Talha Bin Emran

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Verified

Talha verified their affiliation via an institutional email.

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• Doctor of Philosophy (Ph.D.)
• Post Doc Research Trainee at Feinstein Institute for Medical Research

Acute mountain sickness (AMS), high-altitude pulmonary edema (HAPE), and high-altitude cerebral edema (HACE) are three common forms of altitude sickness. These conditions can be life-threatening, with symptoms like fatigue, dizziness, and headaches. Ascending to high elevations increases the likelihood of developing these conditions, with some indi...

Gastrointestinal stromal tumors (GISTs) present unique diagnostic and therapeutic challenges. This review highlights advancements facilitated by molecularly targeted therapies like imatinib for advanced, metastatic, and high-risk GISTs, underscoring their neoadjuvant/adjuvant utility and the importance of multidisciplinary care. Emerging avenues, i...

Interpretability of results remains challenging in most health industries since patients may suffer life-threatening consequences from an inaccurate diagnosis. Artificial intelligence (AI) integration has arisen as a prominent technology in the healthcare sector, transforming the field by advancing early diagnostics, surgeries, and ethical concerns...

Background Diabetes mellitus (DM) is a prevalent chronic metabolic condition characterized by high blood sugar levels, resulting from insufficient insulin production or ineffective insulin use, posing substantial global health issues. Research on the relationship between glycemic status and the ratio of neutrophils to lymphocytes (NLR) and monocyte...

Surgical site infections (SSIs) linger to be among the supreme severe concerns facing today's health care system, triggering significant morbidity and mortality for patients while aggregating the overall budget of health care delivery. According to the Centers for Disease Control and Prevention (CDC), SSI is defined as the infections that arise loc...

Background: The approval of Sucrose Fatty Acid Esters (SFAEs) as food additives/ preservatives with antimicrobial potential has triggered enormous interest in discovering new biological applications. Accordingly, many researchers reported that SFAEs consist of various sugar moieties, and hydrophobic side chains are highly active against certain fun...

Breast cancer remains a leading cause of mortality among women aged 45-55, driven by factors such as hormonal imbalances, iodine deficiency, and aging. Significant side effects and collateral damage to healthy tissues limit the effectiveness of current treatments, such as surgery, chemotherapy, and radiation therapy. Tandyukisin, a marine-derived c...

The progressive nature of neurodegenerative diseases (NDs), such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis, presents substantial problems because current treat- ments are still obscure. Stem cell-based treatments are emerging as a viable solution to address the significant gaps in treating...

SIRT3 modulates reactive oxygen species and helps to reduce oxidative stress, resulting in a neuroprotective effect in Parkinson’s disease. The work seeks to develop and synthesize novel, effective SIRT3 modulators, which will modify SIRT3 expression and generate the neuroprotective effect by downregulating reactive oxygen species. The synthesis of...

Kyasanur Forest Disease (KFD) is a zoonotic disease primarily found in India, spread by Haemaphysalis ticks and caused by the Kyasanur Forest Disease Virus (KFDV) from the Flavivirus genus. Signs and symptoms of the KFD are high body temperature, muscle pain, gastrointestinal issues, and hemorrhages, with a mortality rate of 3% to 5%. Changes in th...

The contamination of water by toxic, non-biodegradable dyes like malachite green (MG) presents serious environmental and health risks, demanding effective and sustainable removal strategies. This study explores the adsorption of MG from aqueous solutions using silver nanoparticles (AgNPs) as adsorbents. The synthesized AgNPs were characterized usin...

Naturally occurring coumarin compounds with the typical benzopyrone framework are found in remarkable concentrations in plants. Moreover, they have also been found in animals, microbes, and other sources. The versatility of the coumarin scaffold extends beyond medicinal chemistry, with applications in agrochemistry, cosmetics, and fragrances. Howev...

Bariatric and metabolic surgery (BMS) is a very effective intervention for obesity and obesity-related metabolic disease. Widespread availability of surgery worldwide has resulted in many patients traveling abroad for medical care outside of their home healthcare systems, most frequently choosing bariatric and metabolic surgery medical tourism (BMS...

