Sylvie Belleville

Sylvie Belleville
Université de Montréal | UdeM · Department of Psychology

About

395
Publications
93,841
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13,530
Citations
Citations since 2016
168 Research Items
7251 Citations
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201620172018201920202021202202004006008001,0001,200
201620172018201920202021202202004006008001,0001,200

Publications

Publications (395)
Article
Objective: The story recall subtest of the Batterie d'Efficience Mnésique (BEM-144) is a verbal episodic memory test that assesses immediate and episodic memory. Variables such as age, sex, and education level can impact performance on this type of memory test, as can cultural differences. Therefore, the purpose of this study was to establish norma...
Presentation
Full-text available
Background: Recent studies have shown greater task-related activation in individuals with mild cognitive impairment (MCI) compared to healthy older adults. It has been suggested that these hyperactivations reflect compensatory processes of brain plasticity in the early phase of AD. When there is loss of structural integrity of a brain region that i...
Poster
Full-text available
Background and Objective. In older adults, executive functions are important for daily-life function and mobility. Evidence suggests that the relationship between cognition and mobility is dynamic and could vary according to individual factors, but whether cardiorespiratory fitness reduces the age-related increase of interdependence between mobilit...
Article
Full-text available
Multidomain interventions have shown tremendous potential for improving cognition in older adults. It is unclear if multidomain interventions can be delivered remotely and whether remote intervention is beneficial for older adults who are vulnerable or at risk of cognitive decline. In a 26-week multi-site, home-based, double-blind, randomized contr...
Article
Full-text available
Long-term use of urate-lowering therapies (ULT) may reduce inflammaging and thus prevent cognitive decline during aging. This article examined the association between long-term use of ULT and cognitive decline among community-dwelling older adults with spontaneous memory complaints. We performed a secondary observational analysis using data of 1673...
Article
The risk of developing Alzheimer’s disease (AD) dementia is higher in females compared to males and is greater in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) than in healthy controls (HC). We used a multivariate behavioral partial least square correlation (PLSC) analysis to examine how relationships betwe...
Article
Full-text available
Background Multidomain trials to prevent dementia by simultaneously targeting multiple risk factors with non-pharmacological lifestyle interventions show promise. Designing trials to evaluate the efficacy of individual interventions and their combinations is methodologically challenging. Determining the efficacy is, nevertheless, important to indiv...
Article
Full-text available
Background In recent years, cognitive training has gained popularity as a cost-effective and accessible intervention aiming at compensating for or even counteracting age-related cognitive declines during adulthood. Whereas the evidence for the effectiveness of cognitive training in general is inconsistent, processing speed training has been a notab...
Article
Full-text available
Brain maintenance refers to the fact that some older adults experience few age-related changes in the brain, which helps maintain their cognition. The goal of this study was to assess maintenance of white matter integrity by testing whether reserve proxies, measuring factors associated to a stimulating lifestyle, affect the maintenance of white mat...
Article
Introduction: Potentially inappropriate medication prescribing (PIP) among older patients is associated with an increased risk of adverse events and hospitalization, and sometimes increased healthcare costs. Objective: The aim of this study was to explore the association between healthcare costs and PIP exposure among older patients. Methods:...
Article
Background Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are suggested to play a role in the prevention of cognitive decline. The evidence may be inconsistent due to methodological issues including interrelations with other long-chain (14 or more carbons) fatty acids (LCFAs) and use of sex as a confounding factor rather than an effect modifier....
Article
Full-text available
Increasing evidence associates apathy with worsening in cognitive performance and greater risk of dementia, in both clinical and healthy older populations. In older adults with neurocognitive disorders, apathy has also been related to specific fronto-subcortical structural abnormalities , thus differentiating apathy and major depressive disorder. Y...
Article
We investigated combining a core AD neuropathology measure (plasma amyloid-beta [Aβ] 42/40) with five plasma markers of inflammation, cellular stress, and neurodegeneration to predict cognitive decline. Among 401 participants free of dementia (median [IQR] age, 76 [73–80] years) from the Multidomain Alzheimer Preventive Trial (MAPT), 28 (7.0%) part...
Article
The goal of this study was to identify the brain mechanisms underlying cognitive reserve using a parametric n-back working memory (WM) task in a sample of healthy older adults. We first identified the WM-related activations associated with years of education and then tested whether these activations mitigated the detrimental impact of age on cognit...
