Sylvie RapiorUniversité de Montpellier | UM1 · Faculté de Pharmacie Laboratoire de Botanique Phytochimie et Mycologie - UMR 5175 CEFE
Sylvie Rapior
Pharmacist, Thesis ès Pharmaceutical Science
Research respond to the 3 major societal challenges: Protect the resources, Feeding the populations, Caring the peoples
About
530
Publications
400,303
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Introduction
My research acts in Life Sciences, Health Care, Biodiversity, Environment, Agriculture, Chemical Ecology finding bioactive compounds, chemotaxonomical markers, mycotoxins, polyphenols, volatile organic compounds from plants and fungi: Extraction, purification, identification, analytical chromatography, NMR, Biological screening.
Keywords: Abietane – Agaricus – Amatoxin – Antioxidant – Antiproliferative – Asplenioideae – Auricularia – Bacteria – Beer – Biodiversity – Boletales – Brunneopicti – Cancer – Cortinarius – Crotalaria – Diabetes – Dryopteris – Fern – Fomes – Fumonisin – Fungi – Geosmin – Hericium – Horsetail – Medicinal Mushroom – Methylobacterium – Mushroom poisoning – Orellanine – Pollen – Polyphenol – Polyporus – Pteridaceae – Rosmarinus – Shiitake – Volatile Organic Compound
Additional affiliations
January 2015 - present
Position
- Professor (Full)
Description
- Botany and Mycology • Identification of plants and macrofungi using morphological and microscopic characters • Identification of morphological related mushroom species to prevent poisonings • Medicinal mushrooms (medicine, food supplements)
June 2011 - June 2011
Position
- Functional phylogenetics of useful microorganisms: Agaricus homobasidiomycetes, biodiversity evaluation, chemical analysis and preservation for human benefits.
Description
- PHC SIAM 2011 Program in Higher Education and Research, Ministry of Education - De Silva et al., 2012a..Fungal Diversity, 55,1-35 - De Silva et al,.,2012b. Fungal Diversity, 56,1-29 - De Silva et al., 2013. Fungal Diversity, 62, 1-40.
September 2005 - present
Position
- Managing Director
Description
- Plants and macrofungi identification. Mushroom poisoning prevention. Identification of primary and secondary metabolites by TLC, HPTLC, OPLC, CC, HPLC. Chemical and biological activity screening of plant and mushroom materials.
Education
October 1990 - September 1992
Plant Research Centre, Agriculture Canada / Carleton University
Field of study
- Fumonisin production by Fusarium moniliforme liquid cultures (Miller et al.,1993. Mycologia, 85, 385-391; Miller et al. 1994. Natural Toxins, 2, 354-359).
October 1983 - September 1988
Faculty of Pharmaceutical Sciences – University Montpellier 1 (France).
Field of study
- Mycology, Mushroom Poisoning, Mycochemistry, Orellanine, Cortinarius (Andary et al. 1989. Lancet, 213; Rapior et al., 1989. Mycopathol., 108, 155-160; Delpech et al., 1990. Presse Méd., 19 (3), 122-124)
October 1981 - September 1983
Faculty of Pharmaceutical Sciences – University Montpellier 1
Field of study
- DEA Chimie thérapeutique (= M Sc). Isolation and structure of orellanine derivatives from Cortinarius orellanus (Andary et al.,1986. Cryptog Mycol., 7, 189-200; Rapior and Andary. 1988; Doc. Mycol.,19 (73), 37-42; Rapior.1989. Doc. Mycol., 20 (77), 25-50)
Publications
Publications (530)
DOI 10.1007/s11557-015-1105-4. Online
Medicinal mushrooms have become a compelling topic because the bioactive compounds they contain promise a plethora of therapeutic properties. Hericium erinaceus commonly known as “Houtou” or “Shishigashira” in China and “Yamabushitake” in Japan, has commonly been prescribed in Traditional Chinese Medicine (TCM)...
