Tanaya Roychowdhury

Tanaya Roychowdhury
Indian Institute of Chemical Biology | IICB · Cancer Biology and Inflammatory Disorder Division (IICB)

Master of Science

About

14
Publications
3,368
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Introduction
I work on cancer biology including epigenetics, calcium signaling , G-quadruplex biology and natural products used for anti cancer treatment

Publications

Publications (14)
Article
Chemoresistance is an imminent therapeutic challenge for breast cancer. Previous evidence suggests that breast cancer stem cells (BCSC) develop resistance through upregulation of stemness and chemo-evasion markers viz. SOX2, OCT4, NANOG, MDR1 and CD44, following anticancer chemotherapeutic treatments. Early studies suggest an inhibitory role of Kae...
Article
Full-text available
G-Quadruplex (GQ) nucleic acids are promising therapeutic targets in anticancer research due to their structural robustness, polymorphism, and gene-regulatory functions. Here, we presented the structure−activity relationship of carbazole-based monocyanine ligands using region-specific functionalization with benzothiazole (TCA and TCZ), lepidine (LC...
Article
Regulation of cancer stemness has recently emerged as a new gain-of-function (GOF) property of mutant p53. In this study, we identify miR-324-5p as a critical epigenetic regulator of cancer stemness and demonstrate its role in mediating GOF-mutant p53-driven stemness phenotypes. We report that miR-324-5p is upregulated in human cancer cell lines an...
Article
c-MYC is deregulated in triple negative breast cancer (TNBC) pointing to be a promising biomarker for breast cancer treatment. Precise level of MYC expression is important in the control of cellular growth and proliferation. Designing of c-MYC-targeted antidotes to restore its basal level of cellular expression holds an optimistic approach towards...
Article
Full-text available
Background and Aim Epithelial ovarian cancer has the deadliest prognosis amongstgynaecological cancers, warranting an unmet need for newer drug targets. Based onits anticancer as well as abortifacient potential, Moringa oleifera Lam. root washypothesized to have some implications in follicle stimulating hormone receptor(FSHR) dependent cancers like...
Article
Full-text available
Genome organization plays a crucial role in gene regulation, orchestrating multiple cellular functions. A meshwork of proteins constituting a three-dimensional (3D) matrix helps in maintaining the genomic architecture. Sequences of DNA that are involved in tethering the chromatin to the matrix are called scaffold/matrix attachment regions (S/MARs),...
Article
Full-text available
Down-regulation or loss of MHC class I expression is a major mechanism used by cancer cells to evade immunosurveillance and increase their oncogenic potential. MHC I mediated antigen presentation is a complex regulatory process, controlled by antigen processing machinery (APM) dictating immune response. Transcriptional regulation of the APM that ca...
Article
Full-text available
https://watermark.silverchair.com/mdy428.012.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAl8wggJbBgkqhkiG9w0BBwagggJMMIICSAIBADCCAkEGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMDRRzKQjcWTAuhnNkAgEQgIICElaVuUjfMJ_8vRDQYyJuxfygIA7ToLfqL2Y367Cfel0fDX0tB_PgzX1Yd4NzYcFHDViR0YFQRStmB2x4eQ-xTzQNhEyI8nfMo93bUy9lT18KInr7W_o53oweqGGoqmwS3ePTcR7ak4d...
Preprint
Full-text available
c-MYC proto-oncogene harbours a transcription-inhibitory quadruplex-forming scaffold (Pu27) upstream P 1 promoter providing anti-neoplastic therapeutic target. Previous reports showed the binding profile of human Cathelicidin peptide (LL37) and telomeric G-quadruplex. Here, we truncated the quadruplex-binding domain of LL37 to prepare a small libra...
Article
Full-text available
c-MYC proto-oncogene harbours a transcription-inhibitory quadruplex-forming scaffold (Pu27) upstream P1 promoter providing anti-neoplastic therapeutic target. Previous reports showed the binding profile of human Cathelicidin peptide (LL37) and telomeric G-quadruplex. Here, we truncated the quadruplex-binding domain of LL37 to prepare a small librar...
Article
Full-text available
A putative anticancer plant alkaloid, Chelerythrine binds to G-quadruplexes at promoters of VEGFA, BCL2 and KRAS genes and down regulates their expression. The association of Chelerythrine to G-quadruplex at the promoters of these oncogenes were monitored using UV absorption spectroscopy, fluorescence anisotropy, circular dichroism spectroscopy, CD...

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