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Peroxiredoxin 6 (PRDX6) is expressed throughout the brain, including the hippocampus, where it plays a potential role in synaptic regulation and forming emotional and spatial memories. PRDX6 is predominantly detected in the female mouse's hippocampus; thus, we investigate the effect of the Prdx6 gene on behavioral phenotypes and synaptic functions...
Fear dysregulation is one of the symptoms found in post-traumatic stress disorder (PTSD) patients. The functional abnormality of the hippocampus is known to be implicated in the development of such pathology. Peroxiredoxin 6 (PRDX6) belongs to the peroxiredoxin family. This antioxidant enzyme is expressed throughout the brain, including the hippoca...
Peroxiredoxin 6 (PRDX6) is expressed dominantly in the astrocytes and exerts either neuroprotective or neurotoxic effects in the brain. Although PRDX6 can modulate several signaling cascades involving cognitive functions, its physiological role in spatial memory has not been investigated yet. This study aims to explore the function of the Prdx6 gen...
The triple transgenic Alzheimer’s disease (3xTg-AD) strain is a common mouse model used for studying the pathology and mechanism of Alzheimer’s disease (AD). The 3xTg-AD strain exhibits two hallmarks of AD, amyloid beta (Aβ) and neurofibrillary tangles. Several studies using different gender and age of 3xTg-AD mice to investigate their behavior phe...
Peroxiredoxin 6 (PRDX6) is a multifunctional enzyme expressed in many organs including the brain. It is known to participate in many psychiatric functions, but its role in fear memory is unknown. The present study demonstrates that PRDX6 plays a critical role in the regulation of fear response. Using Prdx6 knockout (Prdx6-/-) mice, we identified th...
Hi, now i work in 3xTg model and i very new in this field.
If i want to stain amyloid beta which one is good to use for a marker of amyloid beta between 40-42 abeta...or 1-42 abeta?
And which antibody is good for frozen section if i want to stain with DAB?