Ta-Chih Hsiao

Ta-Chih Hsiao
National Taiwan University | NTU · Graduate Institute of Environmental Engineering

Ph.D.
Aerosol Instrumentation, Atmospheric Aerosol & Ambient Monitoring, PM & Nanoparticle Toxicity

About

125
Publications
22,189
Reads
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1,526
Citations
Citations since 2016
93 Research Items
1400 Citations
20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
Additional affiliations
August 2018 - present
National Taiwan University
Position
  • Professor (Associate)
August 2016 - July 2018
National Central University
Position
  • Professor (Associate)
August 2010 - July 2016
National Central University
Position
  • Professor
Education
August 2004 - July 2009
Washington University in St. Louis
Field of study
  • Dept. of Energy, Environmental and Chemical Engineering
August 2001 - June 2003
Stanford University
Field of study
  • Civil and Environmental Engineering
September 1994 - June 1998
National Taiwan University
Field of study
  • Civil Engineering

Publications

Publications (125)
Article
Full-text available
We investigated the effects of antibiotics, drugs, and metals on lung and intestinal microbiomes after sub-chronic exposure of low-level air pollution in ageing rats. Male 1.5-year-old Fischer 344 ageing rats were exposed to low-level traffic-related air pollution via whole-body exposure system for 3 months with/without high-efficiency particulate...
Article
Full-text available
Physicochemical properties of nanoparticles are important in regulating nanoparticle toxicity; however, the contribution of nanoparticle charge remains unclear. The objective of this study was to investigate the pulmonary effects of inhalation of charged soot nanoparticles. We established a stably charged nanoparticle generation system for whole-bo...
Article
Full-text available
Acute exposure to fresh traffic-related air pollutants (TRAPs) can be high for road users, including motorbike drivers, cyclists, and pedestrians. However, evaluating the toxicity of fresh traffic emissions from on-road vehicles is challenging since pollution properties can change dynamically within a short distance and time. This study demonstrate...
Article
Full-text available
Characterizing engineered nanoparticles (ENPs) in complex environmental matrices remains a challenging task. This work presents a two-dimensional size analysis method by combining differential mobility analyzer (DMA) and single-particle inductively coupled plasma-mass spectrometry (spICP-MS) with a new atomizer (ATM)-enabled sample introduction tha...
Article
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This study applied positive matrix factorization (PMF) to identify the sources of size-resolved submicrometer (10–1000 nm) particles and quantify their contributions to impaired visibility based on the particle number size distributions (PNSDs), aerosol light extinction (bp), air pollutants (PM10, PM2.5, SO2, O3, and NO), and meteorological paramet...
Article
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This study investigated the hourly inorganic aerosol chemistry and its impact on atmospheric visibility over an urban area in Central Taiwan, by relying on measurements of aerosol light extinction, inorganic gases, and PM2.5 water-soluble ions (WSIs), and simulations from a thermodynamic equilibrium model. On average, the sulfate (SO4²⁻), nitrate (...
Article
Full-text available
Fine particulate matter (PM2.5) has been linked to cardiopulmonary disease and systemic effects in humans. However, few studies have investigated the particle bioreactivity in Chinese megacities during haze episodes. The objective of this study was to determine the contributions of chemical components in PM2.5 to particle bioreactivity in Chinese m...
Article
The significance of this work is that ambient PM2.5 is a direct transmission mode for influenza virus infection to the human alveolar epithelium. The concentration of PM2.5 was 11.7 ± 5.5 μg/m³ in Taipei during 24 December 2019–13 January 2020. Approximately 79% of inhaled PM2.5 is able to reach the upper-to-lower airway, and 47% of PM2.5 is able t...
Article
Adverse human health effects caused by fine particulate matter (PM2.5) were reported; however, source-specific PM2.5 and its bioreactivity need to be assessed to understand regional human impacts. The objective of this study was to investigate the contributions of PM2.5 to particle bioreactivity in Taichung City, an urban area of west-central Taiwa...
Article
Full-text available
Epidemiological studies identified the relationship between air pollution and pulmonary tuberculosis. Effects of lung-deposited dose of particulate matter (PM) on culture-positive pulmonary tuberculosis remain unclear. This study investigates the association between lung-deposited dose of PM and pulmonary tuberculosis pleurisy. A case-control study...