The adsorption of phenol and Pb2+ from aqueous solutions was achieved using calcined animal waste (cow dung) as a low-cost adsorbent. Fourier transform infrared analysis confirmed the involvement of hydroxyl, carbonate, and possibly silicate functional groups in the adsorption process. Scanning electron microscope images revealed the presence of di...

Neurodegeneration is the progressive loss of neurons that results in neurodegenerative diseases (NDs). Currently, there are few effective treatments for NDs, such as Alzheimer’s disease, Parkinson’s disease, Multiple sclerosis, and Huntington’s disease, which involve gradual neuronal death and cognitive deterioration. Alkaloids are naturally occurr...

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic involvement, inflammation , and the destruction of synovial joints. RA can be categorized as anti-citrullinated protein antibodies-positive or negative based on genetic risk factors and autoantibodies. This review systematically sourced articles related to RA, phyto...

Programmed necrosis, a controlled cell death method that bypasses resistance mechanisms that render apoptosis ineffective, is a potential cancer treatment target. Due to their diverse biological activities and low side effects, natural products are being explored as modulators of programmed necrosis pathways. This review highlights the potential of...

Neurodegenerative diseases (NDs) exhibit significant global public health challenges due to the lack of effective treatments. Berberine (BBR), a natural alkaloid compound in various plants, has been recognized for its potential neuroprotective properties. This review explores the current understanding of BBR's mechanisms of action and its therapeut...

The Oropouche virus (OROV) is an important emerging zoonotic Orthobunyavirus under the family Peribunyaviridae of order Bunyavirales. The OROV is transmitted through sylvatic and urban cycles by biting midge Culicoides paraensis as primary vector and circulating in South and Central America. The OROV has been implicated in more than 30 epidemics wi...

Robotic-assisted bariatric surgery has emerged as a game- changing approach to weight loss therapies, with significant improvements in precision and patient safety above standard laparoscopic procedures. The use of robotic platforms as an adjunct for bariatric surgeries has been connected with a range of outcomes, including operating time, complica...

Transient Receptor Potential Vanilloid 3 (TRPV3) is a thermosensitive calcium-permeable ion channel and has a function in sensory perception, epidermal barrier function, inflammation, and keratinocyte proliferation. TRPV3 dysfunction is linked with chronic pain, atopic dermatitis, and neurodegenerative disorders. This study compared the binding eff...

Sawmill wood waste products were used for the biosorption of nickel ions (Ni(II)) from aqueous solution in batch experiments. Effects of physical parameters such as contact time, initial metal concentration, biosorbent dosage, temperature, and pH on the biosorption capacities of both acid-activated sawmill wood waste products (ASWWP) and unactivate...

Cancer remains a leading cause of mortality globally, necessitating ongoing research and development of innovative therapeutic strategies. Natural products from plants, herbs, and marine species have shown great promise as anti-cancer therapies due to their bioactive components that alter cellular pathways, particularly apoptosis. This review explo...

Flavonoids in fruits, vegetables, and plant-based drinks have potential neuroprotective properties, with clinical research focusing on their role in reducing oxidative stress, controlling inflammation, and preventing apoptosis. Some flavonoids, such as quercetin, kaempferol, fisetin, apigenin, luteolin, chrysin, baicalein, catechin, epigallocatechi...

Artemisia campestris subsp. campestris (tuguft) is a medicinal plant traditionally used in Algerian medicine. This study investigates the chemical composition and bioactivity of its essential oil (ACEO). Gas chromatography-mass spectrometry (GC-MS) analysis identified key compounds, including linalyl acetate (2.92%), geranyl acetate (2.45%), and eu...

Acquired immune deficiency syndrome (AIDS) is the name used to describe several potentially life‐threatening infections and disorders that happen when HIV has severely compromised the immune system. The primary effect of HIV is to decrease host immunity, exposing the host to external pathogens. The development of pharmaceutical drugs that directly...

Background Neurodegenerative diseases (NDs), including Alzheimer‘s disease, Parkinson‘s disease, and Huntington‘s disease, are complex and challenging due to their intricate pathophysiology and limited treatment options. Methods This review systematically sourced articles related to neurodegenerative diseases, neurodegeneration, quercetin, and cli...

