Taner Yıldırmak

• Doctor of Medicine
• instructor person at Okmeydani Training and Research Hospital

Background: Cardiovascular disease (CVD) is a major cause of mortality among people living with HIV (PLWH). We aimed to assess the prevalence of diagnosed CVD and the risk of CVD among PLWH using 5 different tools. Methods: This retrospective, cross-sectional study was conducted in 20 tertiary centers in Türkiye between October 2021 and March 20...

Background: Early immune responses to COVID-19 can help eliminate the virus; therefore, strategies to improve the immune system have become important in disease prevention. Vitamin D plays a crucial role in the immune response to SARS-CoV-2 by increasing the expression of the vitamin D receptor. Objectives: This study investigated the impact of vit...

Objective: The research was conducted to identify the factors influencing social adaptation to the disease in the COVID-19 pandemic. Material and Methods: The cross-sectional study was carried out prospectively in a pandemic hospital in Istanbul between 10 May 2020 and 30 May 2020 after obtaining the permission of the Ministry of Health COVID-19 Sc...

Objective: The study was carried out to determine the sociodemog-raphic, clinical characteristics and difficulties experienced by patients lacking social support during the COVID-19 pandemic. Methods: This cross-sectional study was conducted in a pandemic hospital in Istanbul, between March 11 and May 31, 2020; with 100 patients who received inpati...

Introduction: Saprochaete capitata is a rare cause of invasive fungal infection. Patients with hematological malignancies and those with severe neutropenia are at high risk. It has been generally reported as case reports or small case series in the literature. Here, we report 17 cases of Saprochaete capitata infection detected in our center over a...

Introduction: COVID-19 disease, thought to originate from China, is now a global pandemic. It shows a variety of pulmonary manifestations, mostly in the form of ground-glass opacities with a peripheral distribution. Less common manifestations such as pneumomediastinum have also been reported. The aim of this study is to make a contribution to the l...

Aim To evaluate the clinical factors associated with false-negative RT-PCR result and to report the outcome of a cohort of pregnant women with COVID-19. Methods This cohort study was conducted in a tertiary referral pandemic- hospital and included 56 pregnant women. A study including pregnant women with either a laboratory or clinical diagnosis fo...

Background CoronaVac, an inactivated whole-virion SARS-CoV-2 vaccine, has been shown to be well tolerated with a good safety profile in individuals aged 18 years and older in phase 1/2 trials, and provided a good humoral response against SARS-CoV-2. We present the interim efficacy and safety results of a phase 3 clinical trial of CoronaVac in Turke...

Objective COVID-19 spread worldwide, causing severe morbidity and mortality and this process still continues. The aim of this study to investigate the prognostic value of right ventricular (RV) strain in patients with COVID-19. Methods Consecutive adult patients admitted to the emergency room for COVID-19 between 1 and 30 April were included in th...

Background There is limited evidence on the modification or stopping of antiretroviral therapy (ART) regimens, including novel antiretroviral drugs. The aim of this study was to evaluate the discontinuation of first ART before and after the availability of better tolerated and less complex regimens by comparing the frequency, reasons and associatio...

Aim: Vitamin D, which has immunomodulatory effect, can reduce risk of infections and concentrations of pro-inflammatory cytokines. The aim of this study was to investigate the relationship between the levels of vitamin D and severity of COVID-19. Methods: A total of 204 patients with COVID-19 disease were enrolled in the study. All patients had...

TARK E-Kongre 2020

Objective: COVID-19 is a disease with high mortality, and risk factors for worse clinical outcome have not been well-defined yet. The aim of this study is to delineate the prognostic importance of presence of concomitant cardiac injury on admission in patients with COVID-19. Methods: For this multi-center retrospective study, data of consecutive...

Background/Aims: mbitasvir/paritaprevir/ritonavir (OMV/PTV/r) ± dasabuvir (DSV) ± ribavirin (RBV) combination has demonstrated excellent rates of sustained virologic response (SVR) and a very good safety profile in patients with the chronic hepatitis C virus (HCV) genotype 1 or 4 infections. We aimed to investigate the effectiveness and safety of O...

