Tamara Lazarević-Pašti

Vinča Institute of Nuclear Sciences | VIN · Department of Physical Chemistry

With growing concerns regarding environmental pollution and the need for sustainable waste management practices, this study investigates the potential of utilizing spent coffee grounds (SCG) as a precursor for producing functional carbon materials aimed at organophosphorus pesticide remediation under environmentally relevant conditions. Carbonizati...

This chapter explores the integration of Molecularly Imprinted Polymers (MIPs) into electrochemical sensors, focusing on their applications as artificial antibodies in disease detection and monitoring. After discussing the basic principles of electrochemical sensors, we delve into the versatility of MIPs, which allow for the selective recognition o...

This chapter delves into the rapidly emerging field of molecularly imprinted polymers (MIPs) integrated into optical sensors, exploring their remarkable applications as artificial antibodies for disease detection and monitoring. We embark on the journey by elucidating the fundamental principles of optical sensors, emphasizing their unique ability t...

Efficient removal of different pollutants from the environment has become one of the most important challenges of modern society. The nitrogen-doped carbon cryogels (CCN) were synthesized and characterized using XPS. All investigated materials have similar composition and structural disorder. By analyzing XPS spectra, the content of carbon, oxygen,...

This study investigates using KOH-activated coffee grounds (KACGs) as an effective adsor-bent for removing organophosphorus xenobiotics malathion and chlorpyrifos from water. Malathion and chlorpyrifos, widely used as pesticides, pose significant health risks due to their neurotoxic effects and environmental persistence. Spent coffee grounds, abund...

Traditional medicine has used sage (Salvia officinalis L.) preparations for centuries to prevent and treat various inflammatory and oxidative stress-induced conditions. The aim of this in vitro study was to determine the bioactive properties of a sage leave extract obtained with environmentally friendly aqueous extraction and lyophilisation in prim...

The extensive utilization of the organophosphate pesticide chlorpyrifos, combined with its acute neurotoxicity, necessitates the development of effective strategies for its environmental removal. While numerous methods have been explored for chlorpyrifos removal from water, adsorption is the most promising. We investigated the potential of two cell...

Pesticides pose a significant threat to nontargeted organisms, and their pervasive use makes avoidance challenging. We employed nitrogen-doped carbon cryogels for the removal of organophosphate pesticides. The materials were synthesized and characterized using SEM, Raman spectroscopy, XPS, and BET analysis. Results revealed mesoporous cryogels with...

Citation: Milanković, V.; Tasić, T.; Leskovac, A.; Petrović, S.; Mitić, M.; Lazarević-Pašti, T.; Novković, M.; Potkonjak, N. Metals on the Menu-Analyzing the Presence, Importance, and Consequences. Foods 2024, 13, 1890. https://doi. Abstract: Metals are integral components of the natural environment, and their presence in the food supply is inevita...

Due to extensive food production, organophosphate pesticides (OPs) are widely utilized for crop protection, leading to their presence in the environment. The focus of this study was the design of an efficient aqueous biphasic system (ABS) strategy for OP removal, namely, malathion (MAL), azinphos-methyl (AZM), and chlorpyrifos (CHP) from water. Dif...

Environmental contamination from various industrial sources poses a significant global concern, demanding effective remediation strategies. This study investigates the efficacy of spent coffee grounds-derived carbon material in removing various contaminants, including organophosphate pesticides, pharmaceutical residues, and cationic dyes from aqueo...

Sustainable solutions for environmental remediation are of great interest due to the escalated release of toxic substances into the ecosystem. Here, Ca-impregnated pyro-hydrocarbon (Ca-SMS) was synthesized from spent mushroom substrate (SMS) via hydrothermal carbonization at a relatively low process temperature, followed by subsequent physicochemic...

We have synthesized 22 C-1 functionalized-N-aryl-1,2,3,4-tetrahydroisoquinoline derivatives showing biological activities towards cholinergic enzymes. Synthesis was performed using visible-light-promoted photo-redox chemistry, starting from a common intermediate, and the application of this synthetic methodology drastically simplified synthetic rou...

Organophosphorus neurotoxins (OPNs) are a class of chemical compounds widely known for their potent neurotoxic effects. OPNs work by inhibiting the enzyme acetylcholinesterase (AChE), which breaks down the neurotransmitter acetylcholine in the nervous system. This research investigates using spent coffee grounds carbonized at 900°C and subsequently...

Organophosphates are a class of compounds known for their use as chemical warfare agents. These agents have been utilized in military contexts due to their ability to act as nerve agents, disrupting the nervous system's function. However, beyond their military application, organophosphates pose significant risks to human health and the environment....