Article
Full-text available
Background: Little is known regarding the dose-response function in multidomain interventions for dementia prevention. Method: The Multidomain Alzheimer Preventive Trial is a 3-year randomized controlled trial comprising cognitive training, physical activity, nutrition, and omega-3 polyunsaturated fatty acids for at-risk older adults. The dose d...
Article
Full-text available
Objectives: Immersive virtual reality has tremendous potential to improve cognition in populations with cognitive impairment. We conducted a feasibility and proof-of-concept study to assess the potential of virtual reality and electroencephalography, with or without an intelligent agent, that adapts the presented material to the emotions elicited b...
Article
Full-text available
Background Monocyte Chemoattractant Protein-1 (MCP-1), a glial-derived chemokine, mediates neuroinflammation and may regulate memory outcomes among older adults. We aimed to explore the associations of plasma MCP-1 levels (alone and in combination with β-amyloid deposition—Aβ 42/40 ) with overall and domain-specific cognitive evolution among older...
Article
Full-text available
Introduction: During the COVID-19 pandemic, confinement measures are likely to produce collateral damage to health (stress, confusion, anxiety), especially in frail individuals and those living with cardiovascular disease (CVD). In cardiac patients in particular, these measures dramatically increase the level of physical inactivity and sedentary li...
Article
There is increasing evidence that modifiable lifestyle factors account for around 40% of worldwide dementia cases. Given the multifactorial etiology of dementia, multidomain lifestyle interventions have generated major interest. Results from randomized controlled trials (RCTs) suggest that implementing multidomain interventions in at‐risk individua...
Article
BACKGROUND. The SYNERGIC trial (SYNchronizing Exercises, Remedies in GaIt and Cognition), a large multi-site randomized controlled trial (RCT), showed promising interim results that individuals with Mild Cognitive Impairment (MCI) who received aerobic exercise combined with progressive resistance training and cognitive training improved their globa...
Article
Full-text available
Dose is a critical factor examined in pharmacological treatment. However, little is known about the optimal dosage for non‐pharmacological multidomain interventions as well as the function that relates dose to improvement. These gaps have been assessed in this present study in interaction with individual characteristics, which may moderate the effe...
Article
Cognitive training was found to have a positive effect on the memory of healthy older adults, including long‐term benefits (Rebok et al, 2014). This finding offers hope that cognitive training could contribute to prevention approaches. However, little is known regarding the long‐term benefits of cognitive training in older adults with mild cognitiv...
Article
Objectives This study evaluated the impact of a 12-week, 24-session multimodal group cognitive rehabilitation intervention, the Cognitive Enrichment Program (CEP), on executive functioning and resumption of daily activities after traumatic brain injury (TBI) in older individuals as compared with an active control group that received individual holi...
Article
Full-text available
Systematic reviews and meta-analyses are critical in health-related decision-making, and are considered the gold standard in research synthesis methods. However, with new trials being regularly published and with the development of increasingly rigorous standards of data synthesis, systematic reviews often require much expertise and long periods of...
Article
Full-text available
Background: In the context of the COVID-19 pandemic, lockdown and social distancing measures are applied to prevent the spread of the virus. It is well known that confinement and social isolation can have a negative impact on physical and mental health, including cognition. Physical activity and cognitive training can help enhance older adults’ cog...
Article
Full-text available
Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and cognitive decline in older adults are still limited. 504 older adults (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer’s Preventive Trial (MAPT) and were c...
Article
Background: The presence of subjective cognitive complaints (SCCs) is a core criterion for diagnosis of subjective cognitive decline (SCD); however, no standard procedure for distinguishing normative and non-normative SCCs has yet been established. Objective: To determine whether differentiation of participants with SCD according to SCC severity...
Preprint
Full-text available
Brain maintenance refers to the fact that some older adults experience few age-related changes in the brain, which helps maintain their cognition. Objectives. The goals of this study are to assess maintenance of white matter integrity, test whether lifestyle factors affect the maintenance of white matter integrity, and measure whether maintenance o...
Article
Full-text available
In this proof-of-concept study, we assessed the potential for immersive virtual reality (VR) to measure transfer following strategic memory training, and whether efficacy and transfer are increased when training is complemented by practice in an immersive virtual environment. Forty older adults with subjective memory complaints were trained with th...