Article
In recent years, many sample analyses have revealed that the proportion of nitrate (NO3-) in PM2.5 frequently exceeds that of other major PM2.5 species, such as SO42-, NH4+, and OC. This phenomenon has attracted considerable attention because it could change the direction of PM2.5 control policies. The present study analyzed the long-term trends of...
Article
Full-text available
Source-apportioned particle concentrations are necessary to properly evaluate the health impacts of air pollution. In this study, a measurement station was established at an urban roadside in northern Taiwan to the investigate lung deposited surface area (LDSA) concentration, a relevant metric for the adverse health effects of aerosol exposure, alo...
Article
Traffic-related air pollutants (TRAPs) pose a serious health hazard for residents and commuters in urban areas. In this study, a real-time mobile monitoring system was deployed in Taipei, a typical East Asian city with an overlap of high population density, traffic, and special structures (e.g., viaducts), to capture the on-road TRAPs at different...
Article
The deterioration of visibility due to air pollutants and relative humidity has been a serious environmental problem in eastern Asia. In most previous studies, chemical compositions of atmospheric particles were provided using filter-based offline analyses, which were unable to provide long-term and in-situ measurements that resolve sufficient temp...
Article
Air pollution has been linked to emphysema in chronic obstruction pulmonary disease (COPD). However, the underlying mechanisms in the development of emphysema due to air pollution remain unclear. The objective of this study was to investigate the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibition of prolife...
Article
Full-text available
Exposure to road dust particulate matter (PM) causes adverse health impacts on the human airway. However, the effects of road dust on the upper airway epithelium in humans remain unclear. We investigated the involvement of the epidermal growth factor receptor (EGFR) after PM with an aerodynamic diameter of < 2.5 μm (PM2.5)-induced E-cadherin disrup...
Article
Chlorine dioxide (ClO2) has proven its efficiency as a fumigant toward bacteria and viruses. However, it still has challenges on its portability and simplicity of ClO2 generation to meet the demand for disinfection in public and medical sectors. In this study, ClO2 stripping process via a rotating packed bed (RPB) from the commercial ClO2 solution...
Article
Vehicle emissions are an important source of particulate matter (PM) in urban areas and have well-known adverse health effects on human health. Oxidative potential (OP) is used as a quantification metric for indexing PM toxicity. In this study, by using a liquid spot sampler (LSS) and the dithiothreitol (DTT) assay, the diurnal OP variation was ass...
Article
Full-text available
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) were shown to have potential for immunoregulation and tissue repair. The objective of this study was to investigate the effects of hUC-MSCs on emphysema in chronic obstructive pulmonary disease (COPD). The C57BL/6JNarl mice were exposed to cigarette smoke (CS) for 4 months followed by a...
Article
Southeast Asia is a major biomass burning (BB) source area and BB has been identified as an important source of mercury (Hg) and aerosols to the atmosphere. Previous studies found correlations between atmospheric Hg and Delta-C (BC370–BC880) during the BB episodes in low-elevation BB source areas; however, whether this relationship persists during...
Preprint
Full-text available
Background: Air pollution has been linked to emphysema in chronic obstruction pulmonary disease (COPD). However, the underlying mechanisms in the development of emphysema due to air pollution remain unclear. The objective of this study was to investigate the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibitio...
Article
Full-text available
Quantifying aerosol compositions (e.g., type, loading) from remotely sensed measurements by spaceborne, suborbital and ground-based platforms is a challenging task. In this study, the first and second-order spectral derivatives of aerosol optical depth (AOD) with respect to wavelength are explored to determine the partitions of the major components...
Article
Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) is a type II acute-phase protein; however, the role of pulmonary ITIH4 after exposure to air pollution remains unclear. In this study, we investigated the role of ITIH4 in the lungs in response to air pollution. ITIH4 expression in bronchoalveolar lavage fluid (BAL) of 47 healthy human subjects an...