Objective The aim of this study was to analyze the temporal trends of HIV epidemiology in Turkey from 2011 to 2016. Method Thirty-four teams from 28 centers at 17 different cities participated in this retrospective study. Participating centers were asked to complete a structured form containing questions about epidemiologic, demographic and clinic...

Background: Because of the similar modes of transmission, simultaneous infection of viral hepatitis and HIV increasingly seen as a big problem related to humanity health. Aim: In this study, we aimed to determine the drug mutations in hepatitis B virus (HBV) and/or hepatitis C virus (HCV) co-infected HIV-1 patients in Turkey. Study design: Ret...

Hepatitis B virus (HBV) is an important pathogen responsible for serious diseases like chronic hepatitis, cirrhosis and liver cancer. Turkey is located in the intermediate endemic region based on the average HBV surface antigen positivity. The high replication capacity of HBV and the lack of proofreading activity of the reverse transcriptase (RT) e...

Infections caused by resistant Gram-negative bacteria are seen in increasing frequency. Colistin is used in the treatment of these infections but colistin-resistant bacteria and pan-resistant bacteria have emerged. This situation is thought to become an important health problem in the near future. Various combination therapies are used in the infec...

In people living with human immunodeficiency virus (HIV), several complaints related to the gastrointestinal system, mainly diarrhea can be determined. In our study, we aimed to detect the existence of intestinal parasites with conventional methods based on microscopy and with molecular methods based on multiplex-PCR among 90 anti-retroviral treatm...

Objectives: We described the clinical outcome of the diabetic patients who had foot infections with multidrug resistant organisms. Methods: We included the patients with diabetic foot infections (DFI) from 19 centers, between May 2011 and December 2015. Infection was defined according to IDSA DFI guidelines. Patients with severe infection, compl...

Background: Hepatitis B virus (HBV) has a high mutation rate due to its unusual replication strategy leading to the production of a large number of virions with single and double mutations. The mutations, in turn, are associated with the development of drug resistance to nucleos(t)ide analogs (NUCs) in patients before and during NUCs therapy. Objec...

Comorbidities among HIV infected patients.

Background Cardiovascular disease (CVD) is a major cause of mortality in HIV infected patients. Agreement between commonly used risk prediction equations for classification of high-risk individuals is varied in different populations. We aimed to compare the degree of agreement of four CVD risk calculators in a multicenter cohort. Methods A cross-s...

Opportunistic infections such as cryptosporidiosis and cyclosporiasis are commonly encountered in patients with acquired immunodeficiency syndrome (AIDS). We investigated the existence of opportunistic protozoans that significantly affect the quality of life in HIV-1 infected patients using conventional and molecular methods. The study group compri...

Crimean-Congo haemorrhagic fever is a viral haemorrhagic disease, mostly transmitted by tick bites or through contact with infected animal's blood, and bodily fluids. Nosocomial infections were occasionally reported in healthcare settings. We report nosocomial cluster of Crimean-Congo haemorrhagic fever including the visitor with unknown transmissi...

Background: Drug resistance development is an expected problem during treatment with protease inhibitors (PIs), this is largely due to the fact that Pls are low-genetic barrier drugs. Resistance-associated variants (RAVs) however may also occur naturally, and prior to treatment with Pls, the clinical impact of this basal resistance remains unknown...

Objective: The aim of this study is to investigate if neutrophil CD64 expression in febrile neutropenia patients could be used as an early indicator of bacteriemia. Patients-methods: All consecutive patients, older than 18 years of age and developed febrile neutropenia episodes due to hematological malignancies from February 2013-to July 2013 at...

Background: Before the introduction of direct-acting antivirals in the treatment of chronic hepatitis C patients, the combination of peginterferon alpha and ribavirin was the standard therapy. Observational studies that investigated sustained virological response (SVR) rates by these drugs yielded different outcomes. Aims: The goal of the study...

We aimed to investigate the predictors for the limb loss among diabetic patients with complicated skin-soft tissue infections. In this observational study, consecutive patients with diabetic foot infection (DFI) from 17 centers in Turkey, between May 2011 and May 2013 were included. The Turkish DFI Working Group performed the study. Predictors of l...

