Taiza G S Edwards

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Verified

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• Professor
• Professor at University of São Paulo

INTRODUCTION Brain tumors represent a significant health challenge, with over 300,000 new cases reported worldwide annually. Recent advancements in diagnostic imaging and specialized therapeutic interventions have improved the survival rates and life expectancy for individuals affected by brain tumors, resulting in an increased prevalence of surviv...

Traumatic brain injury is a health condition with high incidence, morbidity and mortality that affects people of all ages, considered a relevant public health problem around the world. Trauma can greatly impact the lives of those affected, from a socioeconomic point of view, in dependence on third parties to carry out basic activities of daily livi...

Objective People exhibiting post-stroke lateropulsion actively push their body across the midline to the more affected side and/or resist weight shift toward the less affected side. Despite its prevalence and associated negative rehabilitation outcomes, no clinical practice guidelines exist for the rehabilitation of post-stroke lateropulsion. We ai...

There is a high demand for stroke rehabilitation in the Brazilian public health system, but most studies that have addressed rehabilitation for unilateral spatial neglect (USN) after stroke have been performed in high-income countries. Therefore, the aim of this study was to analyze USN patient recruitment in a multicenter noninvasive brain stimula...

Post-stroke lateropulsion is prevalent. The global inconsistency in terminology used to describe the condition presents obstacles in accurately comparing research results, reaching consensus on use of measurement tools, agreeing upon a consistent approach to rehabilitation, and translating research to clinical practice. Commencing in 2021, 20 inter...

This supplementary dataset is supportive of the randomized sham-controlled, double-blind, crossover clinical trial investigating polarity- and intensity-dependent effects of high-definition transcranial electrical stimulation (HD-tDCS) applied over the right temporo-parietal junction on mean middle cerebral artery blood flow velocity (MCA-BFv) bila...

Since neuronal activity is coupled with neurovascular activity, we aimed to analyze the cerebral blood flow hemodynamics during and following high-definition transcranial direct current stimulation (HD-tDCS). We assessed the mean middle cerebral artery blood flow velocity (MCA-BFv) bilaterally using transcranial doppler ultrasound, during and after...

Background: Rehabilitation top-down techniques based on brain stimulation present variable outcomes in unilateral spatial neglect (USN) after stroke. This study aimed to examine the effects of physical therapy after anodal and cathodal direct current stimulation (A-tDCS and C-tDCS, respectively) to improve visuospatial and functional impairments i...

Objective: Converging evidence supporting an effect of transcranial direct current stimulation (tDCS) on postural control and human verticality perception highlights this strategy as promising for post-stroke rehabilitation. We have previously demonstrated polarity-dependent effects of high-definition tDCS (HD-tDCS) on weight-bearing asymmetry. How...

Background: Few Brazilian studies investigated risk factors for dysphagia and associated complications in a large cohort. Objective: To investigate frequency, predictors, and associated outcomes of dysphagia in patients up to three months post-stroke. Methods: Prospective cohort study of consecutively admitted patients in a specialized center...

Brazil has a higher rate of dysphagia in stroke patients compared to developed countries, but does not have a fully validated method for early identification of dysphagia in this population. The aim of this study is to translate the TOR-BSST© into Brazilian Portuguese and assess the newly translated version for reliability and validity with Brazili...

Sparse time series models have shown promise for estimating contemporaneous and ongoing brain connectivity. This paper was motivated by a neuroscience experiment, using EEG signal data as the outcome of our established interventional protocol, a new method in neurorehabilitation towards the development of a treatment for visual verticality disorder...

This work aimed to appraise a multivariate time series, high-dimensionality data-set, presented as intervals using a Symbolic Data Analysis (SDA) approach. SDA reduces data dimensionality, considering the complexity of the model information through a set-valued (interval or multi-valued). Additionally, Dynamic Linear Models (DLM) are distinguished...

