Tanja Kottmann

Tanja Kottmann
CRO Dr. med Kottmann · Clinical Research Organization

MD

About

154
Publications
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597
Citations
Citations since 2016
62 Research Items
506 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120

Publications

Publications (154)
Article
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1 Schlüsselwörter Lipödem, Liposuktion, Lipolymphödem, Le-bensqualität, konservative Therapie, Sport, Epidemiologie Zusammenfassung Hintergrund: Beim Lipödem handelt es sich um eine schmerzhafte, anlagebedingte über-mäßige Fettgewebsvermehrung der Extremi-täten bei Frauen. Die Ursache ist unbekannt. Ebenso unbekannt ist die Zahl der betroffenen Fra...
Article
This cross-sectional study aimed to compare clinical oral conditions as well as the self-reported oral health status of biathletes and cross-country skiers (A) to age- and gender-matched non-athletic controls (C). Thirty-one A and 68 C were examined in 2020 regarding caries experience (DMF-T), partially erupted wisdom teeth, non-carious tooth wear...
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The aim of this retrospective study was to investigate whether there would be an association between periodontal disease parameters and positive bacterial findings at the driveline of patients with a left ventricular assist device (LVAD). Patients with an LVAD, who underwent a full oral and microbiological examination between 2016 and 2018, were in...
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Objectives The aim of this cross-sectional study was to compare oral health-related quality of life (OHRQoL) of patients with left ventricular assist device (LVAD) and heart failure (HF). Material and methods Seventy-four patients with LVAD were recruited from University Department for Cardiac Surgery, Leipzig Heart Center, Germany. A group of 72...
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This study aimed at evaluating the effectiveness of an adjuvant chlorhexidine–fluoride varnish (Cervitec F) for prevention and arrest of root caries on elderly participants using quantitative light-induced fluorescence (QLF). 23 participants with two or three non-cavitated root carious lesions were included and assigned to three groups of different...
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Background This cross-sectional study aimed in the comparison of periodontal parameters, number of remaining teeth and oral behaviour between patients with ischemic- (ICM) and non-ischemic dilative cardiomyopathy (DCM). Methods Patients with HF from the Department for Cardiac Surgery at the Heart Center Leipzig were included. The two groups (ICM a...
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AIMS: Most devices for treating ambulatory Class II and III heart failure are linked to electrical pulses. However, a steady electric potential gradient is also necessary for appropriate myocardial performance and may be disturbed by structural heart diseases. We investigated whether chronic application of electrical microcurrent to the heart is fe...
Article
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Aims: Most devices for treating ambulatory Class II and III heart failure are linked to electrical pulses. However, a steady electric potential gradient is also necessary for appropriate myocardial performance and may be disturbed by structural heart diseases. We investigated whether chronic application of electrical microcurrent to the heart is f...
Article
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Background: The present cross-sectional study assessed oral health, nutritional condition, and oral health-related quality of life (OHRQoL) in older German people in need of care. Methods: The participants were recruited from eight nursing homes (including three nursing homes with assisted living) and one mobile nursing service. Oral health, inc...
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Background: This practice-based retrospective study evaluated a screening method for diabetes mellitus (DM) in patients with Stage 3 or 4 periodontitis using the FINDRISC questionnaire. Methods: Patients with Stage 3 or 4 periodontitis who received FINDRISC screening in a German private dental practice were recruited. Individuals with positive F...
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Purpose For this retrospective cohort study, we assessed pertrochanteric fracture types AO/OTA 31-A2. PFNA and DHS were the devices used. We determined both devices in relation to peri-operative variables, postoperative radiographic measurements, implant-related complications and mortality up to 2 years. The null hypothesis was no effect between th...
Article
Background: Focused, high energy shock wave therapy (ESWT) stimulates bone healing by neo-angiogenesis and activating osteocytes. This study investigates if applying an ESWT intraoperatively improves and accelerates the healing of a scaphoid nonunion after reconstruction using a non-vascularized bone graft. Patients and methods: In this prospect...