We evaluated the rates of vancomycin-resistant enterococci (VRE) colonization and VRE-related bacteremia in patients with hematological malignancies in terms of routine screening culture and its cost-effectiveness. All patients of the hematology department who were older than 14 years of age and who developed at least one febrile neutropenia episod...

During the course of an acute brucellosis infection, severe thrombocytopenia, ITP and bleeding are rarely seen and can be misleading for hematological diseases. Our case was a 20-year-old male patient. He had admitted to the Emergency Room with the complaints of gingival bleeding and bleeding of his pimples. His platelet count was 1.6 x 10³ /µL and...

Objective: Candidaemia is the fourth most common cause of nosocomial bloodstream infections. The objective of this paper was to evaluate the risk factors associated with mortality in patients with candidaemia with respect to Candida species and their susceptibilities, retrospectively. Methods: All consecutive patients who developed candidaemia a...

Introduction: Routes of transmission and reasons for HIV testing are important epidemiologic data to analyze the epidemic and to tailor the response to AIDS. The aim of this study was to analyze reasons for testing and transmission ways of HIV among recently diagnosed HIV patients registered in the multicenter HIV-TR cohort in Turkey. Methods: T...

Introduction HIV-TR is a recently established (2012) multicentre cohort in Turkey. The aim of this study is to analyze epidemiological, immunologic and virologic data of recently diagnosed HIV patients. Materials and Methods Epidemiologic, clinical and laboratory data of all patients diagnosed in 2011 and 2012 were recorded by a web-based data col...

Introduction The objective of this study was to determine the transmitted drug resistance mutations (TDRMs) in newly diagnosed HIV-1 positive patients in Turkey. Materials and Methods The study was carried out between 2009 and 2014 and antiretroviral naïve 774 HIV-1 infected patients from 19 Infectious Diseases and Clinical Microbiology Department...

Background The primary objective of this study was to report the incidence of bloodstream infections (BSIs) and clinically or microbiologically proven bacterial or fungal BSIs during neutropenic episodes in patients with hematological malignancies. Methods In this retrospective observational study, all patients in the hematology department older t...

Introduction: We retrospectively evaluated the rates of vancomycin-resistant enterococci (VRE) colonization and VRE-related infections in patients with hematological malignancies. Methodology: All patients in the hematology department of the Ministry of Health Okmeydanı Training and Research Hospital, an 800-bed tertiary hospital in İstanbul, Tu...

Background / Purpose: The aim of this study is to evaluate the patients with intracranial suppurative infection (ISI) in context with clinical, radiological and laboratory findings, and prognosis, retrospectively. Main conclusion: Timely and appropriate management of ISI were likely to be related to our lower sequelae rate (8.6%) compared to r...

The aimof this retrospective, observational study was to evaluate the outcomes of bacteremia attacks during neutropenic episodes caused by chemotherapy in patientswith hematological cancers by assessing mortality, involved pathogens, antimicrobial therapy and treatment responses. Patients whowere older than 14 years of age and developed at least on...

Background Patients with hematological malignancies often develop febrile neutropenia (FN) as a complication of cancer chemotherapy. Primary or secondary antifungal prophylaxis is recommended for patients with hematological malignancies to reduce the risk of invasive fungal infection (IFI). This study retrospectively evaluated the efficacy and pote...

The febrile neutropenia episodes of hematological patients and their outcomes were evaluated with respect to fungal pathogens and antifungal therapy in this retrospective study. All patients, who were older than 14 years of age and developed at least one neutropenic episode after chemotherapy due to hematological cancer from November 2010 to Novemb...

Febrile neutropenia (FN) is generally a complication of cancer chemotherapy. We retrospectively evaluated the febrile neutropenia episodes and their outcomes with respect to modification rates of non-carbapenem-based empirical antibacterial therapy and vancomycin-resistant enterococcus (VRE) colonisation that caused to VRE bacteremia in patients wi...

There are only few urinary schistosomiasis cases reported from Turkey. These recently diagnosed cases are either associated with overseas journeys or observed in foreign citizens visiting our country as afflicted with disease from abroad. Our case was infected when working in Africa and was diagnosed with non-Hodgkin's lymphoma of the bladder by mi...

