Talia Novos

Talia Novos
Prince of Wales Hospital and Community Health Services | POWH · Clinical Chemistry

BSc (Biochemsitry), MND Nutrition and Dietetics

About

18
Publications
522
Reads
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42
Citations
Citations since 2016
14 Research Items
42 Citations
201620172018201920202021202202468101214
201620172018201920202021202202468101214
201620172018201920202021202202468101214
201620172018201920202021202202468101214

Publications

Publications (18)
Article
Full-text available
ABSTRACT Cytomegalovirus infection during antiviral prophylaxis occurs in transplant recipients despite individualized regimens based on renal function. Fifty kidney transplant recipients were assessed between 2016 and 2019 for valganciclovir dosing, ganciclovir exposure, cytomegalovirus infection, and genotypic resistance markers during the first...
Article
Background Plasma-free normetanephrine and metanephrine (metanephrines) are the recommended biomarkers for testing of pheochromocytoma and paraganglioma (PPGL). This study evaluated the status of harmonization of liquid chromatography-tandem mass spectrometry-based measurements of plasma metanephrines and methoxytyramine and clinical interpretation...
Article
Full-text available
Context Germline mutations in the succinate dehydrogenase genes (SDHA/B/C/D, SDHAF2 - collectively, SDHx) have been implicated in paraganglioma (PGL), renal cell carcinoma (RCC), gastrointestinal stromal tumor (GIST) and pituitary adenoma (PA). Negative SDHB tumor staining is indicative of SDH-deficient tumors, usually reflecting an underlying germ...
Article
Metabolomics refers to the detection and measurement of small molecules (metabolites) within biological systems, and is therefore a powerful tool for identifying dysfunctional cellular physiologies. For pheochromocytomas and paragangliomas (PPGLs), metabolomics has the potential to become a routine addition to histology and genomics for precise dia...
Article
Full-text available
Objective Mutations of genes encoding the four subunits of succinate dehydrogenase (SDH) have been associated with pheochromocytoma and paraganglioma (PPGLs), gastrointestinal stromal tumors (GISTs) and renal cell carcinomas (RCCs). These tumors have not been characterized in a way that reflects severity of SDH dysfunction. Mass spectrometric analy...
Data
ROC curve for discriminating SDH-deficient PPGLs from SDH-sufficient PPGLs according to succinate:fumarate ratio. Arrow marks cut-off (highest sensitivity and specificity) value. Area under the curve was equal to 0.80.
Data
ROC curve for discriminating SDH-deficient GISTs from SDH-sufficient GISTs according to succinate:fumarate ratio. Arrow marks cut-off (highest sensitivity and specificity) value. Area under the curve was equal to 1.0.
Data
FFPE specimens from 18 cases of PPGLs, 10 cases of GISTs and 11 cases of RCCs with known mutation status.
Data
ROC curve for discriminating SDH-deficient RCCs from SDH-sufficient RCCs according to succinate:fumarate ratio. Arrow marks cut-off (highest sensitivity and specificity) value. Area under the curve was equal to 1.0.
Data
PPGL FFPE specimens with false-negatives and false-positive succinate:fumarate ratios.
Data
Scatter plot comparing succinate:fumarate ratio between SDH-sufficient PPGLs with VHL mutation (n = 3) and SDH-deficient PPGLs (n = 9), error bars representing SEM from mean (p > 0.05).
Poster
Succinate dehydrogenase (SDH) is a crucial enzyme, catalysing the oxidation of succinate to fumarate in the Krebs cycle. Mutations affecting any of the genes that encode the SDH complex have been associated with the development of a number of tumours, including phaeochromocytomas, paragangliomas, gastrointestional stromal tumours and renal cell car...
Poster
We have developed a rapid, online (SPE) LC-MSMS method, using deuterated internal standards for the simultaneous measurement of mercaptopurine metabolites (6-TGN and 6MMP), which has a faster sample run time, a lower limit of quantitation (LOQ) and greater precision, than previously proposed HPLC methods.
Poster
Accurate measurement of Troponin (Tn) is essential as increased and a rising or falling pattern of Tn results have become part of the universal definition of acute myocardial infarction (AMI). With the introduction of the so-called ‘high-sensitivity’ Troponin (hs-Tn) assays and the 99th percentile of a reference population used as decision threshol...
Poster
External quality assurance programs (QAP) have demonstrated marked inter-laboratory imprecision of immunosuppressant assays by LC-MS/MS in whole blood. The problem was most probably due to the use of non-isotopic internal standards. We assessed the impact of now readily available stable isotope internal standards on the performance of LC-MS/MS assa...
Poster
Troponin (Tn) testing has become part of the universal definition of acute myocardial infarction. Due to the urgency of diagnosis and pressure on emergency departments (ED), there is increasing demand for point-of-care (POC) solutions for TnT testing to achieve rapid triage and fast turn-around time for clinical decision-making and to reduce the le...

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