Tanveer Beg

Tanveer Beg
Jazan University · Department of Biology

PhD

About

62
Publications
48,284
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812
Citations
Introduction
Tanveer Beg has worked at the Department of Biology, Jazan University. He has worked on Genetic Toxicology, Natural Products and Neurotoxicity in animal models of Alzheimer. His last project was "Effect of a flavonoid found in a medicinal plant of Jazan region (Saudi Arabia) on the neurotoxicity in the brain of transgenic Drosophila melanogaster model of Alzheimer's disease".
Additional affiliations
September 2010 - present
Jazan University
Position
  • Research Assistant
September 2010 - present
Jazan University
Position
  • Research Assistant
October 2003 - April 2005
Aligarh Muslim University
Position
  • Project Fellow
Education
October 2003 - January 2009
Aligarh Muslim University
Field of study
  • Genetics

Publications

Publications (62)
Article
Full-text available
Malaria remains one of the leading causes of disease and death in the tropics, mainly of children under 5 years of age. Chloroquine began as a first-line antimalarial in 1946; it became the corner stone of antimalarial chemotherapy for the next 40 years. It is one of the least expensive antimalarials available and is still in widespread use. Chloro...
Article
Background: Alzheimer's disease (AD) is characterized by the accumulation and deposition of β-amyloid peptides leading to a progressive neuronal damage and cell loss. Besides several hypotheses for explaining the neurodegenerative mechanisms, oxidative stress has been considered to be one of them. Till date, there is no cure for AD, but the pathog...
Article
Tangeritin is a pentamethoxy flavone found in tangerine and other citrus peels. The present study was conducted to study the effect of various doses of tangeritin on the toxic effects induced by cyclophosphamide (CP) in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg⁹. Commercially available tangeritin and CP were used....
Book
Full-text available
Preface Microbiology involves the study of microscopic living organisms that consist of bacteria, fungi, algae, protozoa, and infectious agents such as viruses. The study also involves their form, structure, reproduction, physiology, metabolism and classification as well. Most of them are unicellular and all the life processes are performed by a si...
Article
In the present study, copper-doped ZnO nanoparticles (doped ZnO NPs Cu) were synthesized, characterized and evaluated for their possible toxic effects in Drosophila melanogaster (Oregon R). X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy and energy dispersive X-ray spectrometry confirm the formation of doped...
Article
Full-text available
Background: Oxidative stress is thought to be mechanistically involved in PD pathogenesis. Gingerol is a component of ginger and may have antioxidant properties. We studied the effects of gingerol supplementation on oxidative stress in Parkinson_s disease (PD) model flies. Methods: Drosophila expressing human alpha-synuclein (PD flies) were exposed...
Article
Full-text available
Background: There are various genetic models of PD based on alphasynuclein (>S) expression (mutant, or wild type) in mice as well as in flies. The over expression of either wild type or mutant form of >S in transgenic Drosophila leads to the formation of Lewy Bodies (LB) resulting in the loss of dopaminergic neurons and behavioral abnormality. Plan...
Article
Full-text available
Background: The Drosophila model for Parkinson_s Disease (PD) based on wild-type alpha synuclein expression in flies were used in this study. A time dependent loss of dopaminergic neurons and the formation of intracellular aggregates of >S (Lewy bodies) have been reported in the PD model flies. The effect of apigenin, an antioxidant found in most v...
Article
Full-text available
Malaria is a major global health problem, with an estimated 300 to 500 million clinical cases occurring annually. Malaria remains one of the leading causes of disease and death in the tropics, mainly of children under 5 years of age. The most prevalent and dangerous type of malaria is caused by Plasmodium falciparum. P. vivax is a common cause of m...
Article
In India, natural preparations derived from the plants are widely use for the treatments of various diseases. Hence, it becomes necessary to assess the modulating action of the plant extract when associated with other substances. Potassium canrenoate (PC) is a synthetic steroid and is used in the treatment of hypertension. It is not only a genotoxi...
Article
In India, natural preparations derived from plants are widely used for the treatment of various diseases. Hence it becomes necessary to assess the modulating action of the plant extracts when associated with other substances. Ethinylestradiol is not only a genotox-ic agent but also a tumor initiating agent. It is widely used in oral contraceptive f...
Article
