Tatsuya Suda

University of California, Irvine | UCI · Donald Bren School of Information and Computer Sciences

Current IaaS (infrastructure as a service) cloud service may not satisfy communication QoS (quality of service) requirements of delay‐sensitive network applications, if there is a significant physical distance between a server of the network application (NetApp server) at a data center and its network application clients (NetApp clients). In order...

Cancer cells collectively form a large-scale structure for their growth. In this article, we report that HeLa cells, epithelial-like human cervical cancer cells, aggressively migrate on Matrigel and form a large-scale structure in a cell-density-dependent manner. To explain the experimental results, we develop a simple model in which cells interact...

In this paper, we propose a new class of service called server migration service (SMS) to augment the existing IaaS (Infrastructure as a Service). SMS allows servers (server-side processes of a network application) to dynamically and automatically migrate as their clients (client-side processes of a network application) change their locations in or...

Understanding the process of how bio-nanomachines form spatiotemporal patterns is a key to developing practical applications of molecular communication such as biomolecular sensing, targeted drug delivery and tissue regeneration systems. In this paper, we develop a simple mobility model for bio-nanomachines and investigate how bio-nanomachines move...

The authors of this paper have been involved in molecular communication since its conception. The authors describe their decade-and-a-half long personal journey of the molecular communication research and share their observations and thoughts on how the molecular communication research started and expanded to flourish. They also share their thought...

This paper explores dynamic properties of oscillating and propagating patterns in concentration of the information molecule and proposes a new modulation scheme for molecular communication. In the proposed modulation scheme, information molecules transmitted from a sender bio-nanomachine propagate in the environment, chemically react with the molec...

The server migration service (SMS) is an optional service that improves communication QoS of the IaaS cloud service. In the SMS, small-scale data centers (micro data centers) called work places (WPs) are deployed at various locations in the network. In the SMS, a network application (a NW-App) consists of one or more server-side processes of the ap...

In IaaS cloud services, QoS of network applications (NW-Apps) may degrade due to location factors such as significant distance between a server-side application (server) of a NW-App at a data center and a client-side application (client) of the NW-App at a client terminal. In order to shorten the distance and to improve the QoS, server migration se...

In molecular communication, a group of biological nanomachines communicates through exchanging molecules and collectively performs application dependent tasks. An open research issue in molecular communication is to establish interfaces to interconnect the molecular communication environment (e.g., inside the human body) and its external environmen...

A key open research issue in the area of molecular communication is establishing interfaces between a molecular communication environment where molecular communication takes place and its external environment. In this paper, we describe an architecture of externally controllable molecular communication systems and introduce two types of interfaces:...

Molecular communication is an emerging communication paradigm for biological nanomachines. It allows biological nanomachines to communicate through exchanging molecules in an aqueous environment, and it integrates functionalities of individual biological nanomachines. This paper focuses on the layered architecture of molecular communication and res...

Face-to-Face bullying is a traditional form of bullying in which bullies attack victims through physical, verbal, or social attacks. Cyberbullying is a new form of bullying. Cyberbullies abuse digital media to attack victims (such as attacks through websites, social networking services, blogging, e-mail, instant messaging, chat rooms, and cell phon...

We believe that the challenges faced by future network applications, such as scalability, adaptability, and survivability/availability have already been overcome by large scale biological systems and that future network applications will benefit by adopting key biological principles and mechanisms. The Bio-Networking Architecture is a paradigm as w...

This paper describes an architectural design of molecular communication for biological nanomachines to perform cooperative drug delivery, and discusses three key challenges: targeting biological nanomachines to a target site where diseased cells may exist, diagnosis by biological nanomachines to monitor the target site and identify a potential thre...

A disclosed molecular communication system includes a molecular transmitter configured to transmit an information molecule in which prescribed information is encoded, a molecular receiver configured to receive the information molecule, and a molecular capsule configured to carry the information molecule from the molecular transmitter to the molecul...