In this paper, from the practical point of view, we focus on modeling traumatic brain injury data considering different stages of hospitalization, related to patients’ survival rates following traumatic brain injury caused by traffic accidents. From the statistical point of view, the primary objective is related to overcoming the limited number of...

A foundation of medical research is time series analysis—the behavior of variables of interest with respect to time. Time series data are often analyzed using the mean, with statistical tests applied to mean differences, and has the assumption that data are stationary. Although widely practiced, this method has limitations. Here we present an alter...

Verticality misperception after stroke is a frequent neurological deficit that leads to postural imbalance and a higher risk of falls. The posterior thalamic nuclei are described to be involved with verticality perception, but it is unknown if extra-thalamic lesions can have the same effect via diaschisis and degeneration of thalamic nuclei. We inv...

Background The uptake of proven stroke treatments varies widely. We aimed to determine the association of evidence‐based processes of care for acute ischemic stroke ( AIS ) and clinical outcome of patients who participated in the HEADPOST (Head Positioning in Acute Stroke Trial), a multicenter cluster crossover trial of lying flat versus sitting up...

Verticality misperception after stroke is a frequent neurological deficit that leads to postural imbalance and a higher risk of falls. The posterior thalamic nuclei are described to be involved with verticality perception, but it is unknown if extra-thalamic lesions can have the same effect via diaschisis and degeneration of thalamic nuclei. We inv...

on behalf of the HEADPOST (Head Positioning in Acute Stroke Trial) Investigators* Background-The uptake of proven stroke treatments varies widely. We aimed to determine the association of evidence-based processes of care for acute ischemic stroke (AIS) and clinical outcome of patients who participated in the HEADPOST (Head Positioning in Acute Stro...

The recent enhanced sophistication of non-invasive mapping of the human motor cortex using MRI-guided Transcranial Magnetic Stimulation (TMS) techniques, has not been matched by refinement of methods for generating maps from motor evoked potential (MEP) data, or in quantifying map features. This is despite continued interest in understanding cortic...

Background: Using conventional tDCS over the temporo-parietal junction (TPJ) we previously reported that it is possible to manipulate subjective visual vertical (SVV) and postural control. We also demonstrated that high-definition tDCS (HD-tDCS) can achieve substantially greater cortical stimulation focality than conventional tDCS. However, it is c...

Objective: To compare the effects of Transcranial Direct Current Stimulation (tDCS) versus Galvanic Vestibular Stimulation (GVS) on Lateropulsion following stroke. Methods: Patients with Stroke and Burke Lateropulsion Scale (BLS) scores greater than or equal to 2 gave informed consent to receive sinusoidal 1 Hz DC (0-2 mA) anodal stimulation over t...

Perception of verticality is required for normal daily function, yet the typical human detection error range has not been well characterized. Vertical misperception has been correlated with poor postural control and functionality in patients after stroke and after vestibular disorders. Until now, all the published studies that assessed Subjective P...

Dataset and normative calculation. (XLSX)

Evidence suggests that somatosensory electrical stimulation (SES) may decrease the degree of spasticity from neural drives, although there is no agreement between corticospinal modulation and the level of spasticity. Thus, stroke patients and healthy subjects were submitted to SES (3 Hz) for 30' on the impaired and dominant forearms, respectively....

Objective: To assess the effects of 2mA transcranial Direct Current Stimulation (tDCS) over the affected Parietal-Insular-Vestibular Cortex (PIVC) on seated posture of patients with lateropulsion following stroke. We hypothesized that bilateral electrode placement over PIVC (vs active control) would produce a change in seated posture. Background: L...

Objective To verify correlations between age, injury severity, length of stay (LOS), cognition, functional capacity and quality of life (QOL) six months after hospital discharge (HD) of victims of traumatic brain injury (TBI). Method 50 patients consecutively treated in a Brazilian emergency hospital were assessed at admission, HD and six months a...

