Tadashi Kimura

Osaka University | Handai · Division of Obstetrics and Gynecology

Epithelial ovarian cancer is characterized by aggressive peritoneal dissemination. Neutrophils are mobilized to peritoneal cavity in some patients with ovarian cancer dissemination; however, its pathological significance remains unknown. This study aimed to investigate the role of neutrophil extracellular traps (NETs) in ovarian cancer disseminatio...

Precise vaccination data is essential to accurately estimate the effectiveness of the human papillomavirus (HPV) vaccine against HPV‐related cancers. In Japan, the number of subsidized HPV vaccinations can be tracked through registries, but the number of self‐funded vaccinations has not been tracked. The number of individuals who chose to receive t...

Objective To assess the association between gestational age at birth and the risk of growth failure and respiratory symptoms at 3 years of age. Design Cohort study using the Japan Environment and Children’s Study database. Patients A total of 86 158 singleton infants born without physical abnormalities at 32–41 weeks of gestation were enrolled be...

Study question Could controlled ovarian stimulation protocol (progestin-primed ovarian stimulation [PPOS] vs GnRH-antagonist [GnRH-ant]) affect the gene expression of human immune cells (ICs) in preovulatory follicles? Summary answer Proinflammatory cytokine-related gene expression was significantly higher and proinflammatory pathways were also mo...

Importance The Ministry of Health, Labour, and Welfare (MHLW) of Japan aggregates human papillomavirus (HPV) vaccination data across Japan for each fiscal year (FY) by age at vaccination. Birth FY (BFY)–specific vaccination coverage remains unknown. Objective To calculate the BFY-specific vaccination coverage for each FY and the cumulative first-d...

Preterm birth is a serious pregnancy complication that affects neonatal mortality, morbidity and long-term neurological prognosis. Predicting spontaneous preterm delivery (PTD) is important for its management. While excluding the risk of PTD is important, identifying women at high risk of PTD is imperative for medical intervention. Currently used P...

Japan has a particularly critical situation surrounding its collapsed HPV vaccination program for preventing HPV‐caused cervical cancers, a problem exacerbated by the lack of a national immunization database. We have determined the year‐to‐year HPV vaccination uptake by Japanese females and analyzed by birth fiscal year (FY) the monthly number of p...

Simple Summary We demonstrated that small interfering RNA replacement therapy using engineered exosomes exhibits promising effects in treating the peritoneal dissemination of ovarian cancer. Considering that patients with ovarian cancer routinely undergo omentectomy and that exosomes can be extracted from omental fibroblasts without difficulty, eng...

Severe cases of hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome requiring plasma exchange or dialysis should be differentiated from other thrombotic microangiopathy (TMA) and treated appropriately. To evaluate the prevalence and clinical characteristics of such cases in Japan, a questionnaire‐based survey was conducted among ob...

Objective: Neutrophil extracellular trap (NETs) are neutrophil-derived extracellular DNA released in response to inflammation. In contrast to their primary host-defensive role, NETs have been recently reported to promote cancer progression. The aim of this study is to investigate the role of NETs in ovarian cancer progression. Method: The clinical...

Objective: Small cell neuroendocrine carcinoma of the uterine cervix (SCNEC) is extremely rare but highly aggressive and its prognosis is usually poor. Vaccinia-related kinase (VRK)1 is a serine/threonine protein kinase that is involved in cell proliferation by regulating cell-cycle progression and inducing cell-cycle arrest in response to stress s...

Introduction: Previously, we reported that VLDL promoted cell proliferation of epithelial ovarian cancer (EOC) cells in vitro. In vivo, we also confirmed that High-Fat Diet (HFD) strongly promoted the tumor growth of EOC. These results suggest that lipid molecules in HFD might contribute to cell proliferation of EOC cell. In this study, we performe...

