Tahir Kahraman

• Professor
• Professor at Karabük University

Amaç: Bu çalışma, metil paratiyonun akut ve kronik toksisitesi üzerine Nigella sativa nın koruyucu etkisinin değerlendirilmesi için tasarlandı. Materyal ve Metot: Bu çalışmada 56 yetişkin erkek Albino Wistar sıçan kullanıldı ve rastgele dört gruba ayrılmıştır. 1. grup hayvanlara, 1 mL distile su verilmiş ve kontrol grubu olarak değerlendirilmiştir....

Non-steroid anti-inflammatory drug (NSAID)-induced enteropathy is a clinically undesirable but highly prevalent problem. Thiamine pyrophosphate (TPP) has a role in reducing oxidative stress as well as acting as a coenzyme in enzymatic reactions. The aim of this study was to investigate the protective effect of TPP on the damage caused by indomethac...

Purpose: Methotrexate (MTX) is an antineoplastic agent with a wide clinical use. However, its complications in tissues cause limitations. The effects of many compounds have been studied in reducing the toxicity of MTX in liver tissue. There are limited studies on the elimination of this damage with morin hydrate (MH) flavonoid. In this study, we in...

Titanium dioxide is a prevalent food ingredient for human ingestion. We investigated the nephrotoxic effects of titanium dioxide in Wistar albino rats subjected to oral exposure for 14 days. The rats were categorized into four groups (n = 8): (1) control (saline solution), (2) exposure to titanium dioxide (30 mg/kg), (3) exposure to resveratrol (10...

Strese Metabolik Yanıt (Bölüm 16)

BİYOKİMYADA YENİ TEKNİKLER; PROTEOMİK VE TIPTA KULLANIMI

Drugs used for treatment in the clinic also have side effects. As one of these drugs, Methotrexate (MTX) is a folate antagonist antimetabolite that has a wide range of uses in diseases such as cancer and non-cancer autoimmune diseases, inflammatory diseases and abortus. MTX is included in the treatment of diseases such as rheumatoid arthritis, whil...

https://www.gevhernesibe.org/_files/ugd/614b1f_e8c8d2c7a9d540c98f6f4266ae57991f.pdf

Amaç: Diyabet, dünyada halk sağlığı alanında en büyük sorunlardan biridir. Şifalı bitkiler arasında yer alan Vaccinium myrtillus L. özütü, güçlü antioksidan aktiviteye sahiptir. Bu amaçla, deneysel diyabetik sıçanlarda Vaccinium myrtillus ekstraktının serum paraoksonaz (PON1), pankreas enzim düzeyleri ve lipid düzeyleri üzerine olası etkileri araşt...

Objectives Olive ( Olea europaea L.) plays a promising role in pharmaceutical, nutraceutical, and cosmetic production. On the other hand, olive leaf is widely used in folk medicine due to its antihyperglycemic activity. For this aim, possible effects of olive leaf extract (OLE) in the brain tissue of streptozotocin-induced diabetic rats were invest...

Amaç: Siklofosfamid (CP), hepatotoksisite dahil olmak üzere, toksik yan etkilerine rağmen yaygın olarak kullanılan kemoterapötik bir ajandır. Ellajik asit (EA) antioksidan bir ajandır ve serbest radikal süpürücü aktiviteler sergilemektedir. Bu deneysel çalışmada, EA'nın, CP'ye bağlı karaciğer hasarı üzerindeki etkileri araştırılmıştır.Gereç ve Yönt...

Methyl parathion (MP) is an organophospho- rus pesticide that can induce hepatotoxicity in liv- ing organisms. Although many plant extracts have been utilized againts MP injury liver injury, it has not yet known whether 􏰆􏰓􏰄􏰂􏰔􏰔􏰌 􏰁􏰌􏰖􏰓􏰇􏰌 L. extract (NSE) has protective effects or not. We aim to investigate the hepatoprotective effect of 􏰆􏰋􏰏 through th...

Objective: Juniperus communis L. is a shrub belonging to family Cupressaceae L. mainly growth in Eurasia. The antioxidant and antidiabetic activity of aqueous extract of J. communis L. berries indicated benefits as a potent antidiabetic in streptozotocin induced diabetic albino rats. This study was carried out to determine whether J. communis L. oi...

The aim of this study was to investigate the effects of the submaximal running exercise on the GH/IGF-1 axis in the middle aged sedentary non-obese and pre-obese males. Twenty-four healthy volunteer males were divided into two groups and then two subgroups according to their age ranges (20-25 and 35-43) and Body Mass Indexes (BMI) (non-obese-NO and...

Our study developed a quick method for confirmatory analysis of avermectins (abamectin B1a, doramectin, ivermectin B1a, eprinomectin B1a, and moxidectin) in bovine milk according to the European Commission Decision 2002/657/EC requirements. Avermectins were liquid–liquid extracted with acetonitrile, followed by an evaporation step, and then analyze...

