Tanmoy Mukherjee

• Mount Sinai Hospital

Context Carriers of a CYP21A2 pathogenic variant exhibit distinct hormonal differences, yet their impact on assisted reproductive technology outcomes remains unknown. Objective To evaluate whether carriers of a CYP21A2 pathogenic variant exhibit differences in ovarian stimulation response and in vitro fertilization outcomes compared with non-carri...

Purpose: The objective was to evaluate whether the mid-luteal progesterone (MLP) assessment in same-sex female couples benefits clinical outcomes in natural cycles using donor sperm intrauterine insemination (IUI). Methods: This retrospective cohort study included same-sex female couples undergoing donor sperm IUI from January 2004 to April 2022. C...

Study question: Do infertile couples who recently utilized clomiphene citrate (CC) for ovulation induction or ovarian stimulation (<90 days previously) followed by a single euploid embryo transfer (SEET) have lower implantation potential compared with patients who were not exposed to CC within 90 days before embryo transfer (ET)? Summary answer:...

Objectives: There is a need for evidence-based counseling for women with chronic liver disease (LD) who may experience impaired fertility. Currently, the literature on assisted reproductive technology (ART) treatment in women with LD has been limited to a single European case series. We evaluated ART treatment outcomes in LD patients and compared...

Objective To analyze the correlation between TE grading and initial β-hCG serum level after single euploid embryo transfer. Secondarily, to explore the association between TE grading with subsequent IVF outcomes. Design Retrospective cohort analysis. Setting Single, academic, private infertility and assisted reproductive care institute. Patients...

Objective: Although chromosomal heteromorphisms are commonly found in the general population, some researchers have suggested a correlation with higher rates of embryo aneuploidy. This study aimed to assess the rates of embryo aneuploidy in couples who carry a chromosome heteromorphism. Methods: The study included couples who had G-banding karyo...

Objective The coronavirus (COVID-19) pandemic has forever reshaped the United States health care system. However, assisted reproductive technology (ART) treatment remains an essential form of medicine. Reproductive practices have since incorporated vigilant practices regarding social distancing, ample use of Personal Protective Equipment (PPE), and...

OBJECTIVE: To compare obstetrical and neonatal outcomes following single embryo transfer (SET) versus (vs.) multiple embryo transfer (MET) from frozen-thawed embryo transfer cycles (FET) of autologous pre-implan-tation genetic tested for aneuploidy (PGT-A) embryos. DESIGN: Retrospective cohort study from the SART CORS national database. MATERIALS A...

(Abstracted from Hum Reprod 2020;35:1889–1899) Although the physiologic mechanism remains unclear, late follicular phase progesterone elevation (LFPE) commonly occurs during controlled ovarian hyperstimulation (COH) for assisted-reproductive technology (ART) such as in vitro fertilization (IVF). Late follicular phase progesterone elevation has been...

Study question: What is the impact of a late follicular phase progesterone elevation (LFPE) during controlled ovarian hyperstimulation (COH) on embryonic competence and reproductive potential in thaw cycles of preimplantation genetic testing for aneuploidy (PGT-A) screened embryos? Summary answer: Our study findings suggest that LFPE, utilizing...

Objective To analyze outcomes of IVF treatment among women diagnosed with an ovarian dermoid cyst (DC). Methods Retrospective analysis of women with an ovarian DC who underwent IVF with fresh blastocyst transfer at a single center in New York from January 2010 to March 2018. Outcomes were compared between women with conservative treatment and thos...

Study question:Do women with baseline hyperandrogenemia have differential ovarian response, oocyte maturation, and/or embryo quality as compared to normoandrogenemic women? Summary answer: Despite greater ovarian reserve, hyperandrogenemic patients had similar oocyte yield, blastulation, and aneuploidy compared to normoandrogenemic women. Hyperandr...

Study question: Does endometrial biopsy (EMB) and chronic endometritis (CE) screening offer clinical utility in patients following euploid embryo implantation failure? Summary answer: Patients, regardless of endometrial biopsy findings, have similar IVF outcomes on a subsequent treatment cycle as compared with patients who do not undergo endometria...

Objective: To investigate whether the duration of estrogen administration before euploid embryo transfer affects clinical outcome. Design: Retrospective cohort study. Setting: Private, academic fertility center. Patient(s): Patients (n = 1,439) undergoing autologous freeze-only in vitro fertilization with preimplantation genetic testing (PGT...

Objective: To evaluate outcomes of patients with unexplained infertility who underwent letrozole (LET)- stimulated controlled ovarian stimulation (COS) with timed sexual intercourse (IC) as compared to patients treated with clomiphene citrate (CC) and intrauterine insemination (IUI). Study design: A non- randomized, retrospective study where une...

Introduction: Analysis of ectopic pregnancies using traditional cytogenetic techniques has demonstrated a higher than expected increase in aneuploidy of these extrauterine implantation sites. Newer molecular techniques have greater diagnostic accuracy. We sought to evaluate the likeliness of a ectopic implantation of embryos that have undergone pr...

INTRODUCTION: Women faced with infertility are offered a variety of Eastern and Western treatment options, such as complementary and alternative medicine (CAM) and/or assisted reproductive technology (ART) treatments. Women may pursue therapies like acupuncture, in concert with western reproductive endocrinology methods, to improve pregnancy outcom...

Purpose The aim of this study is to compare implantation and live birth rates (LBR) between fresh euploid embryo transfers versus cryo-all cycles with a subsequent embryo transfer into a prepared endometrium. Material and Methods This is a retrospective cohort study. Patients who underwent an IVF cycle with PGS with trophectoderm biopsy from Januar...

Elevated follicle stimulating hormone (FSH) is associated with poor vaginal oocyte retrieval (VOR) outcomes and cycle cancellations but intercycle variability in basal FSH reportedly does not predict ovarian response. We conducted a retrospective cohort study of basal FSH (n = 15573 cycles) in couples (n = 9132) who initiated IVF cycle(s) with basa...

To evaluate the relationship of endometrial thickness (EnT) and endometrial pattern (EnP) to euploid embryo transfer (ET) outcomes. Retrospective cohort. Private academic clinic. Patients (n = 277; age 36.1 ± 4.0 years) whose embryos (n = 476) underwent aneuploidy screening with fresh (n = 176) or frozen (n = 180) ET from July 2010 to March 2014. T...

For more than two decades, embryologists and clinicians have attempted to use pre-implantation genetic screening (PGS) to detect embryonic chromosomal abnormalities in hopes of transferring only reproductively competent embryos. Coinciding with the evolution of the technology, our center has progressed from cell stage biopsy (D3) to blastocyst biop...

Parenting children of opposite genders is a powerful motive for parents to seek "sex-selection" services. Medical beneficence and patient autonomy support making these services available. Our goals in this study included data to permit proper patient educa-tion, assess outcome, and evaluation of potential bi-ases in this technology. IVF/PGD cases f...

To present a case of a fetal loss in which a normal fetal karyotype was obtained by banding studies. Identification of an abnormal maternal karyotype prompted subsequent reanalysis using fluorescence in situ hybridization (FISH). Case report. University-affiliated IVF center. A 32-year-old woman, G1 P0, underwent a fetal loss at 8 weeks, and a suct...