Pathologic tilt of subjective visual vertical (SVV) frequently has adverse functional consequences for patients with stroke and vestibular disorders. Repetitive transcranial magnetic stimulation (rTMS) of the supramarginal gyrus can produce a transitory tilt on SVV in healthy subjects. However, the effect of transcranial direct current stimulation...

Mean and standard error of SVV scores of each subject for tDCS condition Left anode/Right cathode at different times. Before tDCS (T0 = Baseline), during tDCS (T1 = 0.5min: 30 seconds after the start of stimulation; T2 = 15min: 15 minutes after the beginning of stimulation); and after tDCS (T3 = 20min: immediately after; T4 = 35min: 15 minutes afte...

Mean and standard error of SVV scores of each subject for tDCS condition Right anode/Left cathode at different times. Before tDCS (T0 = Baseline), during tDCS (T1 = 0.5min: 30 seconds after the start of stimulation; T2 = 15min: 15 minutes after the beginning of stimulation); and after tDCS (T3 = 20min: immediately after; T4 = 35min: 15 minutes afte...

Dataset. (XLS)

SAS procedures for statistical analysis. (PDF)

Mean and standard error of SVV scores of each subject for sham condition at different times. Before tDCS (T0 = Baseline), during tDCS (T1 = 0.5min: 30 seconds after the start of stimulation; T2 = 15min: 15 minutes after the beginning of stimulation); and after tDCS (T3 = 20min: immediately after; T4 = 35min: 15 minutes after the end of stimulation;...

Deficits of postural control and perceptions of verticality are disabling problems observed in stroke patients that have been recently correlated to each other. However, there is no evidence in the literature confirming this relationship with quantitative posturography analysis. Therefore, the objectives of the present study were to analyze the rel...

Complete Dataset. (XLSX)

Background. The subjective visual vertical (SVV) is a perception often impaired in patients with neurologic disorders and is considered a sensitive tool to detect otolithic dysfunctions. However, it remains unclear whether the semicircular canals (SCCs) are also involved in the visual vertical perception. Objective. The aim of this study was to ana...

Facial fat grafting is not devoid of risks and complications, despite being a widely practiced procedure. In this case report, we describe a novel form of local ischemic complication that occurred secondary to fat grafting. Simultaneously, we propose Hyperbaric Oxygen therapy for the treatment of this situation. We propose that Hyperbaric Oxygen th...

Background: The modified Rankin Scale (mRS) is a commonly used scale to assess the functional outcome after stroke. Several studies on mRS showed good reliability, feasibility, and interrater agreement of this scale using a face-to-face assessment. However, telephone assessment is a more time-efficient way to obtain an mRS grade than a face-to-fac...

Background Obstructive sleep apnea (OSA) is frequent in acute stroke patients and has been associated with higher mortality and worse prognosis. Polysomnography (PSG) is the gold standard diagnostic method for OSA, but it is impracticable as a routine for all acute stroke patients. We evaluated the accuracy of two OSA screening tools, the Berlin Qu...

Background: Dementia is prevalent in patients with right middle cerebral artery (RMCA) stroke and may be reversible in some of them. Memory impairment is required to fulfill clinical criteria for the diagnosis of dementia, and neuropsychological assessment is usually performed after the stroke in those patients to evaluate that domain. Nevertheless...

BACKGROUND: Intracerebral Hemorrhage (ICH) is responsible for 10-30% of all cases of stroke in developing countries. Information about clinical characteristics and long-term follow-up of these patients is still scarce in such population. We prospectively followed a cohort of patient with ICH admitted to our emergency room at a public tertiary cente...

Background: AND AIM: Chagas disease (CD) is a common cause of stroke in undeveloped countries and has become more frequent in the US, where it is largely underestimated. CD related strokes are believed to be mainly cardioembolic but some studies have suggested concomitant cerebral vasculitis. Data on the safety of recanalization therapies in patien...

