Tato M Sokhadze

Tato M Sokhadze
University of South Carolina School of Medicine - Greenville · Department of Biomedical Sciences

PhD

About

120
Publications
32,825
Reads
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2,300
Citations
Additional affiliations
October 2015 - present
University of South Carolina
Position
  • Professor
May 2004 - August 2016
University of Louisville
Position
  • Professor (Associate)
May 2003 - May 2004
Rice University
Position
  • PostDoc Position

Publications

Publications (120)
Article
Objective To explore whether 1 Hz repetitive transcranial magnetic stimulation (rTMS) has positive effects on brain activity and behavior of autistic children with intellectual disability. Methods 32 autistic children with intellectual disability (26 boys and 6 girls) were recruited to participate in this feasibility study. The autistic children w...
Article
Introduction. The authors investigate the problem of developing self-regulation skills in primary schoolchildren with cognitive impairments within the education system. The purpose of the article is to evaluate the effectiveness of implementing the program of psychological support aimed at developing self-regulation as a way of enhancing adaptive s...
Chapter
Emotional impairment is one of the common symptoms of many mental diseases. Being able to learn the emotional reactions from subjects using nonintrusive human-computer interactions (HCI) would provide a novel and efficient approach to assist existing intervention and therapy. Psychologists conducted research using virtual reality (VR) as a tool for...
Chapter
Error monitoring and correction is one of the executive functions and is important for effective goal-directed behavior. Deficient executive functioning, including reduced error monitoring ability, is one of the typical features of such neurodevelopmental disorders as autism spectrum disorder (ASD), probably related to perseverative responding, ste...
Chapter
Neuropathological studies in autism spectrum disorder (ASD) suggest the presence of a neuronal migrational disorder that alters the excitatory–inhibitory bias of the cerebral cortex. More specifically, in ASD, there appears to be widespread loss of parvalbumin (PV)-positive interneurons manifested as abnormalities in gamma oscillations (neural netw...
Chapter
Neurofeedback training is a treatment modality of potential use for improving self-regulation skills in autism spectrum disorder (ASD). Multiple studies using neurofeedback to target symptoms of ASD have been reported. These studies differ among themselves in the type of training (e.g., theta-to-beta ratio, coherence, etc.), topography (Cz or Pz),...
Article
Full-text available
Research suggest that in autism spectrum disorder (ASD) a disturbance in the coordinated interactions of neurons within local networks gives rise to abnormal patterns of brainwave activity in the gamma bandwidth. Low frequency transcranial magnetic stimulation (TMS) over the dorsolateral prefrontal cortex (DLPFC) has been proven to normalize gamma...
Article
Full-text available
Autism spectrum disorder (ASD) is a behaviorally diagnosed neurodevelopmental condition of unknown pathology. Research suggests that abnormalities of elecltroencephalogram (EEG) gamma oscillations may provide a biomarker of the condition. In this study, envelope analysis of demodulated waveforms for evoked and induced gamma oscillations in response...
Article
Despite growing knowledge about autism spectrum disorder (ASD), research findings have not been translated into curative treatment. At present, most therapeutic interventions provide for symptomatic treatment. Outcomes of interventions are judged by subjective endpoints (e.g., behavioral assessments) which alongside the highly heterogeneous nature...
Article
Full-text available
Background: A growing body of literature suggests etiological overlap between Ehlers-Danlos syndrome (EDS)/hypermobility spectrum disorders (HSD) and some cases of autism, although this relationship is poorly delineated. In addition, immune, autonomic, and endocrine dysregulation are reported in both conditions and may be relevant to their respecti...
Preprint
Full-text available
Background A growing body of literature suggests etiological overlap between Ehlers-Danlos syndrome (EDS)/hypermobility spectrum disorders (HSD) and some cases of autism, although this relationship is poorly delineated. In addition, immune, autonomic, and endocrine dysregulation are reported in both conditions and may be relevant to their respectiv...
Article
Full-text available
Background: Autism spectrum disorder (ASD) is a very complex neurodevelopmental disorder, characterized by social difficulties and stereotypical or repetitive behavior. Some previous studies using low-frequency repetitive transcranial magnetic stimulation (rTMS) have proven of benefit in ASD children. Methods: In this study, 32 children (26 male...
Article
Neural networks interaction was studied in healthy men (20-35 years old) who underwent 20 sessions of EEG biofeedback training outside the MRI scanner, with concurrent fMRI-EEG scans at the beginning, middle, and end of the course. The study recruited 35 subjects for EEG biofeedback, but only 18 of them were considered as "successful" in self-regul...
Article
Full-text available