Article
Full-text available
Introduction: Brain activation is hypothesized to form an inverse U-shape in prodromal Alzheimer’s disease (AD), with hyperactivation in the early phase, followed by hypoac- tivation. Methods: Using task-related functional magnetic resonance imaging (fMRI), we tested the inverse U-shape hypothesis with polynomial regressions and between-group compa...
Article
Full-text available
Introduction Cognitive reserve can be defined as a property of the brain that enables an individual to sustain cognitive performance in spite of age-related neural changes. This study uses brain imaging to identify which cognitive reserve mechanisms protect against the detrimental effect of hippocampal atrophy on associative memory. Methods The st...
Article
Full-text available
Background: Working memory (WM) capacity declines with advancing age, which impacts the ability to carry out complex cognitive activities in everyday life. Updating and inhibition processes have been identified as some of the most critical attentional control processes of WM and are linked to age-related WM decline. The general aim of the Attention...
Article
Full-text available
Epidemiological studies have revealed that behavioral and psychological (or non-cognitive) symptoms are risk factors for cognitive decline in older adults. This study aimed to systematically review the literature and determine which behavioral and psychological symptoms are most predictive of future cognitive decline among individuals with no pre-e...
Conference Paper
Background: Individuals with the Val/Val homozygous variation of the catechol‐O‐methyltransferase (COMT) gene possess lower prefrontal dopaminergic levels than Met/‐carriers and show more pronounced age‐related cognitive impairment (Papenberg et al., 2015). The aim of this study was to examine the impact of the COMT genotype profile on the transfer...
Article
Full-text available
Prior studies have reported that older adults can benefit from formal educational programs about dementia. Participating in an online educational program focusing on risk and protective factors could potentially increase participants’ dementia literacy, empowerment, and engagement in brain health promotion, which in turn could reduce their dementia...
Poster
Presence of significant subjective complaints about cognition (SCD) is considered the first behavioral manifestation of Alzheimer disease (AD). However, SCD has not yet overcome the challenge of becoming a reliable preclinical AD marker. Severity indices were proposed to improve the accuracy of complaints when predicting the risk of AD (Jessen et a...
Article
The Canadian Consortium on Neurodegeneration in Aging (CCNA) was founded in 2014 to bring together Canada's dementia research community to work together in a more synergistic manner to catalyze new important progress in dementia research in Canada. Teams are funded to work on questions and themes from basic science to clinical work. An important ne...
Article
Hyperactivation is commonly observed in prodromal Alzheimer’s disease (AD). It is however unknown if it relates to functional network dysfunction, and how hyperactivation‐networks relate to cognitive impairment. We used seed‐based connectivity to assess differences in correlations between activation of hyperactive regions, whole‐brain task‐related...
Article
Full-text available
Background: To prevent age-related cognitive impairment, many intervention programs offer exercises targeting different central cognitive processes. However, the effects of different process-based training programs are rarely compared within equivalent experimental designs. Objective: Using a randomized double-blind controlled trial, this project...
Article
Full-text available
The Fifth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD-5) was a year-long process to synthesize the best available evidence on several topics. Our group undertook evaluation of risk reduction, in eight domains: nutrition; physical activity; hearing; sleep; cognitive training and stimulation; social engagement and...
Article
Objectives This study examined the effect of dietary patterns and engagement in cognitive stimulating lifestyle (CSL) behaviors on the trajectory of global cognition, executive function (EF), and verbal episodic memory (VEM). Methods Western and prudent dietary patterns were empirically derived using food frequency questionnaire responses from 350...
Chapter
Full-text available
Studies support cognitive training as a potentially efficient method to postpone cognitive decline in persons with mild cognitive impairment (MCI). Virtual reality (VR) based serious games have found application in this field due to high level of immersion and interaction possible with the environment. We propose a fully immersive virtual reality 3...
Chapter
In an attempt to make the therapeutic aspect less aversive, more attractive and engaging, virtual reality, an increasingly popular application in healthcare, offers an interesting alternative to pharmacological treatments. Positive emotions may improve the cognitive abilities of people suffering from cognitive impairment. Virtual reality can provid...
Chapter
Alzheimer’s disease is characterised by a slow progression and by an extensive prodromal phase during which symptoms are dormant or very mild. The term mild cognitive impairment (MCI) has been used to refer to older adults who do not meet the criteria for dementia but who present cognitive complaints and whose cognitive abilities do not fall within...
