Tae-Ho Lee

Tae-Ho Lee
Virginia Tech (Virginia Polytechnic Institute and State University) | VT · Department of Psychology

PhD

About

61
Publications
10,138
Reads
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1,266
Citations
Citations since 2017
38 Research Items
1045 Citations
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2017201820192020202120222023050100150200250
Introduction
Additional affiliations
July 2016 - August 2018
University of North Carolina at Chapel Hill
Position
  • PostDoc Position
August 2015 - June 2016
University of Illinois, Urbana-Champaign
Position
  • PostDoc Position
May 2015 - August 2015
University of Southern California
Position
  • PostDoc Position

Publications

Publications (61)
Preprint
Full-text available
The brain connectivity of resting-state fMRI (rs-fMRI) represents an intrinsic state of brain architecture, and it has been used as a useful neural marker for detecting psychiatric conditions as well as for predicting psychosocial characteristics. However, most studies using brain connectivity have focused more on the strength of functional connect...
Preprint
Full-text available
The LC is a brainstem region associated with broad physiological and neural arousal as part of the release of norepinephrine, but it has increasingly been associated with multiple specific cognitive processes. These include sustained attention, deficits in which are associated with a variety of neuropsychological disorders. Neural models of attenti...
Article
The locus coeruleus-noradrenergic system integrates signals about arousal states throughout the brain and helps coordinate cognitive selectivity. However, age-related changes in this system may impact how arousal coordinates selectivity in older adults. To examine this, we compared how increases in emotional arousal modulates cognitive selectivity...
Article
Full-text available
Dysfunctional sociability is a core symptom in autism spectrum disorder (ASD) that may arise from neural-network dysconnectivity between multiple brain regions. However, pathogenic neural-network mechanisms underlying social dysfunction are largely unknown. Here, we demonstrate that circuit-selective mutation (ctMUT) of ASD-risk Shank3 gene within...
Poster
Full-text available
Background: While the negative impacts of caffeinated soda on children’s physical health have been well documented, it remains unexplored if habitual caffeinated soda intake is associated with intellectual capacities in children and predicts higher future substance use. Here, we investigated the neu- rocognitive correlates of daily consumption of c...
Article
Full-text available
Social learning theory posits that adolescents learn to adopt social norms by observing the behaviors of others and internalizing the associated outcomes. However, the underlying neural processes by which social learning occurs is less well-understood, despite extensive neurobiological reorganization and a peak in social influence sensitivity durin...
Preprint
Full-text available
The COVID pandemic has made an unprecedented shift in children's daily lives. Children are increasingly spending time with screens to learn and connect with others. As online environment rapidly substitutes in-person experience, understanding children's neuropsychological trajectories associated with screen experiences is important. Given previous...
Article
Full-text available
Researchers generally agree that when up- and down-regulating emotion, control regions in the prefrontal cortex turn up or down activity in affect-generating brain areas. However, the 'affective dial hypothesis' that turning up and down emotions produces opposite effects in the same affect-generating regions is untested. We tested this hypothesis b...
Article
Full-text available
Mental imagery is an important tool in the cognitive control of emotion. The present study tests the prediction that visual imagery can generate and regulate differential fear conditioning via the activation and prioritization of stimulus representations in early visual cortices. We combined differential fear conditioning with manipulations of view...
Article
Full-text available
BACKGROUND Atypical activity in the salience network and default-mode network (DMN) has been previously reported in individuals with autism spectrum disorder (ASD). However, no study to date has investigated the nature and dynamics of the interaction between these two networks in ASD. METHODS Here, we aimed to characterize the functional connectiv...
Article
Full-text available
The locus coeruleus is critical for selective information processing by modulating the brain’s connectivity configuration. Increasingly, studies have suggested that LC controls sensory inputs at the sensory gating stage. Furthermore, accumulating evidence has shown that young children and older adults are more prone to distraction and filter out ir...
Preprint
Full-text available
The locus coeruleus is critical for selective information processing by modulating brain’s connectivity configuration. Increasingly studies have suggested that LC controls sensory inputs at the sensory gating stage. Furthermore, accumulating evidence has examined that young children and older adults are more prone to distraction and filter out irre...
Preprint
Prior studies on emotion regulation identified a set of brain regions specialized for generating and controlling affect. Researchers generally agree that when up- and down-regulating emotion, control regions in the prefrontal cortex turn up or down activity in affect-generating areas. However, the assumption that turning up and down emotions produc...
Preprint
During a challenge or emotional experience, increases in arousal help us focus on the most salient or relevant details and ignore distracting stimuli. The noradrenergic system integrates signals about arousal states throughout the brain and helps coordinate this adaptive attentional selectivity. However, age-related changes in the noradrenergic sys...
Preprint
Full-text available
