• Home
  • Tannaz Ghaffarzadegan
Tannaz Ghaffarzadegan

Tannaz Ghaffarzadegan
BPC Instruments

PhD in Applied Nutrition

About

13
Publications
1,096
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
102
Citations
Citations since 2016
11 Research Items
99 Citations
20162017201820192020202120220510152025
20162017201820192020202120220510152025
20162017201820192020202120220510152025
20162017201820192020202120220510152025

Publications

Publications (13)
Article
Full-text available
Monobutyrin (MB) and monovalerin (MV), glycerol esters of short-chain fatty acids (SCFAs), have been shown to positively influence lipid profile and biomarkers in the gut and brain. This study examined whether MB and MV in high-fat diets, affected microbiota composition and gut–blood–brain markers in apolipoprotein E deficient (ApoE-/-) rats, a mod...
Article
Diet-induced obesity and insulin resistance have been linked to changes in bile acid (BA) profiles, which in turn are highly dependent on the dietary composition and activity of the gut microbiota. The objective of the present study was to investigate whether the type and level of fiber had an effect on cecal BA composition when included in low- an...
Article
Full-text available
Bile acids (BAs) are known to be involved in cholesterol metabolism but interactions between the diet, BA profiles, gut microbiota and lipid metabolism have not been extensively explored. In the present study, primary and secondary BAs including their glycine and taurine-conjugated forms were quantified in serum of Apoe−/− mice by protein precipita...
Thesis
Full-text available
Bile acids (BA) are formed from cholesterol in the liver and, apart from being part of fat digestion, they also act as signalling molecules in several health-related physiological processes. BA composition is regulated by gut microbiota as well as dietary fibre (DF) and fat in the diet. This thesis describes how different types of DF and fat levels...
Article
Full-text available
Diet-induced obesity and insulin resistance have been linked to changes in bile acid (BA) profiles, which in turn are highly dependent on the dietary composition and activity of the gut microbiota. The objective of the present study was to investigate whether the type and level of fiber had an effect on cecal BA composition when included in low- an...
Article
Full-text available
Bile acids (BAs) act as signaling molecules in various physiological processes, and are related to colonic microbiota composition as well as to different types of dietary fat and fiber. This study investigated whether guar gum and pectin—two fibers with distinct functional characteristics—affect BA profiles, microbiota composition, and gut metaboli...
Data
Correlation between triglyceride and secondary BA levels. (a, b) Correlation between plasma triglyceride levels and cecal levels of LCA (r = 0.35; P < 0.01) (a) and DCA (r = 0.49; P < 0.001) (b). (c, d) Correlation between liver triglyceride levels and cecal levels of LCA (r = 0.44; P < 0.001) (c) and DCA (r = 0.36; P < 0.001) (d). There was no cor...
Data
Supporting tables. This file contains Table A, showing composition of experimental diets (g/kg dwb). Table B, showing Mean relative abundance of bacterial taxa at phylum and genus level in rats fed high-methoxylated pectin (n = 4), medium molecular weight guar gum (n = 5), or fiber-free diet (n = 5) in a high-fat setting. Table C, showing P-values...
Data
Correlation between cholesterol and secondary BAs. (a–c) Correlation between plasma cholesterol and cecal levels of LCA (r = 0.57; P < 0.001) (a), DCA (r = 0.33; P < 0.01) (b), and HDCA (r = 0.35; P < 0.01) (c). (d–f) Correlation between liver cholesterol and cecal levels of LCA (r = 0.62; P < 0.001) (d), DCA (r = 0.32; P < 0.01) (e), and HDCA (r =...
Conference Paper
Full-text available
Introduction In recent years, there has been a great nutritional interest in bile acids (BAs) and there are suggestions that they are involved both in the development of colon cancer and of metabolic diseases. Thus, a low faecal concentration of secondary BAs has been associated with low incidence of colon cancer in humans. The colonic formation of...
Article
Full-text available
A method based on hollow-fibre liquid phase microextraction combined with gas chromatography was developed for determination of specific bile acids in caecal materials of rats. Nine unconjugated bile acids, including the primary bile acids (cholic acid, chenodeoxycholic acid and α-muricholic acid) and the secondary bile acids (lithocholic acid, deo...

Network

Cited By

Projects

Projects (2)