Tatiana Sitnikova

Tatiana Sitnikova
Harvard Medical School | HMS · Athinoula A. Martinos Center for Biomedical Imaging

About

34
Publications
4,273
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1,889
Citations
Citations since 2016
5 Research Items
636 Citations
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2016201720182019202020212022020406080100
2016201720182019202020212022020406080100

Publications

Publications (34)
Article
Full-text available
Background: Transcranial photobiomodulation (tPBM) has recently emerged as a potential cognitive enhancement technique and clinical treatment for various neuropsychiatric and neurodegenerative disorders by delivering invisible near-infrared light to the scalp and increasing energy metabolism in the brain. Objective: We assessed whether transcran...
Preprint
Full-text available
Neurovascular coupling is a dynamic core mechanism supporting brain energy demand. Therefore, even spontaneous changes in neural activity not linked directly to goal-directed behavior are expected to evoke a vascular hemodynamic response (HDR). Here, we developed a novel procedure for estimating transient neural activity states based on source-loca...
Preprint
Full-text available
Objective Our objective was to assess whether transcranial photobiomodulation (tPBM) with near-infrared light (NIR) shows modulatory effects on cerebral electrical activity through electroencephalogram (EEG) and cerebral blood flow (CBF). Background tPBM has emerged as a novel intervention for several neuropsychiatric conditions due to its neuropr...
Article
Full-text available
Introduction The objective of the study is to validate attention and memory tasks that elicit event-related potentials (ERPs) for utility as sensitive biomarkers for early dementia. Methods A 3-choice vigilance task designed to evaluate sustained attention and standard image recognition memory task designed to evaluate attention, encoding, and ima...
Article
Full-text available
Alzheimer's disease (AD) is a prevalent neurodegenerative condition that can lead to severe cognitive and functional deterioration. Functional magnetic resonance imaging (fMRI) revealed abnormalities in AD in intrinsic synchronization between spatially separate regions in the so-called default mode network (DMN) of the brain. To understand the rela...
Article
This overview outlines findings of cognitive and neurocognitive studies on comprehension of verbal, pictorial, and video stimuli in healthy participants and patients with schizophrenia. We present evidence for a distinction between two complementary neurocognitive streams of conceptual analysis during comprehension. In familiar situations, adequate...
Conference Paper
Electrophysiological traits, indexing schizophrenia endophenotypes, were measured in over 600 members of a genetic isolate in Jiri, Nepal, who are members of a single pedigree. Measured traits include P50 and P300 amplitude and latency, and oscillatory brain activity in the gammaband range (35–45 Hz). The power of induced gammaband activity, as mea...
Article
Full-text available
Origins of impaired adaptive functioning in schizophrenia remain poorly understood. Behavioral disorganization may arise from an abnormal reliance on common combinations between concepts stored in semantic memory. Avolition-apathy may be related to deficits in using goal-related requirements to flexibly plan behavior. The authors recorded event-rel...
Article
Full-text available
How do comprehenders build up overall meaning representations of visual real-world events? This question was examined by recording event-related potentials (ERPs) while participants viewed short, silent movie clips depicting everyday events. In two experiments, it was demonstrated that presentation of the contextually inappropriate information in t...
Article
Full-text available
To make sense of a sentence, we must compute morphosyntactic and semantic-thematic relationships between its verbs and arguments and evaluate the resulting propositional meaning against any preceding context and our real-world knowledge. Recent electrophysiological studies suggest that, in comparison with non-violated verbs (e.g. "...at breakfast t...
Article
This chapter begins with a discussion of evidence for distinctions between two semantic comprehension systems in the language domain: a system that maps the perceived information on graded semantic representations and a system that utilizes particular semantic requirements of verbs. It then reviews similar research using static and motion pictures....
Article
Recent event-related potential studies report a P600 effect to incongruous verbs preceded by semantically associated inanimate noun-phrase (NP) arguments, e.g., "eat" in "At breakfast the eggs would eat...". This P600 effect may reflect the processing cost incurred when semantic-thematic relationships between critical verbs and their preceding NP a...
Article
Full-text available
Event-related potentials were measured as subjects read sentences presented word by word. A small N400 and a robust P600 effect were elicited by verbs that assigned the thematic role of Agent to their preceding noun-phrase argument when this argument was inanimate in nature. The amplitude of the P600, but not the N400, was modulated by the transiti...
Article
Full-text available
Event-related potentials to critical verbs were measured as patients with schizophrenia and healthy controls read sentences word by word. Relative to their preceding context, critical verbs were (a) congruous, (b) incongruous and semantically unrelated to individual preceding words (pragmatic-semantic violations), (c) incongruous but semantically r...
Article
Despite decades of research, it remains controversial whether semantic knowledge is anatomically segregated in the human brain. To address this question, we recorded event-related potentials (ERPs) while participants viewed pictures of animals and tools. Within the 200-600-ms epoch after stimulus presentation, animals (relative to tools) elicited a...
Article
Full-text available
The present study examined the functional neuroanatomy of comprehending real-world events in schizophrenia. We recorded functional magnetic resonance imaging (fMRI) data while patients with schizophrenia and matched healthy participants viewed silent video clips of common real-world activities. The final scene in these movies was either congruous o...
Article
The aim of this study was to determine whether or not the brain distinguishes between two types of conceptual relationships between noun-phrases (NPs) and verbs during online processing of simple, unambiguous English sentences. A total of 15 participants read and made plausibility judgments on sentences that were presented word-by-word. Event-relat...
Article
Full-text available
The aim of this study was to gain further insights into how the brain distinguishes between meaning and syntax during language comprehension. Participants read and made plausibility judgments on sentences that were plausible, morphosyntactically anomalous, or pragmatically anomalous. In an event-related potential (ERP) experiment, morphosyntactic a...
Article
Event-related potentials (ERPs) discriminated between contextually appropriate and inappropriate objects appearing in video film clips of common activities. Incongruent objects elicited a larger negative-going deflection, which was similar to the N400 component described previously in association with words and static pictures and which has been ar...
Article
Deficits in language comprehension in schizophrenia were examined using event-related potentials (ERPs). Schizophrenic and healthy participants read sentences in which the first clause ended with a homograph, and the second clause started with a target word that was semantically related to the homograph's dominant meaning (e.g., 1. Diving was forbi...
Article
Full-text available
The process of describing an object's location relative to another object results in ambiguity. How do people handle this ambiguity? The present studies examined spatial language processing when use of different reference frames results in ambiguity. We investigated whether electrophysiological (ERP) measures of cognitive processing may elucidate u...
Article
It has long been known that carbon monoxide (CO) poisoning has a spectrum of effects on cognitive functioning, including memory, perception, and attention. The current study reports the investigation of the effects of CO poisoning on short-term verbal memory, both rote and context aided. Impairment was measured before and after hyperbaric oxygen (H...

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