While the negative impacts of caffeinated soda on children’s physical health have been well documented, it remains unexplored if habitual caffeinated soda intake is associated with intellectual capacities in children. Here, we investigated the behavioral and neural correlates of daily consumption of caffeinated soda on neurocognitive functions incl...
Preprint
Full-text available
Mental imagery is an important tool in the cognitive control of emotion. The present study tests the prediction that visual imagery can generate and regulate differential fear conditioning via the activation and prioritization of stimulus representations in early visual cortices. We combined differential fear conditioning with manipulations of view...
Article
Loss of sociability is a core symptom in autism spectrum disorder (ASD) that may arise from neural network dysconnectivity between multiple brain regions contributing to social behaviors. However, the pathogenic neural network mechanisms underlying social dysfunction of ASD are largely unknown. Here, we demonstrate that the circuit-selective mutati...
Article
Full-text available
This exploratory study examined whether social learning increases similarity in adolescent siblings' behavior and neu-ral patterns during risky decision making. Participants included 86 adolescents (43 sibling dyads; younger siblings: M age = 12.2 years; 22 females; older siblings: M age = 14.6 years; 20 females) who completed questionnaires, and a...
Article
Full-text available
Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, partic...
Article
The current study sought to examine the functional connectivity of resting state networks (RSNs) as they relate to the individual domains of executive functioning (EF). Based on the Unity and Diversity model (Miyake et al., 2000), EF performance was captured using a three-factor model proposed by Karr et al. (2018), which includes inhibition, shift...
Chapter
Psychophysiology measures physiological activities originating from the autonomic nervous system, including eye movement, heart rate, electromyography, and skin conductance resistance, while operators conduct behavioral tasks. Researchers have distinguished psychophysiology from neuroergonomics, the latter of which focuses on neural activities in b...
Article
Full-text available
We examined functional connectivity between the locus coeruleus (LC) and the salience network in healthy young and older adults to investigate why people become more prone to distraction with age. Recent findings suggest that the LC plays an important role in focusing processing on salient or goal-relevant information from multiple incoming sensory...
Article
Full-text available
Decades of developmental research have demonstrated the positive role of parental monitoring during adolescence, a time during which youth seek exploration and show heightened risk taking. The present study employed a novel neural pattern similarity approach to identify neural patterns underpinning parental monitoring, with attention to implication...
Article
Full-text available
The current study examined perceptual differences between adults and youth in perceiving ambiguous facial expressions. We estimated individuals’ internal representation for facial expressions and compared it between age groups (adolescents: N=108, Mage=13.04 years, 43.52% female; adults: N=81, Mage=31.54, 65.43% female). We found that adolescents’...
Article
Full-text available
In younger adults, arousal amplifies attentional focus to the most salient or goal-relevant information while suppressing other information. A computational model of how the locus coeruleus–noradrenaline system can implement this increased selectivity under arousal and a functional magnetic resonance imaging (fMRI) study comparing how arousal affec...
Preprint
Resting state autonomic nervous system activity [ANS] indexed by measures of heart rate [HR] and its variability [HRV], is associated with brain morphology, in particular cortical thickness [CT]. However, findings have been mixed regarding the regions of interest [ROI] associated with HR/HRV and the direction of the association. Sex and age differe...
Article
Full-text available
Previous research has shown associations between brain structure and resting state high‐frequency heart rate variability (HF‐HRV). Age affects both brain structure and HF‐HRV. Therefore we sought to examine the relationship between brain structure and HF‐HRV as a function of age. Data from two independent studies were used for the present analysis....
Article
Full-text available
Recent models posit that bursts of locus ceruleus (LC) activity amplify neural gain such that limited attention and encoding resources focus even more on prioritized mental representations under arousal. Here, we tested this hypothesis in human males and females using fMRI, neuromelanin MRI, and pupil dilation, a biomarker of arousal and LC activit...
Article
Full-text available
The current study aimed to capture empathy processing in an interpersonal context. Mother-adolescent dyads (N=22) each completed an empathy task during fMRI, in which they imagined the target person in distressing scenes as either themselves or their family (i.e., child for the mother, mother for the child). Using multi-voxel pattern approach, we c...
Article
Full-text available
Sleep habits developed in adolescence shape long-term trajectories of psychological, educational, and physiological well-being. Adolescents’ sleep behaviors are shaped by their parents’ sleep at both the behavioral and biological levels. In the current study, we sought to examine how neural concordance in resting-state functional connectivity betwe...
Article
The locus coeruleus (LC) is a key node of the sympathetic nervous system and suppresses parasympathetic activity that would otherwise increase heart rate variability. In the current study, we examined whether LC-MRI contrast reflecting neuromelanin accumulation in the LC was associated with high-frequency heart rate variability (HF-HRV), a measure...
