Taha Nazir

• Doctor of Philosophy
• Head at Advanced Multiple Inc

The extraordinary expansion in the nanomedicine with the development of new nano drug particles made surprising advancement in diagnosis and treatment. Nano drug complexes have amazing medicinal properties and clinical benefits in health care practice. That allows these to attach, absorb and deliver the nano molecule including RNA, DNA, probes and...

Context: deoxyribonucleic acid is under attack continuously by numerous exogenous and endogenous factors.DNA lesions are introduced by the DNA replication. This takes place because of mismatched ribonucleotides or bases that areincorporated randomly by the deoxyribonucleic acid polymerases. Objectives: The study intended to examine the data from st...

Context: A completely unique coronavirus (2019-nCoV), formally referred to as severe acute respiratory syndrome (SARS-CoV-2), appeared in China. SARS-CoV-2 is an etiological mediator of coronavirus 2 (COVID-19), characterized by pneumonic contagion in human beings. In spite of forceful suppression, this virus has spread worldwide. No specific drug...

Introduction: PEG-Interferon and ribavirin had been the mainstay for the treatment of infections caused by HCV. The use of them in the era of Direct Acting Agents might have been lessened but their efficacy in achieving a sustained virological response in clinical practice cannot be doubted. Objective: The goal of the present investigation is to ev...

Scientists can use the Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) protein 9 system, which is a powerful and flexible tool for changing the genome, to change only certain parts of the genome. This has helped researchers figure out how target genes work in biology and disease. CRISPR/Cas9 is made up of...

Because it can make exact double-strand breaks in DNA, CRISPR-Cas9 can help almost every species and type of cell. It is a powerful way to change the DNA code. CRISPR-Cas9 can be used for a lot more than just changing genes. We are close to being able to do high-throughput gene screening, epigenome editing, in-vivo cell tagging, and RNA change. Wit...

Gene editing is now easy to make new disease models through in-vivo and in vitro tests. It can potentially be used to make animals with single-gene or multiple-gene changes. The mutant strains with changed germlines are no longer needed with in vivo gene editing, which uses the CRISPR-Cas9 system to target cells of interest in their normal tissues....

Scientists can use the Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) protein 9 system, which is a powerful and flexible tool for changing the genome, to change only certain parts of the genome. This has helped researchers figure out how target genes work in biology and disease. CRISPR/Cas9 is made up of...

In "genome editing," a type of genetic engineering, DNA is added, taken away, or changed in an organism's genome. Biomedicine, biotechnology, and synthetic biology, just to name a few, have all gained a lot from how often this method is used. Before the editing process can start, a Double-Strand Breaks (DSB) must be made in the DNA at a specific ge...

CRISPR/Cas9-based gene therapy has gotten a lot of interest during last decade. This treatment protocol tries to fix disease-causing traits by changing the DNA code in the exact spot on the chromosome. Therefore, we have tried to elaborate the most current information that shows how well CRISPR/Cas9-based gene therapy works. In vivo methods, like t...

Context: Extraordinary advances in the fields of polymer nanoparticle (nano) drug technology, nanomedicines, nanostructures, and nanoscale sciences have played a key role in the healthcare system. New nanodrug complexes have exceptional pharmacological properties with large surface areas that encourage a formulated medication to distribute, absorb...

The quality control in public and private sector universities improve the over quality of education and professional skills in local and international economy. That also gives confidence and certainty to educational system and help to maintained high quality standards. Additionally, these become important component to deliver and contribute in huma...

Nondisclosure of some immaterial facts would recess the right to information, but it is further determined that the fundamental privilege has also been hurt by some deceptive practices. Where a beneficial amount of facts are actively concealed and fraudulently defected in title. The active concealment of information with the intention of doing perf...

