Tanja Endrass

Tanja Endrass
Technische Universität Dresden | TUD · Department of Psychology

PhD

About

108
Publications
21,438
Reads
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4,199
Citations
Additional affiliations
September 2016 - present
Technische Universität Dresden
Position
  • Professor
October 2012 - August 2016
Otto-von-Guericke-Universität Magdeburg
Position
  • Research Associate
October 2003 - September 2012
Humboldt-Universität zu Berlin

Publications

Publications (108)
Preprint
Theories of addiction posit a deficit in goal-directed behavior and an increased propensity towards habitual actions in individuals with substance use disorders. Control over drug intake is assumed to shift from goal-directed to automatic or habitual motivation as the disorder progresses. Several diagnostic criteria reflect the inability to pursue...
Article
Full-text available
Importance: Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic on AC need to be informed by real-world evidence. Objective: To examine whether lockdown measures are associated with AC and consumption-related temporal and psychological within-person mechanis...
Article
Full-text available
Physical distancing measures during the coronavirus pandemic are associated with increased psychological distress, especially in people with mental disorders. We investigated which social risk and resilience factors influence distress over time in people with pre-existing mental disorders. We conducted a longitudinal online survey with weekly follo...
Article
Background Examining predictive biomarkers to identify individuals who will likely benefit from a specific treatment is important for the development of targeted interventions. The late positive potential (LPP) is a neural marker of attention and elaborated stimulus processing, and increased LPP responses to negative stimuli are characteristic of p...
Article
Anorexia nervosa (AN) is characterized by a relentless pursuit of thinness, despite serious implications for health and social relations. In a previous study wielding the power of computational psychiatry, we found alterations in learning from negative feedback and in neural activity in the posterior medial frontal cortex (pMFC) in young acutely un...
Article
Full-text available
Inhibitory control deficits are associated with substance use disorders (SUDs) and considered a risk factor. Most studies compare SUD groups with unaffected individuals, although the degree of substance use might relate to inhibitory control deficits and explain group differences. This raises the question to which extent these deficits are specific...
Article
Transdiagnostic research and linking behavioral, neural, and symptom measures are important endeavors in clinical neuroscience and biological psychiatry. In this issue of Neuron, Moutoussis et al. (2021) describe a new cognitive construct—decision acuity—that is related to mental health symptoms and distinct resting-state networks.
Article
Full-text available
Background Substance use disorders are reliably associated with high impulsivity and sensation seeking. Importantly, both precede problematic substance use, implicating them as risk factors. Individuals with substance use disorders show variable degrees of substance use (combined quantity and frequency) and substance-related problems and differ in...
Article
Full-text available
Models posit problematic binge‐watching to involve a vicious circle of low motivation for alternative activities, low sensitivity for the consequences of neglected goals, and low self‐control. As such, simultaneously impaired feedback and inhibitory functioning might contribute to binge‐watching. We tested the hypothesis that blunted feedback‐relat...
Article
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Adaptive behavior critically depends on performance monitoring (PM), the ability to monitor action outcomes and the need to adapt behavior. PM-related brain activity has been linked to guiding decisions about whether action adaptation is warranted. The present study examined whether PM-related brain activity in a flanker task, as measured by electr...
Preprint
Full-text available
Background: Substance use disorders are reliably associated with high impulsivity and sensation seeking. Importantly, both precede problematic substance use, implicating them as risk factors. Individuals with substance use disorders show variable degrees of substance use (combined quantity and frequency) and substance-related problems and differ in...
Article
Full-text available
With increasing popularity of internet streaming portals, the question why people develop excessive binge-watching behavior has become a focus of scientific research. The possible negative consequences of this behavior under investigation and its proximity to behavioral addictions is discussed. Since deficits of response inhibition and performance...
Article
Background. Obsessive–compulsive disorder (OCD) is associated with marked anxiety, which triggers repetitive behaviours or mental rituals. The persistence of pathological anxiety and maladaptive strategies to reduce anxiety point to altered emotion regulation. The late positive potential (LPP) is an event-related brain potential (ERP) that reflects...