Amatoxin-containing mushroom poisonings are recorded worldwide and the frequency increases due to confusion with other macrofungi. Affected regions are characterized by important disparities in relation to available technological equipment for analytical identification of amatoxins. In this context the present study was designed to define advantage...
Fungi are an understudied, biotechnologically valuable group of organisms. Due to the immense range of habitats that
fungi inhabit, and the consequent need to compete against a diverse array of other fungi, bacteria, and animals, fungi have
developed numerous survival mechanisms. The unique attributes of fungi thus herald great promise for their ap...
Resistance to apoptosis stands as a roadblock to the successful pharmacological execution of anticancer drug effect. A comprehensive insight into apoptotic signaling pathways and an understanding of the mechanisms of apoptosis resistance are crucial to unveil new drug targets. At this juncture, researchers are heading towards natural sources in par...
Le syndrome phalloïdien est le toxidrome mycotoxique survenant après l’ingestion de certaines espèces de macromycètes, des genres Amanita, Lepiota et Galerina. Amanita phalloides est l’espèce la plus souvent en cause, responsable de plus de 90 % des décès dus à la consommation de champignons. L’alpha-amanitine est responsable de la plupart des effe...
Cavalli M., Fons F. et Rapior S. Approche mycothérapeutique prospective du trouble dépressif par l’utilisation d’Hericium erinaceus. Annales de la Société d’Horticulture et d’Histoire Naturelle de l’Hérault, 162, 5-24 (2023). ___
Le trouble dépressif est une pathologie commune, multifactorielle, polymorphe, et dont le traitement s'avère parfois di...
We selected polypore mushrooms growing in the Mediterranean area of France to screen their antioxidant activity: Ganoderma applanatum, G. lucidum, Inonotus cuticularis, I. hispidus, Trametes hirsuta, and T. versicolor. Our work also evaluated antioxidant capacity from wild and cultivated G. lucidum fruiting bodies to
optimize this biological proper...
Interest in edible and medicinal macrofungi is millennial in terms of their uses in health and food products in Central Asia, while interest in inedible and medicinal macrofungi has grown in popularity in recent years. Edible and inedible medicinal basidiomycetes were collected during field surveys from different regions of Uzbekistan. The morpholo...
Fuscoporia contigua (Pers.) G. Cunn.; Fuscoporia torulosa (Pers.) T. Wagner & M. Fisch. - HYMENOCHAETACEAE
Stereum hirsutum (Willd.) Pers.; Stereum rugosum Pers. - STEREACEAE
Morchella esculenta (L.) Pers.; Morchella steppicola Zerova - MORCHELLACEAE
Sarcodon imbricatus (L.) P. Karst. - BANKERACEAE
Ganoderma adspersum (Schulzer) Donk; Ganoderma applanatum (Pers.) Pat.; Ganoderma lucidum (Curtis) P. Karst.; Ganoderma resinaceum Boud. - GANODERMATACEAE
Lentinus arcularius (Batsch) Zmitr.; Lentinus brumalis (Pers.) Zmitr.; Lentinus ciliatus (Fr.) Zmitr.; Lentinus squarrosulus Mont.; Lentinus tigrinus (Bull.) Fr. - POLYPORACEAE
Laetiporus sulphureus (Bull.) Murrill - FOMITOPSIDACEAE
Cerrena unicolor (Bull.) Murrill - CERRENACEAE