Arylcyclohexylamine Ketamine (HCL) has played an important role in Veterinary and Human Medicine as safe and reliable anesthetic agent but asit produces dysphoria several new derivatives of Ketamine have been synthesized till date. In this Research we have Utilized Mannich reaction to Synthesize The ammonia, primary amine and secondary amine are tr...

The recently explained cytokine which is produced after the stimulation of IFN-c, IL-2 and IL-18 is Interleukin-32 (IL-32). This cytokine has proinflammatory IFN-c, IL-2 and IL-18 are Interleukin-32 (IL-32) mediator's properties that are generally entailed in many diseases, including infections, cancer and chronic inflammation. After the initial st...

Free, fair and ethical process of conduct with the assigned responsibility to completed it with given resources, schedule and environment is called accountability. It is also a confession of an employ to admit an error made in assigned obligations. United State Agency for International Development (USAID), the federal agency, administers civilian f...

Citation: Marwa M. Elmaghrabi et al. Saussurea costus as herbal medicines have immunomodulatory and potential nutraceutical components that may help in ABSTRACT The epidemic associated with the severe acute respiratory syndrome is Corona Viral Disease-2019 (COVID-19) induced thousands of fatalities around the world. The infection was initially iden...

Widespread corruption in developing countries is extended to every sector from government to judiciary, health services, police and education.9,10,11 The problems are become more conventional and despite ongoing calls for reform and attempts to improve, there is little or no evidence of progress in all major areas and departments. 7,8 Thus, in cont...

Context: Arthritis is an inflammatory disease of diarthrodial joints and is associated with swollen inflamed joints, disruption of joints, and loss of integrity of articular cartilage and synovial joints. Objective: The current review intended to examine the data on the epidemiology, causes, clinical diagnosis, and prevention and control of diff...

Article Information: Article Type: Ketamine have played an important role in veterinary medicine as well as in humans. Acting as a safe and reliable anesthetic, ketamine without depressing respiratory and circulatory functions blocks nerve paths. It can be taken(1) orally but most commonly given intramuscularly and via naso-pharyngeal route. "Ketam...

Pharmacists play vital role in health care system; they help to prevent medication errors. At discharge from health care facility 20% to 70% patients have at least one medication discrepancy. Pharmacist has direct impact on reducing readmission in hospitals as well as emergency visits. There is substantial reduction of 67%, 28% and 19% in adverse d...

ABSTRACT Background: Tuberculosis is re-emerging in the form of drug resistant causing deaths of humans throughout the world. In 2015, WHO estimates, this disease developed in 10.4 million and causes death in 1.8 million human population. Moreover, new challenges like TB/HIV coinfection, MDR-TB is resisting to the preventive measures for controllin...

The innovative immunomodulation technologies are excellent tools to synthesis the novel antibodies. The conventional methods are potentially replaced by more précised techniques to obtain the desired antibodies. Particularly the hybridoma technique used to produce the antibodies against targeted antigens. The pathogenic microorganisms, autoimmune a...

The outbreak of Noval Corona Virus-2019 (nCoV-19) has posed potential threat all over the world. [1,8] The clinicians, epidemiologists and health professionals are constantly working to control the outbreak, transmission and related complications of nCoV-19 or COVID-19. [2] Although, the COVID-19 has successfully been control in some parts of the w...

Context • The novel Corona Virus (nCoV-19) was initially reported in Wuhan, China during December 2019, and later people with nCoV-19 were identified in different parts of the world. Infected people had shown symptoms resembling pneumonia, but about 50% of patients were asymptomatic. Objective • The study intended to examine the data from studies o...

The rational treatment and standard clinical care have key value in public health. That helps the health care professionals assure successful treatment and minimize the resistant against antibiotics. Whereas, the drug compliance, therapeutical monitoring and pharmacovigilance are main factors to determine the quality of health care system. Hence; t...

The improvements of counter acting antibody generation systems of various types of immunoglobulins have been created on a vast scale. Miscellaneous scientific tools and skills used to design the most efficient and accurate method. The hybridoma innovation opened a new era in the production of antibodies against target antigens of desirable pathogen...