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PurposeThe aim of this cross-sectional study was to examine the oral health-related quality of life (OHRQoL) in patients after heart transplantation (HTx) and those with heart failure (HF).Methods In total, 186 participants (HTx: 104, HF: 82) were recruited from the University Department for Cardiac Surgery, Leipzig Heart Centre, Germany. OHRQoL wa...
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This retrospective pilot study aimed to detect whether remaining dental/periodontal treatment need and periodontal inflammation after dental clearance would be associated with the initial therapy outcome of adult patients with acute leukemia undergoing induction chemotherapy. Different parameters were assessed from the patients’ records: initial bl...
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Aims: The aim of this cross-sectional study was the assessment of dental behaviour, oral health, as well as oral health-related quality of life of patients with left ventricular assist device (LVAD). Methods and results: Patients (128) with LVAD were recruited from the University Department for Cardiac Surgery at Heart Center, Leipzig, Germany....
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Objectives Aim of this cross-sectional case-control study was the comprehensive examination of oral health, oral behaviour and oral health-related quality of life of patients with tongue piercing. Furthermore, different piercing related factors and the presence of habits should be considered regarding their potential association to piercing-related...
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Background: To assess whether the standardized recommendation of patients with heart failure (HF), left-ventricular assist device (LVAD) and heart transplantation (HTx) to visit their dentist leads to improved oral conditions after 12 months. Methods: Patients from the Department of Cardiothoracic Surgery, Leipzig Heart Centre, Germany were exam...
Article
Objectives: to evaluate the reproducibility of quantitative light-induced fluorescence (QLF) for the detection and assessment of demineralization stages of non-cavitated root surfaces and to determine the correlation between visual inspection and QLF-analysis. Methods: 46 exposed non-cavitated root surfaces of 12 participants were classified in...
Article
Purpose: The aim of this retrospective cross-sectional study was to detect dental health and dental treatment under general anaesthesia, as well as associations to selected parameters in a patient cohort with different disabilities. Material and methods: Patients with disabilities, including mental, physical, combination of mental and physical a...
Article
Background: This retrospective study aimed in the evaluation of oral health and oral health-related quality of life (OHRQoL) of patients with oral dystonia (OD). Material and methods: Seventeen patients with OD (Meige Syndrome: n=11, Oromandibular Dystonia: n=6) were included, of which seven were examined again at three months after botulinum to...
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Background: The aim of this cross-sectional study was the assessment of dental behaviour and oral health condition of heart transplant recipients (HTx) in comparison to patients with heart insufficiency (HI). Methods: Patients attending the Department for Cardiac Surgery, Leipzig Heart Center, Germany were recruited. Standardized questionnaires...
Article
Aim of this cross-sectional study was to investigate the prevalence of selected potentially periodontal pathogenic bacteria in different sites of patients with tongue piercing (TP) in comparison to a control group (C). Fifty participants in each group were recruited. Samples from the biofilm originating from the piercing surface (TP group), periodo...
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Background: Culturing of bronchoalveolar lavage (BAL) fluid is a commonly used method for pathogen detection in pneumonia. However, the sensitivity is low, especially in patients pre-treated with anti-infective agents. The early detection of a pathogen is crucial for the outcome of respiratory tract infections. For bloodstream infections, a multipl...
Conference Paper
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Background CRP and/or ESR are often unreliable indicators of disease activity. Serum markers of endothelial activation may be promising alternatives. We have recently shown that soluble vascular cell adhesion molecule-1 (sVCAM-1) is elevated in patients with positive antinuclear antibodies [1]. We also have described similar findings in another coh...
Article
Background: CRP and/or ESR are often unreliable indicators of disease activity. Serum markers of endothelial activation may be promising alternatives. We have recently shown that soluble vascular cell adhesion molecule-1 (sVCAM-1) is elevated in patients with positive antinuclear antibodies [1]. We also have described similar findings in another co...
Article
Background: CRP and/or ESR are often unreliable indicators of disease activity. Serum markers of endothelial activation may be promising alternatives. We have recently shown that soluble vascular cell adhesion molecule-1 (sVCAM-1) is elevated in patients with positive antinuclear antibodies [1]. We also have described similar findings in another co...