Irpex lacteus (Fr.) Fr. - IRPICACEAE
Auricularia mesenterica (Dicks.) Pers. - AURICULARIACEAE
Flammulina velutipes (Curtis) Singer - PHYSALACRIACEAE
Phellinus igniarius (L.) Quél.; Phellinus pomaceus (Pers.) Maire; Phellinus tremulae (Bondartsev) Bondartsev & P.N. Borisov - HYMENOCHAETACEAE
Trametes betulina (L.) Pilát.; Trametes cinnabarina (Jacq.) Fr.; Trametes gibbosa (Pers.) Fr.; Trametes hirsuta (Wulfen) Lloyd; Trametes pubescens (Schumach.) Pilát; Trametes suaveolens (L.) Fr.; Trametes versicolor (L.) Lloyd - POLYPORACEAE
Fomes fomentarius (L.) Fr. - POLYPORACEAE
Schizophyllum commune Fr.- SCHIZOPHYLLACEAE
Fomitopsis betulina (Bull.) B.K. Cui, M.L. Han & Y.C. Dai; Fomitopsis pinicola (Sw.) P. Karst. - FOMITOPSIDACEAE
Coprinus comatus (O.F. Müll.) Pers. - AGARICACEAE
Lepista irina (Fr.) H.E. Bigelow; Lepista nuda (Bull.) Cooke - TRICHOLOMATACEAE
Cerioporus squamosus (Huds.) Quél.; Cerioporus leptocephalus (Fr.) Zmitr. & Kovalenko - POLYPORACEAE
Fomitiporia hippophaeicola (H. Jahn) Fiasson & Niemelä; Fomitiporia punctata (P. Karst.) Murrill; Fomitiporia robusta (P. Karst.) Fiasson & Niemelä - HYMENOCHAETACEAE
Pleurotus eryngii (DC.) Quél.; Pleurotus ostreatus (Jacq.) P. Kumm. - PLEUROTACEAE
Funalia trogii (Berk.) Bondartsev & Singer - POLYPORACEAE
Laricifomes officinalis (Vill.) Kotl. & Pouzar - FOMITOPSIDACEAE
Grifola frondosa (Dicks.) Gray - GRIFOLACEAE
Agaricus bisporus (J.E. Lange) Imbach; Agaricus campestris L.; Agaricus xanthodermus Genev. - AGARICACEAE
Sanghuangporus lonicerinus (Bondartsev) Sheng H. Wu, L.W. Zhou & Y.C. Dai - HYMENOCHAETACEAE
Bjerkandera adusta (Willd.) P. Karst.; Bjerkandera fumosa (Pers.) P. Karst. - MERULIACEAE
Fungi provide ecological and environmental services to humans, as well as health and nutritional benefits, and are vital to numerous industries. Fermented food and beverage products from fungi are circulating in the market, generating billions of USD.
However, the highest potential monetary value of fungi is their role in blue carbon trading becaus...
Le trouble dépressif est une pathologie commune, multifactorielle, polymorphe, et dont le traitement s’avère parfois difficile. Dans un contexte où la santé mentale devient une préoccupation de santé publique majeure, il est essentiel de disposer d’un arsenal thérapeutique complet, au sein duquel la mycothérapie pourrait bientôt s’imposer. Cette th...
Several human diseases, such as diabetes, cancer, cardiovascular and neurodegenerative disorders, increasingly affect the adult population worldwide. Therefore, scientists have tried to discover new natural sources of medicines, especially from mushrooms, to prevent and treat these diseases. Wild mushrooms and mushrooms growing on solid media or in...
Mahesh C.A. Galappaththi, Nimesha M. Patabendige, Bhagya M.
Premarathne, Kalani K. Hapuarachchi, Saowaluck Tibpromma, Dong-Qin Dai,
Nakarin Suwannarach, Sylvie Rapior, Samantha C. Karunarathna.
A review of Ganoderma triterpenoids and their bioactivities.
Biomolecules, Special Issue Fungal Metabolism - Enzymes and Bioactive Compounds
II, 13 (1)...
Niego A.G.T., Rapior S., Thongklang N., Raspé O., Hyde K.D., Mortimer P.
Reviewing the contributions of macrofungi to forest ecosystem processes and services.