The objective of the study was to evaluate the methods designed for testing the status of iso-tonicity of parenteral products being marketed in Pakistan. This study emphasized the significance of iso-tonicity to reduce side effects for the administration of safe infusions. There were three methods namely cryoscopic method, sodium equivalent method...

Currently a variety of tools and techniques are used to deliver complex medicines. Whereas, certain advanced methods assure the safety and usefulness by regulating the pharmacokinetic and pharmacodynamic. Thus, we aimed this study to develop a novel gastro retentive floating tablets. The formulation was designed to provide the desired controlled an...

Context • The novel Corona Virus (nCoV-19) was initially reported in Wuhan, China during December 2019, and later people with nCoV-19 were identified in different parts of the world. Infected people had shown symptoms resembling pneumonia, but about 50% of patients were asymptomatic. Objective • The study intended to examine the data from studies o...

The corruption is the violence of granted authorities that destroys the basic rights. It has serious consequences on society, system and lives. It also has posed potential threats to the public health care system, complicated the situation and makes extremely difficult to control in rational manner. So, we need the anti-corruption experts to identi...

The philosophy of patient care is a wide and complicated topic of literature. That is elaborated by different health institution to harmonize their local clinical activities. Undoubtedly, that is working successfully to satisfy patients, fulfill the requirement of clinicians and cover maximum mutual benefits within officially allocated budget.

The philosophy of patient care is a wide and complicated topic of literature. That is elaborated by different health institution to harmonize their local clinical activities. Undoubtedly, that is working successfully to satisfy patients, fulfill the requirement of clinicians and cover maximum mutual benefits within officially allocated budget. Howe...

The Mouth Disintegrating Extended Release Telmisartan (MDERT) tablets are designed for adequate pharmacokinetic profile to avoid the unusual peaks and troughs. Although, there are extensive advance techniques used to deliver drugs. But oral route is still remains effective in most of the therapeutical situations. Thus we aimed this study to formula...

Background: The neoplasm is still a potential threat for breast, Non-Small Cell Lung (NSCL) and cervix cancer patients. Those gradually invade into other body organs, inducing complex pathological complications. Whereas, the anticancer drugs suppress the bone marrow, resulting serious hematological toxicities. Thus, the monocytic toxicity may the...

The dangerous resistant bacterial strains or superbugs are potential threats. That needs special attention to address the problem appropriately. The multi-drug resistant and extensive drug resistant M. Tuberculosis are emerging rapidly because of non-compliance and unsupervised indiscriminate use of antibiotics. The cases of Tuberculosis cases have...

The current health practice of Punjab Province of Pakistan needs a serious attention to control the unnecessary drug usage, improve pharmaceutical care and establish excellent public health system. Hence, the health officials of Govt. of Pakistan have established “Drug Regulatory Authority”, and Punjab Health Department has chalked out Punjab Drug...

Current scientific efforts are not successful to inspire the researchers for innovation. However, the competitive environment may offer them new opportunities to discover the new health innovations. Whereas, the scientists are also potentially engaged to figure out more effective therapy plans and curative measures. That may successful enhance the...

The enrolment of new pharmacy student is increasing in the pharmaceutical teaching institutions of United States [1]. Whereas, a massive pharmacy graduates have already migrated, settled and got legal residential status in US, Canada, other European countries. They have successfully passed the professional board exams of respected pharmacy accredit...

Health is an integral part of human life. Therefore, an interactive working is potentially desired to improve the public health. Interprofessional collaboration also helps to improve the overall health care facilities. Hence, we need to design the new plans for dissemination of the relevant information in an innovative manner. Additionally, the aca...

Hepatitis C virus (HCV) is one of the major causes of liver cirrhosis. It is highly mutable, circulates heterogeneously and potentially connected with diverse clinical phenotypes. Thus, we aim this study and collected blood samples from 183 HCV suspicious patients of age 31-58 years during March, 2013 to December, 2014. The prepared specimens were...