Doxorubicin is a well-known DNA intercalating chemotherapy drug that is widely used for treatment of different cancers. Its clinical utility is limited due to the observed genotoxic side effects on healthy cells suggesting that newer combination and genoprotective regimens are urgently needed for the management of doxorubicin chemotherapy. Some die...
Article
Chlormadinone acetate (CMA) is a synthetic progestin. The prolonged use has been reported to be carcinogenic in various experimental animal models. In the present study the effect of CMA was studied along with curcumin at various doses in cultured human lymphocytes using cell viability, lipid peroxidation and DNA damage assay as a parameters. The t...
Article
Antigenotoxic activity of allicin, one of the sulphur compounds of garlic (Allium sativum) which possesses antioxidant and thiol disulphide exchange activity, was studied against estradiol-17beta-induced genotoxic damage using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) as parameters. Approximately 10, 20 and 40 microM of es...
Article
In the present study the antigenotoxic effect of apigenin was studied against a genotoxic dose of ethinylestradiol using the damage parameters of chromosomal aberrations (CAs), sister chromatid exchanges (SCEs) and cell cycle kinetics (CCK). Human peripheral blood lymphocytes were cultured and treated with 10 microM of ethinylestradiol along with d...
Article
Tinidazole (TNZ) is used in the treatment of trichomoniasis, giardiasis and amebiasis. It has been reported as cytotoxic and genotoxic agent in various in vitro and in vivo models. Natural plant products having antioxidant properties can reduce the genotoxic effects of the drugs, if give in combination and thereby reduced the chances of developing...
Article
Cytochrome b5 reductase is a red cell enzyme and is responsible for the reduction of methemoglobin back to hemoglobin. Its activity is increased during malarial infections and ascorbate deficiency. Certain antithyroid and neuroleptic drugs have been reported to affect the expression of cytochrome b5 reductase activity. In the present study we have...
Article
Tea (Camellia sinensis) is a rich source of polyphenols called flavonoids, effective antioxidants found throughout the plant kingdom. A group of flavonoids in green tea are known as catechins. The fresh tea leaves contain four major catechins as colourless water soluble compounds. epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC)...
Article
Mitomycin C (MMC) is an antineoplastic agent used to fight a number of different cancers including cancer of the stomach, colon, rectum, pancreas, breast, lung, uterus, cervix, bladder, head, neck, eye and oesophagus. It is a potent DNA cross-linker. The prolonged use of the drug may result in permanent bone marrow damage and other various types of...
Article
Full-text available
Hydrogen peroxide is one of the reactive oxygen species for cellular injury. It is overproduced during oxidative stress and is known to damage proteins, nucleic acids and cell membranes. The present study was aimed to study the protective effect of ascorbic acid against the toxic doses of hydrogen peroxide using lipid peroxidation and cytokinesis b...
Article
A sample of 312 individuals belonging to Sheikh (80), Pathan (54), Ansari (82), Syed (33), Saifi (33) and Hindu Bania (30) populations were surveyed for four protein and three enzyme loci comprising 12 alleles. The markers used were protein (transferrin, haptoglobin, haemoglobin) and enzyme (lactate dehydrogenase, phosphogluconate dehydrogenase, ad...
Article
Full-text available
In the present study the effect of Centella asiatica L. extract was studied against the genotoxic doses of ethinylestradiol on human lymphocytes culture. The different doses of C. asiatica L. extract i.e. 1.075×10-4, 2.125×10-4 and 3.15×10-4 g/ml were treated separately with 5 μM of ethinylestradiol. Similar treatments were given with 10 μM of ethi...
Article
Full-text available
Tea (Camellia sinensis) is one of the most popular beverages consumed worldwide as an infusion of leaves and isvalued for its medicinal properties. Tea is a rich source of polyphenols called flavonoids, effective antioxidants foundthroughout the plant kingdom. The slight astringent, bitter taste of green tea is attributed to polyphenols. A group of...
Article
Chlormadinone acetate (CMA) is a synthetic progesterone analogue. It has its usage in oral contraceptives formulations and also for estrous synchronization of animals. The aim of the present study is to study the anti- genotoxic activity of the plant infusion against the CMA induced genotoxic damage on cultured human lymphocytes, using chromosomal...
Article
Full-text available
Mental retardation has been the traditional foothold of psychologists and psychometricians, apart from clinicians and biologists. Nearly 30,000 genes control neurogenetic disorders. While these genes are yet to be explored, their ultimate expression and regulation defies a mechanistic model of behavioural and intellectual deficiency. Mental retarda...
Article
Full-text available
