Tanja Verena Werner

Tanja Verena Werner
Protina Pharmazeutische GmbH · Medicine and Science

Dr. rer. nat.

About

40
Publications
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509
Citations
Additional affiliations
May 2006 - March 2010
Technische Universität München
Position
  • PhD Student

Publications

Publications (40)
Article
Full-text available
Magnesium (Mg) supplementation was shown to improve metabolic syndrome (MetS) parameters in hypomagnesemic patients. The current study evaluated the role of Mg in normomagnesemic individuals with MetS. Patients were randomly assigned to 400 mg Mg as Mg citrate or placebo daily for 12 weeks. Blood pressure (BP), HbA1c, plasma concentrations of gluco...
Article
Zusammenfassung Der pH-Wert des gesunden Menschen ist immens wichtig. Schon geringe Abweichungen führen zu massiven Störungen im Stoffwechsel, die unter Umständen lebensbedrohlich sind. Für den korrekten Ablauf biologischer Funktionen ist es wichtig, ein konstantes Verhältnis zwischen Säuren und Basen aufrechtzuerhalten. Ändert sich die Säurekonzen...
Article
Background Atopic dermatitis (AD) is the most common cause of eczema. The skin condition affects millions of people worldwide. Severe cases of AD demand systemic treatment, but most AD cases rely on local therapy with topical corticosteroids, emollients, and moisturizing agents to alleviate eczema. Commonly, derma‐cosmetics with a pH around 5.5 are...
Article
Full-text available
Background/Objectives Metabolism is controlled by macro- and micronutrients. Protein-rich diets should lead to latent acidosis at tissue level with further negative implications. Food supplements with alkaline salts are available and popular pretending to prevent these changes. Subjects/Methods Within a randomised double-blind placebo-controlled t...
Article
Full-text available
Background: Intermittent fasting (IF) combined with exercise has been suggested to enhance weight loss. However, both procedures might negatively influence acid-base status. The aim of this study was to determine the combined effects of IF, exercise training and alkaline supplementation in overweight subjects on body composition and running perfor...
Article
Magnesiumhaushalt und Therapie bei Hypertonie Magnesium ist für den lebenden Organismus ein essentieller Mineralstoff, der in ausreichenden Mengen zugeführt werden muss. Die klinische Bedeutung der Magnesiumüberladung bzw. -intoxikation ist eher gering. Ein Magnesiummangel tritt jedoch beim Menschen häufig auf und kann trotz normaler Ernährung nich...
Article
Der Mineralstoff Magnesium übernimmt eine Vielzahl wichtiger Funktionen im Körper. Eine gute Versorgung mit Magnesium ist wichtig, um einer Reihe von Krankheiten vorzubeugen. Gleichzeitig können verschiedene Erkrankungen durch einen Magnesiummangel mit verursacht werden. Der Magnesiumbedarf ist bei bestimmten Vorerkrankungen sowie zum Beispiel auch...
Article
Full-text available
Background: Low magnesium (Mg) levels are linked to many diseases. Studies suggest that organic salts of Mg are more readily bioavailable than its oxide or inorganic salts used for supplements production. Unfortunately, the plethora of variables in the previous study designs complicates the making of any clear and reliable conclusions. Methods:...
Article
Magnesiummangel ist ein wichtiger Risikofaktor für verschiedene Krankheiten. Die Mechanismen der Magnesiumhomöostase wurden in den letzten Jahren aufgeklärt. Ein Magnesiummangel in der Nahrung führt nicht zu schnellen Mangelsymptomen, da die Knochen die extrazelluläre Magnesiumkonzentration puffern. Die Magnesiumkonzentration im Serum nimmt erst na...
Article
Magnesium research has boomed within the last 20 years. The real breakthrough came at the start of the new millennium with the discovery of a plethora of possible Mg homeostatic factors that, in particular, included putative Mg²⁺ transporters. Until that point, Mg research was limited to biochemical and physiological work, as no target molecular en...
Article
ZUSAMMENFASSUNG Seit einigen Jahren wird die äußerliche Anwendung von Magnesium zur Behandlung von Magnesiummangel und Muskelkrämpfen beworben. Seriöse Studien konnten jedoch keine transdermale Aufnahme des essenziellen Mineralstoffs aus magnesiumreichem Badewasser oder Lotionen nachweisen. Demgegenüber ist die orale Magnesiumsupplementierung in Th...
Article
A pathogenetic role of magnesium deficiency in the development of dementia or Alzheimer's disease has been described. On the other hand, there are data showing a positive effect of magnesium therapy on dementia when given orally or intraveneously. In vascular dementia, 300 - 500 mg magnesium given orally are of benefit for these patients. In additi...
Article
Full-text available
In the following review, we evaluated the current literature and evidence-based data on transdermal magnesium application and show that the propagation of transdermal magnesium is scientifically unsupported. The importance of magnesium and the positive effects of magnesium supplementation are extensively documented in magnesium deficiency, e.g., ca...
Article
Full-text available
Iron replacement therapy is a common treatment in patients with anaemia and Crohn's disease, but oral iron supplements are less tolerated. The pathogenesis of Crohn's disease is attributed to intestinal bacteria and environmental factors that trigger disease in a genetically predisposed host. The aim of this study was to characterise the interrelat...
Article
Environmental factors substantially contribute to the development of chronic intestinal inflammation in the genetically susceptible host. Nutritional components like iron may act as pro-oxidative mediators affecting inflammatory processes and cell stress mechanisms. To better characterize effects of dietary iron on epithelial cell responses under t...
Article
The interaction of nonpathogenic enteric bacteria with intestinal epithelial cells (IEC) in the absence of host-derived Interleukin 10 (IL-10) may contribute to the development of chronic inflammation. Functional proteome analysis of primary IEC from Enterococcus faecalis-monoassociated WT and IL-10-/- mice as well as IL-10 receptor reconstituted I...
Article
Advancing knowledge regarding the cellular mechanisms of intestinal inflammation has led to a better understanding of the disease pathology in patients with inflammatory bowel disease (IBD) including Crohn's disease and ulcerative colitis. It has become clear from numerous studies that enteric bacteria are a critical component in the development an...
Article
The loss of intestinal epithelial cell (IEC) function is a critical component in the initiation and perpetuation of chronic intestinal inflammation in the genetically susceptible host. We applied proteome analysis (PA) to characterize changes in the protein expression profile of primary IEC from patients with Crohn's disease (CD) and ulcerative col...