Article
Purpose: This dental practice-based pilot study aimed to investigate the efficacy of diabetes mellitus (DM) screening based on questionnaire replies. Materials and methods: 116 patients were screened in a private dental practice when visiting the dentist for a regular check-up. The Find-Risk (FR) questionnaire was used for diabetes screening. FR...
Article
Background The influence of singing activities and breathing exercises on the presence of gastroesophageal reflux disease (GERD) symptoms is not clear. While an Austrian study found symptom reduction, an Italian study showed more symptoms in professional opera choristers. These contradictory results may be due to differential intensity of the singi...
Article
Introduction: CGM use is growing in T1D population, especially in the pediatric age group. The continuously growing number of users provides new insights on therapy data as well as a benefit in therapy outcome. But new problems such as allergic reactions to adhesives or annoying frequent sensor changes arise. The “Eversense®” sensor is a subcutaneo...
Article
Objective Postoperative new-onset atrial fibrillation (POAF) is common after cardiac surgery. Much less has been reported about the relationship between fibrosis, inflammation and calcium-induced left atrial (LA) and right atrial (RA) contractile forces and POAF. We sought to identify predictors of POAF: Methods From August 2016 through February 20...
Conference Paper
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Fibrosclerosis of the skin leads to longer term morbidity if not treated by compression. The leg does not have a cylindrical-shape that can be compressed easily but inserts within compression hosiery can target sites shown by Ultrasound to be vulnerable. This study shows that the extra "inserted" pressure is effective in reducing fibrosclerosis, al...
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Introduction: There are increasing demands to perform surgery of hip fractures without delay. However, few studies have assessed the time to surgery in relation to outcome measurements. Methods: A total of 643 consecutive patients with a minimum age of 60 years underwent total hip arthroplasty (THA) for an intracapsular hip fracture. For this retro...
Article
Einleitung: Das Haar wird als wesentlicher Bestandteil unserer Erscheinung wahrgenommen, der unsere Persönlichkeit widerspiegelt. Deswegen ist es nicht verwunderlich das zahlreiche Studien die negativen Auswirkungen des Haarausfalles auf das Wohlbefinden und die Lebensqualität zeigen. Darüber hinaus wurde ein Zusammenhang mit psychischen Problemen...
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Objective Coagulation factor XIII plays a key role in fibrin clot stabilization and epithelial healing. Under chronic inflammatory conditions involving bleeding and an activation of the coagulation cascade, the FXIIIa inversely correlate with disease activity. We assumed that FXIIIa could be a predictor of severity in patients with ulcerative colit...
Article
Einleitung: Die Einführung eines neuen Systems für die robotisch assistierte laparoskopische Chirurgie stellt Fragen der Patientensicherheit in das primäre zentrale Interesse. Nach Einführung des Senhance Telerobotic Systems 2017 wurde daher das TRUST Register (TransEnterix Europäische Patienten-Registerstudie für robotisch unterstützte chirurgisch...
Article
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Purpose The aim of this retrospective cross-sectional study was to evaluate whether salivary findings of active matrix-metalloproteinase 8 (aMMP-8) chairside (point of care; POC) tests were associated with periodontal risk assessment parameters in patients receiving supportive periodontal therapy (SPT). Methods A total of 125 patients receiving re...
Article
Hintergrund Singaktivitäten und Atemübungen können über eine Kräftigung der Zwerchfellschenkel den unteren Ösophagussphinkter stärken und, wie in einer kleinen Grazer Studie gezeigt, auch Refluxsymptome lindern. Anderer-seits berichten zahlreiche Fallstudien und eine Kohortenstudie über vermehrten Reflux insbesondere bei professionellen Opernsänger...
Article
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Background: The aim of this study was to evaluate the oral health-related quality of life (OHRQoL) depending on dental and periodontal health of different patients before and after liver transplantation (pre- and postLTx) compared to a healthy control group (HC). Methods: OHRQoL was rated using the German short form of Oral Health Impact Profile...