Article
Shared psychological processes between individuals occur most between a mother and her child because the mother– child bond is one of the closest forms of human attachment, in which a mother and her child are essentially wired to connect. We recruited mother–child pairs (N dyad = 19; adolescent: M age = 13.74, 11 males; mothers: M age = 44.26), who...
Article
Full-text available
Recent developmental brain imaging studies have demonstrated that negatively coupled prefrontal-limbic circuitry implicates the maturation of brain development in adolescents. Using resting-state functional magnetic resonance imaging (rs-fMRI) and independent component analysis (ICA), the present study examined functional network coupling between p...
Article
The ability to regulate emotion is crucial to promote well-being. Evidence suggests that the medial prefrontal cortex (mPFC) and adjacent anterior cingulate (ACC) modulate amygdala activity during emotion regulation. Yet less is known about whether the amygdala–mPFC circuit is linked with regulation of the autonomic nervous system and whether the r...
Article
Full-text available
Anxiety is associated with an exaggerated expectancy of harm, including overestimation of how likely a conditioned stimulus (CS+) predicts a harmful unconditioned stimulus (US). In the current study we tested whether anxiety-associated expectancy of harm increases primary sensory cortex (S1) activity on non-reinforced (i.e., no shock) CS+ trials. T...
Article
Full-text available
Emotional information receives preferential processing, which facilitates adaptive strategies for survival. However, the presence of emotional stimuli and the arousal they induce also influence how surrounding non-emotional information is processed in memory (Mather and Sutherland, 2011). For example, seeing a highly emotional scene often leads to...
Article
Full-text available
Recent evidence indicates that emotion enhances contrast thresholds in subsequent visual perception (Phelps, Ling, & Carrasco, 2006) and perceptual sensitivity for low-spatial frequency but not high-spatial frequency targets (Bocanegra & Zeelenberg, 2009b). However, these studies just report responses to various frequencies at a fixed contrast leve...
Article
Full-text available
The arousal-biased competition (ABC) model predicts that arousal increases the gain on neural competition between stimuli representations. Thus, the model predicts that arousal simultaneously enhances processing of salient stimuli and impairs processing of relatively less-salient stimuli. We tested this model with a simple dot-probe task. On each t...
Conference Paper
Recent evidence indicates that emotion enhances contrast thresholds (Phelp, Ling & Carrasco, 2006), and perceptual sensitivity for low-spatial-frequency stimuli (Bocanegra & Zeelenberg, 2009). However, these studies report just the responses to various frequencies at a given contrast or vice versa rather than the contrast sensitivity function (CSF)...
Article
Full-text available
Arousal-biased competition theory predicts that arousal biases competition in favor of perceptually salient stimuli and against non-salient stimuli (Mather and Sutherland, 2011). The current study tested this hypothesis by having observers complete many trials in a visual search task in which the target either always was salient (a 55° tilted line...
Article
Full-text available
Certain facial configurations are believed to be associated with distinct affective meanings (i.e. basic facial expressions), and such associations are common across cultures (i.e. universality of facial expressions). However, recently, many studies suggest that various types of contextual information, rather than facial configuration itself, are i...
Data
Average Normative Valence and Arousal (Standard Deviations) and Picture Identification Numbers from the International Affective Picture System for the Negative, Neutral and Positive Pictures Used (valence scale ranging from 1: negative – 9: positive; arousal from 1: calm – 9: aroused). (DOCX)
Article
Full-text available
People from Asian cultures are more influenced by context in their visual processing than people from Western cultures. In this study, we examined how these cultural differences in context processing affect how people interpret facial emotions. We found that younger Koreans were more influenced than younger Americans by emotional background picture...
Conference Paper
Background: When observers view ambiguous figures for prolonged period of time, they experience perceptual alternations between two possible visual interpretations (Leopold & Logothetis, 2003). Dubbed bistable perception, this phenomenon has been considered as a useful means to study visual awareness since it induces spontaneous fluctuation in awar...
Article
Full-text available
In the present study, we investigated the neural correlates underlying the perception of emotion in response to facial stimuli in order to elucidate the extent to which emotional perception is affected by the top-down process. Subjects performed a forced, two-choice emotion discrimination task towards ambiguous visual stimuli consisted of emotional...
Article
We tested whether a conditioned emotional stimulus could facilitate visual processing when presented subliminally. Participants received Pavlovian conditioning in which a fearful expression (conditioned stimulus) was paired with electric finger shock (unconditioned stimulus). In a subsequent session, they were subject to a simple perceptual task in...
Article
Full-text available
People with anxiety disorder display attentional bias toward threat-related objects. Using classical fear conditioning, the authors investigated the possible source of such bias in normal participants. Following differential fear conditioning in which an angry face of either male or female (conditioned stimulus: CS+) was paired with mild electric f...

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Projects (4)
Project
Investigation of arousal in perception and memory