Tayane Fighera

Hospital de Clínicas de Porto Alegre | HCPA · Hospital de Clínicas de Porto Alegre (HCPA)

Objectives: The aim of this study was to explore body composition parameters and hormone levels as risk factors for low bone mass (osteopenia/osteoporosis) in postmenopausal women. Methods: We analyzed biorepository samples from 139 postmenopausal women with no clinical evidence of cardiovascular disease. Inclusion criteria were menopause occurr...

Background: Suppressive levothyroxine therapy (sT4) is a cornerstone in the management of differentiated thyroid cancer (DTC). Long-term sT4 may affect bone mineral density (BMD). We evaluated the effect of sT4 on the bone mass of young DTC patients. Methods: In this cross-sectional study, BMD was evaluated via dual-energy X-ray absorptiometry in D...

Desenvolvido pelo Departamento de Endocrinologia Feminina, Andrologia e Transgeneridade (DEFAT) da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM), este é um volume que em 31 capítulos traz desde conceitos básicos de anatomia e fisiologia até aspectos diagnósticos, éticos e terapêuticos das principais condições ligadas à incongruência d...

Hirsutism is defined as the presence of terminal hair with male pattern distribution in women. While in the general population, hirsutism affects around 4–11% of women, it is the main manifestation of hyperandrogenism in women with polycystic ovary syndrome (PCOS), with a prevalence estimated at 65–75%. Hirsutism in PCOS is associated with both and...

Introduction Systemic sclerosis (SSc) is a chronic disease characterized by autoimmunity, vasculopathy and fibrosis of several organs, such as skin, lungs, and heart. During the disease course, patients with SSc are prone to accumulating multiple organ damage and increasing their vulnerability to adverse outcomes. This increased vulnerability to ad...

Polycystic ovary syndrome, characterized by ovarian dysfunction and androgen excess, is a frequent and complex condition affecting women of reproductive age. Insulin resistance and central adiposity are often present, and women with PCOS are at higher risk for prediabetes and type 2 diabetes. Adipose tissue is regarded as an endocrine organ that sy...

Background: Gender dysphoria is defined as a feeling of distress resulting from the incongruence between the sex assigned at birth and the gender identity, lasting longer than 6 months. In individuals with gender dysphoria, gender-affirming hormone therapy (GAHT) may improve quality of life (QoL). Objectives: We aimed to assess perceived QoL, to co...

Background: Gender dysphoria is defined as a feeling of distress resulting from the incongruence between the gender assigned at birth and the identity gender and lasting longer than 6 months. In individuals with gender dysphoria, gender-affirming hormone therapy(GAHT) may improve quality of life (QoL). Objectives: Here, we aimed to assess perceived...

Objective: To investigate whether increasing protein consumption to twice the recommended daily allowance (RDA) by The Institute of Medicine affects lean body mass (LBM), muscle strength, and physical performance in late postmenopausal women. Methods: Parallel-group randomized trial with 26 apparently healthy women aged ≥ 65 years. Participants...

The effects of gluteal implants on bone mass remain unclear. Transgender women with ILS presented higher BMD in the hip compared with transgender women without implants, while no difference was observed in other sites. These results may be artifactual and suggest using spine/forearm sites for DXA in individuals with ILS. Purpose: The inappropriat...

Background Rheumatoid arthritis (RA) is an inflammatory disease that leads to altered body composition. The loss of lean mass with a preservation or increase in fat mass has been termed rheumatoid cachexia (RC), to contrast with classic cachexia, which is characterized by severe weight loss. There are limited data on the prevalence and progression...

Estrogen deficiency is classically associated with bone loss in both men and women. In transgender women, after being submitted to gender-affirming surgery (GAS), the main goal of hormone therapy (HT) is to maintain the female phenotype and prevent the consequences of the orchiectomy-related hypogonadal state. The aim of this study was to evaluate...

Depois de anos dedicados à especialidade de sua escolha, os médicos atentos aos avanços da Medicina e às possibilidades de aquisição de novos conhecimentos deparam com mais um desafio: a obtenção do título de especialista. Porém, mais do que o reconhecimento de sua trajetória rumo à excelência profissional, o interesse por tal conquista confirma a...

Metformin may decrease cell senescence, including bone; hence we aimed at evaluating the association between metformin use and osteoporosis. This was a cross-sectional study carried out in 1259 Latin American adult women aged 40 or more who were not on anti-osteoporotic drugs, were on metformin and had a bone densitometry performed. Of the whole sa...

Obter uma especialidade é o sonho de muitos médicos que buscam aprofundar os conhecimentos em uma área do vasto universo da Medicina, e alcançar esse sonho não é uma tarefa fácil. Os Títulos de Especialistas conferidos pelas Sociedades Médicas, dentre os quais destacamos o Título de Especialista em Endocrinologia e Metabologia (TEEM), pela Sociedad...

