Takuya Watanabe

Watanabe Internal Medicine Aoyama Clinic · Internal Medicine and Gastroenterology

Follicular lymphoma (FL) is the most common low-grade lymphoma, and although nodal FL is highly responsive to treatment, the majority of patients relapse repeatedly, and the disease has been incurable with a poor prognosis. However, primary FL of the gastrointestinal tract has been increasingly detected in Japan, especially due to recent advances i...

Background To analyze clinical features, treatment, complications, and visual outcomes of ocular sarcoidosis at a tertiary center in Tokyo. Methods Clinical records of 53 patients with ocular sarcoidosis (“definite” or “presumed”) presenting between 2013 and 2018 to the Kyorin Eye Center were retrospectively reviewed. Diagnosis was based on the re...

Purpose: To report on the successful treatment of patients with acute Vogt-Koyanagi-Harada (VKH) disease utilizing the antiviral potential of cyclosporine during the COVID-19 pandemic. Study design: Case series. Methods: Clinical records were retrospectively reviewed of 4 patients presenting with new-onset acute VKH disease who elected to rece...

Background: To evaluate long-term efficacy of infliximab (IFX) in refractory uveoretinitis associated with Behçet's disease (BD) depending on uveoretinitis duration. Methods: Records of 16 patients with BD (32 eyes) followed for >5 years after starting IFX, were retrospectively reviewed. Long-term efficacy was compared between patients with shor...

The retinal pigment epithelium (RPE) is a polarized, monolayer of pigmented cells that forms the outer retinal layer. A key function of the RPE is to maintain the integrity of the photoreceptors mainly via phagocytosis and recycling of the digested photoreceptor outer segments. Moreover, RPE cells are a major source of inflammatory cytokines and ch...

Purpose: The purpose of this study is to describe clinical features and visual outcomes of Japanese patients with posterior scleritis. Methods: Clinical records of 10 patients (13 eyes) presenting between 2006 and 2016 were retrospectively reviewed. Results: The mean age was 50.1 ± 20.8 years; 50% were women, and three patients had bilateral diseas...

Purpose To describe the clinical features, treatment and visual outcomes of Japanese patients with new-onset acute Vogt-Koyanagi-Harada (VKH) disease. Methods Clinical records of 111 patients who presented between 1999 and 2015 to the Ocular Inflammation Service of the Kyorin Eye Center, Tokyo, were reviewed. Results Of the 111 patients (68 women...

Aim To describe clinical features and outcomes of new-onset anterior uveitis associated with poorly controlled or undiagnosed diabetes mellitus. Methods Retrospective analysis of 25 eyes of 18 patients (14 men, 4 women; mean age 44 years) who presented between December 2001 and October 2016 to the Kyorin Eye Center. Results Ocular findings at pre...

Purpose: To compare the efficacy of infliximab (IFX) on refractory uveoretinitis between Behçet disease (BD) patients with short duration (≤18 months, n = 6) versus long duration (>18 months, n = 7) of their ocular disease. Methods: Records of 13 BD patients treated with IFX for 24 months were retrospectively reviewed. Results: Frequency of ocular...

Objectives To analyse clinical features, systemic associations, treatment and visual outcomes of uveitis in children and adolescents at a tertiary centre in Tokyo. Methods Clinical records of 64 patients under the age of 20 years who presented between 2001 and 2013 to the Ocular Inflammation Service of the Kyorin Eye Center, Tokyo were reviewed ret...

Purpose: To determine the changes in the expression profiles of microRNAs (miRNAs) in retinas during the development of experimental autoimmune uveoretinitis (EAU) in rats. Methods: The levels of interleukin-1β (IL-1β) and monocyte chemoattractant protein-1 (MCP-1) were measured in aqueous humour samples and supernatants of homogenised posterior...

To examine spectral-domain optical coherence tomography (SD-OCT) patterns in intraocular lymphoma (IOL). Records of 13 patients (21 eyes) with IOL were retrospectively reviewed. SD-OCT was evaluated at initial visit and during follow-up. SD-OCT images at initial visit demonstrated disruption of the ellipsoid zone (8 eyes, 38.1%) and hyperreflective...

Dehydroxymethylepoxyquinomicin (DHMEQ) is derived from the antibiotic, epoxyquinomicin C, and is a novel low molecular weight nuclear factor-κB (NF-κB) inhibitor. We investigated the effects of DHMEQ on the expression of chemokines and the intercellular adhesion molecule (ICAM)-1 induced by proinflammatory cytokines in cultures of the human corneal...

PurposeTo determine whether all trans-retinoic acid (ATRA) or a synthetic retinoic acid receptor (RAR)-α/β specific agonist, Am80, can reduce the degree of experimental autoimmune optic neuritis (EAON) in mice with experimental autoimmune encephalomyelitis (EAE). Methods Optic neuritis was induced in C57BL/6 mice by immunizing them with myelin olig...