Article
Background: Increased impulsivity is considered to be a core characteristic of borderline personality disorder (BPD) and has been shown to play a significant role in decision making and planning. Neuropsychological studies in BPD revealed impairments of executive functions, and it is assumed that these deficits are related to altered feedback proce...
Article
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Regulation of craving (ROC) is a promising method of intervention in addiction and has received attention in event-related potential (ERP) research investigating the late positive potential (LPP). However, in the face of previously unaligned behavioral and LPP results, the present work aimed to take a first step toward more valid electrocortical ma...
Article
Full-text available
Frequent alcohol binges shift behavior from goal-directed to habitual processing modes. This shift in reward-associated learning strategies plays a key role in the development and maintenance of alcohol use disorders and seems to persist during (early stages of) sobriety in at-risk drinkers. Yet still, it has remained unclear whether this phenomeno...
Article
Full-text available
Adaptive behavior depends on the process of self-regulation. If self-regulation fails, maladaptive behavior may start to predominate, leading to impulsive actions, maladaptive habits, and compulsive behavior patterns. The tendency to develop habitual behavior differs between individuals and appears to be associated with different aspects of regulat...
Chapter
Die Zwangsstörung äußert sich in Gedanken und Handlungen. Die Zwangsgedanken sind wiederkehrende, aufdringliche Gedanken, die oftmals die Angst beinhalten, für ein mögliches Unglück verantwortlich zu sein (z. B. sich mit einer schweren Erkrankung anzustecken). Zwangshandlungen sind wiederkehrende Verhaltensweisen, die eingesetzt werden, um ein befü...
Chapter
Das Kapitel gibt einen Überblick über Störungen im Zusammenhang mit dem Gebrauch psychotroper Substanzen und vergleichbarer Störungen ohne Substanzbezug, vor allem der Störung durch Glücksspielen. Themenschwerpunkte in dieser Einführung sind wichtige Definitionen sowie bedeutsame gemeinsame und unterschiedliche Merkmale der verschiedenen Störungen...
Preprint
Background. Adaptive behavior depends on the process of self-regulation, controlling actions, feel-ings, or thoughts. If self-regulation fails, maladaptive behavior may start to predominate, leading to impulsive actions, maladaptive habits, and compulsive behavior patterns. Habits are triggered au-tomatically, usually without conscious awareness or...
Preprint
Full-text available
With the increasing popularity of internet streaming portals, the question why people develop binge-watching behavior has become a focus of scientific research and its addictive potential is discussed. The current study examined neural correlates of binge-watching during inhibition in a go/nogo task and performance monitoring using electroencephalo...
Article
Full-text available
One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still...
Article
Full-text available
One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still...
Article
Full-text available
The impact of individual differences on performance monitoring and psychopathology is a question of active debate. Personality traits associated with psychopathology may be related to poor internal performance monitoring (as measured by the error-related negativity [ERN]) but intact external performance monitoring (as measured by the reward positiv...
Preprint
Full-text available
The impact of individual differences on performance monitoring and psychopathology is a question of active debate. Personality traits associated with psychopathology may be related to poor internal performance monitoring (as measured by the error-related negativity [ERN]) but intact external performance monitoring (as measured by the reward positiv...
Article
Full-text available
1 st European Congress on Clinical Psychology and Psychological Treatment in Dresden, Germany, 31 October – 2 November 2019
Article
Unpredictability influences emotion and attention, but its effects on goal-directed behavior are unclear. We examined whether unpredictable events interfere with performance, using event-related potentials to specify underlying attentional dynamics. The paradigm involved task-irrelevant distracters of either predictable or unpredictable content (ne...
Article
Background: Patients with obsessive-compulsive disorder (OCD) experience abnormally high levels of uncertainty, and unpredictability is evaluated negatively and not well tolerated. The current study examined neural correlates of attentional processing in response to experimentally induced uncertainty in OCD. Methods: Twenty-four OCD patients and...