Article
Toxicological studies have demonstrated the associations between fine particle (PM2.5) components and various cytotoxic endpoints. However, few studies have investigated the toxicological effects of source-specific PM2.5 at the individual level. To investigate the potential impact of source-specific PM2.5 on cytotoxic effects, we performed repeated...
Conference Paper
In urban areas, traffic emission is a growing concern for ambient air quality and public health. Ultrafine particles (UFP) and black carbon (BC), a fraction of ambient particulate matter (PM), are both closely related to traffic emissions. Characterizing their physical and chemical properties is a crucial step in assessing health effects and air po...
Article
Particle morphology can affect the performance of an electrostatic precipitator air–liquid interface (ESP-ALI) cell exposure system and the resulting cell toxicity. In this study, three types of monodisperse aerosols – spherical sucrose particles, nonspherical align soot aggregates, and nanosilver aggregates/agglomerates – were selected to evaluate...
Preprint
Full-text available
Background: Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) is considered a type II acute-phase protein; however, the role of ITIH4 in the lungs after exposure to fine particulate matter (PM2.5) remains unclear. The objective of this study was to investigate the role of ITIH4 in the lungs in response to PM2.5 exposure. Results: ITIH4 expression...
Article
Full-text available
Introduction: Angiotensin-converting enzyme 2 (ACE2) provides an adhesion site for SARS-CoV-2 infection. Patients with COPD could have severe outcomes after SARS-CoV-2 infection. The objective of this study was to investigate ACE2 regulation by air pollution during the development of COPD. Methods: Sprague Dawley rats were exposed to unconcentrated...
Article
Coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly developed into a pandemic throughout the world. This disease is a highly infectious novel coronavirus and can affect people of all ages. Previous reports observed that particulate matter (PM) prov...
Article
Full-text available
Cigarette smoke (CS) has been reported to induce oxidative stress and inflammatory process in the lungs. However, the role of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in the regulation of pulmonary inflammation remains unclear. The objective of this study is to investigate the effects of hUC-MSCs on lung inflammation in the ac...
Article
Full-text available
The vertical distribution of aerosols is important for accurate surface PM2.5 retrieval and initial modeling forecasts of air pollution, but the observation of aerosol profiles on the regional scale is usually limited. Therefore, in this study, an approach to aerosol extinction profile fitting is proposed to improve surface PM2.5 retrieval from sat...
Article
Full-text available
Epidemiological and toxicological evidence indicates that fine particulate matter (PM2.5, particulate matter < 2.5 µm in aerodynamic diameter) causes cardiopulmonary toxicity; however, its neurotoxic effects remain unclear. The objective of this study was to investigate the role of the neurofilament light (NEFL) serum polypeptide in neurotoxicity....
Article
Removing submicron particles in the size range from 0.1 to 1.0 µm from gas streams is difficult because they cannot be efficiently captured neither through inertial separation nor by diffusion utilized in air pollution control devices. Electrostatic agglomeration is an effective and practical method for improving the removal efficiency of fine part...
Article
Urban wastewater treatment plants (WWTPs) can be an emission source of aerosol particles to the air and this process has the potential to spread emerging pollutants into the air, where the particles can be widely transported over long distances to areas where this pollution is unexpected. This study demonstrates aeration tanks in WWTPs as a potenti...
Article
Air-liquid exchange process could spread pathogens and pharmaceutical emerging pollutants into the air as aerosol particles in an Urban wastewater treatment plants (UWTPs). These particles can later be transported to places where such pollution is unforeseen. In this study, measurements were conducted in the aeration area of a UWTP in northern Taiw...
Article
Neurotoxicity caused by particulate matter (PM) has been highlighted as being a potential risk factor for neurodegenerative diseases. However, the effects of brain inflammation in response to traffic-related PM remain unclear. The objective of this study was to investigate the effects of traffic-related PM on microglial responses. We determined the...
Article
Full-text available
Electrospray-differential mobility analysis coupled to aerosol particle mass analyzer (ES-DMA/APM) was demonstrated for development of metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle...
Article
A custom-built steam-based aerosol collector (SBAC) was developed to improve the detection limits in aerosol chemical analysis. The SBAC was coupled with wet chemical analytical instruments to characterize the chemical composition of ambient particulate matter with high-time resolution. The particulate matter was mixed with a jet of steam and forme...