The common dose of propiverine hydrochloride for the treatment of overactive bladder is 20 mg/day. However, in many instances, due to increased side effects, especially in an advanced age population, the initial dose is only 10 mg/day. In the current study we examined the usefulness and safety of a propiverine hydrochloride regimen with a starting...

We evaluated the efficacy and clinical outcome of retroperitoneal laparoscopic dismembered Anderson-Hynes pyeloplasty for the treatment of primary and secondary ureteropelvic junction obstruction (UPJO). Between February 2006 and September 2009, a total of 11 consecutive cases of retroperitoneal laparoscopic dismembered Anderson-Hynes pyeloplasty (...

We evaluated the effects of intra-vesical injection of botulinum toxin type A in the detrusor muscle in patients with neurogenic overactive bladder (OAB), patients with non-neurogenic overactive bladder and patients with interstitial cystitis. Between January 2003 and December 2006 we treated 30 patients with 100 I. U. to 300 I. U. of botulinum tox...

Chronic ischemia due to arterial sclerosis plays a key role in the development of aging-related bladder dysfunction. In this study we aimed to determine the relationship between pulse wave velocity (PWV) and lower urinary tract symptoms. The study comprised 149 patients who had been examined by PWV with a view to evaluating the presence of arterios...

We evaluated the development of embryos generated from the fertilisation of oocytes with spermatozoa isolated from animals with primary testicular damage (PTD). Embryos derived in vivo or in vitro from oocytes fertilised with spermatozoa produced by PTD rats that had undergone surgical treatment for the PTD (group A1), or PTD rats (group A2), or co...

This review study refers to the possibility to employ PDE5 inhibitors as an adjunct tool for the therapeutic management of male infertility. The literature tends to suggest that PDE5 inhibitors enhance the Leydig cell secretory function and play a role in the regulation of the contractility of the tunica albuginea and the epididymis. In addition, t...

Hepatitis C virus (HCV) infection is a major burden after liver transplantation. There is no effective treatment for these patients, therefore management is challenging. Cyclophilins are essential host factors for HCV replication. We have reported herein the efficacy of divided administration of interferon (IFN) beta plus cyclosporine for chronic h...

To investigate whether high mobility group box protein (HMGB)-1, acting as a novel proinflammatory cytokine, is involved in experimental autoimmune uveoretinitis (EAU). HMGB-1 concentration was measured in aqueous humor, and serum was obtained from Lewis rats immunized with interphotoreceptor retinoid binding protein (IRBP) peptide (R14) and comple...

Rainfall estimates from the Tropical Rainfall Measuring Mission (TRMM) Precipitation Radar (PR) facility algorithm over the eastern Pacific are lower than those from the TRMM Microwave Imager (TMI) facility algorithm and a PR-consistent advanced microwave radiometer algorithm, while they are in good agreement over the western Pacific. We investigat...

We report the case of a 71-year-old female patient with a history of diabetes and neurogenic bladder. Self-catheterization had been demanded, but severe oliguria and progressive anuria had led to the initiation of hemodialysis sessions 7 years ago. Two years ago the patient had an acute myocardial infarction, a ventricular aneurysm and a ventricula...

The aim of this review study is to elucidate the effects that phosphodiesterase 5 (PDE5) inhibitors exert on spermatozoa motility, capacitation process and on their ability to fertilize the oocyte. Second messenger systems such as the cAMP/adenylate cyclase (AC) system and the cGMP/guanylate cyclase (GC) system appear to regulate sperm functions. I...

Pregnancies achieved by assisted reproduction technologies and particularly by ooplasmic injections of either in vivo or in vitro generated immature male germ cells are susceptible to genetic risks inherent to the male population treated with assisted reproduction and additional risks inherent to these innovative procedures. The documented, as well...

Proteins on the membrane of secretory granules (SGs) involved in their biogenesis and exocytosis are poorly characterized compared with those of synaptic vesicle in neurons. Thus the secretory granule membrane was prepared from a mouse pancreatic beta-cell line MIN6 by subcellular fractionation, and protein constituents were analyzed by microscale...

We report a case of benign polyp of the posterior urethra. The patient's first symptoms were dysuria and urethral discomfort. We examined him by urethrocystoscopy, and found a soybean-sized papillary mass at the 7 o'clock position in the distal prostatic urethra. Transurethral resection of the urethral mass was performed and the origin of the lesio...

Microscopic needle-like structures with submicron sizes were observed in the films prepared by electrolysis. Macroscopic needle-like structures with few millimeters length were also assembled by an extraction from nonelectrolysis supersaturated toluene solution. The anisotropic activation energy for two kinds of growing surfaces was investigated fr...