Face-to-Face bullying is a traditional form of bullying in which bullies attack victims through physical, verbal, or social attacks. Cyberbullying is a new form of bullying. Cyberbullies abuse digital media to attack victims (such as attacks through websites, social networking services, blogging, e-mail, instant messaging, chat rooms, and cell phon...

Using network virtualization technologies for network applications (NW-Apps) consisting of server and clients, we can implement a server migration service where there are many server running environments (working places: WPs) inside a network and servers on WPs can migrate to other WPs when communication QoSs in some NW-Apps fall off. Because serve...

Systems of bionanomachines may benefit future applications which require interaction with biological systems at the nano- to microscale. Molecular communication is a suitable communication mechanism for autonomous bionanomachines which are limited in size and capability and for interfacing with biological systems. In molecular communication, a bion...

This paper investigates, through computer simulations, statistical behavior of molecular motors transporting cargos on a network of protein filaments in an engineered environment. This paper also examines how molecular motors' statistical behavior is applied to building. a molecular communication system. A molecular motor, such as kinesin, is a pro...

Cyberbullying is a growing concern in online communications. Cyberbullying has negative impacts such as distress or suicide of a victim. One common type of cyberbullying attack utilizes aggressive forum posts to insult or threaten a victim. Automated tools to classify cyberbullying may aid in avoiding or reducing the negative impacts of cyberbullyi...

This paper describes the possibility of molecular communication as a solution for communication between nanomachines. Nanomachines are artificial or biological nano-scale devices that perform simple computation, sensing, or actuation. Existing communication technologies cannot be applied to nano-scale communication between nanomachines due to diffi...

IntroductionBiologically Inspired Networking ParadigmsConclusion GlossaryCross References

IntroductionObservations of Molecular Communication in Biological SystemsEngineering of Molecular CommunicationEngineering of Molecular Communication NetworksConclusion GlossaryCross References

In recent years, a major factor that has attracted numerous users to the Internet is services, and it is anticipated that this trend will continue into the future. As the Internet of the future becomes increasingly service centric, this brings with it a number of well established challenges. With large volumes of services, service discovery becomes...

In this paper, the authors consider school bullying using digital communication media (such as cell phones, short messaging, emails, blogs, SNS, and BBS) and create a framework whose goal is to help teachers identify whether school bullying is taking place among students. The framework proposed in this paper models interactions among students as a...

Future networks will connect heterogeneous objects and services, and be much larger and more complex than the current networks. We believe that making this future a reality requires a network that exhibits self-organization with inherent support for scalability, mobility, adaptability to environmental changes in network, and survivability/availabil...

Molecular communication is a novel communication paradigm inspired by information processing in biological systems using molecules as information medium. In this study, we achieved the selective propagation of transport vesicles which is an essential technique to establish a molecular communication system using artificial cells. The hybridisation o...

In this paper, we investigated approaches to form a self-organizing microtubule network. Microtubules are protein filaments naturally occurring in the aqueous environment of cells. A microtubule network connects multiple nano- or micro-scale objects (i.e., nanomachines). In the paper, we propose two approaches to form an in vitro microtubule networ...

This chapter provides a comprehensive overview of state-of-the art research on molecular communication—a molecule-based communication paradigm for biological machines. Unlike current telecommunications based on electric or optical signals, molecular communication exploits biological molecules as information carriers. In molecular communication, sen...

Technology is taking us to a world where myriads of heavily networked devices interact with the physical world in multiple ways, and at multiple scales, from the global Internet scale down to micro- and nano-devices. Many of these devices are highly mobile and autonomous, and must adapt to the surrounding environment in a totally distributed and un...

In this paper, we investigate a design of biological excitable media based on non-excitable cells and intercellular calcium signaling mechanisms. The calcium induced calcium release mechanism in non-excitable cells is exploited to transform the non-excitable cells into excitable media that propagate calcium signals cell-to-cell. The biological exci...

