Tarang Sharma

Tarang Sharma
World Health Organization WHO | who

MSc, MPH, PhD

About

36
Publications
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Introduction
Skills and Expertise

Publications

Publications (36)
Article
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Background The National Institute for Health and Care Excellence (NICE) was established in 1999 and provides national guidance and advice to improve health and social care. Several steps in the research cycle have been identified that can support the reduction of waste that occurs in biomedical research. The first step in the process is ensuring ap...
Chapter
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Population aging became a globally widespread phenomenon during the last decades. Its core underlying causes are extended life expectancy at birth, improved early childhood survival, education, absorption of women into the labor markets, and consequences of sexual revolution leading to decreased female fertility. The scale of this demographic trans...
Article
Knowledge translation (KT) is increasingly acknowledged to have the potential to improve policy-making. The value of health information (HI), as part of the KT context, is now also increasingly understood. This paper aims to identify existing tools for the translation of HI into policy-making and to develop a related framework facilitating future a...
Article
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Background The use of research evidence as an input for health decision-making is a need for most health systems. There are a number of approaches for promoting evidence use at different levels of the health system, but knowledge of their effectiveness is still scarce. The objective of this overview was to evaluate the effectiveness of knowledge co...
Article
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Background This overview aimed to synthesize existing systematic reviews to produce a draft framework of evidence-informed health priority setting that supports countries in identifying appropriate steps and methods when developing and implementing national research agendas. Main body We searched Ovid MEDLINE ® and the WHO Institutional Repository...
Article
Full-text available
Abstract Since its inception in 2003, Cost Effectiveness and Resource Allocation journal has come a long way over the past 18 years. Possibly much longer than many of its contemporaries in the blossoming science of health economics might have anticipated. Today, entering 2020 it celebrates the Age of Maturity. We believe that in the third decade of...
Conference Paper
Full-text available
Introduction Evidence Based Medicine (EBM) has a long-standing and well-accepted tradition. In the late 1980s, Eddy and Billings stated that for at least some fields of medicine the existing evidence was of such poor quality that it was impossible to determine what effect the practice had on patients [Eddy 1988]. EBM focuses on the critical apprai...
Article
Objective: To study the drop-out rates in trials of selective serotonin and serotonin-norepinephrine reuptake inhibitors (SSRIs and SNRIs). Methods: This study is a systematic review and meta-analysis of trials. The main outcome measure: Overall drop-out rate. Secondary outcomes were drop-outs due to adverse events and lack of effect. We obtaine...
Article
Full-text available
Background Delays in diagnosis and treatment of pulmonary tuberculosis are a major set-back to global tuberculosis control. There is currently no global evidence on the average delays thus, the most important contributor to total delay is unknown. We aimed to estimate average delay measures and to investigate sources for heterogeneity among studies...
Article
Background Acute psychotic illness, especially when associated with agitated or violent behaviour, can require urgent pharmacological tranquillisation or sedation. In several countries, clinicians often use benzodiazepines (either alone or in combination with antipsychotics) for this outcome. Objectives To examine whether benzodiazepines, alone or...
Article
Full-text available
Objective: The objectives of this review were to identify vaccine economic evaluations that include herd immunity and describe the methodological approaches used. Methods: We used Kim and Goldie's search strategy from a systematic review (1976-2007) of modelling approaches used in vaccine economic evaluations and additionally searched PubMed/MED...
Article
Abstract BACKGROUND: Acute psychotic illness, especially when associated with agitated or violent behaviour, can require urgent pharmacological tranquillisation or sedation. In several countries, clinicians often use benzodiazepines (either alone or in combination with antipsychotics) for this outcome. OBJECTIVES: To examine whether benzodiazepine...
Article
INTRODUCTION We aimed to identify the validity and robustness of effect estimates for serious rare adverse events in clinical study reports of antidepressant trials, across different meta-analysis methods for rare binary events data (1,2). METHODS Four serious rare adverse events (all-cause mortality, suicidality, aggressive behaviour and akathisi...
Article
Full-text available
Objective To study serious harms associated with selective serotonin and serotonin-norepinephrine reuptake inhibitors. Design Systematic review and meta-analysis. Main outcome measures Mortality and suicidality. Secondary outcomes were aggressive behaviour and akathisia. Data sources Clinical study reports for duloxetine, fluoxetine, paroxetine, se...
Article
Full-text available
Objectives: Colloquial evidence (CE) has been described as the informal evidence that helps provide context to other forms of evidence in guidance development. Despite challenges around quality, and the potential biases, the use of CE is becoming increasingly important in assessments where scientific literature is sparse and to also capture the exp...
Article
Full-text available
Haemophilia A is a rare inherited bleeding disorder characterized by an inability of the blood to clot normally. Patients can experience spontaneous or trauma-induced joint and soft tissue bleeding and must keep coagulation factor VIII (FVIII) accessible at all times; thus, FVIII product storage and stability are critical. Our primary objective was...
Article
Full-text available
Despite international agreement that stopping low value practices will increase efficiency, identifying them is difficult and controversial. Opponents of centralized lists of low value practices stress that the actual problem is inappropriate low value use, and better targeting and implementation of treatment thresholds is needed. Our objective was...
Article
Full-text available
The purpose of this paper is to provide an overview of the organisational and procedural arrangements for priority setting in England and Wales. It describes the role of social values in the decision-making process. The processes and content of decisions made by the National Institute for Health and Clinical Excellence are analysed using the framew...
Article
NICE quality standards act as markers of high-quality, cost-effective patient care, covering the treatment and prevention of different diseases and conditions. In this article, the authors outline the recent quality standards for chronic kidney disease. Copyright © 2012 John Wiley & Sons
Article
Recent developments mean that NICE will be increasingly relevant for GPs in the future and bring opportunities to participate in the development of NICE guidance. Copyright © 2010 Wiley Interface Ltd

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Project (1)
Archived project
Working on a statistical paper on meta-analysis of rare events data