The chromosomal inversion (16)(p13q22), which is associated with the M4-eosinophilia subtype of human acute myeloid leukemia, causes the fusion of two distinct genes. The polypeptide encoded by the chimeric gene, PEBP2β/CBFβ-SMMHC, retains the ability to interact with, and dominantly interfere with the function of proteins possessing the Runt homol...

A 2-year old boy visited our clinic with a chief complaint of high fever. A past history of acute renal failure due to cystine stones and cystinuria was expressed. Abdominal rentogenograms and CT demonstrated a right ureteral stone and a left renal stone. Furthermore renogram evaluation indicated non-function of the right kidney and dysfunction in...

Cathode polarization is a major factor of voltage loss in molten carbonate fuel cells (MCFCs), and it is caused by oxygen reduction at the cathode. In order to clarify the interaction between the molten carbonate and the cathode in MCFCs, we have attempted to develop the in situ micro observation using an environmental scanning electron microscope...

The effects of NOx on the performance of MCFC were examined by cyclic voltammetry and bench-scale cell tests with the oxidant gas containing several levels of NOx. NOx poisoning has a larger effect on cell voltage in the early operating stage, but this effect tends to decrease with operating time. The main cause of the cell voltage drop is the incr...

Three types of high-purity germanium (HPGe) detector systems for low-level radioactivity measurement were constructed in the laboratory near sea level. An anti-Compton system was set up by combining a large volume HPGe (rel. eff. 115%) with a well type NaI(Tl). The detection limit (D.L.) of 137Cs of an ashed oyster sample for the anti-Compton mode...

Electrostatic agglomeration is a promising method for improving the submicron particles’ collection efficiency of an electrostatic precipitator. The electrostatic agglomeration coefficient of bipolar charged particles is calculated using a two particles collision model to evaluate the effect of external electric field on the particles agglomeration...

Electrocrystallization of C60 and organic dye cations produces crystals of C60 anion radical salts stabilized by these cations. The ESR spectra of these salts showed typical broad signal which can be ascribed to C60 superimposed by small sharp signals. The conducting properties of some salts of C60 anion radicals stabilized by bulky organic dye cat...

Estimation of the overpotentials due to internal resistance, polarization by electrode reaction and Nernst Loss in Molten Carbonate Fuel Cell (MCFC) was mainly carried out by analyzing the variation of equilibrium output voltage fixed a current density under several gas conditions till now. On the other hand, transient response analysis methods suc...

Streptozotocin-induced diabetic male rats underwent a pressure-flow study (P/Q study) under urethane anesthesia to determine whether partial cystectomy improves the percentage of bladder volume voided (V%) in a large bladder. P/Q studies were performed 12 weeks after the administration of streptozotocin to 8-week-old-rats. P/Q studies were also car...

To evaluate the effects of H2S on the performance of MCFC, the bench-scale cell tests and the half-cell tests were performed with fuel gas containing several levels of H2S. The behaviors of sulfur compounds in the cell depend on the absorption of S on anode Ni and the solubility of H2S by electrolyte. The solubility of H2S by electrolyte relates to...

The molecular packing in β-chitin unit cells was experimentally determined by a combination of unidirectional degradation by Bacillus circulans chitinase A1 and microdiffraction electron crystallography using highly crystalline β-chitin microfibrils from the protective tubes secreted by Lamellibrachia satsuma. The mode of chain packing was found to...

Coal gas is expected to be a major fuel gas for molten carbonate fuel cells (MCFC). Usually, coal gas contains sulfur contaminants that may degrade the MCFC performance. In this study, to evaluate the effects H 2S on the performance of MCFC, bench-scale cell tests were performed with fuel gas containing several levels of H 2S. In the long term expe...

The accuracy of estimated performance of Molten Carbonate Fuel Cell (MCFC) under various operating conditions depends on that of the formulation for reaction overpotential. It has been clarified that the behavior of cathode overpotential is well estimated from the dependence of mixed diffusion of superoxide ion (O2-) and CO2 in (Li + K)/CO3 molten...

The magnetic flux motion is investigated using a high quality YBCO disk in both pulsed and static magnetic field. Correlation between the flux flow and creep is discussed.

High-spin states of the 115Te were studied by in-beam spectroscopy with the 89Y (29Si, p2n) fusion-evaporation reaction at a beam energy of 108 MeV. γ−γ coincidence and γ−γ angular correlation analyses were employed for determining the level scheme of 115Te. We have identified two vibrational-like bands built on the νh11/2 and νg7/2 quasiparticle s...

We have analyzed the submicron-sized particle agglomeration theoretically by solving equations which describe the variation of particle size and charge distribution. Both the uncharged particle agglomeration and the bipolar-charge were calculated. The calculated results show that the bipolar charging is very effective for the particle agglomeration...