There is currently much debate in defining what form the future Internet will take. The current Internet is struggling to meet the needs of an ever-evolving society. This is largely due to the Internet now become a thriving marketplace with services at the core. The range, number and complexity of services are set to increase with an even more dyna...

This paper provides an overview of the molecular communication technology - a biological communication paradigm inspired by cell communication mechanisms. The architecture, features, and current status of molecular communication are summarized.

Molecular communication uses molecules (i.e., chemical signals) as an information carrier and allows biologically- and artificially-created nano- or cell-scale entities to communicate over a short distance. It is a new communication paradigm and is different from the traditional communication that uses electromagnetic waves (i.e., electronic and op...

Molecular communication is the process of transmitting information using molecules as the transmission medium. Molecular communication is suitable for nanomachines which are limited in size and capability and for interfacing with biological systems which perform functions controlled or influenced by molecules. The distance between a transmitter and...

This paper describes construction of a nanosensory device for amplified detection of biologically important amines as chemical signals. The device was inspired by a biological signal transduction system, and was fabricated on an artificial cell membrane through self-organization of the molecular components, such as a synthetic receptor and a natura...

Most of studies on the automated generation of composite Web services create composite services by chaining available services’ inputs and outputs, but do not consider their functional semantics. Therefore, unsatisfied results may be generated against users’ intentions. Furthermore, the time complexity is very high since every possible combination...

In recent years, the notion of service overlay networks has been proposed as a promising solution for providing end-to-end QoS without changing the current Internet architecture. A major issue in deploying service overlay networks is determining how to allocate resources (such as link bandwidth) on a substrate network to overlay networks, while sat...

An important research issue in large scale wireless sensor networks is to efficiently deliver data per user requests, which is referred to as data dissemination. This chapter studies data dissemination in wireless sensor networks deployed in hostile environments. In such type of networks, external catastrophic events can damage sensors at a large s...

Intercellular Ca(2+) waves are commonly observed in many cell types. In non-excitable cells, intercellular Ca(2+) waves are mediated by gap junctional diffusion of a Ca(2+) mobilizing messenger such as IP(3). Since Ca(2+) is heavily buffered in the cytosolic environment, it has been hypothesized that the contribution of the diffusion of Ca(2+) to i...

Storing data on sensor nodes at a specified location is a useful technique for data-centric storage and management of location dependent data on wireless sensor networks. To decrease the cost of accessing these data, arranging replicas of data so that the distance between the consumer nodes and replica holder nodes decreases is desirable. Conventio...

In recent years, service overlay networks have been proposed as a promising solution to provide end-to-end QoS without changing the current Internet architecture. In deploying service overlay networks, one major issue is how to efficiently allocate resources (e.g., link bandwidth) on a substrate network to each application with end-to-end QoS requi...

Molecular communication is a new paradigm for communication between biological nanomachines over a nano- and microscale range. As biological nanomachines (or nanomachines in short) are too small and simple to communicate through traditional communication mechanisms (e.g., through sending and receiving of radio or infrared signals), molecular commun...

This article presents a semantics-based context-aware dynamic service composition framework that composes an application through combining distributed components based on the semantics of components and contexts of users. The proposed framework consists of Component Service Model with Semantics (CoSMoS), Component Runtime Environment (CoRE), and Se...

Molecular communication is a bio-inspired communication paradigm using molecules as information carriers. The molecular communication system includes propagation of information carrier molecules between a molecular sender and a molecular receiver and followed by amplification of the information at the receiver. In this article, we built an example...

For Workshop on Biological and Bio-Inspired Information Theory. Future applications may require communication mechanisms for nanomachines to coordinate with other nano-machines. Nanomachines are artificial or biological macromolecules that perform simple computing, sensing, or actuation. A molecular communication system is one method for communicat...

This chapter describes two branches of biologically inspired approaches to networks: biologically inspired computer networks (i.e., the bio-networking architecture) and biologically inspired nanoscale biological networks (i.e., molecular communication). The first branch, biologically inspired computer networks, applies techniques and algorithms fro...