Introduction/Background Previously, we reported that VLDL promoted cell proliferation of epithelial ovarian cancer (EOC) cells in vitro. In vivo, we also demonstrated that High-Fat Diet (HFD) strongly promoted the tumor growth of EOC than Normal-Diet (ND). These results suggest that lipid molecules in HFD might contribute to cell proliferation of E...

Background: Mesonephric adenocarcinoma (MA) is an uncommon, HPV-independent, malignant neoplasm with mesonephric (Wolffian) differentiation that mainly occurs in the uterine cervix. Recently, mesonephric-like adenocarcinoma (MLA) is characterized as a rare tumor showing similar characteristics to MA in the uterine body and the ovary (WHO Classifica...

Purpose The coronavirus disease of 2019 (COVID-19) pandemic has increased public awareness of infectious diseases and interest in vaccines, including the human papilloma virus (HPV) vaccine. We investigated differences between parental gender and intentions to vaccinate their child for HPV and COVID-19. Methods We analyzed data from Japan’s COVID-...

Background One life event that requires extensive resilience and adaptation is parenting. However, resilience and perceived support in child-rearing vary, making the real-world situation unclear, even with postpartum checkups. Objective This study aimed to explore the psychosocial status of mothers during the child-rearing period from newborn to t...

Pancreatic fistulas are rare after gynecologic surgeries but are sometimes difficult to manage. A 62-year-old woman was admitted to a local hospital with acute abdominal pain. Computed tomography (CT) images showed subileus and an obstruction site in the transverse/descending colon, with invasion of peritoneal metastasis. A metal stent was placed i...

Background: Globally there has been an increase in the number of patients receiving long-term antiresorptive drugs for the treatment of postmenopausal osteoporosis; however, there is little evidence to guide decisions regarding when and how to stop or switch antiresorptive drugs. In this prospective observational study, we investigated the efficacy...

Importance Women with a high level of autistic traits in the general population may experience larger health disparities during pregnancy, particularly women diagnosed with autism spectrum disorder (ASD), which in turn may be associated with increased risk of adverse birth outcomes. Objective To investigate the association between maternal autisti...

In 2013, the national human papillomavirus (HPV) immunization program began. However, in June 2013, Japan's Ministry of Health, Labor and Welfare (MHLW) announced a “temporary” suspension of its recommendation for the human papillomavirus vaccine. Finally, in November 2021, the MHLW ended its suspension of the recommendation of the HPV vaccine. To...

The influence of the coronavirus disease 2019 (COVID-19) pandemic on the number of newly diagnosed gynecological cancers has not been extensively investigated in Japan. This study determined the impact of COVID-19 on the incidence of gynecological cancer. Using the Japanese Society of Obstetricians and Gynecologic Oncology registry database, the di...

Introduction Previously we reported that lipolysis-stimulated lipoprotein receptor (LSR) mediates the cell proliferation via lipid metabolism in epithelial ovarian cancer (EOC). We newly developed anti-LSR antibody. Anti-LSR antibody showed stronger anti-tumor effect against LSR positive EOC cells, especially in High-Fat Diet (HFD) fed mouse compar...

Introduction Endometrial cancer (EC) is the most common gynecological cancer in Japan. The initial treatment of EC is surgery followed by platinum-based chemotherapy, therefore, platinum resistance is major factor of poor prognosis. In this study, we focused on IGF2BP2 which is highly expressed in platinum resistant EC cells and analyze its functio...

Purpose In Japan, Japan’s Ministry of Health, Labor, and Welfare decided to suspend govermental recommendation for HPV vaccination in FY 2013. The HPV vaccination rate for those born in FY 2000 or thereafter declined dramatically. In 2021, the “suspension of recommendation” ended. The catch-up vaccinations for the unvaccinated have been offered nat...

Introduction/Background Endometrial cancer (EC) is the most common gynecological cancer in Japan. The initial treatment of EC is surgery followed by platinum-based chemotherapy, therefore, platinum resistance is major factor of poor prognosis. In this study, we focused on IGF2BP2 which is highly expressed in platinum resistant EC cells and analyze...

