Tamanna Mallick

Indian Institute of Science Education and Research Kolkata · Department of Chemical Sciences

A Cu(I)‐catalyzed 1,3 oxo alkylation of indazole has been developed for constructing N‐1‐alkylated indazolone derivatives. This cascade reaction involves the formation of C−N and C−O bonds through the sequential functionalization of N1 and C3 positions of indazole in 41–89% yields. The photo‐physical studies of the synthesized compounds showed effi...

Fluorescent semiconductor nanocrystals (also known as quantum dots or QDs) have become monumental over the past two decades in the material science as well as biomedical field due to their tunable optical properties. Moreover, the exclusive nature of QDs has always kept it one step ahead of conventional organic fluorophores, particularly in cell im...

Quantum dots (QDs) are a popular agent to use in a wide range of scientific and industrial applications because the molecules consist of an excellent biophysical and optical property, later varies with the compositions from a wide range of visible to infrared wavelength. Being an established fluorescent probe QDs are useful in the long-term, multip...

An organic-inorganic nanohybrid system (AMC-CdS QD) comprised of a fluorescent carbazole analog, AMC (3-amino-N-methyl carbazole), and CdS QDs has been synthesized, which shows promise as a sustainable energy harvesting material. FT-IR and ¹H NMR spectroscopy have ascertained the covalent grafting of the carbazole moieties onto the mercaptopropioni...

We explored the anticancer activity of two synthetic flavonoid-based small molecules, HMDC and HMDF, with bioactive methylenedioxy functionality. HMDF inhibited the proliferation of the p53 wild-type (NCIH460 and A549), and p53 null (NCIH1299) non-small cell lung cancer and breast cancer (MCF-7) cells more potently than HMDC without significant cyt...

We report here an easily implementable, economic and eco-friendly synthetic protocol for the antioxidant (DMAHF/DHF, 3-hydroxyflavone analogs)-wrapped fluorescent graphene oxide (GO). The antioxidant activity of DMAHF was further exploited to reduce GO; whereby DMAHF was oxidized. The mechanistic pathway of this rGO (reduced GO)-synthesis and its c...

Molecular docking studies were done to show the inhibitory effect of two naturally occurring biflavone based anti-HIV agents, hinokiflavone and robustaflavone against the SARS-CoV-2 spike (S) protein mediated attack on the human ACE2 receptors via membrane fusion mechanism. Nefamostat, a FDA approved drug, well-known as a serine protease inhibitor...

4'-N,N-Dimethylamino-3-hydroxyflavone (DMAHF), a synthetic fluorescent flavone analogue with potent antioxidant activity, was explored as a molecular rotor-like fluoroprobe for amyloid aggregations, a causative factor in Alzheimer's disease, Parkinson's disease, type-2 diabetes, etc. During its interactions with (human) insulin amyloid aggregation...

Carbazole based small molecules are noteworthy due to their wide-spectrum of biological activities and characteristic fluorescence properties. Herein, a carbazole based bio-friendly fluorophore, 3-formyl-9-methylcarbazole (3) was covalently anchored on the APTES-modified silica nanoparticle surface which adorned a characteristic fluorescence activi...

The binding interactions between acetylcholinesterase (AChE) and a series of antioxidant flavonoid analogs were studied by fluorescence spectroscopic assay. The present study incorporated different classes of naturally occurring and synthetic flavonoid compounds like flavones, isoflavones, and chalcones as well as a few standard antioxidants. The A...

A synthetic fluorescent antioxidant flavone analog, 4′-N,N-dimethylamino-3-hydroxy flavone (DMAHF) was successfully explored as the green multifunctional agents for the synthesis of stable monometallic Au and Ag and bimetallic Au/Ag alloy nanoparticles with tailor-made morphologies. The synthesis of these nanoparticles were done in three types of s...

Background We have done a systematic study on the antioxidant activity of the methanol and petroleum ether (60-80°C) extracts (MEC and PEC respectively) of Curry leaves (Murraya koenigii Spreng. Family: Rutaceae) using various in-vitro chemical methods. Methods Both of these two extracts were found to be highly efficient in the formation of Ag and...

Six structurally different carbazoles (1-6) were explored as the green reducing agents for the synthesis of the fluorescent Au nanoparticles with tailor-made morphology in anionic (sodium dodecyl sulphate, SDS), cationic (cetyltrimethylammonium bromide, CTAB) and neutral (polyvinylpyrrolidone, PVP) micelle medium. Structure of the carbazoles played...

Spectroscopic, viscometric and molecular docking studies were done to ascertain the occurrence and nature of binding interactions between 4′-N,N-dimethylamino-3-hydroxyflavone (DMAHF), a potent antioxidant flavone analog having intrinsic fluorescence activity and calf thymus deoxyribonucleic acid (ctDNA) in Tris-HCl buffer (pH 7.4) medium. Results...

There is an overwhelming demand for the eco-friendly and cost-efficient synthetic protocols for graphene, reduced graphene oxide and other graphene based products with tailor-made structural properties. In the recent times, various green chemical synthetic methods attracted the interest of the researchers working in the field of graphene-nanochemis...

The visible fluorescent chromophoric moiety present in the water-soluble photoactive yellow protein (PYP) of Ectothiorhodospira halophila is p-hydroxycinnamic acid linked to the cysteine residue (Cys-69) by a thioester bond and it controls the key photoinduced biological processes of the host organism. In the present work, we have synthesized and c...

Two protocols based on (1) the use of leaves of Indian Curry leaf plant (Murraya koenigii Spreng.) as the green adsorbent for toxic organic dye and (2) the use of monometallic Au and Ag nanoparticles (NPs) and bimetallic Ag/Au NPs (synthesized by the aqueous extract of leaves of Indian curry leaf plant) as the green catalysts for the toxic organic...