The Muslims of Aligarh city are predominantly Sunnis, although there are also a considerable number of Shias. Among the Sunnis, approximately a quarter belong to Syed, Sheikh, Moghal and Pathan groups, and three-quarters belong to various lower biradaris. In the present study, 304 women attending the Primary Health Centre of the J. N. Medical Colle...
Article
The aim of this review is to focus some light on the beneficial effects of the tea polyphenols on human health, based on various laboratory, epidemiological and clinical studies carried out on tea and tea polyphenols in the last few years. Tea is second only to water as the most consumed beverage in the world. Tea has been consumed worldwide since...
Article
Mitomycin C and cyclophosphamide are well known anti-tumor drugs. Their genotoxic effects are well established in various test systems. The genotoxic effects in non-tumor cell are of special significance due to the possibility that they may induce secondary tumors in cancer patients. Apigenin is a well known anti-oxidant and possess number of prope...
Article
Full-text available
The aim of this experiment was to find the appropriate dosage at which Testosterone Propionate (TP) is genotoxic enough to cause significant chromosome damage. TP was examined at 10, 20 and 40 μM, respectively and found to be significantly genotoxic at 20 and 40 μM, only in the presence of metabolic activation. Epicatechin Gallate (ECG) proved to b...
Article
Full-text available
Norethandrolone and Oxandrolone were studied for their genotoxic effect on human lymphocyte chromosomes using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) as parameters and subsequently Genistein and Gingerol were used as antigenotoxic agents to ameliorate the genotoxicity induced by the steroids. This experiment was aimed at...
Article
The majority of the Indian population use traditional natural preparations derived from plant material for the treatment of various diseases, and for that reason it becomes necessary to assess the mutagenic potential or modulating action of plants extract when associated with other substances. The genotoxicity testing provides human a risk assessme...
Article
Nordihydroguaiaretic acid (NDGA), a phenolic lignan, was tested for its antigenotoxic potential against chlormadinone acetate (CMA)-induced genotoxic damage in mice bone-marrow cells. Doses of about 22.50 mg/kg body weight of CMA were given along with 1, 5 and 10 mg/kg body weight of NDGA intraperitoneally. The treatment resulted in the reduction o...
Article
This experiment was conducted in order to assess the antigenotoxicity potential of Epigallocatechin-3-gallate (EGCG), a catechin, against genotoxicity induced by anticancer drugs, Methyl methanesulphonate (MMS) and cyclophosphamide (CP), in the form of chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs). These drugs were used at 60...
Article
Although clinical genetics had its roots predating Mendel's discovery, the clinical case histories were not documented in terms of genes or loci. Even when such defects were shown to follow Mendelian rules of transmission, this was not sufficient to manage the problem. It was only when cytogenetic and more precisely biochemical or molecular basis o...
Chapter
In earlier reports, cyproterone acetate (CPA) administration to human lymphocytes in culture was shown to cause chromosomal aberrations and increased sister chromatid exchanges. With a view to study the ameliorative action of ascorbic acid, the treatment of different doses of ascorbic acid were given along with different doses of CPA. The levels of...
Chapter
Full-text available
Synthetic progestins have a wide spread use in medicine but their side effects are often debatable. They are used in oral contraceptives and in hormonal therapy either as single entity drug or in combination with estrogens. Various synthetic progestins have been tested for their genotoxic effects in different experimental models, using different ge...
Chapter
A number of physical and chemical agents have been identified to cause genotoxic effects in cells producing clastogenic, teratogenic, mutagenic and carcinogenic effects at different dosage of administration. Steroids are highly potent chemicals used as contraceptives, antiallergics, anti- inflammatory and antidepressant agents used therapeutically....
Article
Full-text available
The present paper deals with the distribution of ABO, Rh (D) and PTC tasting ability markers to study the genetic structure and microdifferentiation among Muslim populations of Aligarh. We have undertaken a survey of the allele frequencies of the ABO, Rh (D) and PTC tasting ability for different endogamous Muslim groups viz. Syed, Sheikh, Pathan, A...
Article
The anti-genotoxic effect of Ocimum sanctum L. extract was studied against the genotoxic effect induced by a synthetic progestin cyproterone acetate, on human lymphocytes using chromosomal aberrations, mitotic index, sister chromatid exchanges and replication index as a parameters. About 30 microM of cyproterone acetate was treated with O. sanctum...