Introduction/Background Previously we reported that lipolysis-stimulated lipoprotein receptor (LSR) mediates the cell proliferation via lipid metabolism in epithelial ovarian cancer. Our newly anti-LSR antibody demonstrated stronger anti-tumor effect against LSR positive epithelial ovarian cancer cells in High-Fat Diet (HFD) fed mouse compared to N...

Lipolysis‐stimulated lipoprotein receptor (LSR) is known as a lipoprotein receptor. LSR is expressed in various solid tumors, including epithelial ovarian, gastric, and colon cancers. High LSR expression is significantly associated with poor prognosis, but its role in cancer has not been fully elucidated. LSR belongs to the Ig protein superfamily,...

Objective To assess the association between gestational age classification at birth and the risk of neurodevelopmental impairments at age 3 years. Design Cohort study using the Japan Environment and Children’s Study database. Patients A total of 86 138 singleton children born without physical abnormalities at 32–41 weeks of gestation enrolled bet...

Objective: Self-sampled human papillomavirus (HPV) testing is a potential option for cervical cancer screening, but research is scarce in Cambodia. We evaluated the feasibility, accuracy, and acceptability of self-sampled HPV testing using careHPV. Methods: A cross-sectional study including women aged 20-49 years attending 2 national hospitals i...

Background: Prenatal exposure to metallic elements may adversely affect early childhood health. However, more evidence is needed as population-based cohort studies are currently limited. Objectives: We aimed to examine the associations between prenatal metallic (mercury, selenium, and manganese) exposure and the risk of allergic diseases in early c...

The Japanese Ministry of Health, Labor and Welfare (MHLW) temporarily suspended recommendation for HPV vaccinations for girls in June 2013. It resumed its recommendation in November 2021. To compensate for eight years of lost overage, a ‘catch-up HPV vaccination’ program began in April 2022. To determine intervention needs in regards to HPV vaccine...

Study question Could the difference in controlled ovarian stimulation protocol between progestin-primed ovarian stimulation and GnRH-antagonist induce change in the expression genes of human granulosa cells? Summary answer The mitochondrial DNA (mtDNA) gene expression of granulosa cells in patients who underwent progestin-primed ovarian stimulatio...

The clinical features of newly diagnosed cervical cancer in Cambodia are poorly documented. We aimed to describe the histologic type and stage distributions of newly diagnosed cervical cancer patients at the Khmer Soviet Friendship Hospital in Phnom Penh, which is one of the two national cancer centers in Cambodia. A descriptive cross-sectional stu...

Although bevacizumab (BEV) plays a key role in ovarian cancer treatment, BEV resistance is often observed in clinical settings. This study aimed to identify the genes responsible for BEV resistance. C57BL/6 mice inoculated with ID-8 murine ovarian cancer cells were treated with anti-VEGFA antibody or IgG (control) twice weekly for 4 weeks. The mice...

Background: This study aimed to examine the effect of the HMGB1 peptide on Bronchopulmonary dysplasia (BPD)-related lung injury in a mouse model. Results: HMGB1 peptide ameliorates lung injury by suppressing the release of inflammatory cytokines and decreasing soluble collagen levels in the lungs. Single-cell RNA sequencing showed that the pepti...

Background Gynecological cancer is one of the highest risk factors for cancer-associated thrombosis (CAT). Although low-molecular-weight heparin (LMWH) is recommended as an anticoagulant for treating CAT, recent studies have shown that direct oral anticoagulants (DOACs) are an acceptable alternative. Patients with cancer require a series of chemoth...

Background: This study assesses the feasibility of minimally invasive surgery (MIS) for well-selected epithelial ovarian cancer (EOC) patients. Methods: We performed a review of data prospectively collected from a single center from 2017 to 2022. Only patients with histologically confirmed EOC, with a tumor diameter of less than 10 cm, were elig...