An extreme incongruence between sex and gender identity leads individuals with gender dysphoria (GD) to seek cross-sex hormone therapy (CSHT), and gender-affirming surgery (GAS). Although few studies have investigated the effects of CSHT on the brain prior to GAS, no studies in the extant literature have evaluated its impact during hypogonadism in...

In transgender men (FtM), testosterone therapy may induce changes in different body compartments. The aim of this study was to evaluate body fat and muscle mass, visceral adipose tissue and bone mineral density in FtM transgender individuals receiving cross-sex hormone therapy (CSHT). Sixty two FtM were included in the protocol and performed labora...

The profound incongruence between sex and gender identity leads transgender individuals to seek cross-sex hormone therapy (CSHT) and gender affirming surgery (GAS). After GAS, a transient period of hypogonadism is established. Literature suggests that sex hormones exert important effects on the brain during physiologic development and aging. Also,...

Context The impact of long-term cross-hormone therapy (CSHT) in transgender men and women is still uncertain. Objective To perform a systematic review and metanalysis and update the evidence regarding the effects of CSHT on bone mass density (BMD) in transgender men and women. Data sources MEDLINE, Cochrane Central Register of Controlled Trials,...

Introduction: Hormone therapy (HT) is an effective treatment for climacteric symptoms. Nevertheless, combined estrogen-progestin therapy and the oral route seem to entail higher risk of venous thromboembolism (VTE) than estrogen-only therapy and transdermal administration. The present study aimed to investigate the risk of thromboembolic events in...

Objective Cross‐sex hormone therapy (CSHT) has been associated with changes in bone and lean/fat mass. This study assessed BMD, appendicular lean mass (ALM), and total fat mass in transwomen undergoing CSHT. Patients and Design We evaluated 142 transwomen (mean age: 33.7±10.3 years; BMI: 25.4±4.6; 86.6% with previous CSHT) during the first three m...

McCune-Albright syndrome (MAS) is a rare disease defined by the triad of polyostotic fibrous dysplasia of bone, café-au-lait skin spots, and precocious puberty. No available treatment is effective in changing the course of fibrous dysplasia of bone, but symptomatic patients require therapeutic support to reduce bone pain and prevent fractures and d...

Background Rheumatoid arthritis (RA) is a chronic and inflammatory disease that besides articular symptoms leads to loss of muscle mass in presence of stable or increased fat mass (FM), condition defined as rheumatoid cachexia (RC). RC is associated with a worse prognosis, but it is still overlooked in clinical practice. Objectives To evaluate the...

Introduction: Several studies have shown an increased risk of thyroid malignancies in patients with elevated TSH levels, even if these levels fell within the normal range. The aim of this study was to evaluate the relationship between TSH and risk of malignancy in patients with thyroid nodules. Material and methods: We included 622 patients with...

Background: The aim of this study is to evaluate individuals with high BMD and correlate with clinical and laboratory parameters. Methods: We performed a search over the last 4 years, in the archives of bone densitometry of the Department of Endocrinology (Hospital de Clinicas, Federal University of Parana), in all patients with Z-score ≥ 2.0 SD in...

Objective: The objective of this study was to evaluate the efficacy and safety of percutaneous ethanol injection (PEI) in the treatment of benign thyroid nodules. Subjects and methods: We evaluated 120 patients with benign thyroid nodules. Patients underwent evaluation of serum TSH and free T4, cervical ultrasound, and thyroid scintigraphy (in t...

Testosterone is the major gonadal sex steroid produced by the testes in men. Androgens induce male sexual differentiation before birth and sexual maturation during puberty; in adult men, they maintain the function of the male genital system, including spermatogenesis. Testosterone is also produced in smaller amounts by the ovaries in women. The adr...

We report on an adult woman with rare coexistence of acromegaly, pheochromocytoma (PHEO), gastrointestinal stromal tumor (GIST), intestinal polyposis, and thyroid follicular adenoma. At the age of 56, she was diagnosed with acromegaly caused by a pituitary macroadenoma, treated by transsphenoidal surgery, radiotherapy, and octreotide. During routin...

Many pharmacological agents are available for treatment of postmenopausal osteoporosis, including estrogen and the selective modulators of estrogen receptor (SERMS). Bazedoxifene is a third-generation SERM, which acts as estrogen agonist in bone and lipid metabolism and as an antagonist in the breast and endometrium. Studies demonstrated that bazed...

Type 2 Diabetes Mellitus (DM2) is responsible for 90-95% of all diabetes cases, has mono and polygenic inheritance and it is intrinsically linked to obesity, especially visceral obesity. Its incidence has grown worldwide reflecting, ultimately, the dietary behavior changes of the population. It is characterized by defects in the action and secretio...

Subclinical hypothyroidism is defined as an elevated thyroid-stimulating hormone (TSH) level with a normal circulating thyroxine (free T4). When it occurs during the gestation, it can result in obstetrical complications and fetal neurological defects if it will not be treated adequate and precociously. Currently, many controversies regarding the di...