High-spin states of 114Te have been studied using the 89Y(28Si,p2n) and 89Y(29Si,p3n) reactions at beam energies of 106 and 108 MeV, respectively. γ-γ and particle-γ-γ coincidences, directional correlations of oriented states, and excitation functions have been measured using six BGO Compton suppressed Ge detectors and several particle detectors. W...

154Ho was studied via141Pr(16O,3n) reaction at beam energy of 75 MeV. We found two new rotationally aligned bands made of neutron h9/2 and f7/2 orbitals coupled to a proton h11/2 orbital. As with several new high-spin states, up to I=20, the ground state band with odd parity starts to show anomalous signature splitting at I=13 in this doubly odd154...

Iron-polyvinylalcohol (Fe-PVA) complexes have been pyrolysed at the temperatures up to 1000 K, and the iron-carbon composites formed have been characterized. The yield of carbon was much higher for the complexes than for PVA alone. The degree of carbon graphitization and the chemical form of iron species were dependent on the pyrolysis temperature....

Ion-exchange phenomena in the inner phase of resins for ion chromatography were studied by measuring streaming potentials in a flow system. On the basis of the values obtained, the electrostatic behaviour in connection with anion-exchange reactions in the resin phase was evaluated. The electrostatic potentials in the resin phase varied with the exc...

We have systematically studied the size- or frequency- dependent superfluid transition in 4He films adsorbed on porous glasses with pore diameters d's from 50 to 100000A, using two sets of torsional oscillators containing different pore size glasses with a common 4He inlet. It is clarified that the transition temperature Tc is determined by the vor...

A CALCULATION method for predicting the acoustic field of the counter-rotation propeller operation in the flow of a pylon has been developed. The results of sample calculations have demonstrated the capability of estimating the noise caused by the aerodynamic interactions such as wake interaction and potential interaction between two rotors or betw...

In Central Research Institute of Electric Power Industry (CRIEPI) , 10kW class Molten Carbonate Fuel Cell (MCFC) Test Facility has been installed at Yokosuka Laboratory, and operation experiments have been performed. The experimental results are described. An operation experiment of about 250 hours was carried out, using large MCFC stack with the E...

High resolution specific heat measurements have been performed on a single crystal NdCu6 in applied magnetic fields up to 5 T. A magnetic field versus temperature phase diagram is presented.

CeInCu2 is a heavy fermion compound with specific heat coefficient gammaMax = 1.4J/mol.K2, but the ground state is antiferromagnetic. There exists a disorder between the Ce atoms and the In atoms in the Heusler structure. Order parameter is 0.8.

We measured specific heats of RECu6-type magnetic compounds (RE=Nd, Sm and Pr) at 0.1<T<40 K. The results show successive magnetic phase transitions in zero magnetic field for NdCu6 at T=5.66, 5.78, 5.93 and 6.02 K and for SmCu6 at T=5.6 and 9.4 K. From the magnetic specific heat of PrCu6, we propose an energy scheme of 4f levels of the Pr ion unde...

A multimicroprocessor having a hardware circuit designed to aid the synchronization of Central Processing Units (CPUs) and software to schedule tasks on the CPUs is proposed. The system is applied to the calculation of the joint angles of six-axis robot manipulators. It is verified that the scheduling software gives the optimum schedule for an elbo...

The pyrolysis of 2-azidopyrazines led to give 1-cyanoimidazoles, which were hydrolyzed in alkaline and acidic media to the corresponding imidazoles. This ring transformation occurred also by photolysis.

A semiclassical formula is obtained for the Auger spectrum in inner-shell ionisation by electron impact near threshold. The results are compared with those from photoionisation.

Die Chlorpyrazine (Ia)-(Ic) reagieren mit Natriumazid zu den Azidopyrazinen (IIa)- (IIc),die bei h?herer Temperatur quantitativ zu den N-Cyanoimidazolen (IIIa)-(IIIc) pyrolysiert werden.

The 13C chemical shifts of 37 pyrazines, including their N-oxides, are reported. Substituent effects of methyl, phenyl and N-oxide groups on the chemical shifts were examined. To comprehend these effects, the chemical shifts were compared with charge densities calculated by the CNDO/2 method and a good correlation was obtained. 13C, 1H coupling con...

A simple method is proposed for preparing the sources used in 4πβ-counting. With this method using aluminum chloride, the source material is uniformly distributed by the action of the fine particles of the aluminun compound produced in a radioactive solution. The self-absorption of the 59Fe, 60Co, 95Nb, 103Ru and 198Au sources prepared by the metho...

The electrical resistivity measurements were made from 4.2 K to room temperature on 7 at.% Co-doped NiS2 at pressures from 19 to 71 kbar. T2-dependence of electrical resistivity due to the spin fluctuations was found, and the pressure dependence of its coefficient was determined.