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29
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Introduction
Spreading depression.
Computational EEG models.
Largest Lyapunov exponent.
Mutual information.
Education
September 2014 - July 2016
September 2010 - July 2014
Publications
Publications (29)
Background
Spreading depolarization (SD), underlying mechanism of migraine aura and potential activator of pain pathways, is known to elicit transient local silencing cortical activity. Sweeping across the cortex, the electrocorticographic depression is supposed to underlie spreading negative symptoms of migraine aura. Main information about the su...
Growing experimental and clinical evidence indicates the crucial role of network dysfunction in neurological disorders’ pathogenesis, including migraine, one of the most prevalent chronic brain diseases. Episodic headache attacks, frequently unilateral, accompanied by an aura, are associated with migraine. Migraine aura is a neurological condition...
Functional connectivity analysis is gaining more interest due to its promising clinical applications. To study network mechanisms underlying seizure termination and postictal depression, we exploredynamics of interhemispheric functional connectivity near the offset of focal and bilateral seizures in the experimental model of reflex audiogenic epile...
Spreading depolarization (SD), a self-propagated wave of transient depolarization, regularly occurs in the cortex after acute brain insults and is now referred as an important diagnostic and therapeutic target in patients with acute brain injury. Here, we show that the amygdala, the limbic structure responsible for post-injury neuropsychological sy...
We studied the effects of stimulation of the medial septal area on the gene expression in the dorsal and ventral hippocampus. Rats under urethane anesthesia were implanted with a recording electrode in the right hippocampus and stimulating electrode in the dorsal medial septum (dMS) or medial septal nucleus (MSN). After one-hour-long deep brain sti...
We demonstrate the dissipative spatiotemporal patterns that are generated by an active ring resonator based on a magnonic quasicrystal (MQC) with Fibonacci-type structure. The dissipative patterns are formed through the magnetostatic surface spin-wave (MSSW) parametric decay into exchange spin waves (SWs), temporal dispersion of the ring resonator...
Objective:
Growing evidence shows a critical role of network disturbances in the pathogenesis of migraine. Unilateral pattern of neurological symptoms of aura suggests disruption of interhemispheric interactions during the early phase of a migraine attack. Using local field potentials data from the visual and motor cortices, this study explored ef...
A mesoscale network model is proposed for the development of spike and wave discharges (SWDs) in the cortico-thalamo-cortical (C-T-C) circuit. It is based on experimental findings in two genetic models of childhood absence epilepsy–rats of WAG/Rij and GAERS strains. The model is organized hierarchically into two levels (brain structures and individ...
In our study, we compare three popular approaches to directed coupling analysis, in particular transfer entropy and two types of Granger causality, applied to real data from genetic absence epilepsy rats. We have chosen the channels for which the coupling architecture is already well known from previous studies. Recordings from 5 WAG/Rij rats of 8...
Here we consider the possibility to characterize the signal complexity of electroencephalo-grams using calculation of largest Lyapunov exponent explicitly from time series. This would help in detection of seizures, understanding and modeling epileptic activity. Baseline activity and spike-wave discharges (SWDs) were considered as regimes. Three cha...
We present the results of experimental studies of the generation modes of the pulse signals, which are analogs of the time solitons, in a distributed active ring resonator with a drift klystron amplifier and a spin-wave transmission line. The soliton-like pulses are formed under the conditions of the three-wave parametric decay of a surface magneto...
Alzheimer’s disease (AD) is associated with degeneration of cholinergic neurons in the basal forebrain. Administration of the immunotoxin 192IgG-saporin to rats, an animal model of AD, leads to degeneration of cholinergic neurons in the medial septal area. In the present study, cholinergic cell death was induced by intracerebroventricular administr...
Morphology of IBA-stained microglia (A) and GFAP-stained astrocytes (B) in the hippocampal CA3 area in animals where we observed strong changes in the morphology of microglia, which were accompanied by activation of astrocytes. Scale bar, 40 μm.
Immunostaining of choline acetyltransferase in the septal area of control (A) and Ig-saporin-treated (B) rats. (C) Shows the effect of Ig-saporin on the number of ChAT-positive cells in the medial septal nucleus (MSN) + vertical limb of DBB (vDBB) and in the horizontal limb of DBB (hDBB) as well as on total number of cells in both septal areas. All...
Purpose. The aim is to reveal the dependence of Granger causality results on chosen time scales of constructed empirical models in application to the task of investigation of evolution of coupling between brain areas during limbic seizures. Methods. We use combination of methods for coupling analysis of the experimental time series and approaches t...
Purpose:
The organization of neural networks and the mechanisms, which generate the highly stereotypical for absence epilepsy spike-wave discharges (SWDs) is heavily debated. Here we describe such a model which can both reproduce the characteristics of SWDs and dynamics of coupling between brain regions, relying mainly on properties of hierarchica...
Absence seizures are known to be highly non-linear large amplitude oscillations with a well pronounced main time scale. Whilst the appearance of the main frequency is usually considered as a transition from noisy complex dynamics of baseline EEG to more regular absence activity, the dynamical properties of this type of epileptiformic activity in ge...
The generation of quasi-periodic sequences of parametric soliton-like pulses in an active ring res-onator with a ferromagnetic film via the three-wave parametric instability of a magnetostatic surface wave is studied theoretically and experimentally. These dissipative structures form in time due to the competition between the cubic nonlinearity cau...