This observational cohort study aimed to evaluate the association between the duration of neonatal phototherapy and sleep-and-wakefulness states at 1 month, 1.5 years, and 3 years of age. We analysed data from 77,876 infants using the Japan Environment and Children's Study, a nationwide birth cohort study. The participants were divided into three g...

Introduction: Tumor cell spillage during the colpotomy has been suspected as one reason for poor oncologic outcomes in laparoscopic radical hysterectomy (LRH) for cervical cancer. To prevent such tumor spillage in LRH, we focused on use of a Gutclamper which is a device originally designed to clamp the colon and rectum during colorectal resections...

[Objective] Uterine leiomyosarcoma (LMS) has a poor prognosis, and no effective treatment other than surgery has been established. Kinesin family member4A (KIF4A) is a member of the kinesin4 subfamily and plays an important role in cell division. KIF4A has been revealed to play significant roles in some cancers with tumor proliferation. The aim of...

Background: The prognosis of small cell neuroendocrine carcinoma of the uterine cervix (SCNECC) is extremely poor due to the aggressive natural history. Since it is a rare cancer, there are few studies describing its molecular biology. Small cell lung cancer (SCLC) accounts for 95% of small cell carcinomas, therefore, clinically the chemotherapy re...

High-risk human papillomavirus (HPV) infection is the major cause of cervical cancer. However, the factors that modulate the process from infection to carcinogenesis are poorly understood. Although cervical cancer is clinically considered an estrogen-independent tumor, the role of estrogen in cervical cancer, particularly cervical adenocarcinoma, r...

Background/aim: Small cell neuroendocrine carcinoma of the cervix (SCNEC) is a rare disease characterized by a higher incidence of lymphatic invasion, metastasis, and recurrence compared to the squamous cell carcinoma and adenocarcinoma subtypes. Furthermore, it is prone to early distant metastasis and has a poor prognosis. Chemotherapy has an imp...

BACKGROUND One life event requiring the most extensive resilience and adaptation is parenting. However, resilience and perceived support in child rearing are diverse, and the actual situation is unclear, especially after public postpartum checkups. OBJECTIVE To explore the psychosocial status of mothers during the child-rearing period from newborn...

Objective: Childhood IgA vasculitis in remission is not a known risk factor for pregnancy but can lead to complications such as preeclampsia, even in women with a low risk of kidney function decline. Methods: This retrospective study compared pregnancy outcomes between patients with IgA vasculitis with nephropathy (Henoch–Schönlein purpura nephriti...

Purpose: To investigate the clinical practices of diagnosing multicystic cervical lesions as a means to develop a more appropriate diagnostic algorithm for gastric-type adenocarcinoma (GAS) and its precursors. Methods: Clinical information for 159 surgically treated patients for multicystic disease of the uterine cervix was collected from 15 hos...

Objective To clarify the relationship between the number of deliveries and maternal outcomes in Japan, considering the declining birth rate and the evidence that hospitals with few deliveries have medical safety issues. Methods Hospitalizations for deliveries were analyzed using the Diagnosis Procedure Combination database from April 2014 to March...

Objective: To assess whether the coronavirus disease 2019 (COVID-19) mRNA vaccine affects sperm morphokinetics using a computer-assisted semen analyzer and other semen parameters using a sperm chromatin structure assay. Methods: Healthy male volunteers in two Japanese clinics between May 2021 and December 2021 were prospectively analyzed. Participa...

In November of 2021, the government of Japan announced a reversal of its decision, in 2013, to suspend the previous proactive recommendation for HPV vaccination. However, the intention of young girls to receive routine and catch-up vaccinations has not necessarily increased as expected. We conducted a nationwide questionnaire survey by mail in Sept...