Presentation
Introduction in TRUST (The TransEnterix European Patient Registry for Robotic assisted Laparoscopic Procedures in Urology, Abdominal Surgery, Thoracic and Gynecologic Surgery ), explanation of the study design and presenting the first results.
Article
Introduction: Hypertrophic cardiomyopathy (HCM) is characterized by myocardial fibrosis. Osteopontin (OPN) has never been investigated in HCM. Osteopontin is a glycoprotein secreated in different tissues and also by cardiac myocytes and fibroblasts. Thus, reflecting fibrogenesis within the myocardium OPN serum levels were shown to correlate positiv...
Article
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Hintergrund: Tumoren führen oft zu schwersten Schmerzen, die weltweit in der Hälfte der Fälle nicht adäquat behandelt werden. Weiterhin verursachen chronische nicht-maligne Erkrankungen häufig schwerste Schmerzzuständen, die ebenfalls oftmals nur unzureichend behandelt werden. Beide Ursachen bedingen eine deutliche Reduzierung der Lebensqualität. D...
Article
Background: The aim of this study was the investigation of concentration and prevalence of selected periodontal pathogenic bacteria and concentration of active matrix-metalloproteinase-8 (aMMP-8) within a group of patients with inflammatory bowel diseases (IBD) and to compare the results with a group of healthy control subjects (HC). Methods: 59...
Article
Presentation of the early-postoperative course of two patient groups after prophylactic mesh augmentation of the abdominal wall using two different meshes: resorbable synthetic mesh vs. non-resorbable synthetic mesh—a matched-pair analysis
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Purpose: This randomized clinical multicenter study compared different professional preventive approaches on peri-implant inflammation under supportive implant therapy (SIT). Methods: 105 participants (167 implants) were randomly allocated to four groups. All participants were under SIT with a 3-month recall interval. Plaque removal was performe...
Article
Background: Due to demographic change, more proximal femoral fractures can be expected in the future. However, accurate growth rates as well as follow-up research extending more than 1 year postsurgery are still lacking. Materials and methods: First, we defined inclusion and exclusion criteria for the retrospective cohort study. Based on these,...
Article
Background: Incisional hernia prophylaxis after stoma reversal surgery: Presentation of the early-postoperative course of two patient groups after prophylactic mesh augmentation of the abdominal wall using two different meshes: GORE BIO-A mesh vs. DynaMesh CICAT: Primary mesh augmentation followed by primary wound closure is the ideal concept for o...
Poster
Einleitung: In der Klinik für Chirurgie des Klinikums Mittelbaden Baden-Baden (Prof. Dr. Dieter Berger) wurden im Rahmen der Stomarückverlagerungsoperation zwei unterschiedliche Netze als Prophylaxe der Narbenhernie in sublay-Technik verwendet. Von November 2010 bis März 2015 wurden 127 Patienten mit dem resorbierbaren synthetischen Netz GORE® BIO-...
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Background and objectives: The aim of this clinical cross-sectional study was to determine the level of active matrix metalloproteinase-8 (aMMP-8) and periodontal pathogenic bacteria in gingival crevicular fluid in patients with rheumatoid arthritis (RA) with varying periodontal conditions. Material and methods: In total, 103 patients with RA an...
Article
Background/Aims: Basal insulin titration in the real world is mostly guided by health care providers (HCP). Use of health information technology for insulin titration may offer similar glycaemic effectiveness and lead to reduced utilisation of HCP resources. LTHome (LTH) is a web tool that applies a rules engine-based algorithm for insulin titratio...
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Background: This study evaluates periodontal conditions and microbiological findings and their influence on rheumatological disease parameters in patients with rheumatoid arthritis (RA). Methods: 168 RA-patients were included. A healthy control group (HC, n=168) was composed according to age, gender and smoking habits. Rheumatological data (dura...
Poster
Introduction: Hair is perceived as an essential part of our appearance. Numerous studies have shown a negative impact of hair loss on the well-being and quality of life of patients. What is more, a correlation with mental health issues (e.g. low self-confidence) and depression have been observed. Objective: This study investigated the impact of hai...
