Tania Labiano

Complejo Hospitalario de Navarra · Department of Pathology

Objective There is beauty in cytopathology. That beauty and art can be transmitted and shared through fun images on social media. Methods As social media becomes more popular, pathologists and related professionals have started to share the images that they capture at work on their profiles, tagging them with the hashtag #Pathart. #Pathart hashtag...

Introduction Fine needle aspiration cytology (FNAC) is a widely accepted diagnostic technique, but performance varies according to expertise. Little is known about variation in FNAC training practices worldwide. We surveyed pathologists using social media networks to determine FNAC training practices internationally. Design Pathologists were surve...

Lung carcinoma remains one of the most frequent and aggressive human neoplasms. Fortunately, in the last decades, the increasing knowledge of the molecular mechanisms leading to cancer development has allowed the use of targeted therapies with improvement of prognosis in many patients. Clinical management has also changed after the introduction of...

Non-small cell lung cancer (NSCLC) is one of the oncological entities with the greatest evolution in molecular diagnosis due to the large number of diagnostic biomarkers and new treatments approved by international regulatory agencies. An accurate, early diagnosis using the least amount of tissue is the goal for the establishing and developing prec...

In the era of personalized medicine, there is an increasing demand for comprehensive and complex diagnosis using minimally invasive techniques. Nowadays, it is mandatory to integrate biomarkers in the diagnostic process, as well as in the treatment and clinical management of many cancer patients. Patients with non-small cell lung cancer (NSCLC), fo...

Context.— Social media sites are increasingly used for education, networking, and rapid dissemination of medical information, but their utility for facilitating research has remained largely untapped. Objective.— To describe in detail our experience using a social media platform (Twitter) for the successful initiation, coordination, and completion...

Background Twitter is an expanding social media network among cytopathologists to share knowledge. Tweets are made up of text which may also include images or video. All tweets labeled under a hashtag can be tracked. The #FNAFriday hashtag was created in 2015 by one of the authors (X.J.) to build a community of individuals, to educate and share int...

Background&Objectives: Pulmonary sclerosing pneumocytoma (PSP) is a rare benign tumour. The molecular profile of these tumours is not well known. Methods: We performed a clinicopathological, IHC, and molecular study in six PSP. IHC was performed: beta-catenin, ALK, BRAF V600E, ROS1, HER2, and PD-L1. Molecular tests included EGFR, KRAS, and BRAF. FI...

Introducción: El mixoma cardiaco es la neoplasia primaria cardíaca más común en adultos. Aunque su naturaleza es benigna, a menudo debuta con manifestaciones clínicas graves secundarias a embolismos tumorales. Existen dos formas clínicas histológicamente idénticas; casos esporádicos (90%) y casos familiares; dentro del contexto del Síndrome de Carn...

Introducción: El uso profesional de las redes sociales en el ámbito médico se ha incrementado notablemente estos años, sobretodo en especialidades médicas como la Anatomía Patológica. Son muchos los patólogos que usan Twitter (San Francisco, CA, USA) para publicar contenido científico acompañado de imágenes con interés docente y profesional. El obj...

Biopsy site changes in mediastinal lymph nodes (LNs) attributable to prior endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) have not been studied in a systematic manner. Twenty-four contributors from 14 institutions in 5 countries collaborated via social media (Twitter) to retrospectively review consecutive cases of rese...

Radiotherapy can be synergistically combined with immunotherapy in mouse models, extending its efficacious effects outside of the irradiated field (abscopal effects). We previously reported that a regimen encompassing local radiotherapy in combination with anti-CD137 plus anti-PD-1 mAbs achieves potent abscopal effects against syngeneic transplante...

Background & Objective: The link between the immune system and cancer is well known. Lymphocytes are the effector cells that mediate the immune response. The validity of the histological assessment of the tumour infiltrating lymphocytes (TILs) in cancer has been standardized by The International TILs Working group. The aim of the study was to analy...