Article
Full-text available
In earlier reports, norgestrel administration to human lymphocytes in culture was shown to cause chromosomal aberration and increased sister chromatid exchanges. With a view to study the ameliorative action of some antioxidants against this effect, vitamin C and E at varying doses were administerde to human lymphocyte cultures. The levels of chromo...
Article
Full-text available
Genistein, an antioxidant, has earlier been shown to have a protective action against genotoxicity induced by certain drugs. In order to investigate the antimutagenic prop-erty of genistein toxicity in the form of chromosomal aberration (CA) and sister chro-matid exchanges (SCE) were induced by known mutagens-Cyclophosphamide (CP) and Methyl methan...
Article
Antioxidants and plant products are reported to reduce the genotoxic damage of steroids. In our present study we have tested different dosages of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in the presence of S9 mix. Treatments with nordihydroguaiaretic acid (NDGA) results in the reduction of the ge...
Article
Full-text available
Stanozolol and trenbolone, commonly used as performance enhancing and bodybuilding drugs, were studied for their genotoxic effect on human lymphocyte chromosomes using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) as parameters, both in the presence and absence of metabolic activation (S9 mix). This experiment was aimed at fin...
Article
Full-text available
Ascorbic acid is well known antioxidant. The antioxidant property can be helpful in reducing clastogenic, mutagenic and carcinogenic properties of certain chemical agents. In this context, an anticlastogenic activity of ascorbic was studied against the genotoxic damage induced by norethynodrel, using chromosomal aberrations and sister chromatid exc...
Chapter
Full-text available
In the present study we have tested 1, 5, 10 and 20 µM of estradiol-17βfor its genotoxic effects in cultured human peripheral blood lymphocytes in the presence as well as absence of metabolic activation (S9 mix). Estradiol-17β was found genotoxic at 10 and 20 µM in the presence of S9 mix. Further, amounts of 0.5 and 1.0 µM of nordihydroguaiaretic a...
Article
Full-text available
A great biochemist Erwin Chargaff, who discovered the parity theory of the DNA bases, once made a critical remark on the newly developed discipline of bioethics: "A fashion is going around the world, the fashion of bioethics. All the powers have entered into a holy hypocritical alliance with this fashion". With this remark, a parody of the first tw...
Article
Full-text available
Reproductive fitness is best studied by taking together a number of parameters like the mean number of offspring produced and the sex-ratio. The Muslims of Aligarh city are predominantly Sunnis, though a considerable number of Shias are also there. Among the Sunnis approximately one fourth of the population constitute Syed, Sheikh, Moghal and Patha...
Article
Medroxyprogesterone acetate was studied at three different concentrations (1, 5 and 10 microM), for its genotoxic effects in human peripheral blood lymphocyte culture using chromosomal aberrations and sister chromatid exchanges as parameters. Duplicate peripheral blood cultures were treated with three different concentrations (1, 5 and 10 microM) o...
Article
Nordihydroguaiaretic acid (NDGA) is a phenolic lignan and possesses antioxidant and number of properties potentially useful to man. The effect of NDGA was studied against norgestrel induced genotoxic damage, using sister chromatid exchanges (SCEs), chromosomal aberrations (CAs), mitotic index (MI) and replication index (RI) as parameters. Amounts o...
Article
Full-text available
The genotoxicity study of cyproterone acetate was carried out in mouse bone marrow cells using Sister Chromatid Exchanges (SCEs) and Chromosomal Aberrations (CAs) as a parameter. The effect of cyproterone acetate was studied at 6.25, 12.50 and 25.00 mg kg-1 of body weight and was found to be genotoxic at 12.50 and 25.00 mg kg-1 of body weight. Furt...
Article
The genotoxicity of megestrol acetate was studied in mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Megestrol acetate (8.12, 16.25 and 32.50 mg/ kg of body weight) was injected intraperitoneally separately in different groups of animals. Both CAs and SCEs were statistically increased...
Article
Ethinylestradiol, a steroidal estrogen, is widely used with various progestogens in oral contraceptives formulations. There are sufficient evidences for the carcinogenicity of ethinylestradiol in experimental animals. The reports on the genotoxic potential of ethinylestradiol are contradictory. Here in the present study we have tested the genotoxic...

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Project (1)
Project
To study the effect of a flavonoid found in a medicinal plant of Jazan region (Saudi Arabia) on the neurotoxicity in the brain of transgenic Drosophila melanogaster model of Alzheimer's disease