The increasing incidence of neurodegenerative diseases (NDs) and the constraints of existing treatment methods have spurred a keen interest in investigating alternative therapies. Medicinal plants, renowned for their long‐standing use in traditional medicine, offer a hopeful avenue for discovering new neuroprotective agents. This study emphasizes t...

Polyphenols, a diverse group of naturally occurring compounds found in plants, have garnered significant attention for their potential therapeutic properties in treating neurodegenerative diseases (NDs). The Wnt/β‐catenin (WβC) signaling pathway, a crucial player in neurogenesis, neuronal survival, and synaptic plasticity, is involved in several ce...

Pyridine and its derivatives are six-membered aromatic rings containing nitrogen, which are abundant in nature and indispensable in studying heterocyclic chemistry. They constitute significant chemical substances with numerous applications. The application of pyridine derivatives by incorporating metals in modern medicine is growing in relevance. D...

Introduction: Presently, the development of effective vaccines against SARS-CoV-2 is absolutely necessary, especially regarding the emerging of new variants that cause increasing fatalities. Methods: In the present study we designed a mosaic vaccine targeting the mutational spike protein of coronavirus disease 2019 (COVID-19) using a bioinformatics...

In treating type 2 diabetes, avoiding glucose reabsorption (glucotoxicity) and managing hyperglycemia are also important. A metabolic condition known as diabetes (type-2) is characterized by high blood sugar levels in comparison to normal Bilosomes (BLs) containing Dapagliflozin (Dapa) were formulated, optimized, and tested for oral therapeutic eff...

The study explored the efficacy of Salvia chudaei ethanolic extract in managing hyperlipidemia, hyperglycemia, and oxidative stress induced by Triton X‐100 in Wistar rats. Twenty‐four rats were divided into four groups: Control, Salvia chudaei‐treated, Triton‐induced hyperlipidemic, and a combination of Triton + Salvia chudaei treatment. Triton X‐1...

Gastrointestinal stromal tumors (GISTs) present unique diagnostic and therapeutic challenges. This review highlights advancements facilitated by molecularly targeted therapies like imatinib for advanced, metastatic, and high-risk GISTs, underscoring their neoadjuvant/adjuvant utility and the importance of multidisciplinary care. Emerging avenues, i...

This paper explores the potential of generative artificial intelligence (AI) to transform higher education. Generative AI is a technology that can create new content, like text, images, and code, by learning patterns from existing data. As generative AI tools become more popular, there is growing interest in how AI can improve teaching, learning, a...

This study investigates the wound‐healing potential of Euphorbia guyoniana latex (EGL) in male Wistar rats, along with its biochemical composition and biological activities. Phytochemical analysis identified moderate levels of phenolics, flavonoids, and tannins, with HPLC revealing five phenolic compounds. EGL demonstrated strong antioxidant activi...

The growing threat of pollution to global health extends far beyond respiratory and cardiovascular diseases, affecting even our eyes. With increasing industrialization, urbanization, and environmental changes, pollutants have become a major risk factor for ocular health. Airborne contaminants, including particulate matter (PM), ozone (O₃), nitrogen...

The worldwide organ scarcity dilemma is being made worse by some of the recent advances in 3D bioprinting, which offer revolutionary opportunities for the repair of organs and tissues. The method enables the accurate manufacturing of biological tissues by stacking bioinks including cells, biomaterials, and growth factors. Unlike traditional organ t...

Neurological diseases (NDs), including neurodegenerative disorders and acute injuries, are a significant global health concern. The PI3K/Akt/mTOR pathway, a crucial signaling cascade, is responsible for the survival of cells, proliferation, and metabolism. Dysregulation of this pathway has been linked to neurological conditions, indicating its pote...

Cancer progression is primarily driven by the uncontrolled activation of cellular signaling pathways, with the PI3K/Akt/mTOR (PAMT) pathway playing a central role. This pathway significantly contributes to the proliferation and survival of cancer cells, and its hyperactivity is a major challenge in managing several types of malignancies. This artic...

Neurodegenerative diseases (NDs) are caused by the gradual decline of neuronal structure and function, which presents significant challenges in treatment. Cellular stress responses significantly impact the pathophysiology of these disorders, often exacerbating neuronal damage. Plant-derived flavonoids have demonstrated potential as neuroprotective...