We investigated rectal vancomycin-resistant Enterococcus (VRE) colonization rates in the intensive care unit of our hospital. Within the 2-year period, of the 112 patients, VRE was isolated in 21 (18.8%). VRE carriers had significantly higher rates of nasogastric tube or central venous catheter use; more frequent use of third- and fourth-generation...

Purpose: To evaluate the outcomes of the patients who were infected with colistin-only-susceptible (COS) Acinetobacter baumannii and treated with either colistin monotherapy or colistin combined therapy. Materials and methods: This retrospective case-control study was conducted in the training and research hospital with an 800 beds between Augus...

This was to evaluate the history, clinical and laboratory findings, outcome and prognosis of patients with tuberculous meningitis (TBM). Between 1998 and 2009, 60 patients with TBM were evaluated, retrospectively. Overall, 60 patients were selected, of which 33 (55%) were male. The patients' ages ranged from 14 to 62 years. In the majority of the p...

To determine the distribution of viral genotypes for primary or acquired lamivudine resistance. A total of 283 patients with chronic hepatitis B virus (HBV) infection (245 patients with chronic hepatitis B and 38 inactive hepatitis B surface antigen carriers) were included in the study. The HBV genotype was determined by using quantitative real-tim...

Pulmonary involvement of brucellosis rarely occurs due to inhalation of infected aerosol or hematogenous overspreading. The study aimed to reveal the pulmonary manifestations of brucellosis that occur rarely in Brucella infections in the context of six cases in this report. Between 1998-2008, 82 patients with brucellosis treated and followed up at...

A 33-year-old male patient working as a butcher in a market was admitted to our clinic because of persisting fever and chills of 8-day duration, jaundice, disseminated myalgias and headache. Laboratory tests revealed a slight elavation of transaminases, marked hyperbilirubinemia of 17.5 mg/dl, and mild thrombocytopenia. His chest radiography was no...

Serious treatment problems are experienced in nosocomial infections caused by multi-drug resistant Pseudomonas aeruginosa especially in intensive care units. We report a case of multi-drug resistant Pseudomonas aeruginosa meningitis treated succesfully with intrathecal polymyxin B. As the 26 year old female patient operated in the department of neu...

Nur Efe-‹ris, Muret Ersöz-Arat, Funda fiimflek, Taner Y›ld›rmak Okmeydan› E¤itim ve Araflt›rma Hastanesi, ‹nfeksiyon Hastal›klar› ve Klinik Mikrobiyoloji Klini¤i, Okmeydan›-‹stanbul Özet: Yo¤un bak›m ünitelerinde (YBÜ) yatan hastalar›n kültürlerinden izole edilen Candida sufllar›n›n tür düzeyinde tiplendirilmesi ve antifungallere duyarl›l›klar›n› b...

Mucormycosis (or zygomycosis) is the term for infection caused by fungi of the order Mucorales. Mucoraceae may produce severe disease in susceptible individuals, notably patients with diabetes and leukemia. Rhinocerebral mucormycosis most commonly manifests itself in the setting of poorly controlled diabetes, especially with ketoacidosis. A 31-year...

Background: Marginal zinc deficiency has been the matter of interest in recent years and investigations are concentrated on it. Subjects with insufficient zinc consumption diet demonstrate systemic symptoms as reduced appetite, growth retardation in preschool children; immune deficiency, dermatological problems, delayed wound healing in geriatric p...

A total of 259 clinical isolates of nonrepetitive non-typhi salmonellae (NTS) were examined for antibiotic resistance patterns and plasmid content. The antibiotics used were amoxicillin-clavulanic acid (AMC), ampicillin (AM), aztreonam (ATM), carbenicillin (CB), cefixime (CFM), cefotaxime (CTX), cefoxitin (FOX), ceftazidime (CAZ), ceftriaxone (CRO)...

Here we report of adult neurobrucellosis in 5 cases. That are 3,4 % of all burucellosis cases of our department at this study period. Three patients referred from psychiatry or neurolgy clinics. Cerebrospirıal fluid (CSF) findings of the patients were pleocytosis, hypoglycorrachia and hyperproteinorrhachia. Brucella agglutination with coombs was fo...