Article
Virtual impactors can be used as aerosol concentrators as well as particle size classifiers. The flow field and particle trajectory inside a linear slit-type virtual impactor were investigated using a commercial computational fluid dynamics software package. Effects of flow and slit geometry, including the inlet flow (Q in ), the ratio of minor to...
Article
Full-text available
Traffic emission is responsible for most small-sized particulate matter (PM) air pollution in urban areas. Several recent studies have indicated that traffic-related PM may aggravate kidney disease. Furthermore, exposure to particulate air pollution may be related to the risk of chronic kidney disease (CKD). However, the underlying molecular mechan...
Article
The aim of this study is to assess the offshore wind and solar power and to determine whether the future power supply in Taiwan will be stable. The estimated annual offshore wind and solar power generation for 2030 are 11343 GWh and 11367 GWh, respectively. Based on these results, it appears that the annual power supply can easily help balance the...
Article
Full-text available
Background: Effects of air pollution on neurotoxicity and behavioral alterations have been reported. The objective of this study was to investigate the pathophysiology caused by particulate matter (PM) in the brain. We examined the effects of traffic-related particulate matter with an aerodynamic diameter of < 1 μm (PM1), high-efficiency particula...
Article
This study investigated the effects of pollution emissions on the bioreactivity of PM2.5 during Asian dust periods. PM2.5 during the sampling period were 104.2 and 85.7 μg m⁻³ in Xi'an and Beijing, respectively, whereas PM2.5 which originated from the Tengger Desert was collected (dust background). Pollution conditions were classified as non-dust d...
Article
Full-text available
The objective of this study was to identify hazards that occur due to surgical practices and assess exposure to surgical smoke. We investigated nine surgical specialties in their corresponding operating rooms (ORs) for on-line measurements of pollutants and off-line determination of PAHs. Surgery for the face and dentistry generated the smallest pa...
Article
Full-text available
The performance (i.e., cyclone pressure drop and particle penetration curve) of small cyclones with conical contraction bodies was investigated, with the cyclone used either as the size-selective inlet of a miniature/compact particle sensor/monitor or as a personal particle sampler. Prototype cyclones having inner bodies with conical contraction an...
Article
Full-text available
Effective density is a crucial parameter used to predict the transport behaviour and fate of particles in the atmosphere, and to measure instruments used ultimately in the human respiratory tract (Ristimäki et al., 2002). The aerosol particle mass analyser (APM) was first proposed by Ehara et al. (1996) and is used to determine the effective densit...
Article
Full-text available
Effective density is a crucial parameter used to predict the transport behaviour and fate of particles in the atmosphere, and for measuring instruments used ultimately in the human respiratory tract (Ristimäki et al., 2002). The aerosol particle mass analyser (APM) was first proposed by Ehara et al. (1996) and is used to determine the effective den...
Article
The association between short-term exposure to particulate air pollution, especially fine particles, and cardiopulmonary health has been well-established in previous studies. However, previous findings regarding the effect of ultrafine particles (UFPs) on cardiopulmonary health are inconsistent. We repeatedly measured the mass concentrations of UFP...
Article
Full-text available
The present study utilizes air quality modeling to probe the sources and characteristics of PM2.5 (particles less than 2.5 micrometers in aerodynamic diameter) at the northern tip of Taiwan (CAFE station) in the early stage of the Asian haze period. Since CAFE is the first place that is influenced by the Asian haze coming from the north, this study...
Article
Full-text available
We demonstrate a new, facile gas-phase electrostatic approach to successfully quantify equivalent surface area of gra-phene oxide (GO) colloid on a number basis. Mobility diameter (dp,m)-based distribution and the corresponding equiva-lent surface area (SA) of GO colloids (i.e., with different lateral aspect ratios) were able to be identified by el...
Article
Sleep disorders may pose a risk to workers in the workplace. We aimed to investigate the associations between metal fume fine particulate matter (PM2.5) and sleep quality in workers. We assessed the effects of personal exposure to metal fume PM2.5 on lung functions, urinary biomarkers, and sleep quality in shipyard welding workers. In total, 96 wel...