Complex coronary lesions present formidable challenges in interventional cardiology, necessitating innovative approaches for effective management. From myocardial bridging (MB) to ostial lesions and bifurcations, each poses unique anatomical and physiological hurdles. Despite advancements in coronary interventions, addressing these lesions remains...

Background: Oral traditional knowledge disseminates the use of young leaves of Vernonanthura tweediana (Asteraceae) as poultice in feverish cases among family farmers in Santa Catarina, Brazil, but there is a lack of phytochemistry and pharmacological studies on this species, especially those related to volatile organic compounds. Methods: In the p...

This study investigates the wound-healing potential of Euphorbia guyoniana latex (EGL) in male Wistar rats, along with its biochemical composition and biological activities. Phytochemical analysis identified moderate levels of phenolics, flavonoids, and tannins, with HPLC revealing five phenolic compounds. EGL demonstrated strong antioxidant activi...

New emerging trends in postoperative care are increasingly focused on using technology to enhance patient outcomes, minimize postoperative complications, and shorten hospital stays. Telemedicine and remote monitoring technologies must be considered the most significant advancements. Telemedicine offers virtual follow-up visits, reducing hospital re...

From initial planning to postoperative care, artificial intelligence (AI) is improving heart surgery at every step. Machine learning models that anticipate patient-specific risks, including mortality and sequelae, are used in the preoperative phase of AI for the purpose of risk assessment and stratification. These algorithms consistently outperform...

The imidazole scaffold is a cornerstone in medicinal chemistry, widely recognized for its extensive range of biological activities and ability to form stable metal complexes. This review article provides a detailed overview of recent advancements in synthesizing, characterization, and biological evaluation of metal-complexed imidazole derivatives....

Wound healing is a multifaceted, complex process that factors like aging, metabolic diseases, and infections may influence. The potentiality of polyphenols, natural compounds, has shown anti-inflammatory and antimicrobial properties in promoting wound healing and their potential applications in wound management. The studies reviewed indicate that p...

Robotic microsurgery is changing the way surgeons repair fragile tissues like nerves and blood arteries, where accuracy is vital. The conventional manner of microsurgery is restricted by the surgeon’s ability to handle precise motions, since little tremors in control may quickly lead to blunders in suturing or reattaching tiny vessels. Robotic tech...

Introduction and Importance: Bartter syndrome is a rare autosomal recessive disorder affecting renal tubular function, leading to electrolyte and volume homeostasis disturbances. It can also manifest as Bartter-like syndrome, a rare side effect of certain medications. Polymyxin-B, used to treat multidrug-resistant infections, is infrequently assoc...

Background Paroxysmal atrial fibrillation (PAF) significantly impacts patients' lives, contributing to morbidity, reduced quality of life (QoL), and psychological distress. Conventional treatment approaches primarily focus on rhythm control through pharmacologic therapy, often overlooking the patient's holistic well‐being. Hypothesis Cognitive beh...

Kyasanur forest disease (KFD) is an emerging tick-borne viral hemorrhagic fever endemic to the south-western parts of India, particularly in the states of Karnataka, Maharashtra, Kerala, and Tamil Nadu. The disease was first identified in 1957 after an outbreak in the Kyasanur Forest region in Shivamogga district of Karnataka state. In recent times...

Peptic ulcer disease remains a prevalent gastrointestinal disorder worldwide. Current treatments often have limitations, sparking interest in alternative therapies from medicinal plants. This review examines the gastroprotective potential of 54 North African medicinal plants against peptic ulcers. An extensive literature search was conducted, focus...

Caffeine which is 1,3,7-trimethyl xanthine is consumed all over the world and it must be the one of the oldest beverages found. The psychostimulant affects our body through its various components such as caffeic acid, quinic acid, chlorogenic acid, coumarins, flavonoids, and anthocyanins. Caffeine offers cognitive enhancement, physical performance,...

Toxoplasma gondii is a protozoan parasite that causes toxoplasmosis in animals. The present study was conducted to investigate the percentage of toxoplasmosis in goats and their female possessors in the Kurram district Pakistan. A total of 200 blood samples (100 each from goat and their female possessors) were collected randomly from three differen...

