Talal Aburjai

University of Jordan | UJ · Department of Pharmaceutical Sciences

This review explores the significant impact of Artificial Intelligence (AI) and Machine Learning (ML) on pediatric healthcare and education for children with genetic syndromes. Our investigation shows that AI-driven tools, like Google AI's DeepVariant, have greatly improved diagnostic precision. This allows for earlier and more accurate identificat...

This article explores the potential impact of Artificial Intelligence (AI), Machine Learning (ML), CRISPR-Cas9 gene editing, and single-cell RNA sequencing on improving our understanding and management of Autism Spectrum Disorder (ASD) and its gastrointestinal (GI) comorbidities. It examines how these technologies illuminate the complex interplay b...

A novel series of pyrazole, oxadiazole and thiadiazole bearing Nabumetone moiety were designed, synthesized, and evaluated for their anti-inflammatory activity against cyclooxygenase enzyme 2, after Insilico assay (by molecular docking study) a best set has been synthesized and characterized. After prediction of their activity by molecular docking...

Aptamers, which are single-stranded DNA or RNA molecules, are increasingly recognized as important tools in diagnostics and therapeutics across various medical disciplines such as oncology, respiratory diseases, and neurological disorders. This review provides a comprehensive evaluation of the recent progress and obstacles encountered in the field...

The phytochemical composition of Asphodelus aestivus Brot., a plant with therapeutic properties in traditional medicine, remains largely unexplored, particularly in the specific environmental conditions of Jordan. This study utilized advanced LC-MS techniques to comprehensively analyze the secondary metabolites of a plant species endemic to Jordan....

The study aimed to investigate the impact of different concentrations of aqueous suspension of bentonite nanoparticles (ASBN) on the productive performance of broiler chickens. The research was conducted at the University of Jordan poultry farm in Almuwaqar research station. A total of 240 Ross 308 broiler chickens were distributed among four treat...

Purpose: To determine the active principle responsible for the cytotoxic effect of Anthemis palestina (Reut. ex Kotschy) Reut. ex Boiss.(Asteraceae). Methods: A bioassay-guided fractionation was used to isolate the active principle, luteolin, which structure was elucidated using 1H and 13C NMR. The cytotoxic effects of luteolin and doxorubicin (pos...

Introduction and Objective: Medicinal plants were and are still used in traditional herbal medicine in Syria and Jordan (the two main countries in the Levant); to treat many diseases, and documenting this folk and heritage medical knowledge is very important. Materials and Methods: Samples representing local and imported medicinal Plants were recor...

The use of plants as a source of active principles for cosmetics has significantly increased in the last few years. Safety, compatibility with all types of skin, fewer side effects, and availability are among the advantages of herbal cosmetics above synthetic ingredients. The present review aims to explore the most important plants used in cosmetic...

Aims of the Study This study was designed to evaluate the antimicrobial activity of some medicinal plants used among Jordanians for the treatment of gastritis and gastric ulcers against H. pylori. Moreover, plants' inhibitory activity against the H. pylori urease enzyme was also evaluated. Materials and Methods The activity of 11 medicinal plants...

Background As many Jordanians include herbs in their treatment, an ethnopharmacological survey was conducted to identify the most prescribed plants for the treatment of cancer by local herbalists and traditional healers in Jordan, aiming to encourage the prescription that is based on scientific evidence, to tackle some important practices in tradit...

Globally, pharmacy education is evolving to reflect a more patient-centered, interprofessional approach to clinical practice. In the 22 countries of the Arab world, advancements in regulatory support for pharmacy practice and changes to the health care system have been slower than in Europe, Asia, and the Americas. Significant cultural, logistical,...

Nephrolithiasis (kidney stones) impacts a significant group of individuals today as a result of changing lifestyles. Over the past decade, there has been a revival of interest in the study of medicinal plants as a source of potential herbal medicine. Herbal medicine could become a new phase in the medical system for human disease management within...

Introduction and objectives: The Syrian flora includes about 3150 plant species, distributed in 900 genera and 130 families. The Syrian flora includes hundreds of medicinal plants, and hundreds more are used in traditional medicine. In light of the spread of multidrug bacterial resistance phenomenon, researches have been carried out on the antimicr...

Objective: Trifolium pretense considered one of the most important medicinal plant which belongs to Fabaceae family, this plant commonly known as Red clover, its native region is Europe, Western Asia, and northwest Africa, but planted and naturalised in many other regions. The main compoundes found in Trifolium pretense are isoflavones which is det...

Introduction: Helicobacter pylori is Gram-negative helical bacteria that inhibit stomach mucosal lining and establish infection. Urease enzyme was confirmed to be pivotal target in which its suppression will prompt bacteria treatment and eradication. Methods: Series of naturally bioactive compounds were selected based on ethnobotanical and molec...