Fungal Biology Reviews, 44, June, 100294 (2023). doi:10.1016/j.fbr.2022.11.002. hal-03891167 ____
Macrofungi are vital components of any forest ecosystem, performing different roles
crucial...
Solanum is the largest genus in the family Solanaceae with about 2500 identified species
worldwide distributed, except Antarctica. This genus is regarded as economically significant
based on their multiple uses in food crops as well as ornamental and medicinal plants. In
Uzbekistan, about 24 species of Solanaceae have been reported and of these, 7...
Long-term responses in the phenology of Mediterranean macrofungi to climatic changes are poorly documented. Here, we address this issue by comparing the fruiting patterns of 159 fungal species in Southern France between the first half of the 19th century and the first decade of the 21st century. We used a trait-based approach to assess the influenc...
La mission humanitaire à la frontière entre la Pologne et l’Ukraine pour un futur Docteur en Pharmacie a été établie en très peu de temps voire en quelques jours. Nous avons pu récolter un grand nombre de dons. Les partenaires et les membres de différentes communautés se sont également mobilisés pour nous permettre de rallier Medyka. Sur une base d...
Le ganoderme luisant est considéré, en Asie, dès les dynasties mythiques puis impériales chinoises comme une panacée, d’une part à cause de sa rareté, mais aussi grâce à ses nombreuses vertus décrites dans les anciens ouvrages. L’identification et les recherches sur ce champignon ont été longtemps difficiles à cause de sa rareté dans la nature. Cep...
Second ProofHeading (revised on May 26th, 2022). In Europe, amatoxin-containing mushrooms are responsible for most of the deadly poisonings caused by macrofungi. The present work presents a multidisciplinary revision of the European species of Amanita sect. Phalloideae based on morphology, phylogeny, epidemiology, and biochemistry of amatoxins and...
An error occurred in the key : 1. KOH reaction none or only pale cream yellow . . . . . 5 [not 3]
2. Stipe smooth. Ring complete, not lacerated at maturity, membranous, persistent on stipe, made up of mostly filamentous hyphae .. . . . . . . . . . . . . . 3 [not 5]
We all apologize for this mistake.
Badalyan S.M., Barkhudaryan A. et Rapior S.
Medicinal macrofungi as cosmeceuticals: A review.
International Journal of Medicinal Mushrooms, 24 (4), 1-13 (2022). doi:10.1615/IntJMedMushrooms.2022043124. hal-03633501
_____Macrofungi (mushrooms) have been studied for their nutritional value and medicinal properties. However,
progress in the biotechn...
A good quality of life requires maintaining adequate skeletal muscle mass and strength, but therapeutic agents are lacking for this. We developed a bioassay-guided fractionation approach to identify molecules with hypertrophy-promoting effect in human skeletal muscle cells. We found that extracts from rosemary leaves induce muscle cell hypertrophy....
Schizophyllum commune est un champignon basidiomycète faisant partie de la famille des Schizophyllaceae. Il possède une large répartition géographique due, d’une part, au grand nombre de substrats ligneux sur lesquels il peut se développer, et d’autre part, à sa grande résistance aux stress environnementaux et à sa xéro-tolérance découlant de sa mo...
Macrofungi production and economic value have been increasing globally. The demand for macrofungi has expanded rapidly owing to their popularity among consumers, pleasant taste, and unique flavors. The presence of high quality proteins, polysaccharides, unsaturated fatty acids, minerals, triterpene sterols, and secondary metabolites makes macrofung...
Badalyan S.M. et Rapior S. Agaricomycetes mushrooms (Basidiomycota) as potential neuroprotectants. Italian Journal of Mycology, 50, 30-43 (2021). doi:10.6092/issn.2531-7342/12542 _______
The edible and medicinal agaricoid and polyporoid mushrooms (phylum Basidiomycota, order Agaricomycetes) have long been known by humans as valuable food and medici...