Background: The modified Rankin Scale (mRS) is the most commonly used scale to asses functional outcome after stroke. Several studies on mRS have shown good reliability, feasibility and interrater agreement of this scale using a face-to-face assessment and by telephone assessment in developed countries. Nevertheless, it is still uncertain with the...

Background: Obstructive sleep apnea (OSA) is frequent in acute stroke patients and is associated with increased mortality and poor functional outcome. Polysomnography (PSG) is the gold standard diagnostic method for OSA, but it is impracticable as a routine for all acute stroke patients. We evaluated how OSA screening tools such as the Berlin Quest...

To determine the rate of symptomatic intracranial hemorrhage (SIH) and in-hospital mortality among patients with acute ischemic stroke related to Chagas disease (CD) treated with IV tissue plasminogen activator (TPA). In this retrospective cohort study, consecutive stroke patients treated with IV TPA and routinely tested for CD were retrospectively...

A Sindrome do Empurrador (SE), tambem denominada Sindrome de Pusher (do ingles to push, empurrar) ou Sindrome do Nao-alinhamento e um dos mais intrigantes disturbios neurologicos decorrentes de lesoes encefalicas agudas. Pacientes com esta sindrome se inclinam para o lado oposto a lesao encefalica, empurram-se para este lado e resistem quando ha a...

Unlabelled: One resorts to various postural strategies while attempting to maintain balance. Objective: To assess the postural strategies adopted by young and elderly subjects in varying sensory conditions by using a system of tridimensional electromagnetic sensors positioned on the projection of the first thoracic vertebra and on the sacral reg...

Obstructive sleep apnea is frequent during the acute phase of stroke, and it is associated with poorer outcomes. A well-established relationship between supine sleep and obstructive sleep apnea severity exists in non-stroke patients. This study investigated the frequency of supine sleep and positional obstructive sleep apnea in patients with ischem...

The aim of this study was to assess the subjective visual vertical in patients with bilateral vestibular dysfunction and to propose a new method to analyze subjective visual vertical data in these patients. Static subjective visual vertical tests were performed in 40 subjects split into two groups. Group A consisted of 20 healthy volunteers, and Gr...

Unlabelled: Spatial orientation in relation to the gravitational axis is significantly important for the maintenance of the posture, gait and for most of the human's motor activities. The subjective visual vertical exam evaluates the individual's perception of vertical orientation. Objectives: The aims of this study were (1) to develop a virtual...

The objective of this study was to investigate the influence of the obesity and handgrip strength on the static balance of active older women in the opened and closed eyes conditions. Thirty one women aged from 65 to 75 years (16 eutrophic and 15 obese) were evaluated. Mean age and BMI of the eutrophic women were, respectively, 68.3±2.7 years and 2...

To the Editor: We read with interest the article by Abe et al1 regarding the prevalence and length of recovery of pusher behavior (PB) in patients with acute stroke. Their retrospective cohort study included 1660 patients with acute stroke. According to authors, study subjects were daily assessed for PB and were assessed during their initial physi...

The aim of this study was to evaluate the multisegmental static postural balance of active eutrophic and obese elderly women using a three-dimensional system under different sensory conditions. A cross-sectional study was conducted on 31 elderly women (16 eutrophic and 15 obese) aged 65 to 75 years. The following anthropometric measurements were ob...

INTRODUÇÃO: A abdominoplastia é uma das cirurgias estéticas mais realizadas e, como qualquer outro ato cirúrgico, está sujeita a inúmeras complicações, entre as quais os fenômenos tromboembólicos. O objetivo deste estudo foi analisar a incidência de complicações em uma série consecutiva de abdominoplastias, fatores de risco e a eficácia de dois pro...

Pusher behavior (PB) is a disorder of postural control affecting patients with encephalic lesions. This study has aimed to identify the brain substrates that are critical for the occurrence of PB, to analyze the influence of the midline shift (MS) and hemorrhagic stroke volume (HSV) on the severity and prognosis of the PB. We identified 31 pusher p...