Article
Background: Feelings of doubt and perseverative behaviours are key symptoms of obsessive-compulsive disorder (OCD) and have been linked to hyperactive error and conflict signals in the brain. While enhanced neural correlates of error monitoring have been robustly shown, far less is known about conflict processing and adaptation in OCD. Method: W...
Article
Emotional processing is influenced by top-down processes such as reappraisal of emotion-inducing events. Besides one's own stimulus appraisal, information from the social environment can be used to modify the stimulus' meaning. This study investigated whether perspective taking changes participants' brain potentials to unpleasant pictures. Event-re...
Article
Patients with borderline personality disorder (BPD) show deficits in reward-guided decision making and learning. The present study examined risk-taking behavior in combination with feedback processing. Eighteen BPD patients and 18 healthy controls performed a probabilistic two-choice gambling task, while an electroencephalogram was recorded. Option...
Article
Endophenotypes are conceived as measurable but not directly observable features of mental disorders that link clinical symptoms with their genetic underpinnings. They promise to guide the search for specific causal gene variants but also to understand mechanisms of symptom generation more precisely. Several criteria have been listed that must been...
Article
Full-text available
Uncertainty about future threat has been found to be associated with an overestimation of threat probability and is hypothesized to elicit additional allocation of attention. We used event-related potentials to examine uncertainty-related dynamics in attentional allocation, exploiting brain potentials’ high temporal resolution and sensitivity to at...
Article
Full-text available
Brain correlates of performance-monitoring have been shown to be hyperactive in patients with obsessive-compulsive disorder (OCD), indexed by enhanced amplitudes of the error-related negativity (ERN) in the event-related potential (ERP). This hyperactivity was found to be temporally stable, independent of symptom remission, and could not be further...
Article
Background: Obsessive-compulsive disorder (OCD) is associated with marked anxiety, which triggers repetitive behaviours or mental rituals. The persistence of pathological anxiety and maladaptive strategies to reduce anxiety point to altered emotion regulation. The late positive potential (LPP) is an event-related brain potential (ERP) that reflect...
Article
Serotonin (5-HT) has been hypothesized to be implicated in performance monitoring by promoting behavioral inhibition in the face of aversive events. However, it is unclear whether this is restricted to external (punishment) or includes internal (response errors) events. The aim of the current study was to test whether higher 5-HT levels instigate i...
Article
Overactive performance monitoring, as measured by the error-related negativity in the event-related brain potential, represents one of the most robust psychophysiological alterations in obsessive-compulsive disorder (OCD). It has been proposed as an endophenotype for OCD because it is heritable and more prevalent in families of OCD patients. Consis...
Article
Hyperactive performance monitoring, as measured by the error-related negativity (ERN) in the event-related potential, is a reliable finding in obsessive-compulsive disorder (OCD) research and may be an endophenotype of the disorder. Imaging studies revealed inconsistent results as to which brain regions are involved in altered performance monitorin...
Article
Overactive performance monitoring, indexed by greater error-related brain activity, has been frequently observed in individuals with obsessive-compulsive disorder (OCD). Similar alterations have been found in individuals with major depressive and generalized anxiety disorders. The main objective was to extend these findings by investigating perform...
Article
Obsessive-compulsive disorder (OCD) is characterized by overactivity in frontal and striatal brain regions, and event-related potential studies have shown increased brain activity during performance monitoring. The error-related negativity (ERN) is a component of the event-related potential that is observed following incorrect responses, and signal...
Article
The present study investigated the modulation of the N2 and the correct-related negativity (CRN) by conflict frequency. Conflict costs, as measured by reaction times and error rate, were reduced with increasing conflict frequency, indicating improved conflict resolution. N2 amplitudes in incompatible trials increased with higher conflict frequency,...
Article
Hemispheric topography of alpha band power in the electroencephalogram has been linked to approach/avoidance motivation and may index the risk for anxiety disorders and depression. We quantified lower alpha band power (8-10 Hz) in 20 patients with obsessive-compulsive disorder (OCD) and 20 matched healthy controls during blocks of rest and presenta...