Diallo I., Morel S., Vitou M., Michel A., Rapior S., Traoré L., Poucheret P. et Fons F. Ergosterol and amino acids contents of culinary-medicinal Shiitake from various culture conditions. Proceedings (ISSN 2504-3900), 70, 78 (2021). doi:10.3390/foods_2020-07702 ; hal-03088931. ====> Abstract: Lentinus edodes (Shiitake) is an edible mushroom cultiva...
Several edible and medicinal Agaricomycetes mushrooms possess biologically active compounds with different therapeutic effects, such as anti-oxidative, anti-inflammatory, hypocholesterolemic, hypoglycemic, anti-hypertensive, fibrinolytic, thrombolytic, potentially used as cardioprotective remedies. Previous studies have shown that mushrooms possess...
INM : INNOVATIONS SCIENTIFIQUES, ECONOMIQUES ET REGLEMENTAIRES. 9ième conférence internationale sur les interventions non médicamenteuses. iCEPS CONFERENCE 2021, 01 et 02 avril 2021
La Plateforme universitaire CEPS de Montpellier et ses partenaires vous invitent à son 9e congrès international sur l’évaluation des Interventions Non Médicamenteuses...
Cannabis sativa est une espèce végétale dont l’utilisation est controversée en raison de la présence du tétrahydrocannabinol (THC) psychoactif [1]. Cependant, il produit également une autre molécule, le cannabidiol (CBD) aux diverses applications thérapeutiques. En effet, au CBD sont attribuées des propriétés analgésique, antiémétique ou encore ant...
Numerous Plantago species (plantains) are worldwide distributed. Several of them, i.e., Plantago afra L., P. arenaria Waldst. & Kit., P. asiatica L., P. lanceolata L., P. major L. and P. ovata Forssk. are well-known as anti-inflammatory, antioxidant, expectorant and immunomodulatory natural resources [1]. Indeed, they are used in traditional medici...
El Khatib N., Morel M., Hugon G., Rapior S., Carnac G. et Saint N.
Identification of a sesquiterpene lactone from Arctium lappa leaves with antioxidant activity in primary human muscle cells. Molecules Special Issue Antioxidants from Natural Sources: Separation and
Characterization, 26 (5), 1328 (2021). doi:10.3390/molecules26051328. hal-03157239...
Badalyan S.M. et Rapior S. The neurotrophic and neuroprotective potential of macrofungi. In: Medicinal Herbs and Fungi – Neurotoxicity vs. Neuroprotection. Agrawal D.C. et Dhanasekaran M. (Eds). Publisher Springer. Chapter 2: 37-78 (2021). doi:10.1007/978-981-33-4141-8_2 ____ Diversity of wild and cultivated macrofungi as edible and medicinal mushr...
We selected seven wild Basidiomycota and Ascomycota mushrooms to evaluate their antibacterial activity: Cyclocybe aegerita, Cortinarius traganus, Gyroporus castaneus, Neoboletus luridiformis, Rubroboletus lupinus, Gyromitra esculenta, and Helvella crispa. Four mushrooms, three of which have not been tested to date, displayed antibacterial potential...
Badalyan S.M. et Rapior S. Agaricomycetes medicinal mushrooms with potential potential neuroprotective activity growing in rmenia.
Proceedings of the Yerevan State University, Chemistry and Biology, 54 (3), 196-203 (2020). hal-03090953 _____ The Agaricomycetes mushrooms (phylum Basidiomycota) are recognised sources of valuable food and medicines....
iceps e-Conference 2020 postponed to November 24-25th 2020 (Toulouse, France) _______
Poster 41: Pain, increase of body temperature, skin redness and swelling are the main symptoms of the inflammatory process. Inflammation is a well-known contributing factor to many age-related chronic diseases. Mycotherapy is one strategy to prevent or suppress
in...
