Tarynn Witten

Tarynn Witten
Virginia Commonwealth University | VCU · Department of Computer Science,

AB, AB, MS, MS, MSW, PhD

About

172
Publications
44,921
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3,182
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Introduction
Tarynn Witten currently works at the Department of Computer Science,, Virginia Commonwealth University. Her research includes high performance computing, biomedical simulation and modeling, research in support of highly stigmatized minorities, biodemography and quantum phenomenology and computation.
Additional affiliations
January 2001 - present
Virginia Commonwealth University
Position
  • Director, Research & Development

Publications

Publications (172)
Article
The purpose of the current research is to understand concerns about receiving care in a sample of transgender, gender nonbinary, and gender diverse (TGD) adults across the lifespan. A total of 829 participants, predominantly from the United States and Canada, aged 18–70, completed the Trans Metlife Survey on Later-Life Preparedness and Perceptions...
Preprint
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To better understand the potential impact of the gene expression network structure on the dynamics of immune-senescence and defects of cell functions during aging, we investigated network structures in both young and old individuals. We analyzed the gene co-expression networks (GCNs) derived from an aging signature of 130 immune-related genes obtai...
Article
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In this paper we extend the previous work of Witten and her team on defining a classical physics-driven model of survival in aging populations (Eakin, Bull Math Biol 56(6):1121–1141, 1994; Eakin and Witten, Mech Aging Dev 78(2):85–101, 1995; Witten and Eakin, Exp Gerontol 32(2):259–285, 1997) by revisiting the concept of a force of aging and introd...
Article
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Objectives: Data regarding atherogenic dyslipidemia and the inflammation profile in youth with type 2 diabetes is limited and the effect of insulin therapy on these variables has not previously been studied in youth. We determined the impact of insulin therapy on lipid and inflammatory markers in youth with poorly controlled type 2 diabetes. Stud...
Article
Purpose: Transgender and gender nonconforming (TGNC) persons have routinely experienced high rates of violence and discrimination. Discrimination in healthcare can affect the ability of TGNC persons to age successfully as it often deters them from seeking care. The purpose of this study was to determine if anticipation of bias from healthcare prof...
Article
Recently, a large number of mathematical models that are described by delay differential equations (DDEs) have appeared in the life sciences. In this paper, we present a delay differential model to describe influenza A (H1N1) dynamics. We begin by presenting the model with a brief discussion, followed by proving the positivity and boundedness of th...
Article
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Fiber reinforced anisotropic material abounds in biological world. It has been demonstrated in previous theoretical and experimental works that growth of biological soft tubular tissue plays a significant role in morphogenesis and pathology. Here we investigate growth-induced buckling of anisotropic cylindrical tissue, focusing on the effects of ty...
Chapter
Research on behalf of the aging lesbian, gay, bisexual, and transgender (LGBT) population has been mandated by the Institute of Medicine, the National Institutes of Health, and the Centers for Disease Control and Prevention. Despite the growing research efforts in the field of LGBT aging, focused research on the varied challenges of transgender agi...
Article
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Despite the growing visibility and acceptance of transgender and gender nonconforming (TGNC) individuals, TGNC older adults experience many barriers in accessing competent and affirming health and social services due to anti-TGNC prejudice, discrimination, and lack of competent healthcare training on the part of healthcare workers. Clinical geronto...
Chapter
In this chapter we examine a variety of modeling approaches that have been historically used to understand the sub-cellular and cellular biology of aging. We find that there are a large array of methods from discrete to continuous and from deterministic to stochastic. This chapter is not meant to be a comprehensive coverage of all of the modeling e...
Chapter
Full-text available
In this chapter we examine a variety of modeling approaches that have been historically used to understand the sub-cellular and cellular biology of aging. We find that there are a large array of methods from discrete to continuous and from deterministic to stochastic. This chapter is not meant to be a comprehensive coverage of all of the modeling e...
Article
This study is the first to examine the experiences and needs of an international sample of current, English-speaking, bisexual, and transgender-identified adults (trans-bisexuals) on a number of later-life and end-of-life (EOL) perceptions, preparations, and concerns. In particular, the author analyzed a subset (n D 147) of the cross-sectional data...
Article
Despite the fact that LGBT aging often is discussed, the unique needs of the transgenderidentified and gender non-conforming-identified (GNC) populations are still very much overlooked. This article examines some of the historical challenges faced by this population, and reviews their current status, and also discusses some of the important steps t...