Background & Objective: The link between the immune system and cancer is well known. Lymphocytes are the effector cells that mediate the immune response. The validity of the histological assessment of the tumour infiltrating lymphocytes (TILs) in cancer has been standardized by The International TILs Working group. The aim of the study was to analy...

Background: TGF-β has been described as a mediator of fibrosis and scarring. Several studies achieved reduction in experimental scarring through the inhibition of TGF-β. Fibroblasts have been defined as the cell population originating fibrosis, blocking fibroblast invasion may impair epidural fibrosis appearance. For this purpose, biocompatible ma...

Introduction Pathology is a speciality that is often poorly understood, not only by the general public, but also by clinicians. However, the recent widespread use of social media provides an opportunity to increase the visibility and comprehension of our profession. A working group was formed to carry out this task. Material and methods The member...

Resumen Introducción La Anatomía Patológica sigue siendo desconocida, no solo para el público en general, sino también para nuestros compañeros de profesión. El uso generalizado de las redes sociales permite difundir nuestra labor. Por ello, se planteó generar un grupo de trabajo. Material y métodos Se emitió una convocatoria a los socios de la S...

Objective: To review the clinical, radiological and morphological features of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH), an infrequently reported disease. Methods: We reviewed the clinical, radiological and pathological data of six cases diagnosed as DIPNECH between 2010 and 2017 at our Institution. Results: Patients ag...

Objective: Myxoma is the most common primary tumor of heart, although still rare. These tumor are benign but malignant in a sense that often embolizes and may cause severe complications. We report our experience with cadiac myxoma in adults at Complejo Hospitalario de Navarra. Methods: Eight patients resected for primary cardiac tumours between Jan...

Background: Molecular testing to determine gene mutation status is now the recommended standard of care for patients with advanced or metastatic Non-small cell lung cancer (NSCLC). Because the majority of patients with NSCLC present with metastatic disease, minimally invasive procedures are necessary for diagnosis, staging, and molecular analysis....

Purpose The tumour molecular profile predicts the activity of epidermal growth factor receptor (EGFR) inhibitors in non-small-cell lung cancer (NSCLC). However, tissue availability and tumour heterogeneity limit its assessment. We evaluated whether [18F]FDG PET might help predict KRAS and EFGR mutation status in NSCLC. Methods Between January 20...

As a result of therapeutic advances, a revolution is taking place in the lung cancer field with major implications for pathologic diagnosis and tissue management. We report a case of a non-small cell lung carcinoma patient with coexistence of EGFR mutations and ALK-EML4 rearrangements that responded to EGFR inhibitors and in which the development o...

Adult hepatoblastoma (AHB) is a very rare tumor, having been described 45 cases up to June 2012. In contrast to HB in infancy (IHB), it has poor prognosis. We present the case of a 37-year-old asymptomatic woman who consulted for a large –12 cm diameter– mass involving segments 5 and 6 of the liver, and alfa-fetoprotein of 1,556,30 UI/mL. A bisegme...

e19027 Background: About 75% of NSCLC is diagnosed at an advanced stage, thus analysis is often performed from small samples. There is a growing need for multiple biomarker testing when tissue is limited. We evaluated two real-time PCR based assays to assess EGFR and KRAS mutation status in limited tissue specimens and compared results to a lab val...

El struma ovarii maligno es un tumor excepcional. A pesar de su rareza, puede dar metástasis igual que un tumor maligno de origen tiroideo. Presentamos un caso, en una paciente mujer de 56 años, que se inició con metástasis pulmonares y óseas. Aportamos un caso único de struma ovarii maligno que se manifestó con metástasis óseas y se diagnosticó me...

Purpose BMS-936558 is a monoclonal antibody that blocks the PD-1 co-inhibitory receptor expressed by activated T cells. This study describes its activity and safety in pts with previously treated advanced MEL. Methods BMS-936558 was administered IV q2wk to pts with various tumors at 0.1 - 10 mg/kg during dose-escalation and/or cohort expansion. Pt...