Article
Full-text available
Objectives The main objective was to determine the trajectory of instrumental activities of daily living (iADL) decline in persons with mild cognitive impairment (MCI) who progressed towards dementia relative to persons with MCI who remained stable. Methods/Design At study entry, 121 participants met criteria for MCI. Based on the follow‐up, 47 pa...
Article
Full-text available
Background: In older adults, multidomain training that includes physical and cognitive activities has been associated with improvement of physical and cognitive health. The goal of the multisite StayFitLonger study is to assess a home-based computerised training programme, which combines physical exercises, stimulating cognitive activities and vir...
Presentation
Background: Interindividual differences in cognitive performance with age might result from an interaction between genes and modifiable factors. Cognitive training might represent one of the ways by which older adults with a disadvantaged profile can develop resilience later in life. Individuals with the homozygous Val/Val variation of the catechol...
Poster
Full-text available
Background: Individuals with the Val/Val homozygous variation of the catechol-O-methyltransferase (COMT) gene possess lower prefrontal dopaminergic levels than Met/-carriers and show more pronounced age-related cognitive impairment (Papenberg et al., 2015). The aim of this study was to examine the impact of the COMT genotype profile on the transfer...
Article
Full-text available
Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late‐onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Interventi...
Book
It is my pleasure to announce the publication of the book Music and the Aging Brain, edited by Lola Cuddy, Sylvie Belleville and myself. It benefits from the contribution of 30 internationally-renowned researchers in the field of music psychology/neurosciences and presents cutting-edge knowledge about the use of music for the prevention of cognitiv...
Preprint
Full-text available
Systematic reviews and meta-analyses are critical in health-related decision making, and are considered the gold standard in research synthesis methods. However, with new trials being regularly published and with the development of increasingly rigorous standards of data synthesis, systematic reviews often require much expertise and long periods of...
Preprint
Full-text available
Systematic reviews and meta-analyses are critical in health-related decision making, and are considered the gold standard in research synthesis methods. However, with new trials being regularly published and with the development of increasingly rigorous standards of data synthesis, systematic reviews often require much expertise and long periods of...
Article
Full-text available
Background: Consumption of a prudent dietary pattern rich in healthy nutrients is associated with enhanced cognitive performance in older adulthood, while a Western dietary pattern low in healthy nutrients is associated with poor age-related cognitive function. Sex differences exist in dietary intake among older adults; however, there is a paucity...
Presentation
L'objectif de cette étude était d'examiner l'impact des variations génétiques de la catéchol-O-méthyltransférase (COMT) sur l'effet d'entraînement de la mémoire de travail (MdT) chez les personnes âgées. Soixante adultes âgés de 60 à 82 ans ont été aléatoirement assignés à un programme informatisé d’entraînement de la mémoire de travail (Inhibition...
Article
Full-text available
Introduction: Cognitive decline and dementia significantly affect independence and quality of life in older adults; therefore, it is critical to identify effective cognition-oriented treatments (COTs; eg, cognitive training, rehabilitation) that can help maintain or enhance cognitive functioning in older adults, as well as reduce dementia risk or...
Chapter
Patients suffering from Alzheimer’s Disease (AD) exhibit an impairment in performing tasks related to spatial navigation. Tasks which require navigational skills by building a cognitive map of the surrounding are found effective in cognitive training. In this paper we investigated the effect of cognitive training using a fully immersive 3D VR orien...
Chapter
Full-text available
With Alzheimer’s disease becoming more prevalent, finding effective treatment is imperative. While no pharmacological treatment has yet proven to be efficient, we explore how technology can be integrated into non-pharmacological intervention to enhance its benefits. We propose a new and unique version of Music Therapy, an already existing therapy k...
Preprint
Full-text available
Background: Consumption of a prudent dietary pattern rich in healthy nutrients is associated with enhanced cognitive performance in older adulthood, while a Western dietary pattern low in healthy nutrients is associated with poor age-related cognitive function. Sex differences exist in dietary intake among older adults; however, there is a paucity...
Preprint
UNSTRUCTURED Background: To prevent age-related cognitive impairment, many intervention programs offer exercises targeting different central cognitive processes. However, the effects of different process-based training programs are rarely compared within equivalent experimental designs. Using a randomized double-blind controlled trial, this project...