The Mouth Disintegrating Tablets (MDT’s) is continuously growing in clinical practice. The pharmaceuticals researchers are exploring the formulations for extended release dosage form with optimal therapeutic benefits. Hence, we aimed this study to develop the mouth disintegrating telmisartan tablet with extended release profile using response surfa...

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Currently, in modern technology, new and innovative techniques are emerging up in the fieOd of Drug Delivery System. Extended release orally disintegrating technology help’s to maintain a therapeutic range of plasma drug concentrations for a longer time [1,9]. Нerefore� we aimed to present such new and modern drug delivery system with dual characte...

The current health practice of Punjab Province of Pakistan needs a serious attention to control the unnecessary drug usage, improve pharmaceutical care and establish excellent public health system. Hence, the health officials of Govt. of Pakistan have established “Drug Regulatory Authority”, and Punjab Health Department has chalked out Punjab Drug...

Indian subcontinent has been ruled by different empires and dynasties throughout the past. They have brought different curative skill and knowledge. Moreover, the subcontinent surrounded by variety of believes, myths’ and religions. That obviously has significantly influenced the curative philosophy and therapeutic. Hence, we have designed this stu...

The first pharmacy was established during 1863 in Indian subcontinent. That was a commercial business store with pharmacy in Gujrat. After partition in 1947, University of the Punjab, Lahore, West Pakistan continued the already running three year Bachelor of Pharmacy degree program, that was started in 1943. Whereas, the clinical healthcare practic...

Anticancer drugs are used extensively in chemotherapy. Bone marrow suppression is one of their major side effects. Therefore, we aimed this study to investigate the potential leukocytic toxicity induced by vinorelbine in cancer patients. The data of total 60 adult patients were selected and divided into two groups; Group-1 patients received Vinorel...

Punjab Institute of Cardiology; sad demise of cardiac patients The demise of cardiac patients, registered to Punjab Institute of Cardiology, Lahore, in various hospitals due to therapeutical and pharmaceutical error is a grim concern, needs to be addressed on priority. Initially; as per newspapers, there are two types of reports; use of expired or...

The Mouth Disintegrating Tablets (MDT’s) is continuously growing in clinical practice. The pharmaceuticals researchers are exploring the formulations for extended release dosage form with optimal therapeutic benefits. Hence, we aimed this study to develop the mouth disintegrating telmisartan tablet with extended release profile using response surfa...

The standard microbiological examination and immunological investigation gave us more accurate guidelines to reach an appropriate decision regarding the diagnosis of diseases. The physician and pharmacist may then be more confident to design an accurate treatment protocol and correct therapy plan. That potentially helps to offer the standard clinic...

Cancer chemotherapy exerts deleterious effects in patients, causing structural and physiological changes to their vital organs. These drugs are capable of destroying bone marrow cells and may reduce lymphocyte count. This study was aimed to investigate the frequency of lymphocytopenia in cancer patients taking vinorelbine and its combination as par...

Recent reports have shown that certain bacterial strains attain the New Delhi Metallo-beta-lactamase-1 (NDM-1) enzyme and become resistant to a broad range of antibiotics. Similarly, more dangerous "superbugs" of multi-drug resistant (MDR) and extensive drug resistant (XDR) Mycobacterium tuberculosis strains are gradually emerging through rapid gen...

Frontal lobe epilepsy (FLE) is a type of epilepsy in which recurrent seizures arises from the frontal lobes. It is important to characterize frontal lobe epilepsy and distinguish it from non epileptic seizures. In order to investigate therapeutic comprehensions of focal lobe epilepsy this case study was conducted. A 2 year old boy was presented in...

