Tan Khanh Nguyen

• Master of Pharmacy
• Dong A University

Objective Jatropha podagrica is extensively used in traditional medicine to cure several illnesses, including infectious and non-communicable diseases. This current study investigated the effects of extracts from different parts of this plant on the bacteria causing intestinal diseases, including Bacillus cereus, Escherichia coli, and Salmonella sp...

Objective This study focuses on evaluating the inhibitory activity of pongaglabrone and pongapin, isolated from Pongamia pinnata in our previous research, inhibit α-glucosidase, an enzyme involved in carbohydrate metabolism. Inhibition of α-glucosidase is a key target for controlling type 2 diabetes, making these compounds promising candidates for...

In the investigation of the cytotoxic activity against leukemia cells of Vietnamese medicinal plants, we identified the extract of Schima wallichii (DC.) Korth as capable of inhibiting several leukemia cell lines. In this study, we isolated a main compound as kaempferol-3-O-rhamnoside, marking the first report of this compound being isolated from t...

Deubiquitinating enzymes (DUBs) prevent ubiquitination by eliminating ubiquitin from their substrates. Deubiquitinating enzymes have important roles in a number of cell biology subfields that are highly relevant to diseases like neurodegeneration, cancer, autoimmune disorders, and long-term inflammation. Deubiquitinating enzymes feature a well-defi...

Kadsuric acid, a major triterpenoid isolated from the leaves of Vietnamese Kadsura coccinea (Lem.) A.C.Sm., Schisandraceae, exhibited potent cytotoxic effects in some human cancer cells. In this study, the effects of kadsuric acid on pancreatic cancer cells PANC-1 were investigated. The results showed that kadsuric acid exhibited dose-dependent cyt...

Poly ADP-ribose Polymerase 1 (PARP1) là enzym đóng vai trò quan trọng trong việc sửa chữa DNA, phiên mã và tái cấu trúc nhiễm sắc thể của tế bào. Việc tăng biểu hiện của PARP1 cho thấy sự liên quan đến việc ức chế sự phát triển của nhiều dòng tế bào ung thư khác nhau. Trong nghiên cứu này, hai phương pháp sàng lọc bao gồm xây dựng mô hình học máy v...

Kadsuric acid, a major triterpenoid isolated from the leaves of Vietnamese Kadsura coccinea , exhibited potent cytotoxic effects in some human cancer cells. In this study, the effects of kadsuric acid on pancreatic cancer cells PANC-1 were investigated. The results showed that kadsuric acid exhibited dose-dependent cytotoxicity against PANC-1 with...

In this study, a series of secondary metabolites from Ganoderma sp. were screened against Staphylococcus aureus protein targets, including as phosphotransacetylase, clumping factor A, and dihydrofolate reductase, using molecular docking simulations. The chemicals that showed the strongest binding energy with the targeted proteins were ganodermanont...

In this study, chemical components, α-glucosidase inhibitory activities, and molecular modelling studies of the essential oil extracted from the Cleistocalyx operculatus leaves were investigated. In total, thirty compounds were identified using GC/MS, representing 98.3% of the oil. Of these, the two most dominant constituents of the essential oil w...

Goniothalamus elegans Ast is a plant commonly used in traditional medicine for the treatment of heart disease and diarrhea. Although there has been one published study on its chemical composition, limited research has been conducted on its bioactivity. In this study, the aerial part of G. elegans was extracted using the soaking method and further s...

Introduction: Piper lolot is a species of herb used as a popular food in Vietnam. Furthermore, the species has been used as a Vietnamese traditional medicine to treat many diseases. Methods: Chemical constituents in the essential oil from leaves of Piper lolot were determined using GC/MS analysis. The anti-gout and anti-diabetic activities of th...

The potential targeting of xanthine oxidase (XO) for the treatment of gout has been explored through animal and human experiments. To identify potential XO inhibitors, a virtual screening method was utilized to examine fatty acids from Hedyotis pilulifera. Molecular docking results demonstrated that all possible configurations of the fatty acid 9,1...

Two styryl-lactone derivatives (1 and 2) were isolated from the aerial parts of Goniothalamus elegans. Compound 1 is a newly discovered natural product, and compound 2 is reported in this plant for the first time. The absolute configuration of 1 was determined based on the ECD spectrum. The two styryl-lactone derivatives were tested for cytotoxicit...

Background: Staphylococcus aureus is a nosocomial pathogen responsible for many serious infectious diseases in humans. Finding the anti- S. aureus agents is a time-consuming and costly process. Recently, computational methods have provided a better understanding of the interactions between herbal medicine drug targets to help clinical practitioners...

Methicillin-resistant Staphylococcus aureus (MRSA) is a critical pathogen responsible for a wide variety of serious infectious diseases in humans. The accelerated phenomena of drug tolerance, drug resistance, and dysbacteriosis provoked by antibiotic misuse are impeding the effectiveness of contemporary antibiotic therapies primarily used to treat...

Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease with limited treatment options. The widely distributed plant Aloe vera has shown protective effects against NASH in animals, yet the precise mechanism remains unknown. In this study, we investigated the potential mechanisms underlying the anti-NASH effects of Aloe vera...

Nghiên cứu của chúng tôi nhằm đánh giá khả năng ức chế sự phát triển tế bào ung thư của cây Goniothalamus elegans Ast và dự đoán cơ chế tác dụng của các hợp chất phân lập thông qua việc ức chế protein điều hòa quá trình đường phân và apoptosis của TP53 (TIGAR). Cao toàn phần, cao phân đoạn và hợp chất phân lập được thử nghiệm khả năng gây độc tế bà...

Cancer is a major health burden and a leading cause of death worldwide, with numerous new molecules being studied and developed as therapeutic agents. In this study, the cytotoxicity of compounds derived from Goniothalamus elegans was evaluated for possible anticancer activity. It was observed that the crude methanol extract of G. elegans exerted t...

Acetylcholinesterase (AChE) plays an essential role in the cholinergic pathways in Alzheimer's disease. This study used a deep learning model as a powerful virtual tool for discovering AChE inhibitors. The model showed 94.3% accuracy, 97.1% precision, 95.9% recall, and 86.2% specificity. A list of bioactive compounds extracted from Pongamia pinnata...

Members of the Ganodermataceae are used in traditional medicine in Asian countries. In Vietnamese Traditional Medicine, these mushrooms are used to treat several diseases since the 15th century. In this study, five new Ganodermataceae specimens as Ganoderma multiplicatum, Ganoderma sinense, 2 strains of Ganoderma lingzhi, and Amauroderma subresinos...

A machine learning algorithm-based model is a powerful tool for discovering candidate compounds on the breast cancer cell line MCF-7. Using the Lazy Predict Python package, the “Random Forest” algorithm indicates that the highest accuracy is 83.57% in discovering potential compounds. Essential oils from the leaves and stems of Ocimum basilicum, as...

Pogostemon Desf. includes a wide range of taxa found in subtropical and tropical areas. Few works, however, have studied microanatomical characteristics of Pogostemon species and as yet identified features of Pogostemon auricularius (L.) Hassk. Thus, in this paper, we examined the taxonomic implications of root, stem and leaf morphology for species...

Breast cancer is the leading cause of cancer mortality in women. In this study, liriodenine and lysicamine from Goniothalamus elegans Ast. were investigated for their anti-breast cancer activity based on their molecular interactions with three proteins related to breast cancer. Liriodenine had predicted binding affinities for BRCA1, BRCA2, and estr...

Aquilaria crassna Pierre ex Lecomte, Thymelaeaceae, is cultivated for producing resinous heartwood, also called agarwood. Its leaves are a source of herbal tea in Vietnam due to its rich content of polyphenols. However, the α-glucosidase inhibition activity and the contents of phenolic compounds in leaves of different ages have not yet been determi...

Xanthine oxidase (XO) is a potential target for gout disease experiments on animals and humans. Using a molecular docking technique to search for anti-XO compounds from Vietnamese medicinal plants, we discovered that numerous compounds from Uvaria cordata (Dunal) Alston (Annonaceae family) showed this activity. Among these, cordauvarin A exhibited...

Polymerase of influenza virus is made up of three subunits PB1, PB2, and PA, which are involved in viral genome transcription and replication. Purification of sufficient amounts of viral polymerase is essential to understand the catalytic function of viral polymerase. In this study, we generated a viral polymerase expression system in human embryon...

Bài thuốc “Kha tử cam cát thang” gồm 3 vị dược liệu: Cam thảo, Cát cánh và Kha tử, có tác dụng tuyên phế, chỉ khái, lợi hầu, khai âm, trị ho do cảm, khan tiếng, mất tiếng. Tiến hành khảo sát các yếu tố nhiệt độ, thời gian, tá dược để xây dựng công thức và quy trình bào chế cốm hòa tan bằng phương pháp xát hạt ướt. Cao đặc từ bài thuốc Kha tử cam cá...

The coronavirus outbreak of 2019 (COVID‐19) has been seen as a global health concern. The 3‐chymotrpsin‐like protease or SARS‐CoV‐2 main protease, whose ability to control the coronavirus replication, has been a promising target for developing drugs against coronavirus infection. In this study, we used the molecular docking approach to screen natur...

Herein, a novel fluorescent sensor has been developed for the detection of biothiols based on theoretical calculations of the stability constant of the complex between a Cu²⁺ ion and (E)-3-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)-7-(diethylamino) coumarin (BDC) as a fluorescent ligand. In this study, on the basis of density functional theory met...

In the present paper, the ZIF-67/g-C3N4 composite was synthesized and utilized as a modifier for a glassy carbon electrode for the simultaneous voltammetric determination of uric acid (URA) and acetaminophen (ACE) with cetyltrimethylammonium bromide (CTAB) as a discriminating agent. The composite was characterized using X-ray diffraction, scanning...