Efficient removal of different pollutants from the environment has become one of the most important challenges of modern society. The nitrogen-doped carbon cryogels were synthesized and characterized using XPS. All investigated materials have similar composition and structural disorder. By analyzing XPS spectra, the content of carbon, oxygen, and n...

Effective removal of various pollutants from the environment has become one of the most important challenges of modern society. Carbon cryogels doped with nitrogen were synthesized and characterized using FTIR. All investigated materials have similar composition and structural disorder. The application of carbon cryogels doped with nitrogen for ads...

The widespread use of the organophosphate pesticide chlorpyrifos, coupled with its acute neurotoxicity, underscores the urgent need for effective remediation strategies. Among the various methods explored for chlorpyrifos removal from water, adsorption has emerged as the most promising. We investigated the potential of two cellulose-derived porous...

Pesticides are extensively used in agriculture to enhance crop yield and combat pests and pose a significant threat to ecosystems and human health when their residues accumulate in soil and water. Conventional methods of pesticide removal are often costly or introduce secondary pollutants. The increasing worry about pesticides harming the environme...

Pesticides, whether synthetic or natural, are crucial in managing insects, and weeds, and influencing plant growth. However, the widespread use of organophosphates, a highly effective class of chemical pesticides, raises environmental concerns due to their slow biodegradation, resulting in ecosystem and food chain contamination. The inhibitory effe...

Widespread use of toxic organophosphate malathion raises the need to develop efficient procedures for its elimination from the environment. The acute neurotoxicity of malathion is associated with the irreversible inhibition of acetylcholinesterase, the enzyme involved in signal transduction in the nervous system. Its inhibition leads to different n...

Organophosphorus pesticides (OPs) are widely used in agriculture to control pests, but their residues pose significant environmental and health risks. In this study, the potential of spent coffee grounds (SCG) as a sustainable adsorbent for the remediation of organophosphorous pesticides, specifically malathion (MLT) and chlorpyrifos (CHP), was inv...

The removal of environmental pollutants is significant because of their harmful effects on living organisms. Biochar is favorable as a natural adsorbent of environmental pollutants due to its advantages, such as environmental acceptability and economic profitability. This study evaluated the potential of pyrolyzed plum pomace (PyrPP) as an adsorben...

In light of the escalating environmental concerns regarding pesticide accumulation, it is imperative to devise efficient strategies for their removal. Among the various options, activated carbons have emerged as promising candidates for adsorptive pesticide removal due to their many advantages, such as large surface area, well-developed porosity, a...

The extensive use of the toxic organophosphate chlorpyrifos underscores the need for effective methods to eliminate it from the environment. Chlorpyrifos's acute neurotoxicity stems from its irreversible inhibition of acetylcholinesterase, an enzyme crucial for signal transmission in the nervous system. This inhibition can lead to various neurologi...

In recent years, the extensive use of chlorpyrifos (CHP) and malathion (MLT), two common organophosphate (OP) insecticides, has raised concerns about their adverse effects on the environment and human health. These pesticides can contaminate water bodies, soil, and food, posing potential risks to non-target organisms and human populations. Therefor...

Coffee is one of the most popular beverages, with around 10.5 million tons manufactured annually. The same amount of spent coffee grounds (SCGs) might harm the environment if disposed of carelessly. On the other hand, pesticide contamination in food and biowaste is a rising problem. Because pesticides are hazardous and can cause serious health cons...

The increasing usage of pesticides to boost food production inevitably leads to their presence in food samples, requiring the development of efficient methods for their removal. Here, we show that carefully tuned viscose-derived activated carbon fibers can be used for malathion and chlorpyrifos removal from liquid samples, even in complex matrices...

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The Cover Feature shows a metal nanoparticle modified with the amino acid L-methionine and the ad-sorption of the enzyme acetylcholi-nesterase (AChE) on the methionine-capped nanoparticle surface. Methio-nine-capped Ag and Au nanopar-ticles (NPs) were tested as inhibitors of AChE, and they showed moderate inhibitory potential toward AChE. NPs are m...

Growing pollution is making it necessary to find new strategies and materials for the removal of undesired compounds from the environment. Adsorption is still one of the simplest and most efficient routes for the remediation of air, soil, and water. However, the choice of adsorbent for a given application ultimately depends on its performance asses...