Medicinal plants are a rich source of disease-prevention medicinal chemicals, and their health advantages are continually expanding. Traditional treatments can help with a variety of disease conditions, but they need to be scientifically validated before they can be fully utilized. The current study was therefore conducted to evaluate the diuretic...

Today, due to the changing lifestyle, a significant number of people are suffering from nephrolithiasis (kidney stones). Unfortunately, there is no satisfactory medication for use in clinical treatment. The current study is an ethno-pharmacological study aimed at in vitro evaluation of the anti-nephrolithiatic assessment of some selected medicinal...

The present work explored the preventive potential of ethanolic extract of Olea europaea L. (EEOE) leaves against CCl4-induced liver injury in rats. The fingerprint chromatogram of EEOE was determined by HPLC-MS analysis. The antioxidative potential of EEOE was determined by adopting three approved in vitro methods. The EEOE was orally given at a d...

Abstract: Background: Medicinal plants have proven their value as a source of molecules with therapeutic potential, and recent studies have shown that capsaicin has profound anticancer effects in several types of human cancers. However, its clinical use is handicapped due to its poor pharmacokinetics. This study aims to enhance capsaicin's pharmaco...

Background: Medicinal plants have proven their value as a source of molecules with therapeutic potential, and recent studies have shown that capsaicin has profound anticancer effects in several types of human cancers. However, its clinical use is handicapped due to its poor pharmacokinetics. This study aims to enhance capsaicin’s pharmacokinetic pr...

Echinomycin (quinomycin A) is a peptide antibiotic from the quinoxaline family, which has a DNA bifunctional intercalating activity and an inhibitor of hypoxia-inducible factor (HIF1a). Echinomycin was discovered in 1957 as a potent antitumor agent; however, it was not successful in clinical use due to its low water solubility and short half-life....

Antibiotic resistance has become a major worldwide priority, and identifying natural antimicrobial compounds may help overcome this problem. In this study, ethanolic extracts of twelve plants commonly used in traditional medicine were tested against two strains of methicillin‐resistant S. aureus (ATCC 33591 and ATCC 43300) in terms of minimum inhib...

The coronavirus disease 2019 (COVID-19) pandemic, the most important public health problem in 2020, poses severe health and socioeconomic impact. Many people turn to herbal therapy to prevent infection with the virus or alleviate the symptoms caused by it. This study evaluates the patterns of phytotherapy-based product utilization in the prevention...

Background: Cancer is the second leading cause of death globally. Most of the anticancer drugs showed poor selectivity. Medicinal plants have proven, historically, their value as a source of molecules with therapeutic potential. Aim and objective: This study aims to optimize the method of extraction, identification, qualitative and quantitative ana...

COMMENTARY Transforming Pharmacy Education and Practice in the Arab world: A Call-to-Action Abeer M. Al-Ghananeem, PhD Jordan University of Science and Technology, Irbid, Jordan Daniel R. Malcom, PharmD Sullivan University College of Pharmacy, Louisville, Kentucky Samira Shammas, BSPharm Jordan Pharmacists Association, Good Pharmacy Practice Commit...

Abstract: Capsaicin (CAP) is an active component in Capsicum annuum L. known to have anti inflammatory and anticancer activity. CAP is highly lipophilic and suffers low bioavailability. Therefore, developing delivery systems that enhance solubility and bioavailability can provide more promising therapeutic applications for CAP. In the current work,...

Capsaicin (CAP) is an active component in Capsicum annuum L. known to have anti inflammatory and anticancer activity. CAP is highly lipophilic and suffers low bioavailability. Therefore, developing delivery systems that enhance solubility and bioavailability can provide more promising therapeutic applications for CAP. In the current work, CAP was c...

COVID-19 pandemic has spread across the world, which considered a relative of the severe acute respiratory syndrome (SARS), with possibility of transmission from animals to human and effect each of health and economic. Several preventative strategies and non-pharmaceutical interventions have been used to slow down the spread of COVID-19. The questi...

Purpose: To develop a reversed phase high performance liquid chromatography (HPLC) method for the determination of dehydroepiandrosterone (DHEA) in dietary supplements. Methods: A reversed-phase high performance liquid chromatography (HPLC) method was developed for the determination of DHEA in dietary supplements. An isocratic system consisting of...

Purpose: To develop a reversed phase high performance liquid chromatography (HPLC) method for the determination of dehydroepiandrosterone (DHEA) in dietary supplements. Methods: A reversed-phase high performance liquid chromatography (HPLC) method was developed for the determination of DHEA in dietary supplements. An isocratic system consisting...

