Tamara Athamneh

Jordan University of Science and Technology | Just · Nanotechnology Center

Objectives: Nanosuspensions are increasingly recognized as a valuable technology for enhancing poorly water-soluble drugs' solubility and dissolution rate, thereby improving their bioavailability. In this study, we employed ultrasonic-assisted precipitation to fabricate nanosuspensions of indomethacin (IND), utilizing Soluplus® (Sol) as a stabiliz...

Despite the broad spectrum of the antibiotic Azithromycin, its extremely bitter taste after oral dosing decreases patient compliance. This bitter taste can be masked by minimizing Azithromycin interaction with the tasting buds using polymers that are insoluble at salivary pH (6.8–7.4), like the cationic polymers Eudragit EPO and Eudragit S100. The...

Background/Aims As healthy gut flora contributes to mammalian health, the focus of this study is to investigate the effect of the combination of (Uridine, Cytidine, and Zinc) compared to individual supplements on the diversity of gut microbiota in healthy rats, and on other clinical parameters. Methods The 16S rRNA gene sequencing was used to stud...

Probiotics are a mixture of beneficial live bacteria and/or yeasts that naturally exist in our bodies. Recently, numerous studies have focused on the immunostimulatory effects of single-species or killed multi-species probiotic conditioned mediums on macrophages. This study investigates the immunostimulatory effect of commercially available active,...

The use of bio-based raw materials in the manufacture of customized aerogels has increased significantly over the last decade. Combining the advantages of biopolymer sustainability and lower costs when producing aerogels in particulate form, agar aerogel particles were fabricated in this study. They were prepared by successive thermal gelation, eth...

Glioblastoma (GBM) is the most aggressive brain tumor. Despite the intensive treatment and interventions, the median survival of GBM patients remains short. The complex molecular biology underlying GBM, the presence of the brain-blood barrier (BBB), and the existence of a population of stem-like cells responsible for tumor recurrence all contribute...

Background: Probiotics are a mixture of good live bacteria and/or yeasts that naturally survive in our bodies. Recently, loads of studies have focused on their role in the immune system and digestive tract. Accordingly, there are many commercially available probiotic products in the market. This study examines the immunostimulatory effect of commer...

Probiotics are a mixture of beneficial live bacteria and/or yeasts that naturally survive in our bodies. Recently, loads of studies have focused on their role in the immune system and digestive tract. This study examines the immunostimulatory effect of commercially available-probiotic conditioned medium (CM) on RAW264.7 murine macrophages. Probioti...

A screen-printed carbon electrode was used to develop a biosensor with an improved response and selectivity for detecting human epidermal growth factor receptor 2 (HER2). To investigate the performance of the biosensor, electrochemical characterizations such as impedance spectroscopy, differential pulse and cyclic voltammetry were used, in addition...

Aerogels, especially bio-based ones, present a promising option for wound dressing; specifically, because of their low toxicity, high stability, bio-compatibility, and good biological performance. In this study, agar aerogel was prepared and evaluated as novel wound dressing material in an in vivo rat study. Agar hydrogel was prepared by thermal ge...

Nanoliposomes are lipid bilayer nanostructures recently gaining popularity as drug delivery vehicles. Their biocompatibility, safety, high entrapment efficiency and drug release profiles have made them suitable candidates for biomedical applications. The treatment of fungal infec-tions is one of the most significantly researched fields in which nan...

In this study, the effect of titanium dioxide (TiO2) nanoparticles and ciprofloxacin (CIPRO) addition to Polydimethylsiloxane (PDMS) was investigated in terms of enhancement of the antibacterial activity and hydrophobicity. The nanocomposite of PDMS loaded with TiO2 nanoparticles and CIPRO was prepared by mixing the TiO2 nanoparticles and/or CIPRO...

The present study evaluates the effect of calcium alginate aerogel as a potential drug carrier, on the liver and kidney functions, and on the gut microbiota of Wistar rats. The studied alginate aerogel was prepared in the form of nanoparticles using the jet cutting technique, and they were characterized in terms of specific surface areas, outer mor...

In the present study the aerogel technology was used to prepare pulmonary drug carriers consisting of alginate and alginate-hyaluronic acid by an emulsion gelation technique and supercritical CO2 drying. During the preparation process, the emulsification rate and inner phase viscosity were varied to control the diameter of aerogel microspheres. Res...

Polyurea-crosslinked calcium alginate (X-Ca-alginate) and chitosan (X-chitosan) aerogel beads have been prepared via reaction of an aliphatic triisocyanate (Desmodur N3300) with the –OH groups of calcium alginate or the –NH2 groups of chitosan preformed wet gels, forming surface urethane or urea groups, respectively, and the subsequent formation of...

The aim of the present study was the preparation of aerogel microspheres based on alginate and hyaluronic acid for the potential application in pulmonary drug delivery. Both polymers are commonly used in the pharmaceutical and medical fields because of their nontoxicity, biodegradability and biocompatibility characteristics. The bio-based microsphe...

Levodopa is a promising candidate for administration via the transdermal route because it exhibits a short plasma half-life and has a small window of absorption in the upper section of the small intestine. The aim of this study was to prepare stable levodopa transdermal patches. Both xanthan gum and Carbopol 971 polymers were selected with ethylcel...