Article
INTRODUCTION: Periodontitis is still highly prevalent in industrial population whereas at the same time appropriate screening programs are missing. AIM: To evaluate, a self-reported questionnaire about periodontal risk factors in combination with the Periodontal Screening Index (PSI) to identify an existing need for periodontal treatment combined w...
Presentation
Bisher wird die Bienenstock-Inhalationstherapie nur als „Wellness“ angewendet, ohne dass Anspruch auf einen medizinischen Nutzen oder eine medizinische Therapie gestellt wird. Das beecura Bienenstockluft-Therapiesystem BCS-IH16 wird derzeit als erstes Medizinprodukt auf den Markt gebracht. Anzunehmende positive Effekte der Bienenstockinhalation mit...
Article
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Introduction: Periodontitis is still highly prevalent in industrial population whereas at the same time appropriate screening programs are missing. Aim: To evaluate, a self-reported questionnaire about periodontal risk factors in combination with the Periodontal Screening Index (PSI) to identify an existing need for periodontal treatment combine...
Poster
Hintergrund: Die radikale Prostatektomie ist die primäre Therapieform des nicht metastasierten Prostatakarzinoms. Hierbei ist die Resektionsqualität des sich in der Außenzone der Prostata entwickelnden Prostatakarzinoms wesentlich entscheidend für das progressionsfreie Überleben, die Lokalrezidivrate sowie adjuvante Therapieoptionen). Während biolo...
Article
The aim of this study was to compare the microbial analysis methods of polymerase chain reaction (PCR) and real-time PCR (RT-PCR) in terms of detection of five selected potentially periodontal pathogenic bacteria in peri-implant disease. Therefore 45 samples of healthy, mucositis and peri-implantitis (n = 15 each) were assessed according to presenc...
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Skin changes are common in patients on dialysis. This study focused on putative associations of specific skin findings with comorbidities and mortality. We performed a retrospective analysis of data from 508 patients on maintenance hemodialysis therapy in 7 centers in the German State of North Rhine Westphalia. Data had been collected by interview,...
Article
Purpose: Long-term results after treatment of calcaneal fractures are rare. For this reason, we conducted a retrospective follow-up after a minimum of 20 years post surgery. Methods: Between 1990 and 1994, a total of 66 patients received surgical treatment for displaced calcaneal fractures. At that time, osteosynthesis was performed using small,...
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Background: Lipedema is a painful, genetically induced, abnormal deposition of subcutaneous fat in the extremities of women. The pathogenesis is unknown. Also unknown is the number of women affected in Germany. This study presents the epidemiology of the disease. There are currently two treatment options available: Complex physical decongestive the...
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Die Deutsche Hochdruckliga hat eine Umfrage durchgeführt, bei die Leser Angaben zum eigenen Blutdruck, der Diagnostik und Therapie der arteriellen Hypertonie und zu eventuell bekannten Spätschäden gemacht haben. Ein Schwerpunkt der Befragung wurde auf Fragen gelegt, die die Einstellung der Leser zu eigener Diagnostik der Blutdruckwerte, zu Kenntnis...
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In Germany, about 1 million people are affected by atrial fibrillation (AF). Morbidity and mortality are high especially due to the risk of thromboembolic events. A valid risk stratification by the CHADS2 criteria is critical regarding the indication for anticoagulation and thus to improve prognosis. To what extent these criteria and guidelines are...
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The clinical relevance of lipoprotein(a) (Lp(a)) as a cardiovascular risk factor is currently underestimated. The aim of our study was to assess the influence of increased Lp(a) values on the development and severity of coronary artery disease (CAD).In our retrospective analysis of 31,274 patients, who were hospitalized for the first time, we compa...
Article
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Elevated lipoprotein(a) (Lp(a)) levels are an accepted risk factor for coronary heart disease. The role of Lp(a) in the development of extracardiac arteriosclerosis like peripheral arterial disease (PAD) and stenosis of the arteria carotis (ACIS) has hardly been documented so far. We aimed to investigate the incidence of extracardiac arterioscleros...