Background Vemurafenib is approved for the first-line treatment of BRAF-V600E+ metastatic melanoma (MM). Also, preliminary clinical experience with imatinib in MM patients with gene amplification or activating mutations of c-KIT, have shown high response rates and prolonged progression free survival. These results emphasise the importance of molecu...

e18008 Background: ALK gene rearrangements define a new molecular subtype of NSCLC with response to Crizotinib, a dual MET and ALK inhibitor. Analysis of ALK rearrangements has been performed in biopsies or surgical specimens. However, advanced NSCLC is often diagnosed by FNA cytology obtained through minimally invasive techniques, and frequently C...

8572 Background: Vemurafenib is currently the most active first-line treatment in MM patients that harbor BRAF-V600E mutations. The Cobas 4800 BRAF V600 Mutation Test is an FDA-approved, CE-marked test that identifies formalin-fixed-paraffin-embedded samples (FFPE) carrying the BRAF V600E mutation. Fine needle aspirates are frequently the only samp...

Introducción: Los nódulos reumatoides son la manifestación morfológica más típica de la artritis reumatoide, y se observan el 20% de los pacientes. Nódulos morfológicamente indistinguibles se han descrito en otras enfermedades, especialmente de origen autoinmune. Material y Métodos: Presentación de dos casos con nódulos reumatoides en partes blanda...

Objective: The aim of this study was to evaluate what constitutes adequate sampling of prostate transperineal biopsies to improve the accuracy of diagnosis. Method: This study was of 300 consecutively identified prostate transperineal biopsies. Average patient age was 57 years. For all cases, two blocks with at least six cores in each were paraffin...

Cystic lesions of the pancreas are being detected with increasing frequency. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is one of the most precise methods of diagnosis but still has limited accuracy. A new, through-the-needle cytologic brush system (EchoBrush; Cook Medical, Bloomington, Ind) has been approved for use during EUS e...

Epidermal growth factor receptor (EGFR) and K-ras mutations guide treatment selection in non-small cell lung cancer (NSCLC) patients. Although mutation status is routinely assessed in biopsies, cytological specimens are frequently the only samples available. We determined EGFR and K-ras mutations in cytological samples. DNA was extracted from 150 c...

8575 Background: Current advances in the understanding of melanoma biology and genetics gave a solid rationale to introduce different targeted therapies into clinical trials. In patients harbouring BRAF mutations, 60-80% objective response rate has been described after treatment with BRAF inhibitors like PLX4032 or GSK 2118436. Also, preliminary cl...

Introducción: El adenoma del oído medio es un tumor epitelial benigno poco frecuente, no encapsulado, que puede tener diferenciación exocrina y/o neuroendocrina (ANOM). Presentamos un caso que se intervino quirúrgicamente con la sospecha de clínica de glomus timpánico y se diagnosticó intraoperatoriamente y en la biopsia definitiva como ANOM. Mater...

Solitary fibrous tumour (SFT) is a very rare disease in adults, for which the real incidence is unknown. The exact diagnosis is based on pathological and immunohistochemical examination. The treatment continues being surgery with wide safety margins. The prognosis is determined by the resectability, although more studies are required to evaluate th...

Background: We have previously shown that surgery done with 5-ala fluorescence allows highly precise separate sampling of the invasive border of the tumor in glioblastoma (GBM). Nestin is a type VI intermediate filament considered as a marker for tumor stem cell and could be used in the identification of peripheral glioblastoma cells. However, an a...

Background Immunoreactivity for TFE3 is a sensitive marker of tumors with known translocations involving the TFE3 gene. Several cases of PEComas have been reported to be TFE3 positive.We performed a study of TFE3 immunoreactivity and ASPL/TFE3 translocation in PEComa family tumors. Methods 51 renal AML, 2 hepatic AML, 6 PEComas, 2 lymph node (lymph...