There is no accepted pathology to autism spectrum disorders (ASD) but research suggests the presence of an altered excitatory/inhibitory (E/I) bias in the cerebral cortex. Repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive means of modulating the E/I cortical bias with little in terms of side effects. In this study, 124 high...
Article
Full-text available
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder which affects the developmental trajectory in several behavioral domains, including impairments of social communication, cognitive and language abilities. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique, and it was used for mod...
Article
in autism resulting in executive function deficits by measuring performance on cognitive tests with event-related potential (ERP) recording. Analysis of ERP components is one of the most informative dynamic methods of investigation and monitoring of information processing stages in the human brain. Different amplitude and latency characteristics of...
Chapter
The Central Nervous System can be understood as an organization whose levels have been established throughout evolution. In this organization, the cerebral hemispheres occupy the highest level of a hierarchical open system wherein the function of the brain is to match relationships among objects in the surrounding environment. The outer portion of...
Article
Full-text available
Alterations in brain connectivity have been extensively reported in autism spectrum disorder (ASD), while their effects on the topology of brain network are still unclear. This study investigated whether and how the brain networks in children with ASD were abnormally organized with resting state EEG. Temporal synchronization analysis was first appl...
Article
Full-text available
Several studies have shown that children with autism spectrum disorder (ASD) show abnormalities in P3b to targets in standard oddball tasks. The present study employed a three-stimulus visual oddball task with novel distracters that analyzed event-related potentials (ERP) to both target and non-target items at frontal and parietal sites. The task t...
Article
Full-text available
Many children with autism spectrum disorder (ASD) exhibit symptoms associated with autonomic nervous system (ANS) dysfunction indicative of low psychophysiological flexibility. It is suggested that ASD symptoms are associated with generalized abnormalities in the central nervous system, including structures and networks involved in the top-down reg...
Article
Full-text available
This review is aimed at exploring the usefulness of measuring event-related potential (ERP) in cognitive tests and discusses several applications of the ERP technique. Analysis of ERP components is one of the most informative dynamic methods of investigation and monitoring of information processing stages in the human brain. Amplitude and latency o...
Article
Full-text available
The review is aimed to explore the abnormality of neural and functional connectivity in autism resulting in executive function deficits by measuring performance on cognitive tests with event-related potential (ERP) recording. Analysis of ERP components is one of the most informative dynamic methods of investigation and monitoring of information pro...
Article
Full-text available
Autism is a pervasive developmental disorder of childhood characterized by deficits in social interaction, language, and stereotyped behaviors along with a restricted range of interests. It is further marked by an inability to perceive and respond to social and emotional signals in a typical manner. This might due to the functional disconnectivity...
Article
Full-text available
Gamma oscillations are important for the integration of information and are involved in a variety of perceptual, cognitive, and motor process that are affected in autism spectrum disorder (ASD). We used gamma oscillations along with event-related potentials (ERP) as functional markers of response to repetitive transcranial magnetic stimulation (rTM...
Article
Full-text available
Abnormalities in motor skills have been regarded as part of the symptomatology characterizing autism spectrum disorder (ASD). It has been estimated that 80 % of subjects with autism display "motor dyspraxia" or clumsiness that are not readily identified in a routine neurological examination. In this study we used behavioral measures, event-related...
Article
Full-text available
Neurofeedback is a mode of treatment that is potentially useful for improving self-regulation skills in persons with autism spectrum disorder. We proposed that operant conditioning of EEG in neurofeedback mode can be accompanied by changes in the relative power of EEG bands. However, the details on the change of the relative power of EEG bands duri...
Article
Full-text available
EEG biofeedback (so called neurofeedback) is considered as an efficacious treatment for ADHD. We propose that operant conditioning of EEG in neurofeedback training mode, aimed to mitigate inattention and low arousal in ADHD, will be accompanied by changes in EEG bands' relative power. Patients were 18 children diagnosed with ADHD. The neurofeedback...
Article
Abstract: Background: In addition to well-known cognitive impairments, there are disruptions in processing emotions in individuals with substance dependence and in those predisposed to drug abuse. Neurofeedback training-based intervention is one of the potentially efficacious nonpharmacological treatment options for substance use disorders. Several...
Article