The paper "Alpha-gal Syndrome as a Novel Food Allergy: A Case," which was just published and offers a thoughtful summary of this new illness, prompted me to write in response. The paper does a good job of highlighting the difficulties in identifying and treating Alpha-gal Syndrome (AGS), a disorder associated with tick bites that is marked by delay...

Artificial intelligence (AI) is fundamentally transforming the field of surgery, particularly in complex, high-precision procedures. Perhaps among these are the benefits that accrue from AI precision surgery, with all of the theoretical bases encompassed and realized within machine learning algorithms, large data analytics, and real-time intraopera...

IMPHY000797 derivatives have been well known for their efficacy in various diseases. Moreover, IMPHY000797 derivatives have been found to modulate such genes involved in multiple neurological disorders. Hence, this study seeks to identify such genes and the probable molecular mechanism that could be involved in the pathogenesis of Parkinson’s disea...

Neurological disorders (NDs) encompass a range of debilitating conditions that affect the nervous system, including prevalent illnesses such as Alzheimer's disease, Parkinson's disease, and ischemic stroke. Despite significant ongoing studies, effective therapeutic strategies to halt or slow down the progression of these illnesses are still lacking...

In this study, we present a novel green synthesis method for magnesium oxide/magnesium peroxide nanocomposite using citric acid, enhancing both photocatalytic degradation and antioxidant activity. The physical properties and light absorption of the nanostructure were examined using X-ray diffraction, Fourier-transform infrared spectroscopy, scannin...

Multidrug-resistant bacteria have complicated the treatment of gastrointestinal diseases; their microbial resistance stems from the indiscriminate use of medications and the transfer of resistance genes. Varronia curassavica Jacq., a plant traditionally used to treat rheumatic and gastrointestinal diseases in underserved populations, has sparked in...

This study describes the synthesis of N⁵‐(4‐(1H‐benzo[d]imidazol‐2‐yl)phenyl)‐N²‐phenylpyridine‐2,5‐diamine derivatives from Orthophenylenediamine (1) and 4‐aminobenzoic acid (2) and all the synthesized chemical moieties screened against a panel of cancer cell lines resulted in the identification compound 6 a with good anti‐cancer potential and a G...

Integrating AI and Neuroradiology Rapid advancement and transformation of the area of neuroradiography by Artificial Intelligence (AI) is offering creative ideas improving diagnosis accuracy and efficiency. Using AI to detect and segment ischaemic strokes on CT and MRI scans-where it may find major artery occlusions and estimate stroke severity sco...

Mpox is a viral zoonotic disease that presents with skin lesions similar to other conditions like chickenpox, measles, and hand-foot-mouth disease, making accurate diagnosis challenging. Early and precise detection of mpox is critical for effective treatment and outbreak control, particularly in resource-limited settings where traditional diagnosti...

This review aims to summarize the role of alkaloids as potential modulators of the PI3K/Akt/mTOR (PAMT) pathway in cancer therapy. The PAMT pathway plays a critical role in cell growth, survival, and metabolism, and its dysregulation contributes to cancer hallmarks. In healthy cells, this pathway is tightly controlled. However, this pathway is freq...

the current investigation, 109 known ERα inhibitors have been developed in the current research; pharmacophore modeling, Molecular docking, MM‐GBSA, and MD study have been performed to investigate the binding affinity of 9‐anilinoacridines with heterocyclic substitutes as selective ERα inhibitors for breast carcinoma. Pharmacophore model have been...

Tumor infiltrating lymphocytes (TIL) therapy is an adoptive cellular therapy using a patient’s own TILs to target and destroy tumors. Developed by Dr Steven Rosenberg and his team at NIH in 1982, it involves extracting TILs from a tumor, expanding them with interleukin-2 (IL-2) in the lab, and reinfusing them into the patient. Initial studies using...

Eye diseases, such as age-related macular degeneration (AMD) and diabetic retinopathy (DR), impose a substantial health cost on a worldwide scale. Carotenoids have emerged as intriguing candidates for pharmacological treatment of various disorders. Their therapeutic effectiveness, however, is hindered by poor solubility and vulnerability to degrada...