Isoniazid resistant Mycobacterium tuberculosis strains are a serious threat for successful tuberculosis control programs. Therefore, present study was aimed to figure out the pattern and level of resistance of M. tuberculosis against isoniazid. A total of 172 specimens of sputum, pus and bronchial washings; 70.9% males and 29.1% females with 84.30%...

Isoniazid resistant Mycobacterium tuberculosis strains are a serious threat for successful tuberculosis control programs. Therefore, present study was aimed to figure out the pattern and level of resistance of M. tuberculosis against isoniazid. A total of 172 specimens of sputum, pus and bronchial washings; 70.9% males and 29.1% females with 84.30%...

Pharmacy profession is a patient oriented discipline of health care system and covers the clinical, formulation, manufacturing and dispensing segments of pure and crude form of drugs. Therefore; the courses offered in the curriculum of the Pharm D program should logically be matched with contents of their respective titles. But; unluckily, the cour...

Certain environmental factors are very important to stabilize the wild life; avian diseases, vulture crises and ecological annoyance. This should be fixed scientifically to minimize the health hazards. Thus; we have aimed this project to evaluate effects of toxic dosage levels of Ketoprofen in broiler chickens. Two hundred and twenty five (225) hea...

Neutropenia is a kind of leukopenia associated with shortage of neutrophils. It is included by myelotoxic drugs, acute infectious stress and leukemia. The anticancer drugs beside cancer treatment have the deleterious effects on the metabolism and vital organs. These drugs could damage the blood producing cells of bone marrow and reduce the neutroph...

The aim of the present study was to explore the potential effect of the coating material on the aerodynamic particle size distribution (APSD) of formoterol from Oxis Turbohaler® using mixing inlet with Andersen Cascade Impactor (ACI) operated at flow rate of 60 Lmin-1. As the aerodynamic properties of the emitted dose from a dry powder inhaler (DPI...

Rational drug usage, clinical regulations and pharmaceutical care are important features of health practice. Thus; we have aimed case report to elaborate the clinical pharmaceutical services. A 3 year old girl, was presented in a hospital with minor burn that happened by spilt hot water on her wrist. She was in severe pain. The emergency ward staff...

Rational drug usage, clinical regulations and pharmaceutical care are important features of health practice. Thus; we have aimed case report to elaborate the clinical pharmaceutical services. A 3 year old girl, was presented in a hospital with minor burn that happened by spilt hot water on her wrist. She was in severe pain. The emergency ward staff...

The anticancer drugs used in cancer therapy exerts cure along with deleterious effects. They bring structural and physiological changes in vital organs. Basopenia or basocytopenia is one of the major side effects of antineoplastic agents. This study therefore aimed to investigate the alterations in basophile count in cancer patients administered vi...

Poor clinical pharmaceutical system in developing part of the world is big health hurdle. That also is a major reason of drug interactions, wrong medications, clinical errors, medical mistakes and therapeutical complications. We have aimed to uplift the health standards to mitigate drug abuse, enhance rational prescriptions and minimize the causali...

The aim of the present study was to explore the potential effect of the coating material on the aerodynamic particle size distribution (APSD) of formoterol from Oxis Turbohaler ® using mixing inlet with Andersen Cascade Impactor (ACI) operated at flow rate of 60 Lmin -1 . As the aerodynamic properties of the emitted dose from a dry powder inhaler (...

The present study was conducted to find out the ethambutol resistance pattern of indigenous isolates of Mycobacterium tuberculosis from Tuberculosis diagnosed human patients. A total of 172 specimens were collected from six different sources and comprised of 84.9% sputum, 10.5% pus and 4.7% bronchial washings. There were 70.9% males and 29.1% femal...

The present study was conducted to find out the ethambutol resistance pattern of indigenous isolates of Mycobacterium tuberculosis from Tuberculosis diagnosed human patients. A total of 172 specimens were collected from six different sources and comprised of 84.9% sputum, 10.5% pus and 4.7% bronchial washings. There were 70.9% males and 29.1% femal...