Molecular communication is one method for communication among biological nanomachines. Nanomachines are artificial or biological nano-scale devices that perform simple computation, sensing, or actuation. Future applications using nanomachines may require various communication mechanisms. For example, broadcast is one primitive communication for tra...

Molecular communication is engineered biological communication that allows biological devices to communicate through chemical Molecular communication is engineered biological communication that allows biological devices to communicate through chemical signals. Since biological devices are made of biological materials and are not amenable to traditi...

This paper describes research challenges in Molecular Communication, a new and interdisciplinary research area that spans the nanotechnology, biotechnology, and communication technology. Molecular communication allows nanomachines to communicate using molecules as a communication carrier. Key research challenges include controlled propagation of ca...

The utility of a sensor network derives primarily from the sensing data it gathers. Therefore, a critical issue of sensor networks is to efficiently provide sensing coverage. This paper proposes a scheme, enhanced differentiated surveillance (EDS), to maintain the required coverage for sensor networks by establishing working schedules of sensors fo...

Molecular communication is a bio-inspired communication paradigm using molecules as information carriers. In this paper, we built an example molecular communication system in aqueous media, which includes propagation of molecular capsules capable of carrying molecular information between a molecular sender and a molecular receiver and followed ampl...

The authors of this paper have proposed the concept of "molecular communication". The molecular communication uses molecules (i.e., chemical signals) as an information medium and allows biological and artificially-created nano- or cell-scale devices to communicate over a short distance. It is a new and biologically inspired communication paradigm a...

Molecular communication is one method for communication among nano-scale components (artificial or biological) that perform simple computation, sensing, or actuation. Future applications using nano-scale components may require communication mechanisms to coordinate with other components. For example, uni-cast is one primitive communication mechanis...

Molecular communication uses molecules (i.e., chemical signals) as an information carrier and allows biologically- and artificially-created nano- or cell-scale entities to communicate over a short distance. It is a new communication paradigm and is different from the traditional communication paradigm that uses electromagnetic waves (i.e., electron...

This paper proposes a biological cell-based communication pro tocol to enable communication between biological nanodevices. Inspi red by existing communication network protocols, our solution combines two molecular com- puting techniques (DNA and enzyme computing), to design a protocol stack for molecular communication networks. Based on computatio...

The inter-domain Resource Exchange (iREX) architecture uses economic market mechanisms to automate the deployment of end-to-end (E2E) inter-domain (ID) quality of service (QoS) policy among resource consumer and resource provider Internet Service Providers (ISPs). In iREX, each policy reservation is deployed on a single E2E ID path made up of the m...

This research is supported by the NSF through grants ANI‐0083074, ANI‐9903427 and ANI‐0508506, by DARPA through grant MDA972‐99‐1‐0007, by AFOSR through grant MURI F49620‐00‐1‐0330, and by grants from the California MICRO and CoRe programs, Hitachi, Hitachi America, Hitachi CRL, Hitachi SDL, DENSO IT Laboratory, NICT (National Institute of Communic...

The inter-domain resource exchange (iREX) architecture uses economic market mechanisms to automate the ad-hoc negotiation and deployment of end to end inter-domain quality of service policy among resource consumer and resource provider . In this paper, we explore iREX's network load distribution by comparing its performance to a lower bound for net...

A molecular transport system that can achieve autonomous loading/unloading of specified cargoes using DNA hybridization was investigated. The chemical linkages to label micro tubules (MTs) with ssDNAs was examined. The 23-mer spacer was introduced to prevent collapse of ssDNAs onto the MT surface and to keep the single-stranded sticky end free. The...

A microplatform was designed, fabricated, and tested for demonstrating the propagation of molecular signals through a line of patterned HeLa cells expressing gap junction channels (HeLa Cx43 cells). The microplatform was capable of patterning cells onto a predefined design with lithography and surface chemical treatment. Lucifer Yellow was first us...