Research
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IN PRESS: Singh, A. and Dickey, L. (2016). Handbook of Trans-Affirmative Counseling & Psychological Practice. American Psychological Association.
Research
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In this chapter we explore the potential impact of dementia on members of the global trans-identified population. In particular, we will focus on Alzheimer’s disease (AD) due to the loss of identity memory associated with the disease. In a recent study, it was found that dementia was so fearful to some trans-persons, along with the fear of abuse an...
Article
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Airway remodeling in patients with chronic asthma is characterized by thickening and structural change of airway walls. It has been demonstrated in previous theoretical models that changes in airway thickness can have an important mechanical effect, in particular, on the mucosal folding induced by smooth muscle contraction. In this paper, we examin...
Article
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In this paper, we modify our previously developed conjoint tumor-normal cell model in order to make a distinction between tumor cells that are responsive to chemotherapy and those that may show resistance. Using this newly developed core model, the evolution of three cell types: normal, tumor, and drug-resistant tumor cells, is studied through a se...
Article
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This study is the first to examine the experiences and needs of an international sample of current, English-speaking, lesbian, transgender-identified (trans-lesbian) adults around a number of later life and end-of-life perceptions, preparations, and concerns. I analyzed a subset (n = 276) of the cross-sectional data collected from the online Trans...
Article
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This chapter will briefly address the history of systems biology and complexity theory and its use in understanding the dynamics of aging at the 'omic' level of biological organization. Using the idea of treating a biological organism like a network, we will examine how network mathematics, particularly graph theory, can provide deeper insight and...
Article
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This chapter will introduce a few additional network concepts, and then it will focus on the application of the material in the previous chapter to the study of systems biology of aging. In particular, we will examine how the material can be used to study aging networks in two sample species: Caenorhabditis elegans and Saccharomyces cerevisiae. © 2...
Article
Full-text available
This study is the first to examine the experiences and needs of an international sample of current, English-speaking, bisexual and transgender-identified adults (trans-bisexuals) around a number of later-life and end-of-life (EOL) perceptions, preparations and concerns. In particular, I analyzed a subset (n=147) of the cross-sectional data collecte...
Article
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This section includes eighty-six short original essays commissioned for the inaugural issue of TSQ: Transgender Studies Quarterly. Written by emerging academics, community-based writers, and senior scholars, each essay in this special issue, “Postposttranssexual: Key Concepts for a Twenty-First-Century Transgender Studies,” revolves around a partic...
Article
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In this study, the experiences and needs of a sample of 1,963 current, global, English-speaking, transgender-identified adults responding to the Transgender MetLife Survey (TMLS) as related to a number of later-life and end-of-life (EOL) preparations and concerns were examined. EOL concerns are integrated with concerns and challenges around chronic...
Article
Full-text available
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Article
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Species are defined by biological criteria. This characterization, however, misses the most unique aspect of our species; namely, an ability to invent technologies that reduce mortality risks. Old animals are rare in nature, but survival to old age has become commonplace in humans. Science now asks how long can humans live, but we suggest a more ap...
Chapter
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Living systems are not linear in their behaviors. Studying them using the traditional reductionist approaches limits our deeper understanding of their dynamics. Knowledge of the behavior of the parts does not necessarily imply any understanding of the whole organism. Early on, ecologists understood this fact and from their insights emerged the fiel...
Chapter
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This chapter describes the qualitative analysis of responses given by 122 transgender persons aged 61 and older who answered nine questions in an online survey about hopes and fears about aging, strategies for successful aging, and wisdom to convey to younger transgender individuals. More than 70 % stated they believe they are aging successfully. W...
Article
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We propose a biomechanical model for investigating wound contraction mechanism and resulting scarring. Extracellular matrix is modeled as fiber-reinforced anisotropic soft tissue, with its elastic properties dynamically changing with the density and orientation of collagen fibers. Collagen fibers are deposited by fibroblasts infiltrating the wound...
Article
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Religion may enhance successful aging by reducing stress, improving well-being, and augmenting social engagement. However, there is a paucity of research specific to religious affiliation in the elusive transgender-identified population. This exploratory study describes the demographic profile and religious affiliation of 289 transgender adults age...
Article
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We review the recent psychosocial literature on transgender aging. We also report relevant in-press results from the Trans MetLife Survey on Later-Life Preparedness and Perceptions in Transgender-Identified Individuals (TMLS) on end-of-life and later-life trans-aging. To obtain relevant literature, we employed the search engines Google Scholar, Sta...