Background and Aim: Interest in plants with antimicrobial properties has been revived due to emerging problems associated with using antibiotics to eradicate Helicobacter pylori. Accordingly, this study aims to assess the antibacterial effects of Punica granatum and the possible synergistic effect of its extract along with metronidazole against H....

The present study was designed to investigate the anti-nephrolithiatic potential of the aqueous extract of Teucrium polium in male Wistar rats. The experiment was carried out in male rats divided into 4 groups, each of which contain 6 animals. Group I (normal control) received distilled water for 40 days. Group II(nephrolithiatic control) to IV(tre...

COVID-19 pandemic has spread across the world, which considered a relative of the severe acute respiratory syndrome (SARS), with possibility of transmission from animals to human and effect each of health and economic. Several preventative strategies and non-pharmaceutical interventions have been used to slow down the spread of COVID-19. The questi...

COVID-19 pandemic has spread across the world, which considered a relative of the severe acute respiratory syndrome (SARS), with possibility of transmission from animals to human and effect each of health and economic. Several preventative strategies and non-pharmaceutical interventions have been used to slow down the spread of COVID-19. The questi...

The present study was conducted to assess the in vitro activities of folk medicinal plants in combination with levofloxacin against TG1 and mutant KAM3-1(∆acrB-∆tolC) Escherichia coli strains. Plants were chosen based on their traditional use in combination with antibiotics among laymen. Standard protocols were followed to examine the antimicrobial...

COVID-19 pandemic has spread across the world, which considered a relative of the severe acute respiratory syndrome (SARS), with possibility of transmission from animals to human and effect each of health and economic. Several preventative strategies and non-pharmaceutical interventions have been used to slow down the spread of COVID-19. The questi...

COVID-19 pandemic has spread across the world, which considered a relative of the severe acute respiratory syndrome (SARS), with possibility of transmission from animals to human and effect each of health and economic. Several preventative strategies and non-pharmaceutical interventions have been used to slow down the spread of COVID-19. The questi...

Since the ancient ages plant species have been used as key part in traditional medicine and curing practices. Recently a huge body of literature showed that medicinal plant species used by the Jordanian people for the treatment of cancer were screened for their potential as cytotoxic therapy at least in vitro. This review summarizes an updated evid...

Since the ancient ages plant species have been used as key part in traditional medicine and curing practices. Recently a huge body of literature showed that medicinal plant species used by the Jordanian people for the treatment of cancer were screened for their potential as cytotoxic therapy at least in vitro. This review summarizes an updated evid...

Cancer is the second leading cause of death globally. Cancer resistance become a global crisis, as there is no magic treatment till now. Medicinal plants have proven, historically, their value as a source of molecules with therapeutic potential, scientific and research interest is drawing its attention towards naturally-derived compounds in cance...

Helicobacter pylori, a gram-negative bacterium, known factor for chronic active gastritis, stomach and peptic ulceration, which may progress to gastric cancer. It is also associated with other non-gastric diseases such as stroke, diabetes mellitus and alzheimer’s disease. Although conventional treatment achieved a great advancements in controlling...

Ethnopharmacological relevance Gundelia tournefortii is a member of the Asteraceae (Compositae) family which is widely consumed as edible plant in the Eastern Mediterranean. In folkloric medicine, it is used for the treatment of various diseases and conditions, including pain, liver diseases, kidney stones and inflammations. Aim of the study Recen...

Basil (Ocimum basilicum L.) is a culinary herb of the family Lamiaceae and considered as one of the most aromatic plants grow widely at different places around the world [1, 2] .Traditionally, sweet basil has been used as a medicinal plant in the treatment of kidney malfunction, worms, cough, diarrhea and headache. It is a popular a source of essen...

Worldwide, peptic ulcer and gastritis considered to be one ofthe biggest health challenge, Helicobacter pylori is responsible for more than eighty percent of chronic active gastritis where continual infection remains for decennary. However, the success of commercially available drugs for the management of H. pylori has overwhelmed by antibiotic-res...

Worldwide, peptic ulcer and gastritis considered to be one of the biggest health challenge, Helicobacter pylori is responsible for more than eighty percent of chronic active gastritis where continual infection remains for decennary. However, the success of commercially available drugs for the management of H. pylori has overwhelmed by antibiotic-re...

In the current study, the compositions of the essential oil obtained from leaves of Ocimum basilicum ‘Cinnamon’ grown in Jordan in a greenhouse was analysed. The antitumor activity of the essential oil was examined against three different cancer cell lines including MDA-MB-231, MCF7 and U-87 MG. The hydrodistillation method was used to extract the...

Chemical composition of essential oils hydrodistilled from aerial parts of Achillea fragrantissima (Forssk.) Sch. Bip. and Achillea santolina L. growing in Jordan was analysed using GC and GC/MS. The analysis identified 30 compounds in the oil isolated from A. santolina, and 23 and 22 constituents in the oils hydrodistilled from A. fragrantissima c...