iceps e-Conference 2020 postponed to November 24-25th 2020 (Toulouse, France) due to coronavirus _______
Poster 39: About two hundred Plantago species are worldwide distributed. Several Plantago species, i.e., P. asiatica, P. lanceolata, P. major and P. ovata are well-known as antibacterial, anti-inflammatory, antioxidant [1]. Indeed, they are used...
iceps e-conference 2020 postponed to November 24-25th 2020 (Toulouse, France) ___________
Poster 26 : Si la phytothérapie a depuis longtemps acquis ses lettres de noblesses, le champignon demeure le parent pauvre dans le domaine des soins naturels. Cependant, certaines espèces de champignons telle que le ganoderme luisant (Ganoderma lucidum) sont u...
https://bienvieillirinm.fr _______ Méthode : Nous avons conçu de manière collaborative un système permettant aux professionnels d’identifier les publications d’études interventionnelles évaluant des INM pour mieux-vieillir et aux chercheurs de partager leurs publications d’études. Ces études testent les bénéfices et les risques d’INM sur différents...
https://www.inmcancer.fr/ __________Connaître les publications d’études comparatives sur les INM en prévention et soin des cancers.
Open database of publications of interventional studies in cancer prevention and care on non-pharmacological interventions ===> Know the publications of comparative studies on non-pharmacological interventions in cance...
www.niri.fr_________NIRI as world directory of researchers and research organizations on non-pharmacological interventions. _______ Méthode : Nous avons conçu de manière collaborative un système numérique de Science Ouverte listant et cartographiant les chercheurs et les organismes ayant publié au moins une étude sur une INM dans une revue scientif...
Lentinus edodes (Shiitake) is an edible mushroom cultivated and marketed due to its nutritional and medicinal values (1). L. edodes is appreciated for its unique fragrant taste, its high dietetic potential is valuable for health and its bioactive molecules explain its interest as medicinal mushroom (1). This mushroom can be grown using various subs...
Badalyan S.M. et Rapior S. Perspectives of biomedical application of macrofungi. Current Trends in Biomedical Engineering & Biosciences, 19 (5), 556024 (2020). doi:10.19080/CTBEB.2020.19.556024
Current Trends in Biomedical Engineering & Biosciences (ISNN 2572-1151)______ Macrofungi (mushrooms) have widely been appreciated all over the world for the...
Lentinus edodes (= Lentinula edodes) is an edible mushroom grown and marketed for centuries due to its nutritional and medicinal properties. L. edodes has multiple pharmacological activities as antioxidant and anti-inflammatory. Few studies were performed
taking into account the influence of culture conditions to optimize the biological properties...
Bee, Human and Honey: Les abeilles et les Humains cohabitent sur la terre depuis que la race humaine est apparue. Depuis des siècles la biologie de ces insectes est étudiée par les scientifiques et les amoureux de la nature. Leur caractère besogneux et leur organisation en structure eusociale font d'Apis mellifera des insectes fascinants. Tous les...
Medicinal mushrooms have been used for several hundred years, mainly in Asian countries, for the treatment of various pathologies. More recently, they have been used in the treatment of cancer. As part of this thesis, we are particularly interested in the lingzhi mushroom (Ganoderma lucidum) also called immortality fungus, for its anticancer proper...
TITRE : Les composés organiques volatils chez les principales Thélyptéridacées françaises Froissard D., Rapior S., Bessière J.M., Buatois B., Morel S., Sol V. et Fons F. Les thélyptéridacées constituent une famille essentiellement tropicale représentée par seulement cinq espèces en Europe, dont quatre en France : Oreopteris limbosperma, Phegopteris...
Bandara A.R., Rapior S., Mortimer P.E., Kakumyan P., Hyde K.D. et Xu J. 2019. A review of the polysaccharide, protein and selected nutrient content of Auricularia, and their potential pharmacological value. Mycosphere 10 (1), 579-607. doi :10.5943/mycosphere/10/1/10_____Auricularia is a key genus among edible macrofungi, sourced as either wild or c...