Article
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In this paper, we develop a theoretical contribution towards the understanding of the complex behavior of conjoint tumor-normal cell growth under the influence of immuno-chemotherapeutic agents under simple immune system response. In particular, we consider a core model for the interaction of tumor cells with the surrounding normal cells. We then a...
Article
The process of aging can be more complex for transgender and other gender minority persons than for members of normatively identified non-transgender populations (Witten, 2002a, 2002b, 2002c, 2003). There are also often significant differences between the concerns of transgender older adults and those of their lesbian, gay, and bisexual (LGB) peers...
Article
Aging-being old-is defined both biomedically and psychosocioeconomically: "The geriatric or elderly patient is defined as an individual whose biological age is advanced. By definition, such an individual has one or more diseases, one or more silent lesions in various organ systems" (Aronheim, 1992, p. ix). However, there are also links between the...
Article
The graying of the U.S. population draws increasing focus to historically unattended segments of society, including sexual and gender minorities. In this first comprehensive volume to address the challenges of aging in the gay, lesbian, bisexual, transgender, and intersex populations, this text presents what is currently known about aging GLBT indi...
Article
This paper reviews the general biological phenomenon of aging as it applies to cells. Philosophical concepts of aging arising from radiation and evolutionary biology are used as a historical context for our understanding of how cells age. The development of multicellularity, and with it, an extracellular matrix is discussed in order to reveal that...
Article
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In this paper we consider two approaches to examining the complex dynamics of conjoint aging-cancer cellular systems undergoing chemotherapeutic intervention. In particular, we focus on the effect of cells growing conjointly in a culture plate as a precursor to considering the larger multi-dimensional models of such systems. Tumor cell growth is co...
Article
Hemorrhage continues to be a leading cause of death from trauma sustained both in combat and in the civilian setting. New models of hemorrhage may add value in both improving our understanding of the physiologic responses to severe bleeding and as platforms to develop and test new monitoring and therapeutic techniques. We examined changes in oxygen...
Article
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In this paper, we review the literature on global transgender hate crimes, violence, and abuse. We point out that it is possible to infer that this problem is not localized to the United States but rather, represents a global pandemic of focused prejudice. We point out that it can be viewed not only as an extremely serious and immediate public heal...
Article
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The complex interactions that characterize acute wound healing have stymied the development of effective therapeutic modalities. The use of computational models holds the promise to improve our basic approach to understanding the process. By modifying an existing ordinary differential equation model of systemic inflammation to simulate local wound...
Article
Computational models of integrative physiology may serve as a framework for understanding the complex adaptive responses essential for homeostasis in critical illness and resuscitation and may provide insights for design of diagnostics and therapeutics. In this study a computer model of human physiology was compared to results obtained from experim...
Article
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In a previous series of papers, this author investigated many of the challenges of growing old within the transgender population. Challenges with respect to violence, abuse, and hate crimes were examined as they related to institutional organizations such as the health care system, religious organizations, the military, and the legal system. Medica...
Data
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Enrichment of longevity-associated genes in the Composite shortest-path longevity network. (0.08 MB PDF)
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Relation table for the composite shortest path longevity network. (0.16 MB PDF)
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Replicative life span analysis of single-gene deletion strains corresponding to genes in the binding shortest-path longevity network. (0.14 MB PDF)
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Replicative life span analysis of 564 randomly selected single-gene deletion strains. (0.36 MB PDF)
Data
The first neighbors longevity network has less predictive power than the Binding SPLN. (0.17 MB PDF)
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Distribution of mean replicative life spans for 5 and 10 cell sets of BY4742 mother cells. (0.13 MB PDF)
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Set of yeast genes reported to be associated with increased replicative life span used to construct the shortest-path longevity network. (0.11 MB PDF)
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Genes contained in both the randomly selected set of 564 single-gene deletion strains and the predicted longevity associated genes in the binding shortest path longevity network. (0.12 MB PDF)
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Deletion of YPT6, a component of the composite shortest-path longevity network, increases replicative life span. (0.11 MB PDF)
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Components of the Binding shortest-path longevity network. (0.10 MB PDF)
Article
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Given that the established Gerontological literature on the long-term negative impact of violence, abuse, and other negative life events, given that researchers have demonstrated the positive impact of faith, spirituality, and particularly religiosity on long-term health, and given that violence and abuse are a serious, frequent and lifelong experi...