Article
Full-text available
Overactive performance monitoring has been consistently reported in obsessive-compulsive disorder (OCD). OCD is a clinically heterogeneous disorder and is characterized by several symptom dimensions that may have partially distinct neural correlates. We examined whether performance-monitoring alterations are related to symptom severity and symptom...
Article
Successful goal-directed behavior critically depends on performance monitoring, a set of cognitive and affective functions determining whether adaptive control is needed and, if so, which type and magnitude is required. Knowledge of the brain structures involved in such a process has grown enormously, although the time course of performance-monitor...
Article
Full-text available
Hyperactive performance monitoring is a robust finding in obsessive-compulsive disorder (OCD). Patients show increased amplitudes of the error-related negativity (ERN) and correct-related negativity (CRN). Recently, two temporo-spatial factors were shown to contribute to both ERPs in healthy individuals. In the present study, it was investigated wh...
Article
Negative priming (NP) is assumed to indicate the effect of an inhibitory mechanism in selective attention. Previous studies showed inconsistent reductions of the NP effect in patients with obsessive-compulsive disorder (OCD) and schizophrenia. The aim of the present study was to relate NP alterations in two different NP tasks with specific symptom...
Poster
Electrophysiological correlates of probabilistic reversal learning in obsessive-compulsive disorder. Poster presented at the 4th Scientific Meeting of the FESN, 28th Scientific Meeting of the GNP, Berlin, Germany, Sep 12-14.
Article
Full-text available
Zusammenfassung. Die Zwangsstörung ist eine teilweise genetisch vermittelte psychische Störung, die mit neuropsychologischen Be-einträchtigungen einhergeht. Bisher war die Suche nach den genetischen Ursachen wenig erfolgreich, was an der polygenetischen Über-tragung und an der Heterogenität im klinischen Erscheinungsbild der Zwangsstörung liegen kö...
Article
Eine Reihe psychischer Störungen wird im Hinblick auf den DSM-5 aufgrund ihrer Ähnlichkeit, aber auch in Abgrenzung zur Zwangsstörung, als so genannte Zwangsspektrumsstörungen diskutiert. Im Speziellen wird die Einführung einer separaten Kategorie Zwangs- und verwandte Störungen diskutiert, der sowohl die Zwangsstörung als auch Zwangsspektrumsstöru...
Article
Distraction and cognitive reappraisal influence the emotion-generative process at early stages and have been shown to effectively attenuate emotional responding. Inhibiting emotion-expressive behavior is thought to be less beneficial due to later implementation, but empirical results are mixed. Thus, the current study examined the temporal dynamics...
Article
Full-text available
Importance: Neurobiological models of obsessive-compulsive disorder (OCD) predict hyperactivity in brain circuits involving the orbitofrontal cortex and the basal ganglia, but it is unclear whether these areas are also characterized by altered brain network properties. Objectives: To determine regions of abnormal degree connectivity in patients...
Article
Error-processing is increasingly examined using the error-related negativity (ERN) and error positivity (Pe)-event-related potentials (ERPs) that demonstrate trait-like properties and excellent reliability. The current study focuses on construct validity by applying a multitrait-multimethod approach, treating error-related ERPs (i.e., ERN, Pe and t...
Article
Full-text available
Obsessive-compulsive disorder (OCD) patients show hyperactive performance monitoring when monitoring their own actions. Hyperactive performance monitoring is related to OCD symptomatology, like the unflexibility of compulsive behaviors, and was suggested as a potential endophenotype for the disorder. However, thus far the functioning of the perform...
Article
Full-text available
Obsessive-compulsive disorder (OCD) is associated with dysfunctional brain activity in several regions which are also involved in the processing of motivational stimuli. Processing of reward and punishment appears to be of special importance to understand clinical symptoms. There is evidence for higher sensitivity to punishment in patients with OCD...
Article
Introduction: Obsessive-compulsive disorder (OCD) is characterized by a pattern of repetitive, intrusive thoughts and behaviours that patients do not want to but feel they have to perform. Functional brain imaging revealed dysfunctional pathways in OCD involving the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and basal ganglia. St...