.
Article
Little is known about information priorities of people touched by hematologic cancers. We interviewed and surveyed 29 survivors/patients, 13 caregivers, and 19 non-caregiver relatives. Qualitative interviews indicated limited information describing topics other than specific cancer subtypes and treatment options. The survey exercise revealed the fo...
Article
We examined associations between spiritual well-being and CAM use among 4,139 cancer survivors. We also explored the classification of religious/spiritual practices (R/S) as CAMs and alternative subscale structures of the Functional Assessment of Chronic Illness Therapy--Spiritual Well-being (FACIT-Sp). We evaluated three aspects of spirituality, F...
Article
The medical and demographic correlates of complementary and alternative medicine (CAM) use among cancer survivors have been well documented. However, the role of psychological functioning in cancer survivors' CAM use and the degree to which such factors apply to survivors of colorectal cancer require additional study. In addition, sex differences i...
Article
e17504 Methods: Data from CTMS constituents and follow-up information describing enrollment status and barriers to trial participation are reviewed. Results: During 15 months of operation the CTMS provided information to 10,997 individuals; 7,521 (68.39%) used the website only, and 3,476 (31.61%) also contacted the ACS call center. Among 981 of the...
Article
The use of complementary methods (CMs) is widespread and increasing in the United States. Most literature on CM use among cancer survivors focuses on the treatment period, whereas only a few studies address use further along the cancer continuum. This study analyzed the prevalence and the medical and demographic associations of CM use among cancer...
Article
6581 Background: Adult enrollment in cancer clinical trials is 3–5%, even though two thirds of cancer patients are receptive to enrolling in a study. Closing this gap requires convenient delivery of comprehensive information on relevant trials and nearby sites to patients. Methods: The American Cancer Society (ACS) and the Coalition of Cancer Coope...
Article
Epidemiologic studies unequivocally show that greater body mass increases the risk of endometrial cancer, but whether risk varies by use of postmenopausal hormone therapy (HT), location of fat deposition, or cancer subtype is still unclear. We examined these associations among 33,436 postmenopausal women in the Cancer Prevention Study II Nutrition...
Conference Paper
This paper describes the development and evaluation of hematological cancer informational toolkits over the course of a three year study. We discuss the results of formative research to assess the shared and differing informational needs of hematological cancer (specifically leukemia, lymphoma, and multiple myeloma) patients, their caregivers, and...
Article
Case-control studies support a lower risk of endometrial cancer associated with greater vegetable consumption but not fruit consumption. One prospective study suggested an inverse association with fruits and vegetables combined. The authors examined associations for vegetables and fruits separately among women in the American Cancer Society's Cance...
Article
Inaccurate beliefs about cancer risk may contribute to unhealthy lifestyle behaviors and poor adherence to recommended screening and prevention guidelines. To address this issue the current study assessed the prevalence and sociodemographic correlates of scientifically unsubstantiated beliefs about cancer risk in a representative sample of the US p...
Article
Cancer survivors are often highly motivated to seek information about food choices, physical activity, and dietary supplement use to improve their treatment outcomes, quality of life, and survival. To address these concerns, the American Cancer Society (ACS) convened a group of experts in nutrition, physical activity, and cancer to evaluate the sci...
Article
The American Cancer Society (ACS) publishes Nutrition and Physical Activity Guidelines to serve as a foundation for its communication, policy, and community strategies and ultimately, to affect dietary and physical activity patterns among Americans. These Guidelines, published every 5 years, are developed by a national panel of experts in cancer re...
Article
Although the link between postmenopausal breast cancer and adiposity is well established, the association between weight gain and specific histopathologic characteristics of breast carcinoma has not been studied carefully. Using 1200 incident invasive breast cancers among 44,161 postmenopausal women who were not taking hormone therapy in the Americ...
Article
18547 Background: Little is known about how information needs of cancer survivors/patients (S/P), caregivers (CG), and non-caregiver relatives (NCG) evolve during the cancer experience. Methods: We conducted structured interviews of 21 leukemia, lymphoma, and multiple myeloma S/P, 13 CG, and 19 NCG, and asked them to prioritize information needs du...
Article
18501 Background: The low prevalence of clinical trial participation limits progress in clinical research and practice. ACS assists individuals in finding trials appropriate to their medical and personal situation. Methods: The ACS call center and website provide access to a comprehensive cancer clinical trial database and matching software platfor...
Article
Ethnic and racial disparities in cancer outcomes are often attributed to sociodemographic factors, including income, education, insurance status, and access to quality cancer care. Less attention has been directed toward other possible contributors, such as misconceptions about cancer and its treatment. Nine hundred fifty-seven U.S. adults who repo...
Article
Collectively, cardiovascular disease (including stroke), cancer, and diabetes account for approximately two thirds of all deaths in the United States and about 700 billion dollars in direct and indirect economic costs each year. Current approaches to health promotion and prevention of cardiovascular disease, cancer, and diabetes do not approach the...
Article
Many chronic inflammatory conditions increase the risk of cancer in affected tissues. Clinical conditions that involve both inflammation and increased cancer risk include a broad range of immunological disorders, infections (bacterial, helminthic, viral), and chronic chemical and mechanical irritation. For example, the inflammatory bowel diseases,...
Article
Full-text available
To evaluate a method of obtaining conjunctival cells that utilizes aspiration of the conjunctival surface. Eighteen eyes from 16 patients with epibulbar lesions underwent aspiration of the conjunctival surface using a tuberculin syringe without a needle. The aspirated cells were prepared by the cytocentrifuge or Millipore filter technique. The lesi...
Article
Twenty-nine male breast cancers (MBC) were studied to determine the relationship between expression of several prognostic factors and clinical outcome. Immunohistochemistry employing a labeled streptavidin-biotin method was used to detect the presence of estrogen (ER) and progesterone receptors (PR), cathepsin D (CD), c-erbB-2 oncoprotein, epiderma...
Article
In an attempt to address the informational needs of female breast cancer survivors, the American Cancer Society (ACS) develops and distributes written documents. Although this educational effort has been well received, little attention has been given to the suitability of the materials themselves. A random sample of 812 survivors was derived from c...
Article
The American Cancer Society (ACS) has set aggressive challenge goals for the nation to decrease cancer incidence and mortality--and to improve the quality of life of cancer survivors--by the year 2015. To address these critical goals, the ACS publishes the Nutrition and Physical Activity Guidelines to serve as a foundation for its communication, po...