The silver and gold L‐methionine capped nanoparticles (Ag and Au @LM NPs) were analyzed as prospective acetylcholinesterase (AChE) inhibitors to test their potential in the treatment of cognitive impairment in depression and Alzheimer's disease. The stability of NPs, and their ability to inhibit AChE were studied by UV‐Vis and FTIR spectrophotometr...

Organophosphates are mainly used as pesticides to protect crops from pests. Because or-ganophosphate pesticides' use has expanded dramatically worldwide, accurate monitoring of their concentrations in the environment and food has become of utmost importance. Once considered acutely toxic due to acetylcholinesterase inhibition, nowadays organophosph...

Alzheimer's disease (AD) is notorious as a cause of more than 60% of total dementia cases worldwide [1]. It is believed to be the most common cause of dementia nowadays. Currently, more than 44 million people live with AD worldwide [2]. If current trends are continued, rates could exceed 152 million by 2050 [3]. A progressive memory decline is the...

The increase of production and consumption persistently introduce different pollutants into the environment. The constant development and improvement of analytical methods for tracking environmental contaminants are essential. The demand for high sample throughput analysis has hit the spotlight for developing selective sensors to avoid time-consumi...

Due to the accumulation of pesticides in the environment, the development of efficient strategies for their removal is of utmost importance. Activated carbons are currently seen as excellent candidates for adsorptive pesticide removal based on several beneficial properties, like a large surface area, developed porosity, and low price. However, a de...

Widespread use of toxic organophosphate malathion raises the need to develop efficient procedures for its elimination from the environment. The acute neurotoxicity of malathion is associated with irreversible inhibition of acetylcholinesterase, the enzyme involved in signal transduction in the nervous system. Its inhibition leads to different neuro...

Organophosphates are widely used nowadays. They have applications as pesticides, drugs, plasticizers, flame retardants or chemical warfare agents. Their acute toxicity is ascribed to the inhibition of acetylcholinesterase, a key enzyme in the transmission of nerve impulses in animals. Their toxic effects manifest by acetylcholine accumulation in th...

The extensive application of a pesticide, such as malathion, is a potential risk to human health as it can easily enter the food chain. An efficient and economical method for pesticide removal from the environment is necessary. In this work, we prepared a carbon material derived from biowaste (rabbit litter) for the removal of malathion from water....

Organophosphate pesticides are used in large quantities. Once accumulated in the environment, they exhibit toxic effects on non-target organisms. Dimethoate, a frequently used insecticide, and its oxo-analog omethoate inhibit acetylcholinesterase and are toxic for mammals. However, under environmental conditions, they also undergo chemical transfor...

The study of the interactions between nanoparticles (NPs) and proteins has had a pivotal role in facilitating the understanding of biological effects and safe application of NPs after exposure to the physiological environment. Herein, for the first time, the interaction between L-methionine capped silver nanoparticles (AgMet), and bovine serum albu...

The release and accumulation of pesticides in the environment require the development of novel sustainable technologies for their removal. While adsorption is a classical approach, the design of new materials with enhanced adsorption properties could rationalize the remediation routes and decrease potential risks for their non-target organisms, inc...

One of the lessons we learned from the COVID-19 pandemic is that the need for ultrasensitive detection systems is now more critical than ever. While sensors' sensitivity, portability, selectivity, and low cost are crucial, new ways to couple synergistic methods enable the highest performance levels. This review article critically discusses the syne...

Organophosphates are the most widely used group of pesticides globally and are considered one of the most hazardous to vertebrates. The neurotoxic effects of high-level acute poisoning are well established and involve changes in peripheral, autonomic and central nervous system function. These events result in a constellation of physical, cognitive...

Organophosphates are widely used nowadays. They have applications as pesticides, drugs, plasticizers, flame retardants or chemical warfare agents. Their acute toxicity is ascribed to the inhibition of acetylcholinesterase, a key enzyme in the transmission of nerve impulses in animals. Their toxic effects are manifested by the accumulation of acetyl...

Organophosphates are widely used nowadays. They have applications as pesticides, drugs, plasticizers, flame retardants or chemical warfare agents. Their acute toxicity is ascribed to the inhibition of acetylcholinesterase, a key enzyme in the transmission of nerve impulses in animals. Their toxic effects are manifested by the accumulation of acetyl...

Extensive use of pesticides resulting in their accumulation in the environment presents a hazard for their non-target species, including humans. Hence, efficient remediation strategies are needed, and, in this sense, adsorption is seen as the most straightforward approach. We have studied activated carbon fibers (ACFs) derived from viscose fibers i...