Autism spectrum disorder (ASD) is a developmental disorder marked by difficulty in social interactions and communication. ASD also often present symptoms of autonomic nervous system (ANS) functioning abnormalities. In individuals with autism the sympathetic branch of the ANS presents an over-activation on a background of the parasympathetic activit...
Conference Paper
Full-text available
Autism spectrum disorder (ASD) is one of neurodevelopment disorders, which presents with impairments in communication and social skills, and stereotyped, repetitive patterns of behavior. Disturbances of affective reactivity and innate inability to perceive and respond to the social cues including facial emotional expressions in a typical and approp...
Article
Unlabelled: Postmortem studies in autism spectrum disorder (ASD) individuals indicate the presence of abnormalities within the peripheral neuropil space (PNS) of cortical minicolumns. The geometrical orientation of inhibitory elements within the PNS suggests using repetitive transcranial magnetic stimulation (rTMS) to up-regulate their activity. S...
Article
Autism spectrum disorder (ASD) consists of a set of pervasive developmental problems marked by measurable deficits in social interaction and communication, often coupled with specific and repetitive patterns of behavior. Featured restrictions in the capability to communicate and remain attentive can directly relate to the individual’s ability to in...
Article
Full-text available
Autism spectrum disorder (ASD) is one of neurodevelopment disorders, which presents with impairments in communication and social skills, and stereotyped, repetitive patterns of behavior. Disturbances of affective reactivity and innate inability to perceive and respond to the social cues in a typical and appropriate manner, including facial emotiona...
Article
Full-text available
The term autism spectrum disorder (ASD) describes a range of conditions characterized by impairments in social interactions, communication, and by restricted and repetitive behaviors. Autism spectrum disorder may also present with symptoms suggestive of autonomic nervous system (ANS) dysfunction. The objective of this study was to determine the eff...
Article
Full-text available
Autism spectrum disorder (ASD) is a pervasive developmental disorder characterized by deficits in social interaction, language, stereotyped behaviors, and restricted range of interests. In previous studies low frequency repetitive transcranial magnetic stimulation (rTMS) has been used, with positive behavioral and electrophysiological results, for...
Article
Full-text available
Objectives: Reports in autism spectrum disorders (ASD) of a minicolumnopathy with consequent deficits of lateral inhibition help explain observed behavioral and executive dysfunctions. We propose that neuromodulation based on low frequency repetitive Transcranial Magnetic Stimulation (rTMS) will enhance lateral inhibition through activation of inh...
Conference Paper
Background: The study is based on an underlying neuropathology model of autism which emphasizes minicolumnar pathology and lateral inhibition deficits resulting in behavioral and executive dysfunctions. We proposed that neuromodulation based on low frequency repetitive Transcranial Magnetic Stimulation (rTMS) will enhance lateral inhibition throu...
Conference Paper
Background: Motor abnormalities in autism bear the characteristics of precedence and universality that characterize a core symptom. Underlying the motor skill deficits in autism and Asperger syndrome is a dyspraxia that by definition is an inability to plan, organize, and execute movements in the absence of any known physical and/or neurological...
Article
Full-text available
Substance use disorders (SUDs) are among the most common psychiatric conditions, resulting in serious behavioral impairments and cognition decline. Acute and chronic drug abuse, drug dependency and drug withdrawal result in significant alteration of the electroencephalogram (EEG). EEG biofeedback has been used in the treatment of alcohol and mixed...
Article
Full-text available
Neurofeedback is a nonpharmacological treatment for attention-deficit hyperactivity disorder (ADHD). We propose that operant conditioning of electroencephalogram (EEG) in neurofeedback training aimed to mitigate inattention and low arousal in ADHD, will be accompanied by changes in EEG bands' relative power. Patients were 18 children diagnosed with...
Chapter
Recent studies by our group have characterized the neuropathology of autism as that of a minicolumnopathy. Postmortem studies using computerized image analysis of pyramidal cell arrays have found that the brains of autistic individuals have smaller minicolumns with most of the decrease stemming from a reduction in its peripheral neuropil space, wit...
Chapter
Autism is recognized as a pervasive developmental disorder (PDD) usually evident during the first 3 years of life (Ruble and Brown 2003; Volkmar and Pauls 2003). Several neuropsychological models have been proposed to explain the cognitive deficits found in autism spectrum disorders (ASD) (Baron-Cohen 2004), one of which is based on salient deficit...
Article
Full-text available
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive method of altering patterns of brain activity. rTMS has been applied to a wide variety of psychiatric and neurological conditions and is generally regarded as safe without lasting side effects. Within the context of autism spectrum disorders (ASD) rTMS has a unique application as...