Article
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Background: Identification of genes that modulate longevity is a major focus of aging-related research and an area of intense public interest. In addition to facilitating an improved understanding of the basic mechanisms of aging, such genes represent potential targets for therapeutic intervention in multiple age-associated diseases, including can...
Article
“Disparity” implies the existence of a “markedly distinct in quality or character,” difference between one group and another. Some groups, due to elevated stigma associated with group membership, are invisible as a disparate minority and therefore, while there may be a great inequity in healthcare between that group and the normative population, th...
Article
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We present a novel mathematical/computational strategy for predicting genes/proteins associated with aging/longevity. The novelty of our method arises from the topological analysis of an organismal longevity gene/protein network (LGPN), which extends the existing cellular networks. The LGPN nodes represent both genes and corresponding proteins. Lin...
Article
I have the pleasure to present a number of personal experiences that I had with Robert Rosen, both as his student and as a research colleague, and I will describe how this affected my academic career over the past decades. As a matter of fact, Rosen's work with (M,R)-systems as well as his continuing mentorship guided me into my own research in ger...
Chapter
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The linkage between complex, dynamic systems and cellular automata is made quite clear in this monograph. The dynamic portrayal of many phenomena has been shown to mirror reality in several important ways among the studies described. We aver that cellular automata belongs on the pantheon of methods of probing, modeling and even predicting events as...
Article
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Nonhealing wounds represent a significant cause of morbidity and mortality for a large portion of the population. One of the underlying mechanisms responsible for the failure of chronic wounds to heal is an out-of-control inflammatory response that is self-sustaining. Underappreciation of the inherent complexity of the healing wound has led to the...
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The reasons for classifying causes of death into aggregate groups are discussed and the impact of mortality partitions on analyses of mortality is described. Special emphasis is given to a mortality partition that distinguishes between intrinsic causes of death that arise primarily from the failure of biological processes that originate within an o...
Article
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Full-text of this article is not available in this e-prints service. This article was originally published [following peer-review] in Deakin Law Review, published by and copyright Deakin University. Aging is a universal normalising process. No gender identity, no body form, no sex/sexuality is necessarily fixed in time and none of these facets of t...
Article
We construct a general solution to the time-independent forward Boltzmann equation for high energy 4He and its secondaries through bulk matter using the decomposition method.
Article
Current research activities at the Center for the Study of Biological Complexity (CSBC) at Virginia Commonwealth University range through the hierarchy of complex biosystems from water through ecology. To briefly highlight some of these activities, it is convenient to step through this scheme of biological complexity and to illuminate a few active...
Article
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In this paper we discuss middle-to-late life issues of the transgender and intersex communities. We demonstrate that these mid-to-late life issues are richly complex, full of courage, coping, risk, and resilience, and are grounded in a socio-ecological landscape of systemic actual and perceived violence and abuse. We examine how this socio-ecologic...
Article
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Thirty patients received maxillary infiltration and mandibular inferior alveolar nerve block injections with both a traditional syringe and a computerized system, the Wand. Patients noted their preference for either system and rated their injection pain and postoperative discomfort on a ten-point scale for each type of injection. Mean injection dis...
Article
One population is advantaged relative to another by our definition if its survival function is greater at all ages. A population has a lifespan maximum if there is an age at which its survival function becomes exactly zero. Earlier work concerned conditions under which the mortality-rate functions of advantaged and disadvantaged populations display...
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According to J. Caputi, “in mainstream discussion, violent crimes against women are frequently presented as inexplicable and their perpetrators as social deviants ... [Researchers] have argued for an awareness of the sexually political and conformist nature of such crimes and have invented the word ‘gynocide’ to name the range of systematic violenc...
Article
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We review the recent psychosocial literature on transgender aging.. We found two types of articles: LGBT aging-related (or lumped aging) articles and articles that focused specifically on transgender aging, or trans-aging. We found that the articles spoke of concerns and fears regarding discrimination, potential abuse at the hands of caregivers, in...
Article
Recent large-scale experimental population studies have allowed us to probe the dynamics of survival in the "oldest old" of a small number of biological species. The results of these studies add strong support to the validity of a multiphasic survival/mortality model for population survival as has been previously proposed by a number of investigato...
Article
General philosophical aspects of the rendering of scientific data are discussed, with applications to auditory representations of scientific models. Scientific simulations or models of real world phenomena frequently lead to large quantities of complex numerical output. The generating mathematical/computer model is often realized through a set of s...