Over the past few decades, number of cancer cases attributed to environmental and occupational carcinogens of asbestos, arsenic, pesticides, and indoor and outdoor air pollution in high-income countries decreased. For low- to middle-income countries, where industrialization expands, and populations grow, these exposures are expected to increase. St...

Organophosphate pesticides are used in large quantities. However, they exhibit toxic effects on non-target organisms. Dimethoate and its oxo-analog omethoate inhibit acetylcholinesterase and are toxic for mammals. Moreover, they show extreme toxicity for bees. Once in the environment, they undergo chemical transformations and decomposition. We show...

Extensive use of pesticides resulting in their accumulation in the environment presents a hazard for their non-target species, including humans. Hence, efficient remediation strategies are needed, and adsorption is seen as the most straightforward approach in this sense. We have studied activated carbon fibers (ACFs) derived from viscose fibers imp...

Extensive use of pesticides resulting in their accumulation in the environment presents a hazard for their non-target species, including humans. Hence, efficient remediation strategies are needed, and adsorption is seen as the most straightforward approach in this sense. We have studied activated carbon fibers (ACFs) derived from viscose fibers imp...

Acetylcholinesterase is a crucial player in the catalytic hydrolysis of cholinergic neurotransmitters. Recent studies have indicated that acetylcholinesterase is potentially a marker and a regulator of apoptosis, as well as a tumor suppressor with great potential. It was shown that the gene for acetylcholinesterase expression is usually decreased i...

Cover Story: Electrochemical sensors are sensitive, portable, fast, inexpensive, and suitable for online and in situ measurements compared to other methods. In this paper, we provide a survey of electrochemical sensors for the detection of water contaminants, i.e., pesticides, nitrate, nitrite, phosphorus, water hardeners, disinfectant, and other e...

Electrochemical sensors play a significant role in detecting chemical ions, molecules, and pathogens in water and other applications. These sensors are sensitive, portable, fast, inexpensive, and suitable for online and in-situ measurements compared to other methods. They can provide the detection for any compound that can undergo certain transform...

Introduction Alzheimer’s disease and depression are health conditions affecting millions of people around the world. Both are strongly related to the level of the neurotransmitter acetylcholine. Since cholinergic deficit is characteristic of Alzheimer’s disease, acetylcholinesterase inhibitors are applied as relevant drugs for the treatment of this...

(1) Background: The development of highly efficient methods for removing hazardous substances from the environment attracts increasing attention. Understanding the basic principles of the removal processes using graphene materials is equally essential to confirm their application efficiency and safety. (2) Methods: In this contribution, adsorption...

The extensive use of pesticides requires innovative approaches to remediate these compounds from the environment. Carbon materials are traditionally used as adsorbents for removing pesticides, and the development of new families of carbon materials allows more advanced approaches in environmental applications. Using Density Functional Calculations,...

Investigations of interactions of highly toxic substances with various materials by methods of theoretical chemistry are of considerable interest for prediction of their behavior, as it is difficult to investigate experimentally. In this contribution, adsorption of two hazardous organophosphate compounds-dimethoate and sarin-on graphene, has been i...

Investigations of interactions of highly toxic substances with various materials by methods of theoretical chemistry are of considerable interest for prediction of their behavior, as it is difficult to investigate experimentally. In this contribution, adsorption of two hazardous organophosphate compounds – dimethoate and sarin – on graphene, has be...

Organophosphates (OPs) are widely used nowadays. They have an application as pesticides, drugs or chemical warfare agents. Their acute toxicity is ascribed to the inhibition of acetylcholinesterase (AChE), a key enzyme in the transmission of nerve impulses in mammals. Mentioned toxic effect is manifested by the accumulation of acetylcholine and can...

Acetylcholinesterase (AChE) inhibitors are important in the treatment of neurodegenerative diseases. Two inhibitors, 12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate (POM) type structure, have been shown to inhibit AChE activity in nM concentration. Circular dichroism and tryptophan fluorescence spectros...

Esters of organophosphorus acids (OPs) are widely used nowadays. They have an application as pesticides, drugs, or chemical warfare agents. Their acute toxicity is ascribed to the inhibition of acetylcholinesterase (AChE), a key enzyme in the transmission of nerve impulses in mammals. Their toxic effects are manifested by the accumulation of acetyl...

Dimethoate (DMT) is an organophosphate pesticide, which is widely used against insects and mites and their control in agriculture. As other organophosphates, DMT is also an inhibitor of acetylcholinesterase, which is responsible for the disabling of cholinesterase required for the functioning of the central nervous system. This pesticide can invade...