I am a professional developer, Executive Director at IQL Technologies Pvt. Ltd. (aka. Idea Quotient Labs). I have graduated with MSc. Bioinformatics and keenly interested in replicating biological methods and data for human welfare.
Research items (6)
3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) is a major endogenous ligand found in the human serum albumin (HSA) of renal failure patients. It gets accumulated in the HSA and its concentration in sera of patients may reflect the chronicity of renal failure [1-4]. It is considered uremic toxin due to its damaging effect on the renal cell...
If an enzyme/protein is already bound to a ligand, what happens if we introduce another ligand that has higher affinity than one in complex? will it replace the bound ligand?
Background: Single nucleotide substitutions (SNS) in genetic codon are of prime importance due to their ability to alter an amino acid sequence as a result. Given the nature of genetic code, any SNS is expected to change the protein sequence randomly into any of the 64 possible codons. In this paper, we present a theoretical analysis of how single...
My team carried out a theoretical experiment which generated probability matrix with values such as 0/36 and 0/12 and so on. These probabilities are independent of each other and not from the same experiment. How can I account for this while creating a mathematical model?
Do I have to perform normalization of some sort?
What software should I use for this purpose?
FYI, My data consist of probability matrix of protein A, B, C, D, E Mutating into A, B, C, D
Thanks in advance for any help in this regard.
I want to look at complete genome of an organism (lets say Chlamydomonas reinhardii) and know which regions and what genes come after which ones (like a map) and what do they code for. Is there any authentic, scientific tool or a website that can let me do this? Thanks in advance :)
Non self antigens on HeLa cells will make it distinguishable by the immune system. But what is the exact mechanism behind killing of a foreign cell inside the body?