This observational cohort study aimed to examine the association between the duration of phototherapy for neonatal jaundice and the risk of developmental delay at 3 years of age using nationwide birth cohort data. Data from 76,897 infants were analyzed. We divided participants into four groups: no phototherapy, short phototherapy (1–24 h), long pho...

Objective To introduce the Perinatal Early Assessment and Communication system for Emergencies (PEACE), a dedicated internet‐based system for sharing maternal and newborn health information during large‐scale disaster. Methods PEACE was developed by the Japan Society of Obstetrics and Gynecology (JSOG) to enable internet‐based sharing of maternal...

Background Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by anti-HPA alloantibody, and anti-HPA-4b is the most common cause in Japanese. Anti-HPA-5b is frequently detected in pregnant women, but it is still controversial whether anti-HPA-5b causes severe FNAIT.Case presentationA Japanese woman with anti-HPA-4b and anti-HPA-5b all...

Objective: To analyze the effects of in-person attendance at an academic conference held during the Covid-19 pandemic on the health of the attendees, as assessed based on symptoms such as fever and cough attributed to infection with the Covid-19 virus. Methods: A questionnaire was used to survey the members of the Japan Society of Obstetrics and...

No standard treatment has been established for most rare cancers. Here, we report a clinical trial of a biweekly WT1 tri-peptide-based vaccine for recurrent or advanced rare cancers. Due to the insufficient number of patients available for a traditional clinical trial, the trial was designed for rare cancers expressing shared target molecule WT1. T...

Background Epithelial ovarian cancer (EOC) is a lethal malignant tumor, for which new treatment options are urgently required. Lipolysis-stimulated lipoprotein receptor (LSR) is widely expressed in EOC, and it is associated with poor prognosis. In this study, we developed an antibody-drug conjugate (ADC) targeting LSR as a new therapeutic approach...

To improve current infertility treatments, it is important to understand the pathophysiology of implantation failure. However, many molecules are involved in the normal biological process of implantation and the roles of each molecule and the molecular mechanism are not fully understood. This review highlights the hemagglutinating virus of Japan (H...

We aimed to evaluate the response to definitive radiotherapy (RT) for cervical cancer based on histological subtypes and investigate prognostic factors in adenocarcinoma (AC). Of the 396 patients treated with definitive RT between January, 2010 and July, 2020, 327 patients met the inclusion criteria, including 275 with squamous cell carcinoma (SCC)...

Introduction: Currently, the association between the duration of neonatal phototherapy and the risk of allergic disorders has not been reported. This observational cohort study aimed to examine the association between allergic disorders, including food allergies, that are present before 3 years of age and the duration of phototherapy using the nat...

Objectives Epithelial ovarian cancer (EOC) is the leading cause of cancer-related deaths among women, thus new treatment option is urgently required. Lipolysis-stimulated lipoprotein receptor (LSR) is widely expressed in EOC and associated with poor prognosis. In this study, we developed antibody-drug conjugate (ADC) targeting LSR as a new therapy...

Objectives Advanced endometrial cancer (EC) has a poor prognosis. Since the efficacy of current chemotherapy is limited, new therapeutic agents are needed. We focused on lipolysis-stimulated lipoprotein receptor (LSR), a membrane protein highly expressed in EC cells, and developed a new anti-LSR monoclonal antibody (mAb). In this study, we aimed to...

Objectives Previously, we identified lipolysis-stimulated lipoprotein receptor (LSR) as a new target of epithelial ovarian cancer (EOC), and we reported anti-tumor effect of our newly developed monoclonal antibody (mAb) against LSR-positive EOC cells in vitro and in vivo. We also demonstrated that LSR promoted uptake of lipid metabolite in EOC cell...

Selecting the best treatment for individual patients with cancer has attracted attention for improving clinical outcomes. Recent progress in organoid culture may lead to the development of personalized medicine. Unlike molecular-targeting drugs, there are no predictive methods for patient response to standard chemotherapies for ovarian cancer. We p...