The present study was conducted to find out the ethambutol resistance pattern of indigenous isolates of Mycobacterium tuberculosis from Tuberculosis diagnosed human patients. A total of 172 specimens were collected from six different sources and comprised of 84.9% sputum, 10.5% pus and 4.7% bronchial washings. There were 70.9% males and 29.1% femal...

Tea is the most common beverage after it is extracted from the leaves of Camellia sinenesis. It is classified in to fermented tea (Black Tea) and non-fermented tea (green tea). Methanolic extract of tea diluted in methanol and ethanol, which were tested for antibacterial activity against Streptococcus mutans. Methanol was found to be best antimicro...

A vulture crisis is an important environmental problem, which happened because of utilization of unsafe anti-inflammatory and analgesic drugs. The clinical profile of phenylbutazone is not very much different from other NSAID's. Despite of sharing pharmacological usefulness, phenylbutazone also shares unwanted effects which may eventually lead to t...

Eosinopenia is a kind of leukopenia associated with shortage of eosinophils. Its major causes included acute infectious stress, myelotoxic drugs, and leukemia. Chemotherapeutical agents obviously exert remedy along with toxic effects. This study aimed to investigate the alterations in Eosinophil count in cancer patients and was administered vinorel...

Eosinopenia is a kind of leukopenia associated with shortage of eosinophils. Its major causes included acute infectious stress, myelotoxic drugs, and leukemia. Chemotherapeutical agents obviously exert remedy along with toxic effects. This study aimed to investigate the alterations in Eosinophil count in cancer patients and was administered vinorel...

Cancer is fatal dilemma of human life. During the recently ended 20 th century, it was the more feared and in many ways, the most mysterious of the major life threatening diseases. Despite of surprising advancement in applied therapeutics, cancer is still, both in perception and reality, a very real concern of public health. The present study was c...

The anti-pyretic and analgesic effects of dipyrone are similar to those of the other drugs but its toxicity differs significantly. Despite of sharing clinical usefulness, dipyrone share several unwanted side effects, the most common is a propensity to induce sudden and unidentified emergency that can sometimes result into death of patient (Gabriel...

Human body and all biological systems need a wide range of nutrients including minerals to perform various functions and to lead a productive life. Thus a number of minerals' intake daily is recommended for maintenance of sound health (1). Inadequate dietary intake of trace elements in pregnancy has adverse effects on birth weight. Therefore, eleme...

In grades III and IV, the acne is characterized by comedones and pustules and deeper inflamed nodules, which are supposed be the consequence of rupture of the sebaceous duct with extrusion of sebum and bacterial products into the skin tissue. The lesions are likely to extend from the face to the neck and upper trunk and to produce a permanent scarr...

The recently increased tubercular incidence in certain parts of the world compels the need to explore its scientific reasons. For this purpose a total 172 clinical isolates of Mycobacterium tuberculosis were collected from TB diagnosed patients. The culture sensitivity test was performed over Lowenstein Jensen (LJ) medium supplemented with rifampic...

The recently increased tubercular incidence in certain parts of the world compels the need to explore its scientific reasons. For this purpose a total 172 clinical isolates of Mycobacterium tuberculosis were collected from TB diagnosed patients. The culture sensitivity test was performed over Lowenstein Jensen (LJ) medium supplemented with rifampic...

Cancer is fatal dilemma of human life. During the recently ended 20th century, it was the more feared and in many ways, the most mysterious of the major life threatening diseases. Despite of surprising advancement in applied therapeutics, cancer is still, both in perception and reality, a very real concern of public health. The present study was ca...

Cancer is fatal dilemma of human life. During the recently ended 20 th century, it was the more feared and in many ways, the most mysterious of the major life threatening diseases of the word. Despite of surprising advancement in applied therapeutics, cancer is still, both in perception and reality, a very real concern of public health. Therefore p...