After undergoing surgery, some people appear to recuperate more quickly than others. A person’s health, preexisting diseases, and heredity are all potential contributors. Even if person have a genetic predisposition to delayed healing, there are steps one may do to improve his chances of a speedier recovery. Peptides are quickly becoming one of the...

Breast cancer is a multifactorial disease that has become a major health concern worldwide. Epidemiological research strongly suggests a connection between vitamin D deficiency and an increased risk of breast cancer. Studies reveal that particularly postmenopausal women with insufficient vitamin D levels face a notably increased likelihood of devel...

Cardiovascular disease (CVD) relates to a variety of disorders that impact the heart and blood arteries, such as peripheral artery disease, heart failure, coronary artery disease, and stroke. CVD is a major global cause of death that imposes an immense strain on public health and healthcare systems. People of every age group, genders, and socioecon...

More effective and patient-centered dental treatment is on the horizon thanks to the incorporation of artificial intelligence (AI) into current dental software systems. Through the utilization of sophisticated algorithms and data analytics, AI is revolutionizing diagnostic imaging analysis. This allows for the quicker and more precise detection of...

Staphylococcus aureus is a bacterium responsible for resistance to multiple drugs and the efflux system is widely studied among the resistance mechanisms developed by this species. The present study evaluates the inhibition of the MepA efflux pump by thiadiazine-derived compounds. For this purpose, thiadiazine-derived compounds (IJ-14 to IJ-20) wer...

Monoterpenoids, compounds found in various organisms, have diverse applications in various industries. Their effectiveness is influenced by the oil’s chemical composition, which in turn is influenced by plant genotype, environmental conditions, cultivation practices, and plant development stage. They are used in various industries due to their dist...

Pyrrole, with its versatile heterocyclic ring structure, serves as a valuable template for generating a diverse range of lead compounds with various pharmacophores. Researchers and scientists globally are intrigued by pyrrole and its analogs for their broad pharmacological potential, prompting thorough investigations aimed at advancing human welfar...

Candida species are normally commensal yeasts residing in the human body, under certain circumstances, can trigger pathological conditions such as candidiasis, not to mention antifungal resistance. Lippia sidoides Cham., or pepper-rosmarinus, is a native plant found in the Northeastern semi-arid region of Brazil, cited in ethnobotanical studies for...

Constant exposure to harmful substances from both inside and outside the body can mess up the body’s natural ways of keeping itself in balance. This can cause severe skin damage, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. However, plant-derived compounds found in fruits and vegetables have been shown to prote...

Background: Human immunodeficiency virus (HIV) and sexually transmitted infections (STIs) can cause severe and fatal complications; knowledge about these diseases is essential for promoting safe sex practices and modifying behaviours that are harmful to one's health. This study investigates Syrian people's understanding, attitudes, and behaviors t...

Xanthine dehydrogenase (XDH) contributes significantly to generating reactive oxygen species in coronary artery disease (CAD). XDH has been proposed as a therapeutic target, but its genetic variants could affect protein structure and drug response. We aimed to assess protein structure modification occur due to genetic variants and to screen 215 CAD...

Background: Anxiety, stress, depression, and psychosis are conditions related to mental illnesses which interfere with the quality of life. Conventional interest in the preventive and therapeutic potential of natural products or nutraceuticals in disease management has escalated in recent years due to their relatively high safety index and affordab...

In the present work, phytoconstituents from Citrus limon are computationally tested against SARS‐CoV‐2 target protein such as Mpro ‐ (5R82.pdb), Spike ‐ (6YZ5.pdb) &RdRp ‐ (7BTF.pdb) for COVID‐19. Docking was done by glide model, QikProp was performed by in silico ADMET screening & Prime MM‐GB/SA modules were used to define binding energy. When com...

Background: Dipterocarpus turbinatus is a well-known ethnomedicinal plant species. Traditionally, it has been used to treat various medical ailments, including diabetes, diarrhea, tuberculosis, leprosy, ringworm, gonorrhea, ulcers, skin infections, wounds, and burns. The study aimed to assess the pharmacological properties of methanol extract of D....

Environmental, economic, and ethical considerations have come together to make green surgery a need in hospitals. Because of their operations, healthcare institutions have the potential to significantly impact the environment through their use of energy, trash production, and resource depletion. An effort to lessen these effects has been the rise o...