Food restriction is known to decrease lipid peroxidation by causing reduced metabolic rate. During the oxygen metabolism in the body, lipid peroxidation end-products are generated. It is suggested that food restriction causes the enhancement of the antioxidant system.In this study, the alterations of malondialdehid which is one of the end-products...

In the present study, fluoride levels of drinking water from the province of Bitlis and its towns (Adilcevaz, Ahlat, Güroymak, Hizan and Tatvan) were investigated. A total of 164 water samples, collected from tanks or tap in autumn (November 2006) and spring (May 2007) were used as material. The fluoride levels were measured by Orion model 720A pot...

In the present study, microbiological and physicochemical qualities of drinking water obtained from the city of Bitlis and its provinces (Adilcevaz, Ahlât, Guroymak, Hizan and Tatvan) were studied. A total of 164 water samples, collected from tank and tap waters in spring and autumn, were used as material. Aerobic plate counts were carried out by p...

In this study, nitrate and nitrite levels of drinking water in city of Bitlis were investigated. A total of 164 water samples, collected from the tank and tap water in Spring and Autumn were used as material. Analysis performed through spectrometric techniques showed that all samples contained some levels of nitrate and nitrite. The average nitrate...

Objectives: The aim of this study was to investigate the effect of supplemental antioxidant vitamins and minerals on the nitric oxide oxidation products nitrite and nitrate in rabbits after exposure to X-rays. Methods: The animals were divided into two experimental, one control group. The vitamin-supplemented group was given daily oral doses of vit...

Objectives: The aim of this study was to investigate the effect of supplemental antioxidant vitamins and minerals on the nitric oxide oxidation products nitrite and nitrate in rabbits after exposure to X-rays. Methods: The animals were divided into two experimental, one control group. The vitamin-supplemented group was given daily oral doses of vit...

In the present study, microbiological and physicochemical qualities of drinking water obtained from the city of Bitlis and its provinces Adilcevaz, Ahlat, Guroymak, Hizan and Tatvan) were studied. A total of 164 water samples, collected from tank and tap waters in spring and autumn, were used as material. Aerobic plate counts were carried out by po...

The aim of this study was to investigate the effects of supplemental antioxidant vitamins and minerals on lipid peroxidation and on the antioxidant systems in rabbits exposed to X-rays. The rabbits were divided into two experimental groups and one control group, each group containing seven rabbits. The first group (VG) received daily oral doses of...

The aim of this study was to investigate the effect of supplemental antioxidant vitamins and minerals on the erythrocyte concentrations of zinc and copper in rabbits after exposure to X-rays. The animals were divided into two experimental and one control group (CG). The first group (VG) was given daily oral doses of vitamins E and C; supplemental a...

The aim of this study was investigate nitrate and nitrite levels in some traditional foods and drinking water in Van, an endemic upper gastrointestinal (esophageal and gastric) cancer region of Eastern Turkey. Cheese with added herbs, drinking water, bread baked by wood fire and bread baked by burning animal manure specimens collected in the Van re...

The status of nitric oxide oxidation products and antioxidant vitamins were investigated in goats infected with endoparasites and blood parasites (Trichostrongylidae sp. + Protostrongylidae sp. + Eimeria sp. + Babesia sp.), in this study. Eighteen goats were naturally infected with these parasites and ten healthy goats served as controls which had...

This study was carried out to investigate whether Nigella sativa could decrease the lipid peroxidation, increase the anti-oxidant defence system and also prevent the lipid-peroxidation-induced liver damage in experimentally induced diabetic rabbits. Fifteen New Zealand male rabbits were divided into three experimental groups: control, diabetic and...

Nitric oxide (NO) oxidation products (nitrate and nitrite) were analysed in the serum of 12 gastric cancer (Ca), (12 gastric Ca, 12 esophageal Ca) and 12 healthy controls with modified Stahr's method. Helicobacter pylori (H. pylori) infection was diagnosed histopathologically in the gastric cancer and control groups. In the gastric Ca group mean, s...

Vitamin A and Vitamin E have antioxidant properties and their role in the prevention of gastrointestinal cancers by way of scavenging lipid peroxidation products is very important. Vitamin A ester (retinol acetate) and vitamin E isomers (alpha, gamma and total tocopherols) have been investigated in the serum samples and tissue biopsies of 7 esophag...

Özet Bu çalýþmada, Bitlis merkez ve ilçelerindeki (Adilcevaz, Ahlât, Güroymak, Hizan ve Tatvan) içme sularýnýn bazý mikrobiyolojik ve fizikokimyasal niteliði araþtýrýlmýþtýr. Ýlkbahar ve sonbahar mevsimlerinde bölgedeki depo ve musluk sularýndan alýnan toplam 164 örnek materyal olarak kullanýlmýþtýr. Genel canlý sayýmýnda dökme plak yöntemi; entero...