Internet protocol-based multimedia applications are gaining momentum thanks to the great proliferation of the Internet and mass deployment of broadband. The abundance of rich content, heterogeneity of networks, user terminals, and services, along with the surges of multimedia traffic, have convoluted ever-increasing complexity and costs in the oper...

This paper proposes a novel remote user authentication scheme using smart cards which allows both the authentication server (AS) and the user to verify authenticity of each other. Our scheme is efficient enough to resist the known attacks that could be launched against remote user authentication process.

e call's quality of service requirements, connection identifiers at each switch on the route areestablished, and network resources such as bandwidth and buffer space are reserved for the connection.Another important characteristic of ATM is that its network functions are typically implemented inhardware. With the introduction of high speed fiber op...

This paper describes a molecular transport system in molecular communication that uses the machinery in living cells. The molecular transport system requires: 1) loading of the specified cargo molecules at a loading site (at a sender); 2) transport of the loaded cargoes to an unloading site (to a receiver); and 3) unloading of the transported cargo...

This paper describes design and empirically study of a communication interface in molecular communication. The communication interface hides the characteristics of the molecules during the propagation from the sender to a receiver to allow a generic transport of molecules independent of the characteristics. The authors of this paper propose a commu...

Molecular communication is engineered biological communication that allows nanomachines to communicate through chemical signals. Nanomachines are small scale biological devices that either exist in nature or are artificially engineered from biological materials, and that perform simple functions such as sensing, processing, and actuation. As nanoma...

In this paper, we describe a protocol stack to enable communication between biological nano scale (bio-nano) devices. We identify key design considerations and protocol components and suggest suitable molecular computing mechanisms to create these components. Finally, we introduce a modeling and simulation framework for bio-nano communication netwo...

Recently, P2P (Peer-to-Peer) streaming systems have attracted great attention. In P2P streaming systems, streaming data such as video and audio are divided into a number of small pieces for efficient data distribution. This approach allows peers to collect the pieces from each other while playing the streaming data. Our investigation into ecologica...

We consider the problem of moving target tracking in a wireless sensor network (WSN) in which the capability of each sensor has relatively limited performance enabling us to construct large-scale systems/networks at reduced cost. In order to achieve moving target tracking with high resolution, the following two requirements must be satisfied: (I) M...

Owing to numerous potential applications, wireless sensor networks have been attracting significant research effort recently. The critical challenge that wireless sensor networks often face is to sustain long-term operation on limited battery energy. Coverage maintenance schemes can effectively prolong network lifetime by selecting and employing a...

In the current Internet, congestion control is performed jointly by the end systems running the TCP protocol and by routers running active queue management (AQM) algorithms. Due to the TCP protocol's AIMD congestion control algorithm and its round trip time delay to react to packet losses, it is very hard to maintain high TCP throughput with a low...

75-80 Molecular communication, Autonomous molecular propagation system, Biomolecular linear motors, In vitro gliding assay, DNA hybridization, and Reversible loadingThis paper describes a design of a molecular propagation system in molecular communication. Molecular communication is a new communication paradigm where biological and artificially-cre...

IntroductionDynamic FactorsNetwork FunctionsRepresentative Adaptation TechniquesDiscussionConclusion References

This paper describes application of key biological principles and mechanisms to the design of network services. In biological systems, an individual entity (e.g., a bee in a bee colony) follows a simple set of behavior policies (e.g., migration, replication, death), yet a group of entities (e.g., a bee colony) exhibits complex emergent behavior wit...

Owing to numerous potential applications, wireless sensor networks have been attracting significant research effort recently. The critical challenge that wireless sensor networks often face is to sustain long-term operation on limited battery energy. Coverage maintenance schemes can effectively prolong network lifetime by selecting and employing a...

This paper proposes a novel remote user authentication scheme using smart cards which allows both the authentication server (AS) and the user to verify each other's authenticity. Our scheme is efficient enough to resist the known attacks that could be launched against remote user authentication process.

Molecular communication is a n