Globally, cancer remains as one of the leading causes of morbidity and mortality. Although great advancements have been achieved in the treatment and control of cancer progression, significant short comings of the currently available treatment regimens pose serious challenges. Often, a number of undesired side effects occur during chemotherapy that...

Aims: The present study is aimed to evaluate the potential mechanism of antidiabetic action of seed extract celery (Apium graveolens) and its effects on some hematological and biochemical parameters in alloxan-induced diabetic rats. Study Design: Laboratory-experimental design was used in this study. Methodology: This study was conducted on fifty e...

As there is an increasing demand for Capsaicin from pharmaceutical firms worldwide, the aim of the present study is to find a simple, fast, and reproducible method for its extraction from the fruit of capsicum annuum. Soxhlet extraction method using n-hexan as a solvent was used. Capsaicin was isolated and purified using a combination of column chr...

Nephrolithiasis (Kidney stone)is one of the oldest known and common illnesses in the urinary tract system. Most of the people generally can have renal stones at any phase of life. The rate of occurrence of renal calculi is commonly high in males as well as in females. Still, there is no drug that can be reasonably used in the treatment of nephrolit...

Nephrolithiasis (Kidney stone)is one of the oldest known and common illnesses in the urinary tract system. Most of the people generally can have renal stones at any phase of life. The rate of occurrence of renal calculi is commonly high in males as well as in females. Still, there is no drug that can be reasonably used in the treatment of nephrolit...

Effect of some natural products on h- pylori bacteria

The consumption of dietary supplements has nowadays become popular, especially in Jordanian sports clubs and gyms. In fact, there is a widespread idea, among consumers, that these proteins contain hormones in order to increase their efficiency. The objective of this study is to develop a better understanding of customer opinion in an era that incre...

Aims: The present study is aimed to evaluate the potential mechanism of antidiabetic action of seed extract celery (Apium graveolens) and its effects on some hematological and biochemical parameters in alloxan-induced diabetic rats. Study Design: Laboratory-experimental design was used in this study. Methodology: This study was conducted on fifty e...

Several plant preparations and extracts are used in folk medicine for treatment of topical wounds. Yet the validity of their use as well as the mechanism has not been ascertained in well-designed experimental settings. The wound healing activity of a topical hexane extract of Alkanna strigosa roots (HEASR) in excision and incision wound models in r...

Several plant preparations and extracts are used in folk medicine for treatment of topical wounds. Yet the validity of their use as well as the mechanism has not been ascertained in well-designed experimental settings. The wound healing activity of a topical hexane extract of Alkanna strigosa roots (HEASR) in excision and incision wound models in r...

There is a worldwide trend toward the use of natural cosmetics and to formulate high Ultraviolet protection sunscreens using lower concentrations of chemical sunscreens. The addition of natural compounds to the synthetic agents may be an effective strategy to prevent the deleterious effects of UV radiation. New compounds, especially those derived f...

Effective health communication is important for informed decision-making since Patient centered care requires an understanding of the sources patients use to obtain different types of health in information. Recognizing and supporting those who provide health care advice may be an effective way to disseminate health messages to broader audiences. Th...

ABSTRACT Globally, pharmacy education is evolving to reflect a more patient-centered, interprofessional approach to clinical practice. In the 22 countries of the Arab world, advancements in regulatory support for pharmacy practice and changes to the health care system have been slower than in Europe, Asia, and the Americas. Significant cultural, lo...

This study aims to identify bodily-kinesthetic intelligence level among students attending different levels of swimming courses. To investigate students motor intelligence level in relation to gender. To investigate students bodily-kinesthetic intelligence level in relation to swimming course level. To investigate the relation between bodily-kinest...

Effective health communication is important for informed decision-making since Patient centered care requires an understanding of the sources patients use to obtain different types of health in information. Recognizing and supporting those who provide health care advice may be an effective way to disseminate health messages to broader audiences. Th...

This study aims to identify bodily-kinesthetic intelligence level among students attending different levels of swimming courses. To investigate students motor intelligence level in relation to gender. To investigate students bodily-kinesthetic intelligence level in relation to swimming course level. To investigate the relation between bodily-kinest...

Aim: The aim of this study is to investigate the occurrence of potential efflux pump inhibitor (EPI) against AcrAB-TolC efflux pump in the methanol extract of Hibiscus sabdariffa. Materials and Methods: Calyces of H. sabdariffa were purchased from the local market in April 2014, used in methanol extraction. The methanol extract of H. sabdariffa was...

The role of Co-enzyme Q10 in cancer treatment.