Pusher behavior (PB) is a postural control disorder characterized by actively pushing away from the nonparetic side and resisting passive correction with a tendency to fall toward the paralyzed side.1 These patients have no awareness that their active pushing is counterproductive, which precludes the patients from standing without assistance. Seve...

Subjective visual vertical (SVV) evaluates the individual's capacity to determine the vertical orientation. Using a neck brace (NB) allow volunteers' heads fixation to reduce cephalic tilt during the exam, preventing compensatory ocular torsion and erroneous influence on SVV result. To analyze the influence of somatosensory inputs caused by a NB on...

Early detection of postural disorders is essential for timely interventions in patients with imbalance. A pilot study describing a new tool for evaluating static postural balance. A cross-sectional study of a contemporary series. Twenty-five volunteers (15 women and 10 men) were evaluated. The mean age was 25.8 ± 4.2 years, the mean weight was 63.9...

Resumo INTRODUÇÃO: Disfunções no sistema vestibular são responsáveis por diversos sintomas como a tontura, vertigem e desequilíbrio, podendo estar associados ou não a outros sinais e sintomas. As disfunções centrais manifestam sintomas muito semelhantes aos das lesões periféricas, mas podem ser diferenciados por algumas características específicas...

OBJETIVOS: Descrever uma nova metodologia de análise da oscilação postural estática sentada e comparar os resultados de jovens e idosos saudáveis. MÉTODOS: Participaram do estudo 38 indivíduos saudáveis, 17 jovens (idade média 23±2,38 anos) e 21 idosos (idade média 67±2,42 anos). A oscilação postural foi mensurada por meio do sistema eletromagnétic...

OBJETIVOS: Descrever uma nova metodologia de análise da oscilação postural estática sentada e comparar os resultados de jovens e idosos saudáveis. MÉTODOS: Participaram do estudo 38 indivíduos saudáveis, 17 jovens (idade média 23±2,38 anos) e 21 idosos (idade média 67±2,42 anos). A oscilação postural foi mensurada por meio do sistema eletromagnétic...

Assessing interindividual variability of brain activation is of practical importance to the use of functional magnetic resonance imaging (fMRI) in the clinical context. The main objective of this study is to analyze the variability of the oculomotor system through horizontal optokinetic, pursuit and saccadic eye movement stimulations by means of fM...

We report a sequential neuroimaging study in a 48-years-old man with a history of chronic hypertension and lacunar strokes involving the ventral lateral posterior nucleus of the thalamus. The patient developed mild hemiparesis and severe contraversive pushing behavior after an acute hemorrhage affecting the right thalamus. Following standard motor...

A síndrome de Pusher caracteriza-se por uma alteração do equilíbrio na qual pacientes com lesões encefálicas empurram-se em direção ao lado parético utilizando o membro não-afetado. O papel do sistema vestibular na alteração postural da síndrome de Pusher ainda não foi devidamente elucidado. OBJETIVO: Neste estudo objetivamos avaliar o papel dos ca...

Pusher syndrome is an interesting disorder of balance in patients with encephalic lesions characterized by the peculiar behavior of actively pushing away from the non-hemiparetic side and resisting against passive correction, with a tendency to fall toward the paralyzed side. The role of vestibular system on the pushing behavior is not clear. To ev...

Pusher syndrome is a disorder of postural control observed in patients with right or left brain damage associated with hemiparesis. Those patients show a peculiar behavior of actively pushing away from the nonhemiparetic side and resisting against passive correction, with a tendency to fall toward the paralyzed side. Thus far this phenomenon has be...

Background: The vestibular system executes one of the most important functions of the human body: the consciousness of spatial orientation. Studying the intensity, duration and direction of nystagmus optokinetic stimulation we can get precious information about pathological processes in vestibular system. However, before using the methodology in pa...